UniProtKB - Q92990 (GLMN_HUMAN)

BLAST

>sp|Q92990|GLMN_HUMAN Glomulin OS=Homo sapiens OX=9606 GN=GLMN PE=1 SV=2
MAVEELQSIIKRCQILEEQDFKEEDFGLFQLAGQRCIEEGHTDQLLEIIQNEKNKVIIKN
MGWNLVGPVVRCLLCKDKEDSKRKVYFLIFDLLVKLCNPKELLLGLLELIEEPSGKQISQ
SILLLLQPLQTVIQKLHNKAYSIGLALSTLWNQLSLLPVPYSKEQIQMDDYGLCQCCKAL
IEFTKPFVEEVIDNKENSLENEKLKDELLKFCFKSLKCPLLTAQFFEQSEEGGNDPFRYF
ASEIIGFLSAIGHPFPKMIFNHGRKKRTWNYLEFEEEENKQLADSMASLAYLVFVQGIHI
DQLPMVLSPLYLLQFNMGHIEVFLQRTEESVISKGLELLENSLLRIEDNSLLYQYLEIKS
FLTVPQGLVKVMTLCPIETLRKKSLAMLQLYINKLDSQGKYTLFRCLLNTSNHSGVEAFI
IQNIKNQIDMSLKRTRNNKWFTGPQLISLLDLVLFLPEGAETDLLQNSDRIMASLNLLRY
LVIKDNENDNQTGLWTELGNIENNFLKPLHIGLNMSKAHYEAEIKNSQEAQKSKDLCSIT
VSGEEIPNMPPEMQLKVLHSALFTFDLIESVLARVEELIEIKTKSTSEENIGIK

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History
Entry version 153 (07 Nov 2018)
Sequence version 2 (14 Nov 2003)
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Protein

Glomulin

Gene

GLMN

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Isoform 1: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924). Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature (PubMed:11845407). Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281).By similarity4 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

muscle cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11845407
negative regulation of T cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 12604780
neural tube closure Source: Ensembl
positive regulation of cytokine secretion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12604780
positive regulation of interleukin-2 biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12604780
positive regulation of phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 11571281
regulation of gene expression, epigenetic
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12604780
regulation of proteasomal ubiquitin-dependent protein catabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 22405651
vasculogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11845407

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	Q92990
SIGNORⁱ	Q92990

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glomulin Alternative name(s): FK506-binding protein-associated protein Short name: FAP FKBP-associated protein
Gene namesⁱ	Name:GLMN Synonyms:FAP481 Publication, FAP681 Publication, VMGLOM
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000174842.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14373 GLMN
MIMⁱ	601749 gene
neXtProtⁱ	NX_Q92990

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Glomuvenous malformations (GVMs)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionCharacterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_017241	393	Missing in GVMs; loss of interaction with CUL1 and RBX1. 2 Publications		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	219	P → A: Loss of interaction with FKBP4 and FKBP1A. 1 Publication	1
Mutagenesisⁱ	425	K → A: Disrupts interaction with RBX1. Loss of inhibition of SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase activity. 1 Publication	1
Mutagenesisⁱ	476	N → A: Disrupts interaction with RBX1. Loss of inhibition of SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase activity. 1 Publication	1
Mutagenesisⁱ	567	L → A: Disrupts interaction with RBX1. Loss of inhibition of SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase activity. 1 Publication	1
Mutagenesisⁱ	574	R → A: Disrupts interaction with RBX1. Loss of inhibition of SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase activity. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11146
MalaCards human disease database More...MalaCardsⁱ	GLMN
MIMⁱ	138000 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000174842
Orphanetⁱ	83454 Glomuvenous malformation
PharmGKBⁱ	PA134870088

Polymorphism and mutation databases

BioMutaⁱ	GLMN
DMDMⁱ	38372884

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000087513	2 – 594	GlomulinAdd BLAST		593

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Post-translational modificationⁱ

