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UniProtKB - Q92956 (TNR14_HUMAN)

Entry version 217 (23 Feb 2022)
Sequence version 3 (27 Apr 2001)
Previous versions | rss
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Protein

Tumor necrosis factor receptor superfamily member 14

Gene

TNFRSF14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:9462508, PubMed:10754304, PubMed:18193050, PubMed:23761635).

Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022).

Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304).

Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635).

In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).

Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050).

May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044) (By similarity).

In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044) (By similarity).

By similarity7 Publications

(Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.

2 Publications

(Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processAdaptive immunity, Host-virus interaction, Immunity, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92956

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-388841, Costimulation by the CD28 family
R-HSA-5669034, TNFs bind their physiological receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q92956

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92956

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 14
Alternative name(s):
Herpes virus entry mediator A1 Publication
Short name:
Herpesvirus entry mediator A1 Publication
Short name:
HveA1 Publication
Tumor necrosis factor receptor-like 2
Short name:
TR21 Publication
CD_antigen: CD270
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFRSF14Imported
Synonyms:HVEA, HVEM1 Publication
ORF Names:UNQ329/PRO509
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11912, TNFRSF14

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602746, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92956

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000157873

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini39 – 202ExtracellularSequence analysisAdd BLAST164
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 283CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi61Y → A: Abolishes cis interactions with BTLA. 1 Publication1
Mutagenesisi61Y → F: Does not affect cis interactions with BTLA. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		8764

Open Targets

More...OpenTargetsi		ENSG00000157873

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36605

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92956, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TNFRSF14

Domain mapping of disease mutations (DMDM)

More...DMDMi		13878821

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 381 PublicationAdd BLAST38
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003459039 – 283Tumor necrosis factor receptor superfamily member 14Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 531 Publication
Disulfide bondi54 ↔ 671 Publication
Disulfide bondi57 ↔ 751 Publication
Disulfide bondi78 ↔ 931 Publication
Disulfide bondi96 ↔ 1111 Publication
Disulfide bondi99 ↔ 1191 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi121 ↔ 1381 Publication
Disulfide bondi127 ↔ 1351 Publication
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei240PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92956

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92956

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92956

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92956

PeptideAtlas

More...PeptideAtlasi		Q92956

PRoteomics IDEntifications database

More...PRIDEi		Q92956

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75630 [Q92956-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q92956, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92956

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92956

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with the highest expression in lung, spleen and thymus. Expressed in a subpopulation of B cells and monocytes (PubMed:18193050). Expressed in naive T cells (PubMed:19915044).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157873, Expressed in muscle layer of sigmoid colon and 198 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92956, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92956, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000157873, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRAF2, TRAF3 and TRAF5 (PubMed:9153189, PubMed:9162022).

Interacts (via CRD1/TNFR-Cys 1) with CD160; this interaction is direct (PubMed:18193050, PubMed:23761635).

Interacts with LTA and TNFSF14 (PubMed:9462508).

Interacts (via CRD1/TNFR-Cys 1) in cis and trans with BTLA; the cis interactions inhibits the trans interactions (PubMed:19915044, PubMed:16169851).

7 Publications

(Microbial infection) Interacts with herpes simplex virus 1/HHV-1 envelope glycoprotein D.

2 Publications

(Microbial infection) Interacts with herpes simplex virus 2/HHV-2 envelope glycoprotein D.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114298, 31 interactors

Database of interacting proteins

More...DIPi		DIP-34779N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q92956

Protein interaction database and analysis system

More...IntActi		Q92956, 31 interactors

Molecular INTeraction database

More...MINTi		Q92956

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347948

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92956, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1283
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92956

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q92956

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati42 – 75TNFR-Cys 1Add BLAST34
Repeati78 – 119TNFR-Cys 2Add BLAST42
Repeati121 – 162TNFR-Cys 3Add BLAST42

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cysteine rich domain I (CRD1/TNFR-Cys 1) is required for interaction with BY55 and BTLA.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tumor necrosis factor receptor superfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S1XZ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162427

