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Entry version 172 (16 Oct 2019)
Sequence version 3 (28 Mar 2018)
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Protein

Proteoglycan 4

Gene

PRG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.
Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.

Miscellaneous

Different forms varying in molecular weight have been observed. Such forms are possibly due to different levels of glycosylation and protein cleavage (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteoglycan 4
Alternative name(s):
Lubricin
Megakaryocyte-stimulating factor
Superficial zone proteoglycan
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRG4
Synonyms:MSF, SZP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9364 PRG4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604283 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92954

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by the association of congenital or early-onset camptodactyly and non-inflammatory arthropathy with synovial hyperplasia. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure, non-inflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. Some patients also manifest progressive coxa vara deformity and/or non-inflammatory pericardial or pleural effusions.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
10216

MalaCards human disease database

More...
MalaCardsi
PRG4
MIMi208250 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000116690

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2848 Camptodactyly-arthropathy-coxa-vara-pericarditis syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33736

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92954

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRG4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
83288393

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004323225 – 1404Proteoglycan 4Add BLAST1380
ChainiPRO_00000432331307 – 1404Proteoglycan 4 C-terminal partAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 46PROSITE-ProRule annotation
Disulfide bondi30 ↔ 34PROSITE-ProRule annotation
Disulfide bondi34 ↔ 64PROSITE-ProRule annotation
Disulfide bondi44 ↔ 57PROSITE-ProRule annotation
Disulfide bondi44 ↔ 46PROSITE-ProRule annotation
Disulfide bondi50 ↔ 56PROSITE-ProRule annotation
Disulfide bondi57 ↔ 64PROSITE-ProRule annotation
Disulfide bondi70 ↔ 86AlternatePROSITE-ProRule annotation
Disulfide bondi70 ↔ 74AlternatePROSITE-ProRule annotation
Disulfide bondi74 ↔ 104AlternatePROSITE-ProRule annotation
Disulfide bondi84 ↔ 97AlternatePROSITE-ProRule annotation
Disulfide bondi84 ↔ 86AlternatePROSITE-ProRule annotation
Disulfide bondi90 ↔ 96PROSITE-ProRule annotation
Disulfide bondi97 ↔ 104AlternatePROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi123O-linked (GalNAc...) serine1 Publication1
Glycosylationi136O-linked (GalNAc...) serine1 Publication1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240O-linked (GalNAc...) threonine1 Publication1
Glycosylationi253O-linked (GalNAc...) threonine1 Publication1
Glycosylationi277O-linked (GalNAc...) threonine1 Publication1
Glycosylationi291O-linked (GalNAc...) threonine1 Publication1
Glycosylationi305O-linked (GalNAc...) threonine1 Publication1
Glycosylationi306O-linked (GalNAc...) serine1 Publication1
Glycosylationi310O-linked (GalNAc...) threonine1 Publication1
Glycosylationi317O-linked (GalNAc...) serine1 Publication1
Glycosylationi324O-linked (GalNAc...) threonine1 Publication1
Glycosylationi332O-linked (GalNAc...) threonine1 Publication1
Glycosylationi338O-linked (GalNAc...) threonine1 Publication1
Glycosylationi367O-linked (GalNAc...) threonine1 Publication1
Glycosylationi373O-linked (GalNAc...) serine1 Publication1
Glycosylationi376O-linked (GalNAc...) threonine1 Publication1
Glycosylationi384O-linked (GalNAc...) threonine1 Publication1
Glycosylationi385O-linked (GalNAc...) threonine1 Publication1
Glycosylationi388O-linked (GalNAc...) serine1 Publication1
Glycosylationi391O-linked (GalNAc...) threonine1 Publication1
Glycosylationi399O-linked (GalNAc...) threonine1 Publication1
Glycosylationi400O-linked (GalNAc...) threonine1 Publication1
Glycosylationi407O-linked (GalNAc...) threonine1 Publication1
Glycosylationi408O-linked (GalNAc...) threonine1 Publication1
Glycosylationi415O-linked (GalNAc...) threonine1 Publication1
Glycosylationi423O-linked (GalNAc...) threonine1 Publication1
Glycosylationi427O-linked (GalNAc...) serine1 Publication1
Glycosylationi430O-linked (GalNAc...) threonine1 Publication1
Glycosylationi438O-linked (GalNAc...) threonine1 Publication1
Glycosylationi439O-linked (GalNAc...) threonine1 Publication1
Glycosylationi446O-linked (GalNAc...) threonine1 Publication1
Glycosylationi447O-linked (GalNAc...) threonine1 Publication1
Glycosylationi454O-linked (GalNAc...) threonine1 Publication1