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q92990
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92990
PaxDbⁱ	Q92990
PeptideAtlas More...PeptideAtlasⁱ	Q92990
PRIDEⁱ	Q92990
ProteomicsDBⁱ	75652 75653 [Q92990-2]
TopDownProteomicsⁱ	Q92990-1 [Q92990-1]

PTM databases

iPTMnetⁱ	Q92990
PhosphoSitePlusⁱ	Q92990
SwissPalmⁱ	Q92990

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000174842 Expressed in 202 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_GLMN
ExpressionAtlasⁱ	Q92990 baseline and differential
Genevisibleⁱ	Q92990 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031446 HPA031448

HPAⁱ

HPA031446
HPA031448

Interactionⁱ

Subunit structureⁱ

Interacts with FKBP4 and FKBP1A (PubMed:8955134, PubMed:12604780, PubMed:11164950). Isoform 1: Interacts with RBX1 (via RING domain) (PubMed:22405651, PubMed:22748924). Identified in complexes that contain RBX1 plus one of the cullins CUL1, CUL2, CUL3, and CUL4A (PubMed:22405651, PubMed:22748924). Identified in a SCF complex composed of CUL1, RBX1, SKP1, FBXW7 and GLMN (PubMed:22405651). Component of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN (PubMed:12904573). Interacts with unphosphorylated MET and is released upon MET phosphorylation (PubMed:11571281).7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FKBP4	Q02790	3	EBI-726150,EBI-1047444
RBX1	P62877	4	EBI-726150,EBI-398523

GO - Molecular functionⁱ

hepatocyte growth factor receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11571281
ubiquitin protein ligase binding
Source: MGI
Inferred from direct assayⁱ
- 22405651

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116318, 85 interactors
CORUMⁱ	Q92990
IntActⁱ	Q92990, 14 interactors
STRINGⁱ	9606.ENSP00000359385

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	2 – 13	Combined sources	12
Helixⁱ	28 – 37	Combined sources	10
Beta strandⁱ	38 – 40	Combined sources	3
Helixⁱ	43 – 49	Combined sources	7
Helixⁱ	55 – 60	Combined sources	6
Helixⁱ	62 – 65	Combined sources	4
Helixⁱ	66 – 74	Combined sources	9
Beta strandⁱ	80 – 82	Combined sources	3
Helixⁱ	84 – 96	Combined sources	13
Helixⁱ	99 – 101	Combined sources	3
Helixⁱ	102 – 106	Combined sources	5
Helixⁱ	107 – 110	Combined sources	4
Helixⁱ	115 – 117	Combined sources	3
Helixⁱ	118 – 135	Combined sources	18
Helixⁱ	140 – 156	Combined sources	17
Helixⁱ	173 – 192	Combined sources	20
Helixⁱ	199 – 222	Combined sources	24
Helixⁱ	236 – 250	Combined sources	15
Beta strandⁱ	251 – 253	Combined sources	3
Helixⁱ	255 – 257	Combined sources	3
Helixⁱ	283 – 294	Combined sources	12
Turnⁱ	298 – 302	Combined sources	5
Helixⁱ	309 – 324	Combined sources	16
Helixⁱ	329 – 344	Combined sources	16
Helixⁱ	353 – 357	Combined sources	5
Helixⁱ	359 – 374	Combined sources	16
Helixⁱ	378 – 394	Combined sources	17
Helixⁱ	397 – 411	Combined sources	15
Helixⁱ	414 – 430	Combined sources	17
Turnⁱ	440 – 442	Combined sources	3
Helixⁱ	444 – 453	Combined sources	10
Turnⁱ	457 – 461	Combined sources	5
Turnⁱ	464 – 466	Combined sources	3
Helixⁱ	468 – 484	Combined sources	17
Turnⁱ	487 – 489	Combined sources	3
Helixⁱ	494 – 496	Combined sources	3
Helixⁱ	498 – 504	Combined sources	7
Helixⁱ	506 – 533	Combined sources	28
Helixⁱ	553 – 555	Combined sources	3
Helixⁱ	556 – 581	Combined sources	26