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92956

Identification of Orthologs from Complete Genome Data

More...OMAi		GWELPPW

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92956

TreeFam database of animal gene trees

More...TreeFami		TF331157

Family and domain databases

Conserved Domains Database

More...CDDi		cd10582, TNFRSF14, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001368, TNFR/NGFR_Cys_rich_reg
IPR022332, TNFR_14
IPR034031, TNFRSF14/UL144_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00020, TNFR_c6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01965, TNFACTORR14

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00208, TNFR, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00652, TNFR_NGFR_1, 1 hit
PS50050, TNFR_NGFR_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92956-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPPGDWGPP PWRSTPKTDV LRLVLYLTFL GAPCYAPALP SCKEDEYPVG 
        60         70         80         90        100
SECCPKCSPG YRVKEACGEL TGTVCEPCPP GTYIAHLNGL SKCLQCQMCD 
       110        120        130        140        150
PAMGLRASRN CSRTENAVCG CSPGHFCIVQ DGDHCAACRA YATSSPGQRV 
       160        170        180        190        200
QKGGTESQDT LCQNCPPGTF SPNGTLEECQ HQTKCSWLVT KAGAGTSSSH 
       210        220        230        240        250
WVWWFLSGSL VIVIVCSTVG LIICVKRRKP RGDVVKVIVS VQRKRQEAEG 
       260        270        280 
EATVIEALQA PPDVTTVAVE ETIPSFTGRS PNH
Length:283
Mass (Da):30,392
Last modified:April 27, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46CE13C2C70242C1
GO
Isoform 2 (identifier: Q92956-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: MEPPGDWGPP...SKCLQCQMCD → MVSRPPRTPLSPSSWT

Show »
Length:199
Mass (Da):21,351
Checksum:iB14A3275B16BBD66
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Q0M4F6Q0M4_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF14
231Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UPZ7F6UPZ7_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF14
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9A034B9A034_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF14
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SF52A0A0D9SF52_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF14
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135C → R in AAH29848 (Ref. 10) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01300717K → R3 PublicationsCorresponds to variant dbSNP:rs4870EnsemblClinVar.1
Natural variantiVAR_018955117A → T1 PublicationCorresponds to variant dbSNP:rs2234163EnsemblClinVar.1
Natural variantiVAR_018956174G → E1 PublicationCorresponds to variant dbSNP:rs11573986EnsemblClinVar.1
Natural variantiVAR_013440241V → I2 PublicationsCorresponds to variant dbSNP:rs2234167EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0541861 – 100MEPPG…CQMCD → MVSRPPRTPLSPSSWT in isoform 2. 2 PublicationsAdd BLAST100

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U70321 mRNA Translation: AAB58354.1
U81232 mRNA Translation: AAD00505.1
AF153978 mRNA Translation: AAF75588.1
AF373877 mRNA Translation: AAL47717.1
AF373878 mRNA Translation: AAL47718.1
AY358879 mRNA Translation: AAQ89238.1
AK124010 mRNA Translation: BAG53992.1
CR456909 mRNA Translation: CAG33190.1
AY466111 Genomic DNA Translation: AAR23264.1
AL139246 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56089.1
CH471183 Genomic DNA Translation: EAW56090.1
BC002794 mRNA Translation: AAH02794.1
BC029848 mRNA Translation: AAH29848.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44046.1 [Q92956-1]

NCBI Reference Sequences

More...RefSeqi		NP_003811.2, NM_003820.3 [Q92956-1]
XP_016858209.1, XM_017002720.1 [Q92956-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355716; ENSP00000347948; ENSG00000157873
ENST00000621877; ENSP00000478308; ENSG00000273936

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8764

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8764

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000355716.5; ENSP00000347948.4; NM_003820.4; NP_003811.2

