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Protein

Solute carrier organic anion transporter family member 2A1

Gene

SLCO2A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

GO - Molecular functioni

  • lipid transporter activity Source: ProtInc
  • prostaglandin transmembrane transporter activity Source: GO_Central
  • sodium-independent organic anion transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-5619095 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
R-HSA-879518 Transport of organic anions

Protein family/group databases

TCDBi2.A.60.1.19 the organo anion transporter (oat) family

Chemistry databases

SwissLipidsiSLP:000001646

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Prostaglandin transporter
Short name:
PGT
Solute carrier family 21 member 2
Gene namesi
Name:SLCO2A1
Synonyms:OATP2A1, SLC21A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000174640.12
HGNCiHGNC:10955 SLCO2A1
MIMi601460 gene
neXtProtiNX_Q92959

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 52Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini53 – 71ExtracellularSequence analysisAdd BLAST19
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 98CytoplasmicSequence analysis6
Transmembranei99 – 123Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini124 – 167ExtracellularSequence analysisAdd BLAST44
Transmembranei168 – 196Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini197 – 215CytoplasmicSequence analysisAdd BLAST19
Transmembranei216 – 236Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini237 – 254ExtracellularSequence analysisAdd BLAST18
Transmembranei255 – 279Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini280 – 321CytoplasmicSequence analysisAdd BLAST42
Transmembranei322 – 343Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini344 – 363ExtracellularSequence analysisAdd BLAST20
Transmembranei364 – 387Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini388 – 391CytoplasmicSequence analysis4
Transmembranei392 – 415Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini416 – 518ExtracellularSequence analysisAdd BLAST103
Transmembranei519 – 541Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini542 – 550CytoplasmicSequence analysis9
Transmembranei551 – 576Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini577 – 610ExtracellularSequence analysisAdd BLAST34
Transmembranei611 – 629Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini630 – 643CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease.
See also OMIM:614441
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06863685I → F in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs387907296EnsemblClinVar.1
Natural variantiVAR_06863797R → H in PHOAR2. 1 Publication1
Natural variantiVAR_068638181G → A in PHOAR2. 1 Publication1
Natural variantiVAR_068639181G → D in PHOAR2. 1 Publication1
Natural variantiVAR_068640204S → L in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs555934769Ensembl.1
Natural variantiVAR_067598222G → R in PHOAR2. 2 PublicationsCorresponds to variant dbSNP:rs774795340EnsemblClinVar.1
Natural variantiVAR_067599255G → E in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs387906806EnsemblClinVar.1
Natural variantiVAR_068641255G → R in PHOAR2. 1 Publication1
Natural variantiVAR_068642420C → F in PHOAR2; reduced activity. 1 PublicationCorresponds to variant dbSNP:rs387907295EnsemblClinVar.1
Natural variantiVAR_068644556Q → H in PHOAR2. 1 Publication1
Natural variantiVAR_068352557F → S in PHOAR2. 1 Publication1
Natural variantiVAR_068645565W → G in PHOAR2. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6578
MalaCardsiSLCO2A1
MIMi614441 phenotype
OpenTargetsiENSG00000174640
Orphaneti468641 Chronic enteropathy associated with SLCO2A1 gene
2796 Pachydermoperiostosis
PharmGKBiPA35840

Chemistry databases

ChEMBLiCHEMBL2073703
DrugBankiDB00770 Alprostadil
DB04557 Arachidonic Acid
DB01160 Dinoprost Tromethamine
DB00917 Dinoprostone
DB00695 Furosemide
DB03581 Glucose-6-Phosphate
DB02263 Glyceraldehyde-3-Phosphate
DB01088 Iloprost
DB04398 Lactic Acid
DB01174 Phenobarbital
DB01819 Phosphoenolpyruvate
DB00119 Pyruvic acid

Polymorphism and mutation databases

BioMutaiSLCO2A1
DMDMi218511799

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910581 – 643Solute carrier organic anion transporter family member 2A1Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi444 ↔ 470PROSITE-ProRule annotation
Disulfide bondi448 ↔ 459PROSITE-ProRule annotation
Disulfide bondi450 ↔ 474PROSITE-ProRule annotation
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ92959
PaxDbiQ92959
PeptideAtlasiQ92959
PRIDEiQ92959
ProteomicsDBi75631

