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Protein

Homeobox protein DLX-4

Gene

DLX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi117 – 176HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein DLX-4
Alternative name(s):
Beta protein 1
Homeobox protein DLX-7
Homeobox protein DLX-8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DLX4
Synonyms:BP1, DLX7, DLX8, DLX9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000108813.10

Human Gene Nomenclature Database

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HGNCi
HGNC:2917 DLX4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601911 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92988

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Non-syndromic orofacial cleft 15 (OFC15)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC15 inheritance is autosomal dominant.
See also OMIM:616788

Organism-specific databases

DisGeNET

More...
DisGeNETi
1748

MalaCards human disease database

More...
MalaCardsi
DLX4
MIMi616788 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000108813

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
199306 Cleft lip/palate

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27372

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DLX4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85700416

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000490281 – 240Homeobox protein DLX-4Add BLAST240

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q92988

PeptideAtlas

More...
PeptideAtlasi
Q92988

PRoteomics IDEntifications database

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PRIDEi
Q92988

ProteomicsDB human proteome resource

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ProteomicsDBi
75647
75648 [Q92988-2]
75649 [Q92988-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q92988

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q92988

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000108813 Expressed in 100 organ(s), highest expression level in tendon

CleanEx database of gene expression profiles

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CleanExi
HS_DLX4

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92988 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA059933

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108092, 4 interactors

Protein interaction database and analysis system

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IntActi
Q92988, 14 interactors

Molecular INTeraction database

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MINTi
Q92988

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000240306

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q92988

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92988

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0850 Eukaryota
ENOG410ZHZR LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162259

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005493

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92988

KEGG Orthology (KO)

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KOi
K09314

Identification of Orthologs from Complete Genome Data

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OMAi
YLPCQQP

Database of Orthologous Groups

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OrthoDBi
EOG091G0L8C

Database for complete collections of gene phylogenies

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PhylomeDBi
Q92988

TreeFam database of animal gene trees

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TreeFami
TF315720

Family and domain databases

Conserved Domains Database

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CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif

Pfam protein domain database

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Pfami
View protein in Pfam
PF00046 Homeodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00024 HOMEOBOX
PR00031 HTHREPRESSR

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. PubMed:9073066 (AAC51171) sequence may be an additional isoform.
Isoform 1 (identifier: Q92988-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSLPCPLPG RDASKAVFPD LAPVPSVAAA YPLGLSPTTA ASPNLSYSRP
60 70 80 90 100
YGHLLSYPYT EPANPGDSYL SCQQPAALSQ PLCGPAEHPQ ELEADSEKPR
110 120 130 140 150
LSPEPSERRP QAPAKKLRKP RTIYSSLQLQ HLNQRFQHTQ YLALPERAQL
160 170 180 190 200
AAQLGLTQTQ VKIWFQNKRS KYKKLLKQNS GGQEGDFPGR TFSVSPCSPP
210 220 230 240
LPSLWDLPKA GTLPTSGYGN SFGAWYQHHS SDVLASPQMM
Length:240
Mass (Da):26,263
Last modified:January 24, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18EE52CF20C126EB
GO
Isoform 2 (identifier: Q92988-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: MTSLPCPLPG...PAEHPQELEA → MKLSVLPPRSLLAPYTVLCCPP

Show »
Length:168
Mass (Da):18,882
Checksum:i4FFAE12F68694521
GO
Isoform 3 (identifier: Q92988-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: MTSLPCPLPG...PAEHPQELEA → MKLSVLPPRSLLAPYTVLCCPP
     162-240: KIWFQNKRSK...SDVLASPQMM → GPVSSFPISHLPWFSGNSSPSPSCE

Show »
Length:114
Mass (Da):12,713
Checksum:iCF4057EAB2FE0B0B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 94MTSLP…QELEA → GGSLSLPPEPLCARCPTKEG AAPRRPGFWGSLETQAATVW RGRHGHFSCRVRLSRGAARY SRRGQGKPGVTISAARLVFK VLSAGPLTHPAGRSRRLPRG HRLKPLSIALSLCLQCPSSV ISRPRLSPGPSLSAPPYPKL APPPVAELRPPTAGAAVPWL WPSARFLPRVTGPIRVGAPL GAELRLVSPGAVNVGVETLH AE (PubMed:9073066).CuratedAdd BLAST94
Sequence conflicti113P → A in AAC50942 (PubMed:8975708).Curated1
Sequence conflicti203S → Y in AAC50942 (PubMed:8975708).Curated1
Sequence conflicti224A → P in AAC50942 (PubMed:8975708).Curated1
Sequence conflicti235Missing in AAC50942 (PubMed:8975708).Curated1
Isoform 2 (identifier: Q92988-2)
Sequence conflicti8P → H in AAC50942 (PubMed:8975708).Curated1
Sequence conflicti15Y → N in AAC50942 (PubMed:8975708).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0022361 – 94MTSLP…QELEA → MKLSVLPPRSLLAPYTVLCC PP in isoform 2 and isoform 3. 2 PublicationsAdd BLAST94
Alternative sequenceiVSP_017043162 – 240KIWFQ…SPQMM → GPVSSFPISHLPWFSGNSSP SPSCE in isoform 3. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U73328 mRNA Translation: AAC50942.1
AF028235 Genomic DNA Translation: AAC14398.1
AF254115 mRNA Translation: AAG31975.1
AF452638 Genomic DNA Translation: AAL99503.1
BT006978 mRNA Translation: AAP35624.1
CH471109 Genomic DNA Translation: EAW94651.1
CH471109 Genomic DNA Translation: EAW94653.1
CH471109 Genomic DNA Translation: EAW94654.1
CH471109 Genomic DNA Translation: EAW94655.1
BC005812 mRNA Translation: AAH05812.1
BC014419 mRNA Translation: AAH14419.1
BC016145 mRNA Translation: AAH16145.1
U31762 mRNA Translation: AAC51171.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11555.1 [Q92988-1]
CCDS45728.1 [Q92988-2]