Glycosylationi455O-linked (GalNAc...) threonine1 Publication1
Glycosylationi477O-linked (GalNAc...) threonine1 Publication1
Glycosylationi478O-linked (GalNAc...) threonine1 Publication1
Glycosylationi485O-linked (GalNAc...) threonine1 Publication1
Glycosylationi493O-linked (GalNAc...) threonine1 Publication1
Glycosylationi494O-linked (GalNAc...) threonine1 Publication1
Glycosylationi501O-linked (GalNAc...) threonine1 Publication1
Glycosylationi502O-linked (GalNAc...) threonine1 Publication1
Glycosylationi509O-linked (GalNAc...) threonine1 Publication1
Glycosylationi525O-linked (GalNAc...) threonine1 Publication1
Glycosylationi529O-linked (GalNAc...) serine1 Publication1
Glycosylationi532O-linked (GalNAc...) threonine1 Publication1
Glycosylationi540O-linked (GalNAc...) threonine1 Publication1
Glycosylationi541O-linked (GalNAc...) threonine1 Publication1
Glycosylationi553O-linked (GalNAc...) serine1 Publication1
Glycosylationi555O-linked (GalNAc...) threonine1 Publication1
Glycosylationi563O-linked (GalNAc...) threonine1 Publication1
Glycosylationi564O-linked (GalNAc...) threonine1 Publication1
Glycosylationi571O-linked (GalNAc...) threonine1 Publication1
Glycosylationi572O-linked (GalNAc...) threonine1 Publication1
Glycosylationi579O-linked (GalNAc...) threonine1 Publication1
Glycosylationi580O-linked (GalNAc...) threonine1 Publication1
Glycosylationi587O-linked (GalNAc...) threonine1 Publication1
Glycosylationi588O-linked (GalNAc...) threonine1 Publication1
Glycosylationi595O-linked (GalNAc...) threonine1 Publication1
Glycosylationi603O-linked (GalNAc...) threonine1 Publication1
Glycosylationi604O-linked (GalNAc...) threonine1 Publication1
Glycosylationi611O-linked (GalNAc...) threonine1 Publication1
Glycosylationi612O-linked (GalNAc...) threonine1 Publication1
Glycosylationi616O-linked (GalNAc...) threonine1 Publication1
Glycosylationi619O-linked (GalNAc...) threonine1 Publication1
Glycosylationi627O-linked (GalNAc...) threonine1 Publication1
Glycosylationi676O-linked (GalNAc...) threonine1 Publication1
Glycosylationi683O-linked (GalNAc...) threonine1 Publication1
Glycosylationi684O-linked (GalNAc...) threonine1 Publication1
Glycosylationi691O-linked (GalNAc...) threonine1 Publication1
Glycosylationi692O-linked (GalNAc...) threonine1 Publication1
Glycosylationi699O-linked (GalNAc...) threonine1 Publication1
Glycosylationi700O-linked (GalNAc...) threonine1 Publication1
Glycosylationi704O-linked (GalNAc...) threonine1 Publication1
Glycosylationi707O-linked (GalNAc...) threonine1 Publication1
Glycosylationi723O-linked (GalNAc...) threonine1 Publication1
Glycosylationi724O-linked (GalNAc...) threonine1 Publication1
Glycosylationi736O-linked (GalNAc...) threonine1 Publication1
Glycosylationi768O-linked (GalNAc...) threonine1 Publication1
Glycosylationi769O-linked (GalNAc...) threonine1 Publication1
Glycosylationi776O-linked (GalNAc...) threonine1 Publication1
Glycosylationi777O-linked (GalNAc...) threonine1 Publication1
Glycosylationi792O-linked (GalNAc...) threonine1 Publication1
Glycosylationi793O-linked (GalNAc...) threonine1 Publication1
Glycosylationi805O-linked (GalNAc...) threonine1 Publication1
Glycosylationi812O-linked (GalNAc...) serine1 Publication1
Glycosylationi829O-linked (GalNAc...) threonine1 Publication1
Glycosylationi837O-linked (GalNAc...) threonine1 Publication1
Glycosylationi838O-linked (GalNAc...) threonine1 Publication1
Glycosylationi892O-linked (GalNAc...) serine1 Publication1
Glycosylationi900O-linked (GalNAc...) threonine1 Publication1
Glycosylationi930O-linked (GalNAc...) threonine1 Publication1
Glycosylationi931O-linked (GalNAc...) threonine1 Publication1
Glycosylationi962O-linked (GalNAc...) serine1 Publication1
Glycosylationi963O-linked (GalNAc...) threonine1 Publication1
Glycosylationi968O-linked (GalNAc...) threonine1 Publication1
Glycosylationi975O-linked (GalNAc...) threonine1 Publication1
Glycosylationi978O-linked (GalNAc...) threonine1 Publication1
Glycosylationi979O-linked (GalNAc...) threonine1 Publication1
Glycosylationi980O-linked (GalNAc...) threonine1 Publication1
Glycosylationi1039O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi1146 ↔ 1403PROSITE-ProRule annotation
Glycosylationi1159N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1161O-linked (GalNAc...) threonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated (PubMed:16335952).1 Publication
O-glycosylated; contains glycosaminoglycan chondroitin sulfate and keratan sulfate. O-glycosylated with sialylated oligosaccharides which are predominantly represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated O-glycans (PubMed:25187573).1 Publication
The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1306 – 1307Cleavage; by subtilisin-like proprotein convertase 4By similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92954

