TNFRSF14

Functionⁱ

Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.1 Publication

(Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.2 Publications

(Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.2 Publications

GO - Molecular functionⁱ

tumor necrosis factor-activated receptor activity
Source: ProtInc
Traceable author statementⁱ
- 9153189
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279055
virus receptor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 9153189
defense response to Gram-negative bacterium
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
defense response to Gram-positive bacterium
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
immune response
Source: ProtInc
Traceable author statementⁱ
- 9162022
negative regulation of alpha-beta T cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cytokine secretion involved in immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of peptidyl-tyrosine phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of T cell migration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
T cell costimulation Source: Reactome
tumor necrosis factor-mediated signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Host cell receptor for virus entry, Receptor
Biological process	Host-virus interaction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-388841 Costimulation by the CD28 family R-HSA-5669034 TNFs bind their physiological receptors
SignaLinkⁱ	Q92956
SIGNORⁱ	Q92956

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor receptor superfamily member 14 Alternative name(s): Herpes virus entry mediator A Short name: Herpesvirus entry mediator A Short name: HveA Tumor necrosis factor receptor-like 2 Short name: TR2 CD_antigen: CD270
Gene namesⁱ	Name:TNFRSF14 Synonyms:HVEA, HVEM ORF Names:UNQ329/PRO509
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000157873.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11912 TNFRSF14
MIMⁱ	602746 gene
neXtProtⁱ	NX_Q92956

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	39 – 202	ExtracellularSequence analysisAdd BLAST	164
Transmembraneⁱ	203 – 223	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	224 – 283	CytoplasmicSequence analysisAdd BLAST	60

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8764
Open Targets More...OpenTargetsⁱ	ENSG00000157873
PharmGKBⁱ	PA36605

Polymorphism and mutation databases

BioMutaⁱ	TNFRSF14
DMDMⁱ	13878821

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 38	1 PublicationAdd BLAST		38
ChainⁱPRO_0000034590	39 – 283	Tumor necrosis factor receptor superfamily member 14Add BLAST		245

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	42 ↔ 53
Disulfide bondⁱ	54 ↔ 67
Disulfide bondⁱ	57 ↔ 75
Disulfide bondⁱ	78 ↔ 93
Disulfide bondⁱ	96 ↔ 111
Disulfide bondⁱ	99 ↔ 119
Glycosylationⁱ	110	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	121 ↔ 138
Disulfide bondⁱ	127 ↔ 135
Glycosylationⁱ	173	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	240	PhosphoserineCombined sources	1

Post-translational modificationⁱ

N-glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q92956
PaxDbⁱ	Q92956
PeptideAtlas More...PeptideAtlasⁱ	Q92956
PRIDEⁱ	Q92956
ProteomicsDBⁱ	75630

PTM databases

iPTMnetⁱ	Q92956
PhosphoSitePlusⁱ	Q92956

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with the highest expression in lung, spleen and thymus.

Gene expression databases

Bgeeⁱ	ENSG00000157873 Expressed in 183 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExⁱ	HS_TNFRSF14
ExpressionAtlasⁱ	Q92956 baseline and differential
Genevisibleⁱ	Q92956 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB026150 CAB030007 HPA006404

HPAⁱ

CAB026150
CAB030007
HPA006404

Interactionⁱ

Subunit structureⁱ

Interacts with TRAF2, TRAF3 and TRAF5.3 Publications

(Microbial infection) Interacts with herpes simplex virus 1/HHV-1 envelope glycoprotein D.2 Publications

(Microbial infection) Interacts with herpes simplex virus 2/HHV-2 envelope glycoprotein D.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
TNFSF14	O43557	5	EBI-1056653,EBI-524131
TRAF2	Q12933	2	EBI-1056653,EBI-355744
TRAF2	Q12933-2	4	EBI-1056653,EBI-355760
TRAF5	O00463	5	EBI-1056653,EBI-523498

GO - Molecular functionⁱ

ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279055

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114298, 30 interactors
Database of interacting proteins More...DIPⁱ	DIP-34779N
ELMⁱ	Q92956
IntActⁱ	Q92956, 29 interactors
Molecular INTeraction database More...MINTⁱ	Q92956
STRINGⁱ	9606.ENSP00000347948