Show more details

3D structure databases

ProteinModelPortalⁱ	Q92990
SMRⁱ	Q92990
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 553	Alpha-helical region with structural similarity to HEAT repeats1 PublicationAdd BLAST		552
Regionⁱ	300 – 594	Important for interaction with RBX11 PublicationAdd BLAST		295

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	123 – 126	Poly-Leu		4
Compositional biasⁱ	273 – 278	Poly-Glu		6

Domainⁱ

The C-terminal half of the protein is important for interaction with RBX1.1 Publication

Phylogenomic databases

eggNOGⁱ	ENOG410IG4H Eukaryota ENOG410YJ4Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018446
HOGENOMⁱ	HOG000043079
HOVERGENⁱ	HBG044811
InParanoidⁱ	Q92990
OMAⁱ	YFLMLDL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G054M
PhylomeDBⁱ	Q92990
TreeFamⁱ	TF105319

Family and domain databases

InterProⁱ	View protein in InterPro IPR019516 Glomulin/ALF4 IPR013877 YAP-bd/ALF4/Glomulin
PANTHERⁱ	PTHR15430 PTHR15430, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08568 Kinetochor_Ybp2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q92990-1) [UniParc]FASTA Add to basket

Also known as: FAP68, FKBP-associated protein 68 kDa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVEELQSII KRCQILEEQD FKEEDFGLFQ LAGQRCIEEG HTDQLLEIIQ 
        60         70         80         90        100
NEKNKVIIKN MGWNLVGPVV RCLLCKDKED SKRKVYFLIF DLLVKLCNPK 
       110        120        130        140        150
ELLLGLLELI EEPSGKQISQ SILLLLQPLQ TVIQKLHNKA YSIGLALSTL 
       160        170        180        190        200
WNQLSLLPVP YSKEQIQMDD YGLCQCCKAL IEFTKPFVEE VIDNKENSLE 
       210        220        230        240        250
NEKLKDELLK FCFKSLKCPL LTAQFFEQSE EGGNDPFRYF ASEIIGFLSA 
       260        270        280        290        300
IGHPFPKMIF NHGRKKRTWN YLEFEEEENK QLADSMASLA YLVFVQGIHI 
       310        320        330        340        350
DQLPMVLSPL YLLQFNMGHI EVFLQRTEES VISKGLELLE NSLLRIEDNS 
       360        370        380        390        400
LLYQYLEIKS FLTVPQGLVK VMTLCPIETL RKKSLAMLQL YINKLDSQGK 
       410        420        430        440        450
YTLFRCLLNT SNHSGVEAFI IQNIKNQIDM SLKRTRNNKW FTGPQLISLL 
       460        470        480        490        500
DLVLFLPEGA ETDLLQNSDR IMASLNLLRY LVIKDNENDN QTGLWTELGN 
       510        520        530        540        550
IENNFLKPLH IGLNMSKAHY EAEIKNSQEA QKSKDLCSIT VSGEEIPNMP 
       560        570        580        590 
PEMQLKVLHS ALFTFDLIES VLARVEELIE IKTKSTSEEN IGIK

Length:594

Mass (Da):68,208

Last modified:November 14, 2003 - v2

Checksum:ⁱCE19050F1F692378

Isoform 2 (identifier: Q92990-2) [UniParc]FASTA Add to basket

Also known as: FAP48, FKBP-associated protein 48 kDa

The sequence of this isoform differs from the canonical sequence as follows:
406-417: CLLNTSNHSGVE → EHVTTNGLQDHS
418-594: Missing.

