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Protein

Tumor necrosis factor receptor superfamily member 14

Gene

TNFRSF14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.1 Publication
(Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.2 Publications
(Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.2 Publications

GO - Molecular functioni

  • tumor necrosis factor-activated receptor activity Source: ProtInc
  • ubiquitin protein ligase binding Source: UniProtKB
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-388841 Costimulation by the CD28 family
R-HSA-5669034 TNFs bind their physiological receptors
SignaLinkiQ92956
SIGNORiQ92956

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 14
Alternative name(s):
Herpes virus entry mediator A
Short name:
Herpesvirus entry mediator A
Short name:
HveA
Tumor necrosis factor receptor-like 2
Short name:
TR2
CD_antigen: CD270
Gene namesi
Name:TNFRSF14
Synonyms:HVEA, HVEM
ORF Names:UNQ329/PRO509
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000157873.17
HGNCiHGNC:11912 TNFRSF14
MIMi602746 gene
neXtProtiNX_Q92956

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 202ExtracellularSequence analysisAdd BLAST164
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 283CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8764
OpenTargetsiENSG00000157873
PharmGKBiPA36605

Polymorphism and mutation databases

BioMutaiTNFRSF14
DMDMi13878821

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 381 PublicationAdd BLAST38
ChainiPRO_000003459039 – 283Tumor necrosis factor receptor superfamily member 14Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 53
Disulfide bondi54 ↔ 67
Disulfide bondi57 ↔ 75
Disulfide bondi78 ↔ 93
Disulfide bondi96 ↔ 111
Disulfide bondi99 ↔ 119
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi121 ↔ 138
Disulfide bondi127 ↔ 135
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei240PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ92956
PaxDbiQ92956
PeptideAtlasiQ92956
PRIDEiQ92956
ProteomicsDBi75630

PTM databases

iPTMnetiQ92956
PhosphoSitePlusiQ92956

Expressioni

Tissue specificityi

Widely expressed, with the highest expression in lung, spleen and thymus.

Gene expression databases

BgeeiENSG00000157873 Expressed in 183 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExiHS_TNFRSF14
ExpressionAtlasiQ92956 baseline and differential
GenevisibleiQ92956 HS

Organism-specific databases

HPAiCAB026150
CAB030007
HPA006404

Interactioni

Subunit structurei

Interacts with TRAF2, TRAF3 and TRAF5.3 Publications
(Microbial infection) Interacts with herpes simplex virus 1/HHV-1 envelope glycoprotein D.2 Publications
(Microbial infection) Interacts with herpes simplex virus 2/HHV-2 envelope glycoprotein D.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114298, 30 interactors
DIPiDIP-34779N
ELMiQ92956
IntActiQ92956, 29 interactors
MINTiQ92956
STRINGi9606.ENSP00000347948

Structurei

Secondary structure

1283
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92956
SMRiQ92956
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92956

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 75TNFR-Cys 1Add BLAST34
Repeati78 – 119TNFR-Cys 2Add BLAST42
Repeati121 – 162TNFR-Cys 3Add BLAST42

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX15 Eukaryota
ENOG410ZEC2 LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000065766
HOVERGENiHBG072084
InParanoidiQ92956
KOiK05152
OMAiCRVCDPA
OrthoDBiEOG091G03XW
PhylomeDBiQ92956
TreeFamiTF331157

Family and domain databases

CDDicd10582 TNFRSF14, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022332 TNFR_14
IPR034031 TNFRSF14/UL144_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01965 TNFACTORR14
SMARTiView protein in SMART
SM00208 TNFR, 3 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92956-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPPGDWGPP PWRSTPKTDV LRLVLYLTFL GAPCYAPALP SCKEDEYPVG
60 70 80 90 100
SECCPKCSPG YRVKEACGEL TGTVCEPCPP GTYIAHLNGL SKCLQCQMCD
110 120 130 140 150
PAMGLRASRN CSRTENAVCG CSPGHFCIVQ DGDHCAACRA YATSSPGQRV
160 170 180 190 200
QKGGTESQDT LCQNCPPGTF SPNGTLEECQ HQTKCSWLVT KAGAGTSSSH
210 220 230 240 250
WVWWFLSGSL VIVIVCSTVG LIICVKRRKP RGDVVKVIVS VQRKRQEAEG
260 270 280
EATVIEALQA PPDVTTVAVE ETIPSFTGRS PNH
Length:283
Mass (Da):30,392
Last modified:April 27, 2001 - v3
Checksum:i46CE13C2C70242C1
GO
Isoform 2 (identifier: Q92956-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: MEPPGDWGPP...SKCLQCQMCD → MVSRPPRTPLSPSSWT

