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UniProtKB - Q92973 (TNPO1_HUMAN)

Entry version 220 (29 Sep 2021)
Sequence version 2 (22 Sep 2009)
Previous versions | rss
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Protein

Transportin-1

Gene

TNPO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571).

Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).

Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19 (By similarity).

Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571).

By similarity5 Publications

(Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei468Important for interaction with cargo nuclear localization signals1 Publication1
Sitei738Important for interaction with cargo nuclear localization signals1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Protein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92973

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-5620924, Intraflagellar transport
R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92973

Protein family/group databases

Transport Classification Database

More...TCDBi		1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transportin-1
Alternative name(s):
Importin beta-2
Karyopherin beta-2
M9 region interaction protein
Short name:
MIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNPO1
Synonyms:KPNB2, MIP1, TRN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6401, TNPO1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602901, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92973

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000083312

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi468W → A: Abolishes interaction with the ADAR nuclear localization signal. Abolishes ADAR nuclear import. 1 Publication1
Mutagenesisi738W → A: Abolishes interaction with the ADAR nuclear localization signal. Abolishes ADAR nuclear import. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3842

Open Targets

More...OpenTargetsi		ENSG00000083312

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30192

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92973, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TNPO1

Domain mapping of disease mutations (DMDM)

More...DMDMi		259016171

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001207651 – 898Transportin-1Add BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q92973-2)
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92973

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92973

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92973

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92973

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92973

PeptideAtlas

More...PeptideAtlasi		Q92973

PRoteomics IDEntifications database

More...PRIDEi		Q92973

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75635 [Q92973-1]
75636 [Q92973-2]
75637 [Q92973-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q92973, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92973

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q92973

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92973

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q92973

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000083312, Expressed in thoracic mammary gland and 259 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92973, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92973, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000083312, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a complex that contains TNPO1, RAN and RANBP1 (PubMed:9428644). Binds HNRPA1, HNRPA2, HNRNPDL, RPL23A, RPS7, RPL5, RAN and SRP19.

Interacts with H2A, H2B, H3 and H4 histones (By similarity).

Interacts with isoform 1 and isoform 5 of ADAR/ADAR1 (via DRBM 3 domain) (PubMed:19124606, PubMed:24753571).

Interacts with SNAI1 (via zinc fingers); the interaction mediates SNAI1 nuclear import (PubMed:19386897).

Interacts with SNAI2 (via zinc fingers) (PubMed:19386897).

By similarity6 Publications

(Microbial infection) Binds to HIV-1 Rev.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110040, 136 interactors

Database of interacting proteins

More...DIPi		DIP-29335N

Protein interaction database and analysis system

More...IntActi		Q92973, 66 interactors

Molecular INTeraction database

More...MINTi		Q92973

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000336712

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92973, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1898
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92973

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q92973

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati19 – 46HEAT 11 PublicationAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 109Importin N-terminalPROSITE-ProRule annotationAdd BLAST69
Repeati51 – 89HEAT 21 PublicationAdd BLAST39
Repeati98 – 131HEAT 31 PublicationAdd BLAST34
Repeati137 – 174HEAT 41 PublicationAdd BLAST38
Repeati181 – 211HEAT 51 PublicationAdd BLAST31
Repeati224 – 251HEAT 61 PublicationAdd BLAST28
Repeati263 – 290HEAT 71 PublicationAdd BLAST28
Repeati306 – 397HEAT 81 PublicationAdd BLAST92
Repeati405 – 433HEAT 91 PublicationAdd BLAST29
Repeati445 – 472HEAT 101 PublicationAdd BLAST28
Repeati486 – 519HEAT 111 PublicationAdd BLAST34
Repeati527 – 560HEAT 121 PublicationAdd BLAST34
Repeati568 – 606HEAT 131 PublicationAdd BLAST39
Repeati614 – 665HEAT 141 PublicationAdd BLAST52
Repeati676 – 707HEAT 151 PublicationAdd BLAST32
Repeati715 – 748HEAT 161 PublicationAdd BLAST34
Repeati756 – 791HEAT 171 PublicationAdd BLAST36
Repeati799 – 832HEAT 181 PublicationAdd BLAST34
Repeati841 – 872HEAT 191 PublicationAdd BLAST32
Repeati875 – 895HEAT 201 PublicationAdd BLAST21

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni347 – 374DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi359 – 374Acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the importin beta family. Importin beta-2 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2023, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155389

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008136_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92973

Identification of Orthologs from Complete Genome Data

More...OMAi		INVFTPR

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92973

TreeFam database of animal gene trees

More...TreeFami		TF300825

Family and domain databases

Database of protein disorder

More...DisProti		DP01457

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 2 hits

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00094

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR001494, Importin-beta_N
IPR040122, Importin_beta