PTM databases

iPTMnetiQ92959
PhosphoSitePlusiQ92959

Expressioni

Tissue specificityi

Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart.1 Publication

Gene expression databases

BgeeiENSG00000174640 Expressed in 188 organ(s), highest expression level in right lung
CleanExiHS_SLCO2A1
ExpressionAtlasiQ92959 baseline and differential
GenevisibleiQ92959 HS

Organism-specific databases

HPAiHPA013742

Interactioni

Protein-protein interaction databases

IntActiQ92959, 1 interactor
STRINGi9606.ENSP00000311291

Chemistry databases

BindingDBiQ92959

Structurei

Secondary structure

1643
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92959
SMRiQ92959
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92959

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini438 – 496Kazal-likePROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG108345
InParanoidiQ92959
KOiK14345
OMAiIPCAHFL
OrthoDBiEOG091G08QD
PhylomeDBiQ92959
TreeFamiTF317540

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q92959-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLLPKLGAS QGSDTSTSRA GRCARSVFGN IKVFVLCQGL LQLCQLLYSA
60 70 80 90 100
YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVHRPRL
110 120 130 140 150
IGIGGLFLAA GAFILTLPHF LSEPYQYTLA STGNNSRLQA ELCQKHWQDL
160 170 180 190 200
PPSKCHSTTQ NPQKETSSMW GLMVVAQLLA GIGTVPIQPF GISYVDDFSE
210 220 230 240 250
PSNSPLYISI LFAISVFGPA FGYLLGSVML QIFVDYGRVN TAAVNLVPGD
260 270 280 290 300
PRWIGAWWLG LLISSALLVL TSFPFFFFPR AMPIGAKRAP ATADEARKLE
310 320 330 340 350
EAKSRGSLVD FIKRFPCIFL RLLMNSLFVL VVLAQCTFSS VIAGLSTFLN
360 370 380 390 400
KFLEKQYGTS AAYANFLIGA VNLPAAALGM LFGGILMKRF VFSLQAIPRI
410 420 430 440 450
ATTIITISMI LCVPLFFMGC STPTVAEVYP PSTSSSIHPQ SPACRRDCSC
460 470 480 490 500
PDSIFHPVCG DNGIEYLSPC HAGCSNINMS SATSKQLIYL NCSCVTGGSA
510 520 530 540 550
SAKTGSCPVP CAHFLLPAIF LISFVSLIAC ISHNPLYMMV LRVVNQEEKS
560 570 580 590 600
FAIGVQFLLM RLLAWLPSPA LYGLTIDHSC IRWNSLCLGR RGACAYYDND
610 620 630 640
ALRDRYLGLQ MGYKALGMLL LCFISWRVKK NKEYNVQKAA GLI
Length:643
Mass (Da):70,044
Last modified:December 16, 2008 - v2
Checksum:iA1FF933246480984
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EU40E7EU40_HUMAN
Solute carrier organic anion transp...
SLCO2A1
567Annotation score:
F8W9W8F8W9W8_HUMAN
Solute carrier organic anion transp...
SLCO2A1
415Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9A → V in AAC09469 (PubMed:8787677).Curated1
Sequence conflicti9A → V in AAC62004 (PubMed:9618293).Curated1
Sequence conflicti228V → I in AAC09469 (PubMed:8787677).Curated1
Sequence conflicti228V → I in AAC62004 (PubMed:9618293).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06863685I → F in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs387907296EnsemblClinVar.1
Natural variantiVAR_06863797R → H in PHOAR2. 1 Publication1
Natural variantiVAR_068638181G → A in PHOAR2. 1 Publication1
Natural variantiVAR_068639181G → D in PHOAR2. 1 Publication1
Natural variantiVAR_068640204S → L in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs555934769Ensembl.1
Natural variantiVAR_067598222G → R in PHOAR2. 2 PublicationsCorresponds to variant dbSNP:rs774795340EnsemblClinVar.1
Natural variantiVAR_067599255G → E in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs387906806EnsemblClinVar.1
Natural variantiVAR_068641255G → R in PHOAR2. 1 Publication1
Natural variantiVAR_053674396A → T2 PublicationsCorresponds to variant dbSNP:rs34550074Ensembl.1
Natural variantiVAR_068642420C → F in PHOAR2; reduced activity. 1 PublicationCorresponds to variant dbSNP:rs387907295EnsemblClinVar.1
Natural variantiVAR_068643445R → C1 PublicationCorresponds to variant dbSNP:rs146970901Ensembl.1
Natural variantiVAR_068644556Q → H in PHOAR2. 1 Publication1
Natural variantiVAR_068352557F → S in PHOAR2. 1 Publication1
Natural variantiVAR_068645565W → G in PHOAR2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70867 mRNA Translation: AAC09469.1
AF056732
, AF056719, AF056720, AF056721, AF056722, AF056723, AF056724, AF056725, AF056726, AF056727, AF056728, AF056729, AF056730, AF056731 Genomic DNA Translation: AAC62004.1
CH471052 Genomic DNA Translation: EAW79156.1
BC041140 mRNA Translation: AAH41140.2
BC051347 mRNA Translation: AAH51347.1
CCDSiCCDS3084.1
RefSeqiNP_005621.2, NM_005630.2
UniGeneiHs.518270