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	46 – 49	Combined sources	4
Beta strandⁱ	52 – 55	Combined sources	4
Beta strandⁱ	61 – 65	Combined sources	5
Beta strandⁱ	69 – 71	Combined sources	3
Beta strandⁱ	74 – 77	Combined sources	4
Beta strandⁱ	86 – 88	Combined sources	3
Helixⁱ	101 – 103	Combined sources	3
Beta strandⁱ	105 – 109	Combined sources	5
Beta strandⁱ	113 – 115	Combined sources	3
Beta strandⁱ	118 – 121	Combined sources	4
Beta strandⁱ	125 – 131	Combined sources	7
Beta strandⁱ	134 – 140	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q92956
SMRⁱ	Q92956
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q92956

EvolutionaryTraceⁱ

Q92956

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	42 – 75	TNFR-Cys 1Add BLAST	34
Repeatⁱ	78 – 119	TNFR-Cys 2Add BLAST	42
Repeatⁱ	121 – 162	TNFR-Cys 3Add BLAST	42

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IX15 Eukaryota ENOG410ZEC2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119204
HOGENOMⁱ	HOG000065766
HOVERGENⁱ	HBG072084
InParanoidⁱ	Q92956
KEGG Orthology (KO) More...KOⁱ	K05152
OMAⁱ	RTENTVC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03XW
PhylomeDBⁱ	Q92956
TreeFamⁱ	TF331157

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10582 TNFRSF14, 1 hit
InterProⁱ	View protein in InterPro IPR001368 TNFR/NGFR_Cys_rich_reg IPR022332 TNFR_14 IPR034031 TNFRSF14/UL144_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00020 TNFR_c6, 1 hit
PRINTSⁱ	PR01965 TNFACTORR14
SMARTⁱ	View protein in SMART SM00208 TNFR, 3 hits
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 1 hit PS50050 TNFR_NGFR_2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q92956-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPPGDWGPP PWRSTPKTDV LRLVLYLTFL GAPCYAPALP SCKEDEYPVG 
        60         70         80         90        100
SECCPKCSPG YRVKEACGEL TGTVCEPCPP GTYIAHLNGL SKCLQCQMCD 
       110        120        130        140        150
PAMGLRASRN CSRTENAVCG CSPGHFCIVQ DGDHCAACRA YATSSPGQRV 
       160        170        180        190        200
QKGGTESQDT LCQNCPPGTF SPNGTLEECQ HQTKCSWLVT KAGAGTSSSH 
       210        220        230        240        250
WVWWFLSGSL VIVIVCSTVG LIICVKRRKP RGDVVKVIVS VQRKRQEAEG 
       260        270        280 
EATVIEALQA PPDVTTVAVE ETIPSFTGRS PNH

Length:283

Mass (Da):30,392

Last modified:April 27, 2001 - v3

Checksum:ⁱ46CE13C2C70242C1

GO

Isoform 2 (identifier: Q92956-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-100: MEPPGDWGPP...SKCLQCQMCD → MVSRPPRTPLSPSSWT

« Hide

        10         20         30         40         50
MVSRPPRTPL SPSSWTPAMG LRASRNCSRT ENAVCGCSPG HFCIVQDGDH 
        60         70         80         90        100
CAACRAYATS SPGQRVQKGG TESQDTLCQN CPPGTFSPNG TLEECQHQTK 
       110        120        130        140        150
CSWLVTKAGA GTSSSHWVWW FLSGSLVIVI VCSTVGLIIC VKRRKPRGDV 
       160        170        180        190 
VKVIVSVQRK RQEAEGEATV IEALQAPPDV TTVAVEETIP SFTGRSPNH

Show »