Protein sequence database of the Protein Information Resource

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PIRi
G01958

NCBI Reference Sequences

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RefSeqi
NP_001925.2, NM_001934.3 [Q92988-2]
NP_612138.1, NM_138281.2 [Q92988-1]
XP_016879780.1, XM_017024291.1 [Q92988-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.591167

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000240306; ENSP00000240306; ENSG00000108813 [Q92988-1]
ENST00000411890; ENSP00000410622; ENSG00000108813 [Q92988-2]
ENST00000611342; ENSP00000480366; ENSG00000108813 [Q92988-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1748

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1748

UCSC genome browser

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UCSCi
uc002ipv.4 human [Q92988-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73328 mRNA Translation: AAC50942.1
AF028235 Genomic DNA Translation: AAC14398.1
AF254115 mRNA Translation: AAG31975.1
AF452638 Genomic DNA Translation: AAL99503.1
BT006978 mRNA Translation: AAP35624.1
CH471109 Genomic DNA Translation: EAW94651.1
CH471109 Genomic DNA Translation: EAW94653.1
CH471109 Genomic DNA Translation: EAW94654.1
CH471109 Genomic DNA Translation: EAW94655.1
BC005812 mRNA Translation: AAH05812.1
BC014419 mRNA Translation: AAH14419.1
BC016145 mRNA Translation: AAH16145.1
U31762 mRNA Translation: AAC51171.1
CCDSiCCDS11555.1 [Q92988-1]
CCDS45728.1 [Q92988-2]
PIRiG01958
RefSeqiNP_001925.2, NM_001934.3 [Q92988-2]
NP_612138.1, NM_138281.2 [Q92988-1]
XP_016879780.1, XM_017024291.1 [Q92988-2]
UniGeneiHs.591167

3D structure databases

ProteinModelPortaliQ92988
SMRiQ92988
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108092, 4 interactors
IntActiQ92988, 14 interactors
MINTiQ92988
STRINGi9606.ENSP00000240306

PTM databases

iPTMnetiQ92988
PhosphoSitePlusiQ92988

Polymorphism and mutation databases

BioMutaiDLX4
DMDMi85700416

Proteomic databases

PaxDbiQ92988
PeptideAtlasiQ92988
PRIDEiQ92988
ProteomicsDBi75647
75648 [Q92988-2]
75649 [Q92988-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1748
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240306; ENSP00000240306; ENSG00000108813 [Q92988-1]
ENST00000411890; ENSP00000410622; ENSG00000108813 [Q92988-2]
ENST00000611342; ENSP00000480366; ENSG00000108813 [Q92988-3]
GeneIDi1748
KEGGihsa:1748
UCSCiuc002ipv.4 human [Q92988-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1748
DisGeNETi1748
EuPathDBiHostDB:ENSG00000108813.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DLX4
HGNCiHGNC:2917 DLX4
HPAiHPA059933
MalaCardsiDLX4
MIMi601911 gene
616788 phenotype
neXtProtiNX_Q92988
OpenTargetsiENSG00000108813
Orphaneti199306 Cleft lip/palate
PharmGKBiPA27372

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0850 Eukaryota
ENOG410ZHZR LUCA
GeneTreeiENSGT00940000162259
HOVERGENiHBG005493
InParanoidiQ92988
KOiK09314
OMAiYLPCQQP
OrthoDBiEOG091G0L8C
PhylomeDBiQ92988
TreeFamiTF315720

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DLX4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1748

Protein Ontology

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PROi
PR:Q92988

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000108813 Expressed in 100 organ(s), highest expression level in tendon
CleanExiHS_DLX4
GenevisibleiQ92988 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDLX4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92988
Secondary accession number(s): D3DTX2
, D3DTX3, O60480, Q13265, Q6PJK0, Q9HBE0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 24, 2006
Last modified: December 5, 2018
This is version 164 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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