UniProtKB - Q92973 (TNPO1_HUMAN)
Transportin-1
TNPO1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 468 | Important for interaction with cargo nuclear localization signals1 Publication | 1 | |
Sitei | 738 | Important for interaction with cargo nuclear localization signals1 Publication | 1 |
GO - Molecular functioni
- nuclear import signal receptor activity Source: GO_Central
- nuclear localization sequence binding Source: GO_Central
- Ran GTPase binding Source: InterPro
- RNA binding Source: UniProtKB
GO - Biological processi
- intraciliary transport involved in cilium assembly Source: Reactome
- protein import into nucleus Source: UniProtKB
- regulation of mRNA stability Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q92973 |
Reactomei | R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-5620924, Intraflagellar transport R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transportin-1Alternative name(s): Importin beta-2 Karyopherin beta-2 M9 region interaction protein Short name: MIP |
Gene namesi | Name:TNPO1 Synonyms:KPNB2, MIP1, TRN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6401, TNPO1 |
MIMi | 602901, gene |
neXtProti | NX_Q92973 |
VEuPathDBi | HostDB:ENSG00000083312.17 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: GO_Central
Other locations
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 468 | W → A: Abolishes interaction with the ADAR nuclear localization signal. Abolishes ADAR nuclear import. 1 Publication | 1 | |
Mutagenesisi | 738 | W → A: Abolishes interaction with the ADAR nuclear localization signal. Abolishes ADAR nuclear import. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3842 |
OpenTargetsi | ENSG00000083312 |
PharmGKBi | PA30192 |
Miscellaneous databases
Pharosi | Q92973, Tbio |
Genetic variation databases
BioMutai | TNPO1 |
DMDMi | 259016171 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120765 | 1 – 898 | Transportin-1Add BLAST | 898 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q92973-2) | |||||
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q92973 |
jPOSTi | Q92973 |
MassIVEi | Q92973 |
MaxQBi | Q92973 |
PaxDbi | Q92973 |
PeptideAtlasi | Q92973 |
PRIDEi | Q92973 |
ProteomicsDBi | 75635 [Q92973-1] 75636 [Q92973-2] 75637 [Q92973-3] |
PTM databases
iPTMneti | Q92973 |
MetOSitei | Q92973 |
PhosphoSitePlusi | Q92973 |
SwissPalmi | Q92973 |
Expressioni
Gene expression databases
Bgeei | ENSG00000083312, Expressed in thoracic mammary gland and 258 other tissues |
ExpressionAtlasi | Q92973, baseline and differential |
Genevisiblei | Q92973, HS |
Organism-specific databases
HPAi | ENSG00000083312, Low tissue specificity |
Interactioni
Subunit structurei
Identified in a complex that contains TNPO1, RAN and RANBP1 (PubMed:9428644). Binds HNRPA1, HNRPA2, HNRNPDL, RPL23A, RPS7, RPL5, RAN and SRP19.
Interacts with H2A, H2B, H3 and H4 histones (By similarity).
Interacts with isoform 1 and isoform 5 of ADAR/ADAR1 (via DRBM 3 domain) (PubMed:19124606, PubMed:24753571).
Interacts with SNAI1 (via zinc fingers); the interaction mediates SNAI1 nuclear import (PubMed:19386897).
Interacts with SNAI2 (via zinc fingers) (PubMed:19386897).
By similarity6 Publications(Microbial infection) Binds to HIV-1 Rev.