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92954

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92954

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92954

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92954

PeptideAtlas

More...
PeptideAtlasi
Q92954

PRoteomics IDEntifications database

More...
PRIDEi
Q92954

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75624 [Q92954-1]
75625 [Q92954-2]
75626 [Q92954-3]
75627 [Q92954-4]
75628 [Q92954-5]
75629 [Q92954-6]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q92954

GlyConnect protein glycosylation platform

More...
GlyConnecti
762

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92954

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92954

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116690 Expressed in 117 organ(s), highest expression level in synovial joint

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92954 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92954 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028523

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115511, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q92954, 6 interactors

Molecular INTeraction database

More...
MINTi
Q92954

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000399679

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92954

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 69SMB 1PROSITE-ProRule annotationAdd BLAST44
Domaini66 – 108SMB 2PROSITE-ProRule annotationAdd BLAST43
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati348 – 35518
Repeati356 – 3632; approximate8
Repeati364 – 37138
Repeati372 – 3784; approximate7
Repeati379 – 38658
Repeati387 – 3936; approximate7
Repeati394 – 40178
Repeati402 – 40988
Repeati410 – 41798
Repeati418 – 425108
Repeati426 – 43211; approximate7
Repeati433 – 440128
Repeati441 – 448138
Repeati449 – 456148
Repeati457 – 464158
Repeati465 – 47116; approximate7
Repeati472 – 479178
Repeati480 – 48718; approximate8
Repeati488 – 49519; approximate8
Repeati496 – 503208
Repeati504 – 511218
Repeati512 – 519228
Repeati520 – 527238
Repeati528 – 53424; approximate7
Repeati535 – 542258
Repeati543 – 54926; approximate7
Repeati550 – 557278
Repeati558 – 565288
Repeati566 – 573298
Repeati574 – 581308
Repeati582 – 589318
Repeati590 – 597328
Repeati598 – 60533; approximate8
Repeati606 – 613348
Repeati614 – 62135; approximate8
Repeati622 – 62936; approximate8
Repeati638 – 64537; approximate8
Repeati662 – 66938; approximate8
Repeati678 – 685398
Repeati686 – 693408
Repeati694 – 701418
Repeati702 – 70942; approximate8
Repeati710 – 71743; approximate8
Repeati718 – 725448
Repeati731 – 73845; approximate8
Repeati739 – 74646; approximate8
Repeati747 – 75447; approximate8
Repeati755 – 76248; approximate8
Repeati763 – 770498
Repeati771 – 778508
Repeati779 – 78651; approximate8
Repeati787 – 794528
Repeati800 – 80753; approximate8
Repeati808 – 81554; approximate8
Repeati816 – 82355; approximate8
Repeati824 – 83156; approximate8
Repeati832 – 839578
Repeati840 – 847588
Repeati848 – 85559; approximate8
Repeati1148 – 1191Hemopexin 1Add BLAST44
Repeati1192 – 1239Hemopexin 2Add BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni348 – 85559 X 8 AA repeats of K-X-P-X-P-T-T-XAdd BLAST508

