RIT1

Functionⁱ

Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.2 Publications

Miscellaneous

Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation.

Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.

Activity regulationⁱ

Alternates between an inactive form bound to GDP and an active form bound to GTP.

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	28 – 35	GTPBy similarity	8
Nucleotide bindingⁱ	75 – 79	GTPBy similarity	5
Nucleotide bindingⁱ	134 – 137	GTPBy similarity	4

GO - Molecular functionⁱ

calmodulin binding
Source: ProtInc
Traceable author statementⁱ
- 8918462
GTPase activity
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 10545207
GTP binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 10545207

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

Ras protein signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 23791108
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 8918462

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-187706 Signalling to p38 via RIT and RIN
SIGNORⁱ	Q92963

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: GTP-binding protein Rit1 Alternative name(s): Ras-like protein expressed in many tissues Ras-like without CAAX protein 1
Gene namesⁱ	Name:RIT1 Synonyms:RIBB, RIT, ROC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143622.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10023 RIT1
MIMⁱ	609591 gene
neXtProtⁱ	NX_Q92963

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Noonan syndrome 8 (NS8)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_070150	57	A → G in NS8; results in increased ELK1 transcriptional activation; results in increased MAPK-ERK signaling. 2 PublicationsCorresponds to variant dbSNP:rs672601334EnsemblClinVar.	1
Natural variantⁱVAR_070151	81	E → G in NS8; results in increased ELK1 transcriptional activation. 1 PublicationCorresponds to variant dbSNP:rs869025193EnsemblClinVar.	1
Natural variantⁱVAR_070152	82	F → L in NS8; results in increased ELK1 transcriptional activation. 1 PublicationCorresponds to variant dbSNP:rs730881014EnsemblClinVar.	1
Natural variantⁱVAR_070156	90	M → I in NS8; results in increased MAPK-ERK signaling. 2 PublicationsCorresponds to variant dbSNP:rs483352822EnsemblClinVar.	1
Natural variantⁱVAR_070157	95	G → A in NS8; results in increased ELK1 transcriptional activation. 1 PublicationCorresponds to variant dbSNP:rs672601335EnsemblClinVar.	1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	35	S → N: Dominant negative. Loss of interaction with AFDN, RLF and RALGDS. 1 Publication	1
Mutagenesisⁱ	53	T → S: Loss of interaction with AFDN, RLF and RALGDS; when associated with L-79. 1 Publication	1
Mutagenesisⁱ	55	E → G: Loss of interaction with AFDN, but not with RLF and RALGDS; when associated with L-79. 1 Publication	1
Mutagenesisⁱ	79	Q → L: Constitutively active. Dramatic reduction of the rate of GTP hydrolysis. Loss of interaction with AFDN, RLF and RALGDS; when associated with S-53. Loss of interaction with AFDN; when associated with G-55. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6016
MalaCards human disease database More...MalaCardsⁱ	RIT1
MIMⁱ	615355 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000143622
Orphanetⁱ	648 Noonan syndrome
PharmGKBⁱ	PA35528

Polymorphism and mutation databases

BioMutaⁱ	RIT1
DMDMⁱ	38258628

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000082725	1 – 219	GTP-binding protein Rit1Add BLAST		219

Proteomic databases

EPDⁱ	Q92963
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92963
PaxDbⁱ	Q92963
PeptideAtlas More...PeptideAtlasⁱ	Q92963
PRIDEⁱ	Q92963
ProteomicsDBⁱ	75632

PTM databases

iPTMnetⁱ	Q92963
PhosphoSitePlusⁱ	Q92963

Expressionⁱ

Tissue specificityⁱ

Expressed in many tissues.

Gene expression databases

Bgeeⁱ	ENSG00000143622 Expressed in 214 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_RIT1
ExpressionAtlasⁱ	Q92963 baseline and differential
Genevisibleⁱ	Q92963 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053249

HPAⁱ

HPA053249

Interactionⁱ

Subunit structureⁱ

Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state. Interacts with RGL3 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
RLF	Q13129	3	EBI-365845,EBI-958266

With

Entry

#Exp.