1 PublicationBinary interactionsi
Hide detailsQ92973
With | #Exp. | IntAct |
---|---|---|
GRB2 [P62993] | 2 | EBI-286693,EBI-401755 |
HNRNPA1 - isoform A1-A [P09651-2] | 2 | EBI-286693,EBI-352677 |
HNRNPM [P52272] | 3 | EBI-286693,EBI-486809 |
Isoform 2 [Q92973-2]
With | #Exp. | IntAct |
---|---|---|
FUS [P35637] | 2 | EBI-11022821,EBI-400434 |
GO - Molecular functioni
- Ran GTPase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 110040, 123 interactors |
DIPi | DIP-29335N |
IntActi | Q92973, 62 interactors |
MINTi | Q92973 |
STRINGi | 9606.ENSP00000336712 |
Miscellaneous databases
RNActi | Q92973, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q92973 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92973 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 19 – 46 | HEAT 11 PublicationAdd BLAST | 28 | |
Domaini | 41 – 109 | Importin N-terminalPROSITE-ProRule annotationAdd BLAST | 69 | |
Repeati | 51 – 89 | HEAT 21 PublicationAdd BLAST | 39 | |
Repeati | 98 – 131 | HEAT 31 PublicationAdd BLAST | 34 | |
Repeati | 137 – 174 | HEAT 41 PublicationAdd BLAST | 38 | |
Repeati | 181 – 211 | HEAT 51 PublicationAdd BLAST | 31 | |
Repeati | 224 – 251 | HEAT 61 PublicationAdd BLAST | 28 | |
Repeati | 263 – 290 | HEAT 71 PublicationAdd BLAST | 28 | |
Repeati | 306 – 397 | HEAT 81 PublicationAdd BLAST | 92 | |
Repeati | 405 – 433 | HEAT 91 PublicationAdd BLAST | 29 | |
Repeati | 445 – 472 | HEAT 101 PublicationAdd BLAST | 28 | |
Repeati | 486 – 519 | HEAT 111 PublicationAdd BLAST | 34 | |
Repeati | 527 – 560 | HEAT 121 PublicationAdd BLAST | 34 | |
Repeati | 568 – 606 | HEAT 131 PublicationAdd BLAST | 39 | |
Repeati | 614 – 665 | HEAT 141 PublicationAdd BLAST | 52 | |
Repeati | 676 – 707 | HEAT 151 PublicationAdd BLAST | 32 | |
Repeati | 715 – 748 | HEAT 161 PublicationAdd BLAST | 34 | |
Repeati | 756 – 791 | HEAT 171 PublicationAdd BLAST | 36 | |
Repeati | 799 – 832 | HEAT 181 PublicationAdd BLAST | 34 | |
Repeati | 841 – 872 | HEAT 191 PublicationAdd BLAST | 32 | |
Repeati | 875 – 895 | HEAT 201 PublicationAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 358 – 376 | Asp/Glu-rich (acidic)Add BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2023, Eukaryota |
GeneTreei | ENSGT00940000155389 |
HOGENOMi | CLU_008136_0_0_1 |
InParanoidi | Q92973 |
OMAi | WRRFADQ |
PhylomeDBi | Q92973 |
TreeFami | TF300825 |
Family and domain databases
DisProti | DP01457 |
Gene3Di | 1.25.10.10, 2 hits |
IDEALi | IID00094 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR001494, Importin-beta_N IPR040122, Importin_beta |
PANTHERi | PTHR10527, PTHR10527, 1 hit |
Pfami | View protein in Pfam PF03810, IBN_N, 1 hit |
SMARTi | View protein in SMART SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50166, IMPORTIN_B_NT, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVWDRQTKME YEWKPDEQGL QQILQLLKES QSPDTTIQRT VQQKLEQLNQ
60 70 80 90 100
YPDFNNYLIF VLTKLKSEDE PTRSLSGLIL KNNVKAHFQN FPNGVTDFIK
110 120 130 140 150
SECLNNIGDS SPLIRATVGI LITTIASKGE LQNWPDLLPK LCSLLDSEDY
160 170 180 190 200
NTCEGAFGAL QKICEDSAEI LDSDVLDRPL NIMIPKFLQF FKHSSPKIRS
210 220 230 240 250
HAVACVNQFI ISRTQALMLH IDSFIENLFA LAGDEEPEVR KNVCRALVML
260 270 280 290 300
LEVRMDRLLP HMHNIVEYML QRTQDQDENV ALEACEFWLT LAEQPICKDV
310 320 330 340 350
LVRHLPKLIP VLVNGMKYSD IDIILLKGDV EEDETIPDSE QDIRPRFHRS
360 370 380 390 400