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi159 – 188Ser-richAdd BLAST30

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1565 Eukaryota
ENOG410XQ5D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063751

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115691

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92954

Identification of Orthologs from Complete Genome Data

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OMAi
QTDPNDT

Database of Orthologous Groups

More...
OrthoDBi
419397at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92954

TreeFam database of animal gene trees

More...
TreeFami
TF332780

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00094 HX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.110.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00045 Hemopexin, 1 hit
PF01033 Somatomedin_B, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00022 SOMATOMEDINB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00120 HX, 2 hits
SM00201 SO, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50923 SSF50923, 1 hit
SSF90188 SSF90188, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 2 hits
PS00524 SMB_1, 2 hits
PS50958 SMB_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q92954-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWKTLPIYL LLLLSVFVIQ QVSSQDLSSC AGRCGEGYSR DATCNCDYNC
60 70 80 90 100
QHYMECCPDF KRVCTAELSC KGRCFESFER GRECDCDAQC KKYDKCCPDY
110 120 130 140 150
ESFCAEVHNP TSPPSSKKAP PPSGASQTIK STTKRSPKPP NKKKTKKVIE
160 170 180 190 200
SEEITEEHSV SENQESSSSS SSSSSSSTIR KIKSSKNSAA NRELQKKLKV
210 220 230 240 250
KDNKKNRTKK KPTPKPPVVD EAGSGLDNGD FKVTTPDTST TQHNKVSTSP
260 270 280 290 300
KITTAKPINP RPSLPPNSDT SKETSLTVNK ETTVETKETT TTNKQTSTDG
310 320 330 340 350
KEKTTSAKET QSIEKTSAKD LAPTSKVLAK PTPKAETTTK GPALTTPKEP
360 370 380 390 400
TPTTPKEPAS TTPKEPTPTT IKSAPTTPKE PAPTTTKSAP TTPKEPAPTT
410 420 430 440 450
TKEPAPTTPK EPAPTTTKEP APTTTKSAPT TPKEPAPTTP KKPAPTTPKE
460 470 480 490 500
PAPTTPKEPT PTTPKEPAPT TKEPAPTTPK EPAPTAPKKP APTTPKEPAP
510 520 530 540 550
TTPKEPAPTT TKEPSPTTPK EPAPTTTKSA PTTTKEPAPT TTKSAPTTPK
560 570 580 590 600
EPSPTTTKEP APTTPKEPAP TTPKKPAPTT PKEPAPTTPK EPAPTTTKKP
610 620 630 640 650
APTTPKEPAP TTPKETAPTT PKKLTPTTPE KLAPTTPEKP APTTPEELAP
660 670 680 690 700
TTPEEPTPTT PEEPAPTTPK AAAPNTPKEP APTTPKEPAP TTPKEPAPTT
710 720 730 740 750
PKETAPTTPK GTAPTTLKEP APTTPKKPAP KELAPTTTKE PTSTTSDKPA
760 770 780 790 800
PTTPKGTAPT TPKEPAPTTP KEPAPTTPKG TAPTTLKEPA PTTPKKPAPK
810 820 830 840 850
ELAPTTTKGP TSTTSDKPAP TTPKETAPTT PKEPAPTTPK KPAPTTPETP
860 870 880 890 900
PPTTSEVSTP TTTKEPTTIH KSPDESTPEL SAEPTPKALE NSPKEPGVPT
910 920 930 940 950
TKTPAATKPE MTTTAKDKTT ERDLRTTPET TTAAPKMTKE TATTTEKTTE
960 970 980 990 1000
SKITATTTQV TSTTTQDTTP FKITTLKTTT LAPKVTTTKK TITTTEIMNK
1010 1020 1030 1040 1050
PEETAKPKDR ATNSKATTPK PQKPTKAPKK PTSTKKPKTM PRVRKPKTTP
1060 1070 1080 1090 1100
TPRKMTSTMP ELNPTSRIAE AMLQTTTRPN QTPNSKLVEV NPKSEDAGGA
1110 1120 1130 1140 1150
EGETPHMLLR PHVFMPEVTP DMDYLPRVPN QGIIINPMLS DETNICNGKP
1160 1170 1180 1190 1200
VDGLTTLRNG TLVAFRGHYF WMLSPFSPPS PARRITEVWG IPSPIDTVFT
1210 1220 1230 1240 1250
RCNCEGKTFF FKDSQYWRFT NDIKDAGYPK PIFKGFGGLT GQIVAALSTA
1260 1270 1280 1290 1300
KYKNWPESVY FFKRGGSIQQ YIYKQEPVQK CPGRRPALNY PVYGETTQVR
1310 1320 1330 1340 1350
RRRFERAIGP SQTHTIRIQY SPARLAYQDK GVLHNEVKVS ILWRGLPNVV
1360 1370 1380 1390 1400
TSAISLPNIR KPDGYDYYAF SKDQYYNIDV PSRTARAITT RSGQTLSKVW