« Hide

        10         20         30         40         50
MAVEELQSII KRCQILEEQD FKEEDFGLFQ LAGQRCIEEG HTDQLLEIIQ 
        60         70         80         90        100
NEKNKVIIKN MGWNLVGPVV RCLLCKDKED SKRKVYFLIF DLLVKLCNPK 
       110        120        130        140        150
ELLLGLLELI EEPSGKQISQ SILLLLQPLQ TVIQKLHNKA YSIGLALSTL 
       160        170        180        190        200
WNQLSLLPVP YSKEQIQMDD YGLCQCCKAL IEFTKPFVEE VIDNKENSLE 
       210        220        230        240        250
NEKLKDELLK FCFKSLKCPL LTAQFFEQSE EGGNDPFRYF ASEIIGFLSA 
       260        270        280        290        300
IGHPFPKMIF NHGRKKRTWN YLEFEEEENK QLADSMASLA YLVFVQGIHI 
       310        320        330        340        350
DQLPMVLSPL YLLQFNMGHI EVFLQRTEES VISKGLELLE NSLLRIEDNS 
       360        370        380        390        400
LLYQYLEIKS FLTVPQGLVK VMTLCPIETL RKKSLAMLQL YINKLDSQGK 
       410 
YTLFREHVTT NGLQDHS

Show »

Length:417

Mass (Da):48,166

Checksum:ⁱEFA18B54B381E2AD

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

M0QXG8	M0QXG8_HUMAN	Glomulin Glomulin	GLMN	297	Annotation score:
M0QX84	M0QX84_HUMAN	Glomulin Glomulin	GLMN	245	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_061653	336	L → S. Corresponds to variant dbSNP:rs35258161EnsemblClinVar.		1
Natural variantⁱVAR_017241	393	Missing in GVMs; loss of interaction with CUL1 and RBX1. 2 Publications		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_008882	406 – 417	CLLNT…HSGVE → EHVTTNGLQDHS in isoform 2. 1 PublicationAdd BLAST		12
Alternative sequenceⁱVSP_008883	418 – 594	Missing in isoform 2. 1 PublicationAdd BLAST		177

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U73704 mRNA Translation: AAC50908.1 AJ347709 mRNA Translation: CAC69882.1 AJ302735 mRNA Translation: CAC82938.1 AJ302727 AJ302734 Genomic DNA Translation: CAC88124.1 AL451010 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW73098.1 BC001257 mRNA Translation: AAH01257.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS738.1 [Q92990-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001306612.1, NM_001319683.1 NP_444504.1, NM_053274.2 [Q92990-1] XP_011538848.1, XM_011540546.2 [Q92990-1]
UniGeneⁱ	Hs.49105

Genome annotation databases

Ensemblⁱ	ENST00000370360; ENSP00000359385; ENSG00000174842 [Q92990-1] ENST00000495106; ENSP00000436829; ENSG00000174842 [Q92990-2]
GeneIDⁱ	11146
KEGGⁱ	hsa:11146
UCSC genome browser More...UCSCⁱ	uc001dor.4 human [Q92990-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q92990	Uncharacterized protein		CHLSB		625	UniRef90_Q92990
Uncharacterized protein (Fragment)		AILME		600
glomulin isoform X1		Enhydra lutris kenyoni		600
glomulin isoform X1		URSMA		600
Uncharacterized protein		MUSPF		600
+94
Q92990-2	GLMN isoform 2		PONAB		417	UniRef90_Q92990-2
GLMN isoform 2		PANTR		417

Protein	Similar proteins		Species	Score	Length	Source
Q92990	Glomulin		MOUSE		596	UniRef50_Q92990
Uncharacterized protein		CHLSB		625
glomulin isoform X1		Enhydra lutris kenyoni		600
glomulin isoform X1		NEOSC		600
Uncharacterized protein (Fragment)		AILME		600
+415
Q92990-2	GLMN isoform 2		PONAB		417	UniRef50_Q92990-2
GLMN isoform 2		PANTR		417
Glomulin (Fragment)		CALMI		412
UPI00044342B4		MONDO		501
UPI00057A4FBB		CAMBA		418

