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Protein

Ninjurin-1

Gene

NINJ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations.

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ninjurin-1
Alternative name(s):
Nerve injury-induced protein 1
Gene namesi
Name:NINJ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000131669.9
HGNCiHGNC:7824 NINJ1
MIMi602062 gene
neXtProtiNX_Q92982

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 80ExtracellularSequence analysisAdd BLAST80
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 120CytoplasmicSequence analysisAdd BLAST19
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 152ExtracellularSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4814
OpenTargetsiENSG00000131669
PharmGKBiPA31631

Polymorphism and mutation databases

BioMutaiNINJ1
DMDMi317373398

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001596431 – 152Ninjurin-1Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei21PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92982
MaxQBiQ92982
PaxDbiQ92982
PeptideAtlasiQ92982
PRIDEiQ92982
ProteomicsDBi75642

PTM databases

iPTMnetiQ92982
PhosphoSitePlusiQ92982

Expressioni

Tissue specificityi

Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin.

Inductioni

By nerve injury both in dorsal root ganglion neurons and in Schwann cells.

Gene expression databases

BgeeiENSG00000131669 Expressed in 190 organ(s), highest expression level in blood
CleanExiHS_NINJ1
GenevisibleiQ92982 HS

Organism-specific databases

HPAiHPA045063

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-2802124,EBI-10171697

Protein-protein interaction databases

BioGridi110879, 2 interactors
CORUMiQ92982
IntActiQ92982, 34 interactors
STRINGi9606.ENSP00000364595

Structurei

3D structure databases

ProteinModelPortaliQ92982
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ninjurin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWIJ Eukaryota
ENOG4111RPK LUCA
GeneTreeiENSGT00390000012754
HOGENOMiHOG000037625
HOVERGENiHBG052622
InParanoidiQ92982
OMAiNINHYAN
OrthoDBiEOG091G0W0Q
PhylomeDBiQ92982
TreeFamiTF323538

Family and domain databases

InterProiView protein in InterPro
IPR007007 Ninjurin
IPR015639 Ninjurin1
PANTHERiPTHR12316 PTHR12316, 1 hit
PTHR12316:SF19 PTHR12316:SF19, 1 hit
PfamiView protein in Pfam
PF04923 Ninjurin, 1 hit

Sequencei

Sequence statusi: Complete.

Q92982-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSGTEEYEL NGGLPPGTPG SPDASPARWG WRHGPINVNH YASKKSAAES
60 70 80 90 100
MLDIALLMAN ASQLKAVVEQ GPSFAFYVPL VVLISISLVL QIGVGVLLIF
110 120 130 140 150
LVKYDLNNPA KHAKLDFLNN LATGLVFIIV VVNIFITAFG VQKPLMDMAP

QQ
Length:152
Mass (Da):16,345
Last modified:January 11, 2011 - v2
Checksum:iFEACA99450187855
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025549110A → D3 PublicationsCorresponds to variant dbSNP:rs2275848Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72661 mRNA Translation: AAB17560.1
U91512 mRNA Translation: AAC14593.1
AF029251 Genomic DNA Translation: AAC39574.1
BT007164 mRNA Translation: AAP35828.1
AL451065 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62856.1
BC000298 mRNA Translation: AAH00298.1
BC004440 mRNA Translation: AAH04440.1
BC019336 mRNA Translation: AAH19336.2
BC048212 mRNA Translation: AAH48212.1
CCDSiCCDS6703.1
RefSeqiNP_004139.2, NM_004148.3
UniGeneiHs.494457

Genome annotation databases

EnsembliENST00000375446; ENSP00000364595; ENSG00000131669
GeneIDi4814
KEGGihsa:4814
UCSCiuc004atg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72661 mRNA Translation: AAB17560.1
U91512 mRNA Translation: AAC14593.1
AF029251 Genomic DNA Translation: AAC39574.1
BT007164 mRNA Translation: AAP35828.1
AL451065 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62856.1
BC000298 mRNA Translation: AAH00298.1
BC004440 mRNA Translation: AAH04440.1
BC019336 mRNA Translation: AAH19336.2
BC048212 mRNA Translation: AAH48212.1
CCDSiCCDS6703.1
RefSeqiNP_004139.2, NM_004148.3
UniGeneiHs.494457

3D structure databases

ProteinModelPortaliQ92982
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110879, 2 interactors
CORUMiQ92982
IntActiQ92982, 34 interactors
STRINGi9606.ENSP00000364595

PTM databases

iPTMnetiQ92982
PhosphoSitePlusiQ92982

Polymorphism and mutation databases

BioMutaiNINJ1
DMDMi317373398

Proteomic databases

EPDiQ92982
MaxQBiQ92982
PaxDbiQ92982
PeptideAtlasiQ92982
PRIDEiQ92982
ProteomicsDBi75642

Protocols and materials databases

DNASUi4814
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375446; ENSP00000364595; ENSG00000131669
GeneIDi4814
KEGGihsa:4814
UCSCiuc004atg.4 human

Organism-specific databases

CTDi4814
DisGeNETi4814
EuPathDBiHostDB:ENSG00000131669.9
GeneCardsiNINJ1
H-InvDBiHIX0008176
HGNCiHGNC:7824 NINJ1
HPAiHPA045063
MIMi602062 gene
neXtProtiNX_Q92982
OpenTargetsiENSG00000131669
PharmGKBiPA31631
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWIJ Eukaryota
ENOG4111RPK LUCA
GeneTreeiENSGT00390000012754
HOGENOMiHOG000037625
HOVERGENiHBG052622
InParanoidiQ92982
OMAiNINHYAN
OrthoDBiEOG091G0W0Q
PhylomeDBiQ92982
TreeFamiTF323538

Miscellaneous databases

ChiTaRSiNINJ1 human
GeneWikiiNINJ1
GenomeRNAii4814
PROiPR:Q92982
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131669 Expressed in 190 organ(s), highest expression level in blood
CleanExiHS_NINJ1
GenevisibleiQ92982 HS

Family and domain databases

InterProiView protein in InterPro
IPR007007 Ninjurin
IPR015639 Ninjurin1
PANTHERiPTHR12316 PTHR12316, 1 hit
PTHR12316:SF19 PTHR12316:SF19, 1 hit
PfamiView protein in Pfam
PF04923 Ninjurin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNINJ1_HUMAN
AccessioniPrimary (citable) accession number: Q92982
Secondary accession number(s): Q6GU89, Q8WUV5, Q9BT07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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