Genome annotation databases

EnsembliENST00000310926; ENSP00000311291; ENSG00000174640
GeneIDi6578
KEGGihsa:6578
UCSCiuc003eqa.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Solute carrier organic anion transporter family, member 2A1 (SLCO2A1)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70867 mRNA Translation: AAC09469.1
AF056732
, AF056719, AF056720, AF056721, AF056722, AF056723, AF056724, AF056725, AF056726, AF056727, AF056728, AF056729, AF056730, AF056731 Genomic DNA Translation: AAC62004.1
CH471052 Genomic DNA Translation: EAW79156.1
BC041140 mRNA Translation: AAH41140.2
BC051347 mRNA Translation: AAH51347.1
CCDSiCCDS3084.1
RefSeqiNP_005621.2, NM_005630.2
UniGeneiHs.518270

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MRRX-ray1.60P178-187[»]
ProteinModelPortaliQ92959
SMRiQ92959
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ92959, 1 interactor
STRINGi9606.ENSP00000311291

Chemistry databases

BindingDBiQ92959
ChEMBLiCHEMBL2073703
DrugBankiDB00770 Alprostadil
DB04557 Arachidonic Acid
DB01160 Dinoprost Tromethamine
DB00917 Dinoprostone
DB00695 Furosemide
DB03581 Glucose-6-Phosphate
DB02263 Glyceraldehyde-3-Phosphate
DB01088 Iloprost
DB04398 Lactic Acid
DB01174 Phenobarbital
DB01819 Phosphoenolpyruvate
DB00119 Pyruvic acid
SwissLipidsiSLP:000001646

Protein family/group databases

TCDBi2.A.60.1.19 the organo anion transporter (oat) family

PTM databases

iPTMnetiQ92959
PhosphoSitePlusiQ92959

Polymorphism and mutation databases

BioMutaiSLCO2A1
DMDMi218511799

Proteomic databases

EPDiQ92959
PaxDbiQ92959
PeptideAtlasiQ92959
PRIDEiQ92959
ProteomicsDBi75631

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310926; ENSP00000311291; ENSG00000174640
GeneIDi6578
KEGGihsa:6578
UCSCiuc003eqa.4 human

Organism-specific databases

CTDi6578
DisGeNETi6578
EuPathDBiHostDB:ENSG00000174640.12
GeneCardsiSLCO2A1
H-InvDBiHIX0024333
HGNCiHGNC:10955 SLCO2A1
HPAiHPA013742
MalaCardsiSLCO2A1
MIMi601460 gene
614441 phenotype
neXtProtiNX_Q92959
OpenTargetsiENSG00000174640
Orphaneti468641 Chronic enteropathy associated with SLCO2A1 gene
2796 Pachydermoperiostosis
PharmGKBiPA35840
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG108345
InParanoidiQ92959
KOiK14345
OMAiIPCAHFL
OrthoDBiEOG091G08QD
PhylomeDBiQ92959
TreeFamiTF317540

Enzyme and pathway databases

ReactomeiR-HSA-5619095 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
R-HSA-879518 Transport of organic anions

Miscellaneous databases

ChiTaRSiSLCO2A1 human
EvolutionaryTraceiQ92959
GeneWikiiSLCO2A1
GenomeRNAii6578
PROiPR:Q92959
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174640 Expressed in 188 organ(s), highest expression level in right lung
CleanExiHS_SLCO2A1
ExpressionAtlasiQ92959 baseline and differential
GenevisibleiQ92959 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSO2A1_HUMAN
AccessioniPrimary (citable) accession number: Q92959
Secondary accession number(s): Q86V98, Q8IUN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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