YNCP
Length:1,404
Mass (Da):151,061
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FE71EA184B03972
GO
Isoform B (identifier: Q92954-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.

Show »
Length:1,363
Mass (Da):146,502
Checksum:i57256AC90E61EE30
GO
Isoform C (identifier: Q92954-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-199: Missing.

Show »
Length:1,311
Mass (Da):141,090
Checksum:iD7D6209FBB0581B2
GO
Isoform D (identifier: Q92954-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.
     107-199: Missing.

Show »
Length:1,270
Mass (Da):136,531
Checksum:i35D5DCF77028AA12
GO
Isoform E (identifier: Q92954-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.
     412-841: Missing.

Note: No experimental confirmation available.
Show »
Length:933
Mass (Da):102,513
Checksum:iB883773C5BC21A23
GO
Isoform F (identifier: Q92954-6) [UniParc]FASTAAdd to basket
Also known as: Hemangiopoietin, HAPO

The sequence of this isoform differs from the canonical sequence as follows:
     157-199: Missing.

Show »
Length:1,361
Mass (Da):146,452
Checksum:i75109738F5EED204
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLR3E9PLR3_HUMAN
Proteoglycan 4
PRG4
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KP74J3KP74_HUMAN
Proteoglycan 4
PRG4
853Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti604T → A in AAB09089 (Ref. 1) Curated1
Sequence conflicti1340S → G in AAT74746 (Ref. 4) Curated1
Sequence conflicti1380V → G in AAT74746 (Ref. 4) Curated1
Sequence conflicti1397 – 1404SKVWYNCP → FK in AAT74746 (Ref. 4) Curated8

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024023180R → W1 PublicationCorresponds to variant dbSNP:rs2273779EnsemblClinVar.1
Natural variantiVAR_0515591130N → S. Corresponds to variant dbSNP:rs10158395Ensembl.1
Natural variantiVAR_0515601272I → T. Corresponds to variant dbSNP:rs1293985Ensembl.1
Natural variantiVAR_0515611296T → M1 PublicationCorresponds to variant dbSNP:rs12134934Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01646726 – 66Missing in isoform B, isoform D and isoform E. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_016468107 – 199Missing in isoform C and isoform D. CuratedAdd BLAST93
Alternative sequenceiVSP_016469157 – 199Missing in isoform F. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_016470412 – 841Missing in isoform E. 1 PublicationAdd BLAST430

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U70136 mRNA Translation: AAB09089.1
AK131434 mRNA Translation: BAD18580.1
AL133553 Genomic DNA No translation available.
KF455089 Genomic DNA No translation available.
AY653037 mRNA Translation: AAT74745.1
AY653038 mRNA Translation: AAT74746.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1369.1 [Q92954-1]
CCDS44287.1 [Q92954-3]
CCDS44288.1 [Q92954-2]
CCDS81411.1 [Q92954-6]

NCBI Reference Sequences

More...
RefSeqi
NP_001121180.2, NM_001127708.2 [Q92954-2]
NP_001121181.2, NM_001127709.2 [Q92954-3]
NP_001121182.2, NM_001127710.2 [Q92954-4]
NP_001290161.1, NM_001303232.1 [Q92954-6]
NP_005798.3, NM_005807.4 [Q92954-1]
XP_016855491.1, XM_017000002.1
XP_016855492.1, XM_017000003.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367483; ENSP00000356453; ENSG00000116690 [Q92954-2]
ENST00000367485; ENSP00000356455; ENSG00000116690 [Q92954-3]
ENST00000445192; ENSP00000399679; ENSG00000116690 [Q92954-1]
ENST00000635041; ENSP00000489292; ENSG00000116690 [Q92954-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10216