Show »
Length:199
Mass (Da):21,351
Checksum:iB14A3275B16BBD66
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Q0M4F6Q0M4_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF14
231Annotation score:
B9A034B9A034_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF14
193Annotation score:
F6UPZ7F6UPZ7_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF14
183Annotation score:
A0A0D9SF52A0A0D9SF52_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF14
25Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135C → R in AAH29848 (Ref. 10) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01300717K → R3 PublicationsCorresponds to variant dbSNP:rs4870EnsemblClinVar.1
Natural variantiVAR_018955117A → T1 PublicationCorresponds to variant dbSNP:rs2234163EnsemblClinVar.1
Natural variantiVAR_018956174G → E1 PublicationCorresponds to variant dbSNP:rs11573986EnsemblClinVar.1
Natural variantiVAR_013440241V → I2 PublicationsCorresponds to variant dbSNP:rs2234167EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0541861 – 100MEPPG…CQMCD → MVSRPPRTPLSPSSWT in isoform 2. 2 PublicationsAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70321 mRNA Translation: AAB58354.1
U81232 mRNA Translation: AAD00505.1
AF153978 mRNA Translation: AAF75588.1
AF373877 mRNA Translation: AAL47717.1
AF373878 mRNA Translation: AAL47718.1
AY358879 mRNA Translation: AAQ89238.1
AK124010 mRNA Translation: BAG53992.1
CR456909 mRNA Translation: CAG33190.1
AY466111 Genomic DNA Translation: AAR23264.1
AL139246 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56089.1
CH471183 Genomic DNA Translation: EAW56090.1
BC002794 mRNA Translation: AAH02794.1
BC029848 mRNA Translation: AAH29848.1
CCDSiCCDS44046.1 [Q92956-1]
RefSeqiNP_003811.2, NM_003820.3 [Q92956-1]
XP_016858209.1, XM_017002720.1 [Q92956-2]
UniGeneiHs.512898
Hs.682060

Genome annotation databases

EnsembliENST00000355716; ENSP00000347948; ENSG00000157873 [Q92956-1]
ENST00000621877; ENSP00000478308; ENSG00000273936 [Q92956-1]
GeneIDi8764
KEGGihsa:8764
UCSCiuc001ajr.4 human [Q92956-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70321 mRNA Translation: AAB58354.1
U81232 mRNA Translation: AAD00505.1
AF153978 mRNA Translation: AAF75588.1
AF373877 mRNA Translation: AAL47717.1
AF373878 mRNA Translation: AAL47718.1
AY358879 mRNA Translation: AAQ89238.1
AK124010 mRNA Translation: BAG53992.1
CR456909 mRNA Translation: CAG33190.1
AY466111 Genomic DNA Translation: AAR23264.1
AL139246 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56089.1
CH471183 Genomic DNA Translation: EAW56090.1
BC002794 mRNA Translation: AAH02794.1
BC029848 mRNA Translation: AAH29848.1
CCDSiCCDS44046.1 [Q92956-1]
RefSeqiNP_003811.2, NM_003820.3 [Q92956-1]
XP_016858209.1, XM_017002720.1 [Q92956-2]
UniGeneiHs.512898
Hs.682060

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JMAX-ray2.65B39-199[»]
2AW2X-ray2.80B/Y39-142[»]
4FHQX-ray2.25A39-162[»]
4RSUX-ray2.30D/E/F/J/K/L39-162[»]
ProteinModelPortaliQ92956
SMRiQ92956
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114298, 30 interactors
DIPiDIP-34779N
ELMiQ92956
IntActiQ92956, 29 interactors
MINTiQ92956
STRINGi9606.ENSP00000347948

PTM databases

iPTMnetiQ92956
PhosphoSitePlusiQ92956

Polymorphism and mutation databases

BioMutaiTNFRSF14
DMDMi13878821

Proteomic databases

EPDiQ92956
PaxDbiQ92956
PeptideAtlasiQ92956
PRIDEiQ92956
ProteomicsDBi75630

Protocols and materials databases

DNASUi8764
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355716; ENSP00000347948; ENSG00000157873 [Q92956-1]
ENST00000621877; ENSP00000478308; ENSG00000273936 [Q92956-1]
GeneIDi8764
KEGGihsa:8764
UCSCiuc001ajr.4 human [Q92956-1]

Organism-specific databases

CTDi8764
DisGeNETi8764
EuPathDBiHostDB:ENSG00000157873.17
GeneCardsiTNFRSF14
HGNCiHGNC:11912 TNFRSF14
HPAiCAB026150
CAB030007
HPA006404
MIMi602746 gene
neXtProtiNX_Q92956
OpenTargetsiENSG00000157873
PharmGKBiPA36605
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX15 Eukaryota
ENOG410ZEC2 LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000065766
HOVERGENiHBG072084
InParanoidiQ92956
KOiK05152
OMAiCRVCDPA
OrthoDBiEOG091G03XW
PhylomeDBiQ92956
TreeFamiTF331157

Enzyme and pathway databases

ReactomeiR-HSA-388841 Costimulation by the CD28 family
R-HSA-5669034 TNFs bind their physiological receptors
SignaLinkiQ92956
SIGNORiQ92956

Miscellaneous databases

ChiTaRSiTNFRSF14 human
EvolutionaryTraceiQ92956
GeneWikiiTNFRSF14
GenomeRNAii8764
PROiPR:Q92956
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157873 Expressed in 183 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExiHS_TNFRSF14
ExpressionAtlasiQ92956 baseline and differential
GenevisibleiQ92956 HS

Family and domain databases

CDDicd10582 TNFRSF14, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022332 TNFR_14
IPR034031 TNFRSF14/UL144_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01965 TNFACTORR14
SMARTiView protein in SMART
SM00208 TNFR, 3 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTNR14_HUMAN
AccessioniPrimary (citable) accession number: Q92956
Secondary accession number(s): B3KW30
, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q96J31, Q9UM65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: September 12, 2018
This is version 197 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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