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Entry version 160 (16 Oct 2019)
Sequence version 2 (16 Dec 2008)
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Protein

Solute carrier organic anion transporter family member 2A1

Gene

SLCO2A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5619095 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
R-HSA-879518 Transport of organic anions

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.60.1.19 the organo anion transporter (oat) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001646

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Prostaglandin transporter
Short name:
PGT
Solute carrier family 21 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLCO2A1
Synonyms:OATP2A1, SLC21A2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10955 SLCO2A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601460 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92959

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 52Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini53 – 71ExtracellularSequence analysisAdd BLAST19
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 98CytoplasmicSequence analysis6
Transmembranei99 – 123Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini124 – 167ExtracellularSequence analysisAdd BLAST44
Transmembranei168 – 196Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini197 – 215CytoplasmicSequence analysisAdd BLAST19
Transmembranei216 – 236Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini237 – 254ExtracellularSequence analysisAdd BLAST18
Transmembranei255 – 279Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini280 – 321CytoplasmicSequence analysisAdd BLAST42
Transmembranei322 – 343Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini344 – 363ExtracellularSequence analysisAdd BLAST20
Transmembranei364 – 387Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini388 – 391CytoplasmicSequence analysis4
Transmembranei392 – 415Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini416 – 518ExtracellularSequence analysisAdd BLAST103
Transmembranei519 – 541Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini542 – 550CytoplasmicSequence analysis9
Transmembranei551 – 576Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini577 – 610ExtracellularSequence analysisAdd BLAST34
Transmembranei611 – 629Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini630 – 643CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06863685I → F in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs387907296EnsemblClinVar.1
Natural variantiVAR_06863797R → H in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs1376989560Ensembl.1
Natural variantiVAR_068638181G → A in PHOAR2. 1 Publication1
Natural variantiVAR_068639181G → D in PHOAR2. 1 Publication1
Natural variantiVAR_068640204S → L in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs555934769Ensembl.1
Natural variantiVAR_067598222G → R in PHOAR2. 2 PublicationsCorresponds to variant dbSNP:rs774795340EnsemblClinVar.1
Natural variantiVAR_067599255G → E in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs387906806EnsemblClinVar.1
Natural variantiVAR_068641255G → R in PHOAR2. 1 Publication1
Natural variantiVAR_068642420C → F in PHOAR2; reduced activity. 1 PublicationCorresponds to variant dbSNP:rs387907295EnsemblClinVar.1
Natural variantiVAR_068644556Q → H in PHOAR2. 1 Publication1
Natural variantiVAR_068352557F → S in PHOAR2. 1 Publication1
Natural variantiVAR_068645565W → G in PHOAR2. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6578

MalaCards human disease database

More...
MalaCardsi
SLCO2A1
MIMi614441 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000174640

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
468641 Chronic enteropathy associated with SLCO2A1 gene
2796 Pachydermoperiostosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35840

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92959

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2073703

Drug and drug target database

More...
DrugBanki
DB00770 Alprostadil
DB04557 Arachidonic Acid
DB04551 beta-D-fructofuranose 1,6-bisphosphate
DB01160 Dinoprost tromethamine
DB00917 Dinoprostone
DB00695 Furosemide
DB03581 Glucose-6-Phosphate
DB02263 Glyceraldehyde-3-Phosphate
DB01088 Iloprost
DB04398 Lactic acid
DB01174 Phenobarbital
DB01819 Phosphoenolpyruvate
DB02056 Prostaglandin D2
DB00119 Pyruvic acid
DB11753 Rifamycin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLCO2A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
218511799

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910581 – 643Solute carrier organic anion transporter family member 2A1Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi444 ↔ 470PROSITE-ProRule annotation
Disulfide bondi448 ↔ 459PROSITE-ProRule annotation
Disulfide bondi450 ↔ 474PROSITE-ProRule annotation
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92959

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92959

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92959

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92959

PeptideAtlas

More...
PeptideAtlasi
Q92959

PRoteomics IDEntifications database

More...
PRIDEi
Q92959

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75631

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92959

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92959

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174640 Expressed in 188 organ(s), highest expression level in right lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92959 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92959 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013742

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q92959, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000311291

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q92959

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1643
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92959

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q92959

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini438 – 496Kazal-likePROSITE-ProRule annotationAdd BLAST59