IntAct

Notes

RLF

Q13129

3

EBI-365845,EBI-958266

GO - Molecular functionⁱ

calmodulin binding
Source: ProtInc
Traceable author statementⁱ
- 8918462

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111948, 14 interactors
IntActⁱ	Q92963, 12 interactors
STRINGⁱ	9606.ENSP00000357306

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	22 – 27	Combined sources	6
Helixⁱ	34 – 43	Combined sources	10
Beta strandⁱ	56 – 62	Combined sources	7
Beta strandⁱ	64 – 67	Combined sources	4
Beta strandⁱ	69 – 75	Combined sources	7
Beta strandⁱ	95 – 101	Combined sources	7
Helixⁱ	105 – 109	Combined sources	5
Helixⁱ	111 – 121	Combined sources	11
Beta strandⁱ	129 – 134	Combined sources	6
Helixⁱ	139 – 141	Combined sources	3
Helixⁱ	146 – 155	Combined sources	10
Beta strandⁱ	160 – 162	Combined sources	3
Helixⁱ	165 – 167	Combined sources	3
Helixⁱ	171 – 182	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	Q92963
SMRⁱ	Q92963
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133678
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q92963
KEGG Orthology (KO) More...KOⁱ	K07832
OMAⁱ	FRYYIDD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UAU
PhylomeDBⁱ	Q92963
TreeFamⁱ	TF315072

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q92963-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSGTRPVGS CCSSPAGLSR EYKLVMLGAG GVGKSAMTMQ FISHRFPEDH 
        60         70         80         90        100
DPTIEDAYKI RIRIDDEPAN LDILDTAGQA EFTAMRDQYM RAGEGFIICY 
       110        120        130        140        150
SITDRRSFHE VREFKQLIYR VRRTDDTPVV LVGNKSDLKQ LRQVTKEEGL 
       160        170        180        190        200
ALAREFSCPF FETSAAYRYY IDDVFHALVR EIRRKEKEAV LAMEKKSKPK 
       210 
NSVWKRLKSP FRKKKDSVT

Length:219

Mass (Da):25,145

Last modified:February 1, 1997 - v1

Checksum:ⁱ7F957871F836AE92

GO

Isoform 2 (identifier: Q92963-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-36: Missing.

« Hide

        10         20         30         40         50
MTMQFISHRF PEDHDPTIED AYKIRIRIDD EPANLDILDT AGQAEFTAMR 
        60         70         80         90        100
DQYMRAGEGF IICYSITDRR SFHEVREFKQ LIYRVRRTDD TPVVLVGNKS 
       110        120        130        140        150
DLKQLRQVTK EEGLALAREF SCPFFETSAA YRYYIDDVFH ALVREIRRKE 
       160        170        180 
KEAVLAMEKK SKPKNSVWKR LKSPFRKKKD SVT

Show »

Length:183

Mass (Da):21,633

Checksum:ⁱ61CFC2E07B180267

GO

Isoform 3 (identifier: Q92963-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MERWLFLGATEEGPKRTM

« Hide

        10         20         30         40         50
MERWLFLGAT EEGPKRTMDS GTRPVGSCCS SPAGLSREYK LVMLGAGGVG 
        60         70         80         90        100
KSAMTMQFIS HRFPEDHDPT IEDAYKIRIR IDDEPANLDI LDTAGQAEFT 
       110        120        130        140        150
AMRDQYMRAG EGFIICYSIT DRRSFHEVRE FKQLIYRVRR TDDTPVVLVG 
       160        170        180        190        200
NKSDLKQLRQ VTKEEGLALA REFSCPFFET SAAYRYYIDD VFHALVREIR 
       210        220        230 
RKEKEAVLAM EKKSKPKNSV WKRLKSPFRK KKDSVT

Note: No experimental confirmation available.

Show »