RTVAQQHDED GIEEEDDDDD EIDDDDTISD WNLRKCSAAA LDVLANVYRD
410 420 430 440 450
ELLPHILPLL KELLFHHEWV VKESGILVLG AIAEGCMQGM IPYLPELIPH
460 470 480 490 500
LIQCLSDKKA LVRSITCWTL SRYAHWVVSQ PPDTYLKPLM TELLKRILDS
510 520 530 540 550
NKRVQEAACS AFATLEEEAC TELVPYLAYI LDTLVFAFSK YQHKNLLILY
560 570 580 590 600
DAIGTLADSV GHHLNKPEYI QMLMPPLIQK WNMLKDEDKD LFPLLECLSS
610 620 630 640 650
VATALQSGFL PYCEPVYQRC VNLVQKTLAQ AMLNNAQPDQ YEAPDKDFMI
660 670 680 690 700
VALDLLSGLA EGLGGNIEQL VARSNILTLM YQCMQDKMPE VRQSSFALLG
710 720 730 740 750
DLTKACFQHV KPCIADFMPI LGTNLNPEFI SVCNNATWAI GEISIQMGIE
760 770 780 790 800
MQPYIPMVLH QLVEIINRPN TPKTLLENTA ITIGRLGYVC PQEVAPMLQQ
810 820 830 840 850
FIRPWCTSLR NIRDNEEKDS AFRGICTMIS VNPSGVIQDF IFFCDAVASW
860 870 880 890
INPKDDLRDM FCKILHGFKN QVGDENWRRF SDQFPLPLKE RLAAFYGV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EW37 | E7EW37_HUMAN | Transportin-1 | TNPO1 | 136 | Annotation score: | ||
S4R398 | S4R398_HUMAN | Transportin-1 | TNPO1 | 193 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 104 | L → S in AAB68948 (Ref. 3) Curated | 1 | |
Sequence conflicti | 225 | I → T in AAC50723 (PubMed:8808633).Curated | 1 | |
Sequence conflicti | 669 | Q → L in AAB68948 (Ref. 3) Curated | 1 | |
Sequence conflicti | 880 | F → L in BAG62638 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038028 | 1 – 9 | MVWDRQTKM → M in isoform 2. 2 Publications | 9 | |
Alternative sequenceiVSP_038029 | 69 – 118 | Missing in isoform 3. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70322 mRNA Translation: AAC50723.1 Different initiation. U72069 mRNA Translation: AAB58254.1 U72395 mRNA Translation: AAB68948.1 AK301021 mRNA Translation: BAG62638.1 BC040340 mRNA Translation: AAH40340.1 Different initiation. |
CCDSi | CCDS4016.1 [Q92973-2] CCDS43329.1 [Q92973-1] |
RefSeqi | NP_002261.3, NM_002270.3 [Q92973-1] NP_694858.1, NM_153188.2 [Q92973-2] XP_005248557.1, XM_005248500.2 |
Genome annotation databases
Ensembli | ENST00000337273; ENSP00000336712; ENSG00000083312 [Q92973-1] ENST00000506351; ENSP00000425118; ENSG00000083312 [Q92973-2] ENST00000523768; ENSP00000428899; ENSG00000083312 [Q92973-3] |
GeneIDi | 3842 |
KEGGi | hsa:3842 |
UCSCi | uc003kci.5, human [Q92973-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70322 mRNA Translation: AAC50723.1 Different initiation. U72069 mRNA Translation: AAB58254.1 U72395 mRNA Translation: AAB68948.1 AK301021 mRNA Translation: BAG62638.1 BC040340 mRNA Translation: AAH40340.1 Different initiation. |
CCDSi | CCDS4016.1 [Q92973-2] CCDS43329.1 [Q92973-1] |
RefSeqi | NP_002261.3, NM_002270.3 [Q92973-1] NP_694858.1, NM_153188.2 [Q92973-2] XP_005248557.1, XM_005248500.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1QBK | X-ray | 3.00 | B | 9-898 | [»] | |
2H4M | X-ray | 3.05 | A/B | 376-898 | [»] | |
A/B | 9-343 | [»] | ||||
2OT8 | X-ray | 3.10 | A/B | 9-331 | [»] | |
A/B | 375-898 | [»] | ||||
2QMR | X-ray | 3.00 | A/B/C/D | 9-898 | [»] | |
2Z5J | X-ray | 3.40 | A | 9-898 | [»] | |
2Z5K | X-ray | 2.60 | A | 9-898 | [»] | |
2Z5M | X-ray | 3.00 | A | 9-898 | [»] | |
2Z5N | X-ray | 3.20 | A | 9-898 | [»] | |
2Z5O | X-ray | 3.20 | A | 9-898 | [»] | |
4FDD | X-ray | 2.30 | A | 9-331 | [»] | |
A | 375-898 | [»] | ||||
4FQ3 | X-ray | 3.00 | A | 9-898 | [»] | |
4JLQ | X-ray | 3.05 | A | 9-331 | [»] | |
A | 375-898 | [»] | ||||
4OO6 | X-ray | 2.70 | A | 375-898 | [»] | |