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3626 Eukaryota
ENOG410XRSF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182739

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231269

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92959

KEGG Orthology (KO)

More...
KOi
K14345

Identification of Orthologs from Complete Genome Data

More...
OMAi
FFFPRYM

Database of Orthologous Groups

More...
OrthoDBi
1556205at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92959

TreeFam database of animal gene trees

More...
TreeFami
TF317540

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP

The PANTHER Classification System

More...
PANTHERi
PTHR11388 PTHR11388, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00805 oat, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q92959-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLLPKLGAS QGSDTSTSRA GRCARSVFGN IKVFVLCQGL LQLCQLLYSA
60 70 80 90 100
YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVHRPRL
110 120 130 140 150
IGIGGLFLAA GAFILTLPHF LSEPYQYTLA STGNNSRLQA ELCQKHWQDL
160 170 180 190 200
PPSKCHSTTQ NPQKETSSMW GLMVVAQLLA GIGTVPIQPF GISYVDDFSE
210 220 230 240 250
PSNSPLYISI LFAISVFGPA FGYLLGSVML QIFVDYGRVN TAAVNLVPGD
260 270 280 290 300
PRWIGAWWLG LLISSALLVL TSFPFFFFPR AMPIGAKRAP ATADEARKLE
310 320 330 340 350
EAKSRGSLVD FIKRFPCIFL RLLMNSLFVL VVLAQCTFSS VIAGLSTFLN
360 370 380 390 400
KFLEKQYGTS AAYANFLIGA VNLPAAALGM LFGGILMKRF VFSLQAIPRI
410 420 430 440 450
ATTIITISMI LCVPLFFMGC STPTVAEVYP PSTSSSIHPQ SPACRRDCSC
460 470 480 490 500
PDSIFHPVCG DNGIEYLSPC HAGCSNINMS SATSKQLIYL NCSCVTGGSA
510 520 530 540 550
SAKTGSCPVP CAHFLLPAIF LISFVSLIAC ISHNPLYMMV LRVVNQEEKS
560 570 580 590 600
FAIGVQFLLM RLLAWLPSPA LYGLTIDHSC IRWNSLCLGR RGACAYYDND
610 620 630 640
ALRDRYLGLQ MGYKALGMLL LCFISWRVKK NKEYNVQKAA GLI
Length:643
Mass (Da):70,044
Last modified:December 16, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1FF933246480984
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EU40E7EU40_HUMAN
Solute carrier organic anion transp...
SLCO2A1
567Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9W8F8W9W8_HUMAN
Solute carrier organic anion transp...
SLCO2A1
415Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9A → V in AAC09469 (PubMed:8787677).Curated1
Sequence conflicti9A → V in AAC62004 (PubMed:9618293).Curated1
Sequence conflicti228V → I in AAC09469 (PubMed:8787677).Curated1
Sequence conflicti228V → I in AAC62004 (PubMed:9618293).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06863685I → F in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs387907296EnsemblClinVar.1
Natural variantiVAR_06863797R → H in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs1376989560Ensembl.1
Natural variantiVAR_068638181G → A in PHOAR2. 1 Publication1
Natural variantiVAR_068639181G → D in PHOAR2. 1 Publication1
Natural variantiVAR_068640204S → L in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs555934769Ensembl.1
Natural variantiVAR_067598222G → R in PHOAR2. 2 PublicationsCorresponds to variant dbSNP:rs774795340EnsemblClinVar.1
Natural variantiVAR_067599255G → E in PHOAR2. 1 PublicationCorresponds to variant dbSNP:rs387906806EnsemblClinVar.1
Natural variantiVAR_068641255G → R in PHOAR2. 1 Publication1
Natural variantiVAR_053674396A → T2 PublicationsCorresponds to variant dbSNP:rs34550074Ensembl.1
Natural variantiVAR_068642420C → F in PHOAR2; reduced activity. 1 PublicationCorresponds to variant dbSNP:rs387907295EnsemblClinVar.1
Natural variantiVAR_068643445R → C1 PublicationCorresponds to variant dbSNP:rs146970901Ensembl.1
Natural variantiVAR_068644556Q → H in PHOAR2. 1 Publication1
Natural variantiVAR_068352557F → S in PHOAR2. 1 Publication1
Natural variantiVAR_068645565W → G in PHOAR2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U70867 mRNA Translation: AAC09469.1
AF056732
, AF056719, AF056720, AF056721, AF056722, AF056723, AF056724, AF056725, AF056726, AF056727, AF056728, AF056729, AF056730, AF056731 Genomic DNA Translation: AAC62004.1
CH471052 Genomic DNA Translation: EAW79156.1
BC041140 mRNA Translation: AAH41140.2
BC051347 mRNA Translation: AAH51347.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3084.1