Length:199

Mass (Da):21,351

Checksum:ⁱB14A3275B16BBD66

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F6Q0M4	F6Q0M4_HUMAN	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 14	TNFRSF14	231	Annotation score:
B9A034	B9A034_HUMAN	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 14	TNFRSF14	193	Annotation score:
F6UPZ7	F6UPZ7_HUMAN	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 14	TNFRSF14	183	Annotation score:
A0A0D9SF52	A0A0D9SF52_HUMAN	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 14	TNFRSF14	25	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	135	C → R in AAH29848 (Ref. 10) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_013007	17	K → R3 PublicationsCorresponds to variant dbSNP:rs4870EnsemblClinVar.	1
Natural variantⁱVAR_018955	117	A → T1 PublicationCorresponds to variant dbSNP:rs2234163EnsemblClinVar.	1
Natural variantⁱVAR_018956	174	G → E1 PublicationCorresponds to variant dbSNP:rs11573986EnsemblClinVar.	1
Natural variantⁱVAR_013440	241	V → I2 PublicationsCorresponds to variant dbSNP:rs2234167EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054186	1 – 100	MEPPG…CQMCD → MVSRPPRTPLSPSSWT in isoform 2. 2 PublicationsAdd BLAST		100

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U70321 mRNA Translation: AAB58354.1 U81232 mRNA Translation: AAD00505.1 AF153978 mRNA Translation: AAF75588.1 AF373877 mRNA Translation: AAL47717.1 AF373878 mRNA Translation: AAL47718.1 AY358879 mRNA Translation: AAQ89238.1 AK124010 mRNA Translation: BAG53992.1 CR456909 mRNA Translation: CAG33190.1 AY466111 Genomic DNA Translation: AAR23264.1 AL139246 Genomic DNA No translation available. CH471183 Genomic DNA Translation: EAW56089.1 CH471183 Genomic DNA Translation: EAW56090.1 BC002794 mRNA Translation: AAH02794.1 BC029848 mRNA Translation: AAH29848.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44046.1 [Q92956-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_003811.2, NM_003820.3 [Q92956-1] XP_016858209.1, XM_017002720.1 [Q92956-2]
UniGeneⁱ	Hs.512898 Hs.682060

Genome annotation databases

Ensemblⁱ	ENST00000355716; ENSP00000347948; ENSG00000157873 [Q92956-1] ENST00000621877; ENSP00000478308; ENSG00000273936 [Q92956-1]
GeneIDⁱ	8764
KEGGⁱ	hsa:8764
UCSC genome browser More...UCSCⁱ	uc001ajr.4 human [Q92956-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92956	Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator), isoform CRA_a		HUMAN		283	UniRef100_Q92956
Uncharacterized protein		GORGO		183
Tumor necrosis factor receptor superfamily member 14 (Fragment)		HUMAN		183
Tumor necrosis factor receptor superfamily member 14 (Fragment)		HUMAN		231
UPI00002039F9		HUMAN		184

Protein	Similar proteins		Species	Score	Length	Source
Q92956	Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator), isoform CRA_a		HUMAN		283	UniRef90_Q92956
Uncharacterized protein		GORGO		183
TNF receptor superfamily member 14		PANTR		283
Uncharacterized protein		PANPA		283
TNFRSF14 isoform 6		PONAB		283
+10
Q92956-2	Uncharacterized protein		PONAB		206	UniRef90_Q92956-2

Protein	Similar proteins		Species	Score	Length	Source
Q92956	Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator), isoform CRA_a		HUMAN		283	UniRef50_Q92956
Uncharacterized protein		GORGO		183
TNF receptor superfamily member 14		PANTR		283
Uncharacterized protein		PANPA		283
TNFRSF14 isoform 6		PONAB		283
+27
Q92956-2	Uncharacterized protein		PONAB		206	UniRef50_Q92956-2
ELR1-insert		HORSE		193
Uncharacterized protein		RHIRO		193
Uncharacterized protein		RHIBE		193
Uncharacterized protein		COLAP		193
+18

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U70321 mRNA Translation: AAB58354.1 U81232 mRNA Translation: AAD00505.1 AF153978 mRNA Translation: AAF75588.1 AF373877 mRNA Translation: AAL47717.1 AF373878 mRNA Translation: AAL47718.1 AY358879 mRNA Translation: AAQ89238.1 AK124010 mRNA Translation: BAG53992.1 CR456909 mRNA Translation: CAG33190.1 AY466111 Genomic DNA Translation: AAR23264.1 AL139246 Genomic DNA No translation available. CH471183 Genomic DNA Translation: EAW56089.1 CH471183 Genomic DNA Translation: EAW56090.1 BC002794 mRNA Translation: AAH02794.1 BC029848 mRNA Translation: AAH29848.1
CCDSⁱ	CCDS44046.1 [Q92956-1]
RefSeqⁱ	NP_003811.2, NM_003820.3 [Q92956-1] XP_016858209.1, XM_017002720.1 [Q92956-2]
UniGeneⁱ	Hs.512898 Hs.682060