The PANTHER Classification System

More...PANTHERi		PTHR10527, PTHR10527, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03810, IBN_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00913, IBN_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50166, IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92973-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVWDRQTKME YEWKPDEQGL QQILQLLKES QSPDTTIQRT VQQKLEQLNQ 
        60         70         80         90        100
YPDFNNYLIF VLTKLKSEDE PTRSLSGLIL KNNVKAHFQN FPNGVTDFIK 
       110        120        130        140        150
SECLNNIGDS SPLIRATVGI LITTIASKGE LQNWPDLLPK LCSLLDSEDY 
       160        170        180        190        200
NTCEGAFGAL QKICEDSAEI LDSDVLDRPL NIMIPKFLQF FKHSSPKIRS 
       210        220        230        240        250
HAVACVNQFI ISRTQALMLH IDSFIENLFA LAGDEEPEVR KNVCRALVML 
       260        270        280        290        300
LEVRMDRLLP HMHNIVEYML QRTQDQDENV ALEACEFWLT LAEQPICKDV 
       310        320        330        340        350
LVRHLPKLIP VLVNGMKYSD IDIILLKGDV EEDETIPDSE QDIRPRFHRS 
       360        370        380        390        400
RTVAQQHDED GIEEEDDDDD EIDDDDTISD WNLRKCSAAA LDVLANVYRD 
       410        420        430        440        450
ELLPHILPLL KELLFHHEWV VKESGILVLG AIAEGCMQGM IPYLPELIPH 
       460        470        480        490        500
LIQCLSDKKA LVRSITCWTL SRYAHWVVSQ PPDTYLKPLM TELLKRILDS 
       510        520        530        540        550
NKRVQEAACS AFATLEEEAC TELVPYLAYI LDTLVFAFSK YQHKNLLILY 
       560        570        580        590        600
DAIGTLADSV GHHLNKPEYI QMLMPPLIQK WNMLKDEDKD LFPLLECLSS 
       610        620        630        640        650
VATALQSGFL PYCEPVYQRC VNLVQKTLAQ AMLNNAQPDQ YEAPDKDFMI 
       660        670        680        690        700
VALDLLSGLA EGLGGNIEQL VARSNILTLM YQCMQDKMPE VRQSSFALLG 
       710        720        730        740        750
DLTKACFQHV KPCIADFMPI LGTNLNPEFI SVCNNATWAI GEISIQMGIE 
       760        770        780        790        800
MQPYIPMVLH QLVEIINRPN TPKTLLENTA ITIGRLGYVC PQEVAPMLQQ 
       810        820        830        840        850
FIRPWCTSLR NIRDNEEKDS AFRGICTMIS VNPSGVIQDF IFFCDAVASW 
       860        870        880        890 
INPKDDLRDM FCKILHGFKN QVGDENWRRF SDQFPLPLKE RLAAFYGV
Length:898
Mass (Da):102,355
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B880D9E7CA6798F
GO
Isoform 2 (identifier: Q92973-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MVWDRQTKM → M

Show »
Length:890
Mass (Da):101,310
Checksum:i4762DB4895472D10
GO
Isoform 3 (identifier: Q92973-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-118: Missing.

Show »
Length:848
Mass (Da):96,901
Checksum:i6DF034D06DC572B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EW37E7EW37_HUMAN
Transportin-1
TNPO1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TBF0A0A7P0TBF0_HUMAN
Transportin-1
TNPO1
858Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T944A0A7P0T944_HUMAN
Transportin-1
TNPO1
756Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T9C0A0A7P0T9C0_HUMAN
Transportin-1
TNPO1
797Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0Z4D3A0A7P0Z4D3_HUMAN
Transportin-1
TNPO1
870Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R398S4R398_HUMAN
Transportin-1
TNPO1
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50723 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH40340 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104L → S in AAB68948 (Ref. 3) Curated1
Sequence conflicti225I → T in AAC50723 (PubMed:8808633).Curated1
Sequence conflicti669Q → L in AAB68948 (Ref. 3) Curated1
Sequence conflicti880F → L in BAG62638 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0380281 – 9MVWDRQTKM → M in isoform 2. 2 Publications9
Alternative sequenceiVSP_03802969 – 118Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U70322 mRNA Translation: AAC50723.1 Different initiation.
U72069 mRNA Translation: AAB58254.1
U72395 mRNA Translation: AAB68948.1
AK301021 mRNA Translation: BAG62638.1
BC040340 mRNA Translation: AAH40340.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4016.1 [Q92973-2]
CCDS43329.1 [Q92973-1]

NCBI Reference Sequences

More...RefSeqi		NP_002261.3, NM_002270.3 [Q92973-1]
NP_694858.1, NM_153188.2 [Q92973-2]
XP_005248557.1, XM_005248500.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000337273; ENSP00000336712; ENSG00000083312 [Q92973-1]
ENST00000506351; ENSP00000425118; ENSG00000083312 [Q92973-2]
ENST00000523768; ENSP00000428899; ENSG00000083312 [Q92973-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3842