Length:236

Mass (Da):27,148

Checksum:ⁱB6B991C6D3668388

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

V9GY29	V9GY29_HUMAN	GTP-binding protein Rit1 GTP-binding protein Rit1	RIT1	92	Annotation score:
V9GYC3	V9GYC3_HUMAN	GTP-binding protein Rit1 GTP-binding protein Rit1	RIT1	151	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_070149	35	S → T Probable disease-associated mutation found in patients with features of Noonan syndrome. 1 PublicationCorresponds to variant dbSNP:rs869025189EnsemblClinVar.	1
Natural variantⁱVAR_070150	57	A → G in NS8; results in increased ELK1 transcriptional activation; results in increased MAPK-ERK signaling. 2 PublicationsCorresponds to variant dbSNP:rs672601334EnsemblClinVar.	1
Natural variantⁱVAR_070151	81	E → G in NS8; results in increased ELK1 transcriptional activation. 1 PublicationCorresponds to variant dbSNP:rs869025193EnsemblClinVar.	1
Natural variantⁱVAR_070152	82	F → L in NS8; results in increased ELK1 transcriptional activation. 1 PublicationCorresponds to variant dbSNP:rs730881014EnsemblClinVar.	1
Natural variantⁱVAR_070153	82	F → V Probable disease-associated mutation found in patients with features of Noonan syndrome. 1 PublicationCorresponds to variant dbSNP:rs869025194EnsemblClinVar.	1
Natural variantⁱVAR_070154	83	T → P Probable disease-associated mutation found in patients with features of Noonan syndrome. Corresponds to variant dbSNP:rs869025195EnsemblClinVar.	1
Natural variantⁱVAR_070155	89	Y → H Probable disease-associated mutation found in patients with features of Noonan syndrome. 1 PublicationCorresponds to variant dbSNP:rs869025197EnsemblClinVar.	1
Natural variantⁱVAR_070156	90	M → I in NS8; results in increased MAPK-ERK signaling. 2 PublicationsCorresponds to variant dbSNP:rs483352822EnsemblClinVar.	1
Natural variantⁱVAR_070157	95	G → A in NS8; results in increased ELK1 transcriptional activation. 1 PublicationCorresponds to variant dbSNP:rs672601335EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045306	1 – 36	Missing in isoform 2. 1 PublicationAdd BLAST		36
Alternative sequenceⁱVSP_047114	1	M → MERWLFLGATEEGPKRTM in isoform 3. Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U71203 mRNA Translation: AAB42213.1 Y07566 mRNA Translation: CAA68851.1 U78165 mRNA Translation: AAB64246.1 AF084462 mRNA Translation: AAD13021.1 AF493923 mRNA Translation: AAM12637.1 AK298768 mRNA Translation: BAG60910.1 AK314239 mRNA Translation: BAG36908.1 CR407639 mRNA Translation: CAG28567.1 AL139128 Genomic DNA No translation available. AL355388 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53024.1 BC104186 mRNA Translation: AAI04187.1 BC104187 mRNA Translation: AAI04188.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1123.1 [Q92963-1] CCDS58036.1 [Q92963-2] CCDS58037.1 [Q92963-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001243749.1, NM_001256820.1 [Q92963-2] NP_001243750.1, NM_001256821.1 [Q92963-3] NP_008843.1, NM_006912.5 [Q92963-1]
UniGeneⁱ	Hs.491234

Genome annotation databases

Ensemblⁱ	ENST00000368322; ENSP00000357305; ENSG00000143622 [Q92963-3] ENST00000368323; ENSP00000357306; ENSG00000143622 [Q92963-1] ENST00000539040; ENSP00000441950; ENSG00000143622 [Q92963-2]
GeneIDⁱ	6016
KEGGⁱ	hsa:6016
UCSC genome browser More...UCSCⁱ	uc001fmh.3 human [Q92963-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92963	RIT1 isoform 3		PANTR		236	UniRef100_Q92963
Uncharacterized protein		COLAP		236
RIT1 isoform 3		PONAB		236
Uncharacterized protein		CERAT		236
Uncharacterized protein		RHIRO		236
+17
Q92963-2	Uncharacterized protein		CAMFR		722	UniRef100_S9YXC4
GTP-binding protein Rit1 isoform X2		TARSY		183
RIT1 isoform 2		PONAB		183
RIT1 isoform 2		PANTR		183
Uncharacterized protein		MACNE		183
+3

Protein	Similar proteins		Species	Score	Length	Source
Q92963	RIT1 isoform 3		PANTR		236	UniRef90_Q92963
Uncharacterized protein		COLAP		236
RIT1 isoform 3		PONAB		236
Uncharacterized protein		CERAT		236
Uncharacterized protein		RHIRO		236
+32
Q92963-2	Uncharacterized protein		CAMFR		722	UniRef90_S9YXC4
GTP-binding protein Rit1 isoform X2		TARSY		183
RIT1 isoform 2		PONAB		183
RIT1 isoform 2		PANTR		183
Uncharacterized protein		MACNE		183
+3