NCBI Reference Sequences

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RefSeqi
NP_005621.2, NM_005630.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000310926; ENSP00000311291; ENSG00000174640

Database of genes from NCBI RefSeq genomes

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GeneIDi
6578

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6578

UCSC genome browser

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UCSCi
uc003eqa.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Solute carrier organic anion transporter family, member 2A1 (SLCO2A1)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70867 mRNA Translation: AAC09469.1
AF056732
, AF056719, AF056720, AF056721, AF056722, AF056723, AF056724, AF056725, AF056726, AF056727, AF056728, AF056729, AF056730, AF056731 Genomic DNA Translation: AAC62004.1
CH471052 Genomic DNA Translation: EAW79156.1
BC041140 mRNA Translation: AAH41140.2
BC051347 mRNA Translation: AAH51347.1
CCDSiCCDS3084.1
RefSeqiNP_005621.2, NM_005630.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MRRX-ray1.60P178-187[»]
SMRiQ92959
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ92959, 1 interactor
STRINGi9606.ENSP00000311291

Chemistry databases

BindingDBiQ92959
ChEMBLiCHEMBL2073703
DrugBankiDB00770 Alprostadil
DB04557 Arachidonic Acid
DB04551 beta-D-fructofuranose 1,6-bisphosphate
DB01160 Dinoprost tromethamine
DB00917 Dinoprostone
DB00695 Furosemide
DB03581 Glucose-6-Phosphate
DB02263 Glyceraldehyde-3-Phosphate
DB01088 Iloprost
DB04398 Lactic acid
DB01174 Phenobarbital
DB01819 Phosphoenolpyruvate
DB02056 Prostaglandin D2
DB00119 Pyruvic acid
DB11753 Rifamycin
SwissLipidsiSLP:000001646

Protein family/group databases

TCDBi2.A.60.1.19 the organo anion transporter (oat) family

PTM databases

iPTMnetiQ92959
PhosphoSitePlusiQ92959

Polymorphism and mutation databases

BioMutaiSLCO2A1
DMDMi218511799

Proteomic databases

EPDiQ92959
jPOSTiQ92959
MassIVEiQ92959
PaxDbiQ92959
PeptideAtlasiQ92959
PRIDEiQ92959
ProteomicsDBi75631

Genome annotation databases

EnsembliENST00000310926; ENSP00000311291; ENSG00000174640
GeneIDi6578
KEGGihsa:6578
UCSCiuc003eqa.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6578
DisGeNETi6578

GeneCards: human genes, protein and diseases

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GeneCardsi
SLCO2A1
HGNCiHGNC:10955 SLCO2A1
HPAiHPA013742
MalaCardsiSLCO2A1
MIMi601460 gene
614441 phenotype
neXtProtiNX_Q92959
OpenTargetsiENSG00000174640
Orphaneti468641 Chronic enteropathy associated with SLCO2A1 gene
2796 Pachydermoperiostosis
PharmGKBiPA35840

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00950000182739
HOGENOMiHOG000231269
InParanoidiQ92959
KOiK14345
OMAiFFFPRYM
OrthoDBi1556205at2759
PhylomeDBiQ92959
TreeFamiTF317540

Enzyme and pathway databases

ReactomeiR-HSA-5619095 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
R-HSA-879518 Transport of organic anions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLCO2A1 human
EvolutionaryTraceiQ92959

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLCO2A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6578
PharosiQ92959

Protein Ontology

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PROi
PR:Q92959

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000174640 Expressed in 188 organ(s), highest expression level in right lung
ExpressionAtlasiQ92959 baseline and differential
GenevisibleiQ92959 HS

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSO2A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92959
Secondary accession number(s): Q86V98, Q8IUN2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 16, 2008
Last modified: October 16, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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