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1JMA	X-ray	2.65	B	39-199	[»]
	2AW2	X-ray	2.80	B/Y	39-142	[»]
	4FHQ	X-ray	2.25	A	39-162	[»]
	4RSU	X-ray	2.30	D/E/F/J/K/L	39-162	[»]
ProteinModelPortalⁱ	Q92956
SMRⁱ	Q92956
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114298, 30 interactors
DIPⁱ	DIP-34779N
ELMⁱ	Q92956
IntActⁱ	Q92956, 29 interactors
MINTⁱ	Q92956
STRINGⁱ	9606.ENSP00000347948

PTM databases

iPTMnetⁱ	Q92956
PhosphoSitePlusⁱ	Q92956

Polymorphism and mutation databases

BioMutaⁱ	TNFRSF14
DMDMⁱ	13878821

Proteomic databases

EPDⁱ	Q92956
PaxDbⁱ	Q92956
PeptideAtlasⁱ	Q92956
PRIDEⁱ	Q92956
ProteomicsDBⁱ	75630

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8764
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000355716; ENSP00000347948; ENSG00000157873 [Q92956-1] ENST00000621877; ENSP00000478308; ENSG00000273936 [Q92956-1]
GeneIDⁱ	8764
KEGGⁱ	hsa:8764
UCSCⁱ	uc001ajr.4 human [Q92956-1]

Organism-specific databases

CTDⁱ	8764
DisGeNETⁱ	8764
EuPathDBⁱ	HostDB:ENSG00000157873.17
GeneCardsⁱ	TNFRSF14
HGNCⁱ	HGNC:11912 TNFRSF14
HPAⁱ	CAB026150 CAB030007 HPA006404
MIMⁱ	602746 gene
neXtProtⁱ	NX_Q92956
OpenTargetsⁱ	ENSG00000157873
PharmGKBⁱ	PA36605
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IX15 Eukaryota ENOG410ZEC2 LUCA
GeneTreeⁱ	ENSGT00760000119204
HOGENOMⁱ	HOG000065766
HOVERGENⁱ	HBG072084
InParanoidⁱ	Q92956
KOⁱ	K05152
OMAⁱ	RTENTVC
OrthoDBⁱ	EOG091G03XW
PhylomeDBⁱ	Q92956
TreeFamⁱ	TF331157

Enzyme and pathway databases

Reactomeⁱ	R-HSA-388841 Costimulation by the CD28 family R-HSA-5669034 TNFs bind their physiological receptors
SignaLinkⁱ	Q92956
SIGNORⁱ	Q92956

Miscellaneous databases

ChiTaRSⁱ	TNFRSF14 human
EvolutionaryTraceⁱ	Q92956
GeneWikiⁱ	TNFRSF14
GenomeRNAiⁱ	8764
Protein Ontology More...PROⁱ	PR:Q92956
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000157873 Expressed in 183 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExⁱ	HS_TNFRSF14
ExpressionAtlasⁱ	Q92956 baseline and differential
Genevisibleⁱ	Q92956 HS

Family and domain databases

CDDⁱ	cd10582 TNFRSF14, 1 hit
InterProⁱ	View protein in InterPro IPR001368 TNFR/NGFR_Cys_rich_reg IPR022332 TNFR_14 IPR034031 TNFRSF14/UL144_N
Pfamⁱ	View protein in Pfam PF00020 TNFR_c6, 1 hit
PRINTSⁱ	PR01965 TNFACTORR14
SMARTⁱ	View protein in SMART SM00208 TNFR, 3 hits
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 1 hit PS50050 TNFR_NGFR_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNR14_HUMAN
Accessionⁱ	Q92956Primary (citable) accession number: Q92956 Secondary accession number(s): B3KW30 Q9UM65
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	April 27, 2001
	Last modified:	November 7, 2018
	This is version 198 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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Supporting data

UniProtKB - Q92956 (TNR14_HUMAN)

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Tumor necrosis factor receptor superfamily member 14

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