Protein	Similar proteins		Species	Score	Length	Source
Q92963	GTP-binding protein Rit1		MOUSE		219	UniRef50_Q92963
RIT1 isoform 3		PANTR		236
Uncharacterized protein		COLAP		236
RIT1 isoform 3		PONAB		236
Uncharacterized protein		CERAT		236
+184
Q92963-2	KH homology domain-containing protein 4	)	HUMAN		614	UniRef50_Q7Z7F0
KH homology domain-containing protein 4		MOUSE		612
KH homology domain-containing protein 4		CHICK		619
Nuclear ribonucleoprotein K homology domain protein		MACMU		614
KH domain containing 4, pre-mRNA splicing factor		PANTR		614
+266

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U71203 mRNA Translation: AAB42213.1 Y07566 mRNA Translation: CAA68851.1 U78165 mRNA Translation: AAB64246.1 AF084462 mRNA Translation: AAD13021.1 AF493923 mRNA Translation: AAM12637.1 AK298768 mRNA Translation: BAG60910.1 AK314239 mRNA Translation: BAG36908.1 CR407639 mRNA Translation: CAG28567.1 AL139128 Genomic DNA No translation available. AL355388 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53024.1 BC104186 mRNA Translation: AAI04187.1 BC104187 mRNA Translation: AAI04188.1
CCDSⁱ	CCDS1123.1 [Q92963-1] CCDS58036.1 [Q92963-2] CCDS58037.1 [Q92963-3]
RefSeqⁱ	NP_001243749.1, NM_001256820.1 [Q92963-2] NP_001243750.1, NM_001256821.1 [Q92963-3] NP_008843.1, NM_006912.5 [Q92963-1]
UniGeneⁱ	Hs.491234

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4KLZ	X-ray	2.30	A	19-189	[»]
ProteinModelPortalⁱ	Q92963
SMRⁱ	Q92963
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111948, 14 interactors
IntActⁱ	Q92963, 12 interactors
STRINGⁱ	9606.ENSP00000357306

PTM databases

iPTMnetⁱ	Q92963
PhosphoSitePlusⁱ	Q92963

Polymorphism and mutation databases

BioMutaⁱ	RIT1
DMDMⁱ	38258628

Proteomic databases

EPDⁱ	Q92963
MaxQBⁱ	Q92963
PaxDbⁱ	Q92963
PeptideAtlasⁱ	Q92963
PRIDEⁱ	Q92963
ProteomicsDBⁱ	75632

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000368322; ENSP00000357305; ENSG00000143622 [Q92963-3] ENST00000368323; ENSP00000357306; ENSG00000143622 [Q92963-1] ENST00000539040; ENSP00000441950; ENSG00000143622 [Q92963-2]
GeneIDⁱ	6016
KEGGⁱ	hsa:6016
UCSCⁱ	uc001fmh.3 human [Q92963-1]

Organism-specific databases

CTDⁱ	6016
DisGeNETⁱ	6016
EuPathDBⁱ	HostDB:ENSG00000143622.10
GeneCardsⁱ	RIT1
HGNCⁱ	HGNC:10023 RIT1
HPAⁱ	HPA053249
MalaCardsⁱ	RIT1
MIMⁱ	609591 gene 615355 phenotype
neXtProtⁱ	NX_Q92963
OpenTargetsⁱ	ENSG00000143622
Orphanetⁱ	648 Noonan syndrome
PharmGKBⁱ	PA35528
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00860000133678
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q92963
KOⁱ	K07832
OMAⁱ	FRYYIDD
OrthoDBⁱ	EOG091G0UAU
PhylomeDBⁱ	Q92963
TreeFamⁱ	TF315072

Enzyme and pathway databases

Reactomeⁱ	R-HSA-187706 Signalling to p38 via RIT and RIN
SIGNORⁱ	Q92963

Miscellaneous databases

ChiTaRSⁱ	RIT1 human
GeneWikiⁱ	RIT1
GenomeRNAiⁱ	6016
Protein Ontology More...PROⁱ	PR:Q92963
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143622 Expressed in 214 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_RIT1
ExpressionAtlasⁱ	Q92963 baseline and differential
Genevisibleⁱ	Q92963 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RIT1_HUMAN
Accessionⁱ	Q92963Primary (citable) accession number: Q92963 Secondary accession number(s): B4DQE8 , O00646, O00720, Q5VY89, Q5VY90
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
	Last sequence update:	February 1, 1997
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q92963 (RIT1_HUMAN)

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GTP-binding protein Rit1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