Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 185 (10 Apr 2019)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Interferon regulatory factor 7

Gene

IRF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.By similarity4 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

In the absence of viral infection, maintained as a monomer in an autoinhibited state and phosphorylation disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi11 – 126IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST116

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processAntiviral defense, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-877300 Interferon gamma signaling
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-918233 TRAF3-dependent IRF activation pathway
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q92985

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q92985

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon regulatory factor 7
Short name:
IRF-7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IRF7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185507.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6122 IRF7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605047 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92985

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency 39 (IMD39)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency causing severe, life-threatening acute respiratory distress upon infection with H1N1 influenza A.
See also OMIM:616345
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073779410F → V in IMD39; loss of function mutation; shows abnormal localization to the cytoplasm rather than the nucleus. 1 PublicationCorresponds to variant dbSNP:rs786205223EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi90G → T: Loss of acetylation, increased DNA-binding and activity; when associated with R-93. 1 Publication1
Mutagenesisi92K → R: Loss of acetylation, DNA-binding and activity. 1 Publication1
Mutagenesisi93T → R: Loss of acetylation, increased DNA-binding and activity; when associated with T-90. 1 Publication1
Mutagenesisi477 – 479SLS → ALA: Complete loss of TBK1 and IKKE phosphorylation. 1 Publication3

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3665

MalaCards human disease database

More...
MalaCardsi
IRF7
MIMi616345 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000185507

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29921

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IRF7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242593

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001545621 – 503Interferon regulatory factor 7Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei92N6-acetyllysine; by KAT2A and KAT2B1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki444Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linki446Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Modified residuei471PhosphoserineBy similarity1
Modified residuei472PhosphoserineBy similarity1
Modified residuei475PhosphoserineBy similarity1
Modified residuei477Phosphoserine; by TBK1 and IKKE1 Publication1
Modified residuei479Phosphoserine; by TBK1 and IKKE1 Publication1
Modified residuei483PhosphoserineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei487PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation inhibits its DNA-binding ability and activity.1 Publication
In response to a viral infection, phosphorylated on Ser-477 and Ser-479 by TBK1 and IKBKE1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway, phosphorylated by IRAK1.4 Publications
TRAF6-mediated ubiquitination is required for IRF7 activation.By similarity
Sumoylated by TRIM28, which inhibits its transactivation activity.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92985

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92985

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92985

PeptideAtlas

More...
PeptideAtlasi
Q92985

PRoteomics IDEntifications database

More...
PRIDEi
Q92985

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75643
75644 [Q92985-2]
75645 [Q92985-3]
75646 [Q92985-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92985

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92985

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in spleen, thymus and peripheral blood leukocytes.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By type I interferon (IFN) and viruses.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185507 Expressed in 186 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92985 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92985 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017694
HPA052757

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3. Interacts with TICAM1 and TICAM2. Interacts with MYD88 AND TRAF6.6 Publications
(Microbial infection) Interacts with Epstein-Barr virus LF2 and LMP1.2 Publications
(Microbial infection) Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7.1 Publication
(Microbial infection) Interacts with human herpes virus 8/HHV-8 proteins ORF45 and vIRF-1.1 Publication
(Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein HBZ.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109873, 42 interactors

Database of interacting proteins

More...
DIPi
DIP-34895N

Protein interaction database and analysis system

More...
IntActi
Q92985, 28 interactors

Molecular INTeraction database

More...
MINTi
Q92985

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380697

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1503
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O61X-ray2.80A8-125[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q92985

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92985

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWNR Eukaryota
ENOG4111G85 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160931

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111812

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG105600

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92985

KEGG Orthology (KO)

More...
KOi
K09447

Identification of Orthologs from Complete Genome Data

More...
OMAi
VMLQDNS

Database of Orthologous Groups

More...
OrthoDBi
648909at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92985

TreeFam database of animal gene trees

More...
TreeFami
TF328512

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00103 IRF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
2.60.200.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019817 Interferon_reg_fac_CS
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR019471 Interferon_reg_factor-3
IPR017855 SMAD-like_dom_sf
IPR008984 SMAD_FHA_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11949 PTHR11949, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00605 IRF, 1 hit
PF10401 IRF-3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00267 INTFRNREGFCT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00348 IRF, 1 hit
SM01243 IRF-3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00601 IRF_1, 1 hit
PS51507 IRF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q92985-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALAPERAAP RVLFGEWLLG EISSGCYEGL QWLDEARTCF RVPWKHFARK
60 70 80 90 100
DLSEADARIF KAWAVARGRW PPSSRGGGPP PEAETAERAG WKTNFRCALR
110 120 130 140 150
STRRFVMLRD NSGDPADPHK VYALSRELCW REGPGTDQTE AEAPAAVPPP
160 170 180 190 200
QGGPPGPFLA HTHAGLQAPG PLPAPAGDKG DLLLQAVQQS CLADHLLTAS
210 220 230 240 250
WGADPVPTKA PGEGQEGLPL TGACAGGPGL PAGELYGWAV ETTPSPGPQP
260 270 280 290 300
AALTTGEAAA PESPHQAEPY LSPSPSACTA VQEPSPGALD VTIMYKGRTV
310 320 330 340 350
LQKVVGHPSC TFLYGPPDPA VRATDPQQVA FPSPAELPDQ KQLRYTEELL
360 370 380 390 400
RHVAPGLHLE LRGPQLWARR MGKCKVYWEV GGPPGSASPS TPACLLPRNC
410 420 430 440 450
DTPIFDFRVF FQELVEFRAR QRRGSPRYTI YLGFGQDLSA GRPKEKSLVL
460 470 480 490 500
VKLEPWLCRV HLEGTQREGV SSLDSSSLSL CLSSANSLYD DIECFLMELE