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3842

UCSC genome browser

More...UCSCi		uc003kci.5, human [Q92973-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70322 mRNA Translation: AAC50723.1 Different initiation.
U72069 mRNA Translation: AAB58254.1
U72395 mRNA Translation: AAB68948.1
AK301021 mRNA Translation: BAG62638.1
BC040340 mRNA Translation: AAH40340.1 Different initiation.
CCDSiCCDS4016.1 [Q92973-2]
CCDS43329.1 [Q92973-1]
RefSeqiNP_002261.3, NM_002270.3 [Q92973-1]
NP_694858.1, NM_153188.2 [Q92973-2]
XP_005248557.1, XM_005248500.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QBKX-ray3.00B9-898[»]
2H4MX-ray3.05A/B376-898[»]
A/B9-343[»]
2OT8X-ray3.10A/B9-331[»]
A/B375-898[»]
2QMRX-ray3.00A/B/C/D9-898[»]
2Z5JX-ray3.40A9-898[»]
2Z5KX-ray2.60A9-898[»]
2Z5MX-ray3.00A9-898[»]
2Z5NX-ray3.20A9-898[»]
2Z5OX-ray3.20A9-898[»]
4FDDX-ray2.30A9-331[»]
A375-898[»]
4FQ3X-ray3.00A9-898[»]
4JLQX-ray3.05A9-331[»]
A375-898[»]
4OO6X-ray2.70A375-898[»]
A9-331[»]
5J3VX-ray3.05A/B9-331[»]
A/B375-898[»]
5TQCX-ray3.00A9-343[»]
A375-898[»]
5YVGX-ray4.05A/B9-344[»]
A/B376-898[»]
5YVHX-ray3.15A9-344[»]
A376-898[»]
5YVIX-ray2.90A9-344[»]
A376-898[»]
7CYLX-ray2.70A9-344[»]
A376-898[»]
SMRiQ92973
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110040, 136 interactors
DIPiDIP-29335N
IntActiQ92973, 66 interactors
MINTiQ92973
STRINGi9606.ENSP00000336712

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

GlyGeniQ92973, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ92973
MetOSiteiQ92973
PhosphoSitePlusiQ92973
SwissPalmiQ92973

Genetic variation databases

BioMutaiTNPO1
DMDMi259016171

Proteomic databases

EPDiQ92973
jPOSTiQ92973
MassIVEiQ92973
MaxQBiQ92973
PaxDbiQ92973
PeptideAtlasiQ92973
PRIDEiQ92973
ProteomicsDBi75635 [Q92973-1]
75636 [Q92973-2]
75637 [Q92973-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4275, 296 antibodies

The DNASU plasmid repository

More...DNASUi		3842

Genome annotation databases

EnsembliENST00000337273; ENSP00000336712; ENSG00000083312 [Q92973-1]
ENST00000506351; ENSP00000425118; ENSG00000083312 [Q92973-2]
ENST00000523768; ENSP00000428899; ENSG00000083312 [Q92973-3]
GeneIDi3842
KEGGihsa:3842
UCSCiuc003kci.5, human [Q92973-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3842
DisGeNETi3842

GeneCards: human genes, protein and diseases

More...GeneCardsi		TNPO1
HGNCiHGNC:6401, TNPO1
HPAiENSG00000083312, Low tissue specificity
MIMi602901, gene
neXtProtiNX_Q92973
OpenTargetsiENSG00000083312
PharmGKBiPA30192
VEuPathDBiHostDB:ENSG00000083312

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2023, Eukaryota
GeneTreeiENSGT00940000155389
HOGENOMiCLU_008136_0_0_1
InParanoidiQ92973
OMAiINVFTPR
PhylomeDBiQ92973
TreeFamiTF300825

Enzyme and pathway databases

PathwayCommonsiQ92973
ReactomeiR-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-5620924, Intraflagellar transport
R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation
SIGNORiQ92973

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3842, 196 hits in 1036 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TNPO1, human
EvolutionaryTraceiQ92973

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Transportin_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3842
PharosiQ92973, Tbio

Protein Ontology

More...PROi		PR:Q92973
RNActiQ92973, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000083312, Expressed in thoracic mammary gland and 259 other tissues
ExpressionAtlasiQ92973, baseline and differential
GenevisibleiQ92973, HS

Family and domain databases

DisProtiDP01457
Gene3Di1.25.10.10, 2 hits
IDEALiIID00094
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR001494, Importin-beta_N
IPR040122, Importin_beta
PANTHERiPTHR10527, PTHR10527, 1 hit
PfamiView protein in Pfam
PF03810, IBN_N, 1 hit
SMARTiView protein in SMART
SM00913, IBN_N, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166, IMPORTIN_B_NT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNPO1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92973
Secondary accession number(s): B4DVC6, Q92957, Q92975
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: September 29, 2021
This is version 220 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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