UCSC genome browser

More...UCSCi		uc001ajr.4, human [Q92956-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70321 mRNA Translation: AAB58354.1
U81232 mRNA Translation: AAD00505.1
AF153978 mRNA Translation: AAF75588.1
AF373877 mRNA Translation: AAL47717.1
AF373878 mRNA Translation: AAL47718.1
AY358879 mRNA Translation: AAQ89238.1
AK124010 mRNA Translation: BAG53992.1
CR456909 mRNA Translation: CAG33190.1
AY466111 Genomic DNA Translation: AAR23264.1
AL139246 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56089.1
CH471183 Genomic DNA Translation: EAW56090.1
BC002794 mRNA Translation: AAH02794.1
BC029848 mRNA Translation: AAH29848.1
CCDSiCCDS44046.1 [Q92956-1]
RefSeqiNP_003811.2, NM_003820.3 [Q92956-1]
XP_016858209.1, XM_017002720.1 [Q92956-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JMAX-ray2.65B39-199[»]
2AW2X-ray2.80B/Y39-142[»]
4FHQX-ray2.25A39-162[»]
4RSUX-ray2.30D/E/F/J/K/L39-162[»]
5T2QX-ray1.90A/B39-142[»]
5T2RX-ray2.10A/B39-142[»]
6NG3X-ray2.88A39-143[»]
7MSGX-ray3.50D/E/F39-143[»]
SMRiQ92956
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114298, 31 interactors
DIPiDIP-34779N
ELMiQ92956
IntActiQ92956, 31 interactors
MINTiQ92956
STRINGi9606.ENSP00000347948

PTM databases

GlyGeniQ92956, 2 sites
iPTMnetiQ92956
PhosphoSitePlusiQ92956

Genetic variation databases

BioMutaiTNFRSF14
DMDMi13878821

Proteomic databases

EPDiQ92956
jPOSTiQ92956
MassIVEiQ92956
PaxDbiQ92956
PeptideAtlasiQ92956
PRIDEiQ92956
ProteomicsDBi75630 [Q92956-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1626, 784 antibodies from 45 providers

The CPTC Antibody Portal

More...CPTCi		Q92956, 1 antibody

The DNASU plasmid repository

More...DNASUi		8764

Genome annotation databases

EnsembliENST00000355716; ENSP00000347948; ENSG00000157873
ENST00000621877; ENSP00000478308; ENSG00000273936
GeneIDi8764
KEGGihsa:8764
MANE-SelectiENST00000355716.5; ENSP00000347948.4; NM_003820.4; NP_003811.2
UCSCiuc001ajr.4, human [Q92956-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8764
DisGeNETi8764

GeneCards: human genes, protein and diseases

More...GeneCardsi		TNFRSF14
HGNCiHGNC:11912, TNFRSF14
HPAiENSG00000157873, Low tissue specificity
MIMi602746, gene
neXtProtiNX_Q92956
OpenTargetsiENSG00000157873
PharmGKBiPA36605
VEuPathDBiHostDB:ENSG00000157873

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S1XZ, Eukaryota
GeneTreeiENSGT00940000162427
InParanoidiQ92956
OMAiGWELPPW
PhylomeDBiQ92956
TreeFamiTF331157

Enzyme and pathway databases

PathwayCommonsiQ92956
ReactomeiR-HSA-388841, Costimulation by the CD28 family
R-HSA-5669034, TNFs bind their physiological receptors
SignaLinkiQ92956
SIGNORiQ92956

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8764, 5 hits in 1035 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TNFRSF14, human
EvolutionaryTraceiQ92956

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TNFRSF14

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8764
PharosiQ92956, Tbio

Protein Ontology

More...PROi		PR:Q92956
RNActiQ92956, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000157873, Expressed in muscle layer of sigmoid colon and 198 other tissues
ExpressionAtlasiQ92956, baseline and differential
GenevisibleiQ92956, HS

Family and domain databases

CDDicd10582, TNFRSF14, 1 hit
InterProiView protein in InterPro
IPR001368, TNFR/NGFR_Cys_rich_reg
IPR022332, TNFR_14
IPR034031, TNFRSF14/UL144_N
PfamiView protein in Pfam
PF00020, TNFR_c6, 1 hit
PRINTSiPR01965, TNFACTORR14
SMARTiView protein in SMART
SM00208, TNFR, 3 hits
PROSITEiView protein in PROSITE
PS00652, TNFR_NGFR_1, 1 hit
PS50050, TNFR_NGFR_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR14_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92956
Secondary accession number(s): B3KW30
, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q96J31, Q9UM65
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: February 23, 2022
This is version 217 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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