QPA
Length:503
Mass (Da):54,278
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9863C147514652DE
GO
Isoform B (identifier: Q92985-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     228-256: Missing.

Show »
Length:474
Mass (Da):51,459
Checksum:iF98A7B630497BDD0
GO
Isoform C (identifier: Q92985-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     152-164: GGPPGPFLAHTHA → AQGSLLGSCTGGQ
     165-503: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:164
Mass (Da):18,036
Checksum:i6FC0146AD190006D
GO
Isoform D (identifier: Q92985-4) [UniParc]FASTAAdd to basket
Also known as: H

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MALAPE → MPVPERPAAGPDSPRPGTR

Show »
Length:516
Mass (Da):55,635
Checksum:i0A659B0BD1FE30F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9RSF4M9RSF4_HUMAN
Interferon regulatory factor 7 tran...
IRF7
487Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSE3E9PSE3_HUMAN
Interferon regulatory factor 7
IRF7
397Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR03E9PR03_HUMAN
Interferon regulatory factor 7
IRF7
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIA7E9PIA7_HUMAN
Interferon regulatory factor 7
IRF7
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISC0A0A3B3ISC0_HUMAN
Interferon regulatory factor 7
IRF7
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISS4A0A3B3ISS4_HUMAN
Interferon regulatory factor 7
IRF7
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ11E9PQ11_HUMAN
Interferon regulatory factor 7
IRF7
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITQ5A0A3B3ITQ5_HUMAN
Interferon regulatory factor 7
IRF7
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027957179K → E2 PublicationsCorresponds to variant dbSNP:rs1061502Ensembl.1
Natural variantiVAR_061273204D → N. Corresponds to variant dbSNP:rs41313489Ensembl.1
Natural variantiVAR_073779410F → V in IMD39; loss of function mutation; shows abnormal localization to the cytoplasm rather than the nucleus. 1 PublicationCorresponds to variant dbSNP:rs786205223EnsemblClinVar.1
Natural variantiVAR_034017412Q → R1 PublicationCorresponds to variant dbSNP:rs1131665Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0027571 – 6MALAPE → MPVPERPAAGPDSPRPGTR in isoform D. 2 Publications6
Alternative sequenceiVSP_002758152 – 164GGPPG…AHTHA → AQGSLLGSCTGGQ in isoform C. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_002759165 – 503Missing in isoform C. 1 PublicationAdd BLAST339
Alternative sequenceiVSP_002760228 – 256Missing in isoform B. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U73036 mRNA Translation: AAB17190.1
U53830 mRNA Translation: AAB80686.1
U53831 mRNA Translation: AAB80688.1
U53832 mRNA Translation: AAB80690.1
U53832 mRNA Translation: AAB80691.1
AF076494 mRNA Translation: AAC70999.1
CH471158 Genomic DNA Translation: EAX02360.1
BC136555 mRNA Translation: AAI36556.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7703.1 [Q92985-1]
CCDS7704.1 [Q92985-2]
CCDS7705.1 [Q92985-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001563.2, NM_001572.3 [Q92985-1]
NP_004020.1, NM_004029.2 [Q92985-2]
NP_004022.2, NM_004031.2 [Q92985-4]
XP_005252963.1, XM_005252906.3
XP_016873163.1, XM_017017674.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.166120

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330243; ENSP00000329411; ENSG00000185507 [Q92985-4]
ENST00000348655; ENSP00000331803; ENSG00000185507 [Q92985-2]
ENST00000397566; ENSP00000380697; ENSG00000185507 [Q92985-4]
ENST00000397574; ENSP00000380704; ENSG00000185507 [Q92985-1]
ENST00000469048; ENSP00000434607; ENSG00000185507 [Q92985-3]
ENST00000525445; ENSP00000434009; ENSG00000185507 [Q92985-1]
ENST00000533182; ENSP00000433903; ENSG00000185507 [Q92985-3]
ENST00000612534; ENSP00000479615; ENSG00000276561 [Q92985-4]
ENST00000621391; ENSP00000480358; ENSG00000276561 [Q92985-1]
ENST00000632827; ENSP00000488039; ENSG00000276561 [Q92985-4]
ENST00000633274; ENSP00000488591; ENSG00000276561 [Q92985-3]
ENST00000633943; ENSP00000488666; ENSG00000276561 [Q92985-2]
ENST00000634105; ENSP00000488581; ENSG00000276561 [Q92985-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3665