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10216

UCSC genome browser

More...
UCSCi
uc001grt.5 human [Q92954-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70136 mRNA Translation: AAB09089.1
AK131434 mRNA Translation: BAD18580.1
AL133553 Genomic DNA No translation available.
KF455089 Genomic DNA No translation available.
AY653037 mRNA Translation: AAT74745.1
AY653038 mRNA Translation: AAT74746.1
CCDSiCCDS1369.1 [Q92954-1]
CCDS44287.1 [Q92954-3]
CCDS44288.1 [Q92954-2]
CCDS81411.1 [Q92954-6]
RefSeqiNP_001121180.2, NM_001127708.2 [Q92954-2]
NP_001121181.2, NM_001127709.2 [Q92954-3]
NP_001121182.2, NM_001127710.2 [Q92954-4]
NP_001290161.1, NM_001303232.1 [Q92954-6]
NP_005798.3, NM_005807.4 [Q92954-1]
XP_016855491.1, XM_017000002.1
XP_016855492.1, XM_017000003.1

3D structure databases

SMRiQ92954
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115511, 2 interactors
IntActiQ92954, 6 interactors
MINTiQ92954
STRINGi9606.ENSP00000399679

PTM databases

CarbonylDBiQ92954
GlyConnecti762
iPTMnetiQ92954
PhosphoSitePlusiQ92954

Polymorphism and mutation databases

BioMutaiPRG4
DMDMi83288393

Proteomic databases

EPDiQ92954
jPOSTiQ92954
MassIVEiQ92954
MaxQBiQ92954
PaxDbiQ92954
PeptideAtlasiQ92954
PRIDEiQ92954
ProteomicsDBi75624 [Q92954-1]
75625 [Q92954-2]
75626 [Q92954-3]
75627 [Q92954-4]
75628 [Q92954-5]
75629 [Q92954-6]

Genome annotation databases

EnsembliENST00000367483; ENSP00000356453; ENSG00000116690 [Q92954-2]
ENST00000367485; ENSP00000356455; ENSG00000116690 [Q92954-3]
ENST00000445192; ENSP00000399679; ENSG00000116690 [Q92954-1]
ENST00000635041; ENSP00000489292; ENSG00000116690 [Q92954-6]
GeneIDi10216
KEGGihsa:10216
UCSCiuc001grt.5 human [Q92954-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10216
DisGeNETi10216

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRG4
HGNCiHGNC:9364 PRG4
HPAiHPA028523
MalaCardsiPRG4
MIMi208250 phenotype
604283 gene
neXtProtiNX_Q92954
OpenTargetsiENSG00000116690
Orphaneti2848 Camptodactyly-arthropathy-coxa-vara-pericarditis syndrome
PharmGKBiPA33736

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00530000063751
HOGENOMiHOG000115691
InParanoidiQ92954
OMAiQTDPNDT
OrthoDBi419397at2759
PhylomeDBiQ92954
TreeFamiTF332780

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PRG4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PRG4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10216
PharosiQ92954

Protein Ontology

More...
PROi
PR:Q92954

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116690 Expressed in 117 organ(s), highest expression level in synovial joint
ExpressionAtlasiQ92954 baseline and differential
GenevisibleiQ92954 HS

Family and domain databases

CDDicd00094 HX, 1 hit
Gene3Di2.110.10.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom
PfamiView protein in Pfam
PF00045 Hemopexin, 1 hit
PF01033 Somatomedin_B, 2 hits
PRINTSiPR00022 SOMATOMEDINB
SMARTiView protein in SMART
SM00120 HX, 2 hits
SM00201 SO, 2 hits
SUPFAMiSSF50923 SSF50923, 1 hit
SSF90188 SSF90188, 2 hits
PROSITEiView protein in PROSITE
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 2 hits
PS00524 SMB_1, 2 hits
PS50958 SMB_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRG4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92954
Secondary accession number(s): Q6DNC4
, Q6DNC5, Q6ZMZ5, Q9BX49
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 28, 2018
Last modified: October 16, 2019
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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