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U73704 mRNA Translation: AAC50908.1 AJ347709 mRNA Translation: CAC69882.1 AJ302735 mRNA Translation: CAC82938.1 AJ302727 AJ302734 Genomic DNA Translation: CAC88124.1 AL451010 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW73098.1 BC001257 mRNA Translation: AAH01257.1
CCDSⁱ	CCDS738.1 [Q92990-1]
RefSeqⁱ	NP_001306612.1, NM_001319683.1 NP_444504.1, NM_053274.2 [Q92990-1] XP_011538848.1, XM_011540546.2 [Q92990-1]
UniGeneⁱ	Hs.49105

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4F52	X-ray	3.00	E/F	1-594	[»]
ProteinModelPortalⁱ	Q92990
SMRⁱ	Q92990
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116318, 85 interactors
CORUMⁱ	Q92990
IntActⁱ	Q92990, 14 interactors
STRINGⁱ	9606.ENSP00000359385

PTM databases

iPTMnetⁱ	Q92990
PhosphoSitePlusⁱ	Q92990
SwissPalmⁱ	Q92990

Polymorphism and mutation databases

BioMutaⁱ	GLMN
DMDMⁱ	38372884

Proteomic databases

EPDⁱ	Q92990
MaxQBⁱ	Q92990
PaxDbⁱ	Q92990
PeptideAtlasⁱ	Q92990
PRIDEⁱ	Q92990
ProteomicsDBⁱ	75652 75653 [Q92990-2]
TopDownProteomicsⁱ	Q92990-1 [Q92990-1]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000370360; ENSP00000359385; ENSG00000174842 [Q92990-1] ENST00000495106; ENSP00000436829; ENSG00000174842 [Q92990-2]
GeneIDⁱ	11146
KEGGⁱ	hsa:11146
UCSCⁱ	uc001dor.4 human [Q92990-1]

Organism-specific databases

CTDⁱ	11146
DisGeNETⁱ	11146
EuPathDBⁱ	HostDB:ENSG00000174842.16
GeneCardsⁱ	GLMN
HGNCⁱ	HGNC:14373 GLMN
HPAⁱ	HPA031446 HPA031448
MalaCardsⁱ	GLMN
MIMⁱ	138000 phenotype 601749 gene
neXtProtⁱ	NX_Q92990
OpenTargetsⁱ	ENSG00000174842
Orphanetⁱ	83454 Glomuvenous malformation
PharmGKBⁱ	PA134870088
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IG4H Eukaryota ENOG410YJ4Z LUCA
GeneTreeⁱ	ENSGT00390000018446
HOGENOMⁱ	HOG000043079
HOVERGENⁱ	HBG044811
InParanoidⁱ	Q92990
OMAⁱ	YFLMLDL
OrthoDBⁱ	EOG091G054M
PhylomeDBⁱ	Q92990
TreeFamⁱ	TF105319

Enzyme and pathway databases

Reactomeⁱ	R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	Q92990
SIGNORⁱ	Q92990

Miscellaneous databases

ChiTaRSⁱ	GLMN human
GeneWikiⁱ	GLMN
GenomeRNAiⁱ	11146
Protein Ontology More...PROⁱ	PR:Q92990
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000174842 Expressed in 202 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_GLMN
ExpressionAtlasⁱ	Q92990 baseline and differential
Genevisibleⁱ	Q92990 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019516 Glomulin/ALF4 IPR013877 YAP-bd/ALF4/Glomulin
PANTHERⁱ	PTHR15430 PTHR15430, 1 hit
Pfamⁱ	View protein in Pfam PF08568 Kinetochor_Ybp2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GLMN_HUMAN
Accessionⁱ	Q92990Primary (citable) accession number: Q92990 Secondary accession number(s): Q5VVC3, Q9BVE8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 14, 2003
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - Q92990 (GLMN_HUMAN)

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Glomulin

GLMN

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