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3665

UCSC genome browser

More...
UCSCi
uc001lqg.3 human [Q92985-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73036 mRNA Translation: AAB17190.1
U53830 mRNA Translation: AAB80686.1
U53831 mRNA Translation: AAB80688.1
U53832 mRNA Translation: AAB80690.1
U53832 mRNA Translation: AAB80691.1
AF076494 mRNA Translation: AAC70999.1
CH471158 Genomic DNA Translation: EAX02360.1
BC136555 mRNA Translation: AAI36556.1
CCDSiCCDS7703.1 [Q92985-1]
CCDS7704.1 [Q92985-2]
CCDS7705.1 [Q92985-4]
RefSeqiNP_001563.2, NM_001572.3 [Q92985-1]
NP_004020.1, NM_004029.2 [Q92985-2]
NP_004022.2, NM_004031.2 [Q92985-4]
XP_005252963.1, XM_005252906.3
XP_016873163.1, XM_017017674.1
UniGeneiHs.166120

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O61X-ray2.80A8-125[»]
ProteinModelPortaliQ92985
SMRiQ92985
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109873, 42 interactors
DIPiDIP-34895N
IntActiQ92985, 28 interactors
MINTiQ92985
STRINGi9606.ENSP00000380697

PTM databases

iPTMnetiQ92985
PhosphoSitePlusiQ92985

Polymorphism and mutation databases

BioMutaiIRF7
DMDMi116242593

Proteomic databases

EPDiQ92985
MaxQBiQ92985
PaxDbiQ92985
PeptideAtlasiQ92985
PRIDEiQ92985
ProteomicsDBi75643
75644 [Q92985-2]
75645 [Q92985-3]
75646 [Q92985-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330243; ENSP00000329411; ENSG00000185507 [Q92985-4]
ENST00000348655; ENSP00000331803; ENSG00000185507 [Q92985-2]
ENST00000397566; ENSP00000380697; ENSG00000185507 [Q92985-4]
ENST00000397574; ENSP00000380704; ENSG00000185507 [Q92985-1]
ENST00000469048; ENSP00000434607; ENSG00000185507 [Q92985-3]
ENST00000525445; ENSP00000434009; ENSG00000185507 [Q92985-1]
ENST00000533182; ENSP00000433903; ENSG00000185507 [Q92985-3]
ENST00000612534; ENSP00000479615; ENSG00000276561 [Q92985-4]
ENST00000621391; ENSP00000480358; ENSG00000276561 [Q92985-1]
ENST00000632827; ENSP00000488039; ENSG00000276561 [Q92985-4]
ENST00000633274; ENSP00000488591; ENSG00000276561 [Q92985-3]
ENST00000633943; ENSP00000488666; ENSG00000276561 [Q92985-2]
ENST00000634105; ENSP00000488581; ENSG00000276561 [Q92985-3]
GeneIDi3665
KEGGihsa:3665
UCSCiuc001lqg.3 human [Q92985-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3665
DisGeNETi3665
EuPathDBiHostDB:ENSG00000185507.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IRF7
HGNCiHGNC:6122 IRF7
HPAiCAB017694
HPA052757
MalaCardsiIRF7
MIMi605047 gene
616345 phenotype
neXtProtiNX_Q92985
OpenTargetsiENSG00000185507
PharmGKBiPA29921

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWNR Eukaryota
ENOG4111G85 LUCA
GeneTreeiENSGT00940000160931
HOGENOMiHOG000111812
HOVERGENiHBG105600
InParanoidiQ92985
KOiK09447
OMAiVMLQDNS
OrthoDBi648909at2759
PhylomeDBiQ92985
TreeFamiTF328512

Enzyme and pathway databases

ReactomeiR-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-877300 Interferon gamma signaling
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-918233 TRAF3-dependent IRF activation pathway
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
SignaLinkiQ92985
SIGNORiQ92985

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IRF7 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IRF7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3665

Protein Ontology

More...
PROi
PR:Q92985

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185507 Expressed in 186 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiQ92985 baseline and differential
GenevisibleiQ92985 HS

Family and domain databases

CDDicd00103 IRF, 1 hit
Gene3Di1.10.10.10, 1 hit
2.60.200.10, 1 hit
InterProiView protein in InterPro
IPR019817 Interferon_reg_fac_CS
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR019471 Interferon_reg_factor-3
IPR017855 SMAD-like_dom_sf
IPR008984 SMAD_FHA_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11949 PTHR11949, 1 hit
PfamiView protein in Pfam
PF00605 IRF, 1 hit
PF10401 IRF-3, 1 hit
PRINTSiPR00267 INTFRNREGFCT
SMARTiView protein in SMART
SM00348 IRF, 1 hit
SM01243 IRF-3, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS00601 IRF_1, 1 hit
PS51507 IRF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRF7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92985
Secondary accession number(s): B9EGL3
, O00331, O00332, O00333, O75924, Q9UE79
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: April 10, 2019
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again