A | 9-331 | [»] | ||||
5J3V | X-ray | 3.05 | A/B | 9-331 | [»] | |
A/B | 375-898 | [»] | ||||
5TQC | X-ray | 3.00 | A | 9-343 | [»] | |
A | 375-898 | [»] | ||||
5YVG | X-ray | 4.05 | A/B | 9-344 | [»] | |
A/B | 376-898 | [»] | ||||
5YVH | X-ray | 3.15 | A | 9-344 | [»] | |
A | 376-898 | [»] | ||||
5YVI | X-ray | 2.90 | A | 9-344 | [»] | |
A | 376-898 | [»] | ||||
SMRi | Q92973 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110040, 123 interactors |
DIPi | DIP-29335N |
IntActi | Q92973, 62 interactors |
MINTi | Q92973 |
STRINGi | 9606.ENSP00000336712 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | Q92973 |
MetOSitei | Q92973 |
PhosphoSitePlusi | Q92973 |
SwissPalmi | Q92973 |
Genetic variation databases
BioMutai | TNPO1 |
DMDMi | 259016171 |
Proteomic databases
EPDi | Q92973 |
jPOSTi | Q92973 |
MassIVEi | Q92973 |
MaxQBi | Q92973 |
PaxDbi | Q92973 |
PeptideAtlasi | Q92973 |
PRIDEi | Q92973 |
ProteomicsDBi | 75635 [Q92973-1] 75636 [Q92973-2] 75637 [Q92973-3] |
Protocols and materials databases
Antibodypediai | 4275, 285 antibodies |
DNASUi | 3842 |
Genome annotation databases
Ensembli | ENST00000337273; ENSP00000336712; ENSG00000083312 [Q92973-1] ENST00000506351; ENSP00000425118; ENSG00000083312 [Q92973-2] ENST00000523768; ENSP00000428899; ENSG00000083312 [Q92973-3] |
GeneIDi | 3842 |
KEGGi | hsa:3842 |
UCSCi | uc003kci.5, human [Q92973-1] |
Organism-specific databases
CTDi | 3842 |
DisGeNETi | 3842 |
GeneCardsi | TNPO1 |
HGNCi | HGNC:6401, TNPO1 |
HPAi | ENSG00000083312, Low tissue specificity |
MIMi | 602901, gene |
neXtProti | NX_Q92973 |
OpenTargetsi | ENSG00000083312 |
PharmGKBi | PA30192 |
VEuPathDBi | HostDB:ENSG00000083312.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2023, Eukaryota |
GeneTreei | ENSGT00940000155389 |
HOGENOMi | CLU_008136_0_0_1 |
InParanoidi | Q92973 |
OMAi | WRRFADQ |
PhylomeDBi | Q92973 |
TreeFami | TF300825 |
Enzyme and pathway databases
PathwayCommonsi | Q92973 |
Reactomei | R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-5620924, Intraflagellar transport R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation |
Miscellaneous databases
BioGRID-ORCSi | 3842, 177 hits in 891 CRISPR screens |
ChiTaRSi | TNPO1, human |
EvolutionaryTracei | Q92973 |
GeneWikii | Transportin_1 |
GenomeRNAii | 3842 |
Pharosi | Q92973, Tbio |
PROi | PR:Q92973 |
RNActi | Q92973, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000083312, Expressed in thoracic mammary gland and 258 other tissues |
ExpressionAtlasi | Q92973, baseline and differential |
Genevisiblei | Q92973, HS |
Family and domain databases
DisProti | DP01457 |
Gene3Di | 1.25.10.10, 2 hits |
IDEALi | IID00094 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR001494, Importin-beta_N IPR040122, Importin_beta |
PANTHERi | PTHR10527, PTHR10527, 1 hit |
Pfami | View protein in Pfam PF03810, IBN_N, 1 hit |
SMARTi | View protein in SMART SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50166, IMPORTIN_B_NT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNPO1_HUMAN | |
Accessioni | Q92973Primary (citable) accession number: Q92973 Secondary accession number(s): B4DVC6, Q92957, Q92975 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | September 22, 2009 | |
Last modified: | February 10, 2021 | |
This is version 217 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM