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Entry version 170 (03 Jul 2019)
Sequence version 2 (25 Oct 2002)
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Protein

Potassium voltage-gated channel subfamily B member 2

Gene

KCNB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by quinine at micromolar levels. Modestly sensitive to millimolar levels of tetraethylammonium (TEA) and 4-aminopyridine (4-AP).By similarity1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Homotetrameric channels expressed in xenopus oocytes or in mammalian non-neuronal cells display delayed-rectifier voltage-dependent potassium currents which are activated during membrane depolarization, i.e within a risetime of about 20 msec. After that, inactivate very slowly. Their activation requires low threshold potentials of about -20 to -30 mV, with a midpoint activation at about 10 mV. For inactivation, the voltage at half-maximal amplitude is about -30 mV. Channels have an unitary conductance of about 14 pS. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system and post-translational modifications.1 Publication

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      GO - Biological processi

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionIon channel, Potassium channel, Voltage-gated channel
      Biological processIon transport, Potassium transport, Transport
      LigandPotassium

      Enzyme and pathway databases

      Reactome - a knowledgebase of biological pathways and processes

      More...
      Reactomei
      R-HSA-1296072 Voltage gated Potassium channels

      Protein family/group databases

      Transport Classification Database

      More...
      TCDBi
      1.A.1.2.25 the voltage-gated ion channel (vic) superfamily

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      Potassium voltage-gated channel subfamily B member 2Imported
      Alternative name(s):
      Voltage-gated potassium channel subunit Kv2.2
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:KCNB2Imported
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

      Organism-specific databases

      Human Gene Nomenclature Database

      More...
      HGNCi
      HGNC:6232 KCNB2

      Online Mendelian Inheritance in Man (OMIM)

      More...
      MIMi
      607738 gene

      neXtProt; the human protein knowledge platform

      More...
      neXtProti
      NX_Q92953

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

      Topology

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 190CytoplasmicBy similarityAdd BLAST190
      <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei191 – 212Helical; Name=Segment S1By similarityAdd BLAST22
      Topological domaini213 – 232ExtracellularBy similarityAdd BLAST20
      Transmembranei233 – 254Helical; Name=Segment S2By similarityAdd BLAST22
      Topological domaini255 – 265CytoplasmicBy similarityAdd BLAST11
      Transmembranei266 – 284Helical; Name=Segment S3By similarityAdd BLAST19
      Topological domaini285 – 296ExtracellularBy similarityAdd BLAST12
      Transmembranei297 – 317Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
      Topological domaini318 – 332CytoplasmicBy similarityAdd BLAST15
      Transmembranei333 – 354Helical; Name=Segment S5By similarityAdd BLAST22
      Topological domaini355 – 368ExtracellularBy similarityAdd BLAST14
      <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei369 – 380Helical; Name=Pore helixBy similarityAdd BLAST12
      Intramembranei381 – 388By similarity8
      Topological domaini389 – 395ExtracellularBy similarity7
      Transmembranei396 – 424Helical; Name=Segment S6By similarityAdd BLAST29
      Topological domaini425 – 911CytoplasmicBy similarityAdd BLAST487

      Keywords - Cellular componenti

      Cell membrane, Cell projection, Membrane

      <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

      Organism-specific databases

      DisGeNET

      More...
      DisGeNETi
      9312

      Open Targets

      More...
      OpenTargetsi
      ENSG00000182674

      The Pharmacogenetics and Pharmacogenomics Knowledge Base

      More...
      PharmGKBi
      PA30025

      Chemistry databases

      ChEMBL database of bioactive drug-like small molecules

      More...
      ChEMBLi
      CHEMBL2321618

      Drug and drug target database

      More...
      DrugBanki
      DB06637 Dalfampridine

      IUPHAR/BPS Guide to PHARMACOLOGY

      More...
      GuidetoPHARMACOLOGYi
      547

      Polymorphism and mutation databases

      BioMuta curated single-nucleotide variation and disease association database

      More...
      BioMutai
      KCNB2

      Domain mapping of disease mutations (DMDM)

      More...
      DMDMi
      24418855

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000540481 – 911Potassium voltage-gated channel subfamily B member 2Add BLAST911

      Amino acid modifications

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
      <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei448PhosphoserineBy similarity1

      <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

      Phosphorylated.By similarity

      Keywords - PTMi

      Glycoprotein, Phosphoprotein

      Proteomic databases

      jPOST - Japan Proteome Standard Repository/Database

      More...
      jPOSTi
      Q92953

      PaxDb, a database of protein abundance averages across all three domains of life

      More...
      PaxDbi
      Q92953

      PeptideAtlas

      More...
      PeptideAtlasi
      Q92953

      PRoteomics IDEntifications database

      More...
      PRIDEi
      Q92953

      ProteomicsDB human proteome resource

      More...
      ProteomicsDBi
      75623

      PTM databases

      iPTMnet integrated resource for PTMs in systems biology context

      More...
      iPTMneti
      Q92953

      Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

      More...
      PhosphoSitePlusi
      Q92953

      <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

      Gene expression databases

      Bgee dataBase for Gene Expression Evolution

      More...
      Bgeei
      ENSG00000182674 Expressed in 69 organ(s), highest expression level in buccal mucosa cell

      Genevisible search portal to normalized and curated expression data from Genevestigator

      More...
      Genevisiblei
      Q92953 HS

      Organism-specific databases

      Human Protein Atlas

      More...
      HPAi
      HPA065970

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

      Homotetramer or heterotetramer with KCNB1. Heterotetramer with KCNS1 and KCNS2.

      By similarity

      GO - Molecular functioni

      Protein-protein interaction databases

      The Biological General Repository for Interaction Datasets (BioGrid)

      More...
      BioGridi
      114724, 7 interactors

      Protein interaction database and analysis system

      More...
      IntActi
      Q92953, 5 interactors

      Molecular INTeraction database

      More...
      MINTi
      Q92953

      STRING: functional protein association networks

      More...
      STRINGi
      9606.ENSP00000430846

      Chemistry databases

      BindingDB database of measured binding affinities

      More...
      BindingDBi
      Q92953

      <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

      3D structure databases

      SWISS-MODEL Repository - a database of annotated 3D protein structure models

      More...
      SMRi
      Q92953

      Database of comparative protein structure models

      More...
      ModBasei
      Search...

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      Motif

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi381 – 386Selectivity filterBy similarity6

      <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

      The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

      <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

      Keywords - Domaini

      Transmembrane, Transmembrane helix

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...
      eggNOGi
      KOG3713 Eukaryota
      COG1226 LUCA

      Ensembl GeneTree

      More...
      GeneTreei
      ENSGT00940000161902

      The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

      More...
      HOGENOMi
      HOG000113206

      InParanoid: Eukaryotic Ortholog Groups

      More...
      InParanoidi
      Q92953

      KEGG Orthology (KO)

      More...
      KOi
      K04886

      Identification of Orthologs from Complete Genome Data

      More...
      OMAi
      SHNCRQD

      Database of Orthologous Groups

      More...
      OrthoDBi
      203440at2759

      Database for complete collections of gene phylogenies

      More...
      PhylomeDBi
      Q92953

      TreeFam database of animal gene trees

      More...
      TreeFami
      TF313103

      Family and domain databases

      Gene3D Structural and Functional Annotation of Protein Families

      More...
      Gene3Di
      1.20.120.350, 1 hit

      Integrated resource of protein families, domains and functional sites

      More...
      InterProi
      View protein in InterPro
      IPR000210 BTB/POZ_dom
      IPR005821 Ion_trans_dom
      IPR003968 K_chnl_volt-dep_Kv
      IPR003973 K_chnl_volt-dep_Kv2
      IPR005826 K_chnl_volt-dep_Kv2.2
      IPR011333 SKP1/BTB/POZ_sf
      IPR003131 T1-type_BTB
      IPR028325 VG_K_chnl
      IPR027359 Volt_channel_dom_sf

      The PANTHER Classification System

      More...
      PANTHERi
      PTHR11537 PTHR11537, 1 hit

      Pfam protein domain database

      More...
      Pfami
      View protein in Pfam
      PF02214 BTB_2, 1 hit
      PF00520 Ion_trans, 1 hit
      PF03521 Kv2channel, 1 hit

      Protein Motif fingerprint database; a protein domain database

      More...
      PRINTSi
      PR01515 KV22CHANNEL
      PR01491 KVCHANNEL
      PR01495 SHABCHANNEL

      Simple Modular Architecture Research Tool; a protein domain database

      More...
      SMARTi
      View protein in SMART
      SM00225 BTB, 1 hit

      Superfamily database of structural and functional annotation

      More...
      SUPFAMi
      SSF54695 SSF54695, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      Q92953-1 [UniParc]FASTAAdd to basket
      « Hide
              10         20         30         40         50
      MAEKAPPGLN RKTSRSTLSL PPEPVDIIRS KTCSRRVKIN VGGLNHEVLW
      60 70 80 90 100
      RTLDRLPRTR LGKLRDCNTH ESLLEVCDDY NLNENEYFFD RHPGAFTSIL
      110 120 130 140 150
      NFYRTGKLHM MEEMCALSFG QELDYWGIDE IYLESCCQAR YHQKKEQMNE
      160 170 180 190 200
      ELRREAETMR EREGEEFDNT CCPDKRKKLW DLLEKPNSSV AAKILAIVSI
      210 220 230 240 250
      LFIVLSTIAL SLNTLPELQE TDEFGQLNDN RQLAHVEAVC IAWFTMEYLL
      260 270 280 290 300
      RFLSSPNKWK FFKGPLNVID LLAILPYYVT IFLTESNKSV LQFQNVRRVV
      310 320 330 340 350
      QIFRIMRILR ILKLARHSTG LQSLGFTLRR SYNELGLLIL FLAMGIMIFS
      360 370 380 390 400
      SLVFFAEKDE DATKFTSIPA SFWWATITMT TVGYGDIYPK TLLGKIVGGL
      410 420 430 440 450
      CCIAGVLVIA LPIPIIVNNF SEFYKEQKRQ EKAIKRREAL ERAKRNGSIV
      460 470 480 490 500
      SMNLKDAFAR SMELIDVAVE KAGESANTKD SADDNHLSPS RWKWARKALS
      510 520 530 540 550
      ETSSNKSFEN KYQEVSQKDS HEQLNNTSSS SPQHLSAQKL EMLYNEITKT
      560 570 580 590 600
      QPHSHPNPDC QEKPERPSAY EEEIEMEEVV CPQEQLAVAQ TEVIVDMKST
      610 620 630 640 650
      SSIDSFTSCA TDFTETERSP LPPPSASHLQ MKFPTDLPGT EEHQRARGPP
      660 670 680 690 700
      FLTLSREKGP AARDGTLEYA PVDITVNLDA SGSQCGLHSP LQSDNATDSP
      710 720 730 740 750
      KSSLKGSNPL KSRSLKVNFK ENRGSAPQTP PSTARPLPVT TADFSLTTPQ
      760 770 780 790 800
      HISTILLEET PSQGDRPLLG TEVSAPCQGP SKGLSPRFPK QKLFPFSSRE
      810 820 830 840 850
      RRSFTEIDTG DDEDFLELPG AREEKQVDSS PNCFADKPSD GRDPLREEGS
      860 870 880 890 900
      VGSSSPQDTG HNCRQDIYHA VSEVKKDSSQ EGCKMENHLF APEIHSNPGD
      910
      TGYCPTRETS M
      Length:911
      Mass (Da):102,563
      Last modified:October 25, 2002 - v2
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2261D7D6280CF81A
      GO

      <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

      The sequence AAB08433 differs from that shown. Reason: Frameshift at position 768.Curated

      Experimental Info

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti161 – 162ER → DG in AAP46292 (Ref. 1) Curated2
      Sequence conflicti528S → F in AAP46292 (Ref. 1) Curated1

      Natural variant

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035774450V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs770305852Ensembl.1
      Natural variantiVAR_034050657E → G. Corresponds to variant dbSNP:rs16938507Ensembl.1

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...
      EMBLi

      GenBank nucleotide sequence database

      More...
      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...
      DDBJi
      Links Updated
      AF450111 mRNA Translation: AAP46292.1
      AF338730 mRNA Translation: AAK16585.1
      U69962 mRNA Translation: AAB08433.1 Frameshift.

      The Consensus CDS (CCDS) project

      More...
      CCDSi
      CCDS6209.1

      NCBI Reference Sequences

      More...
      RefSeqi
      NP_004761.2, NM_004770.2

      Genome annotation databases

      Ensembl eukaryotic genome annotation project

      More...
      Ensembli
      ENST00000523207; ENSP00000430846; ENSG00000182674

      Database of genes from NCBI RefSeq genomes

      More...
      GeneIDi
      9312

      KEGG: Kyoto Encyclopedia of Genes and Genomes

      More...
      KEGGi
      hsa:9312

      UCSC genome browser

      More...
      UCSCi
      uc003xzb.3 human

      Keywords - Coding sequence diversityi

      Polymorphism

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      AF450111 mRNA Translation: AAP46292.1
      AF338730 mRNA Translation: AAK16585.1
      U69962 mRNA Translation: AAB08433.1 Frameshift.
      CCDSiCCDS6209.1
      RefSeqiNP_004761.2, NM_004770.2

      3D structure databases

      SMRiQ92953
      ModBaseiSearch...

      Protein-protein interaction databases

      BioGridi114724, 7 interactors
      IntActiQ92953, 5 interactors
      MINTiQ92953
      STRINGi9606.ENSP00000430846

      Chemistry databases

      BindingDBiQ92953
      ChEMBLiCHEMBL2321618
      DrugBankiDB06637 Dalfampridine
      GuidetoPHARMACOLOGYi547

      Protein family/group databases

      TCDBi1.A.1.2.25 the voltage-gated ion channel (vic) superfamily

      PTM databases

      iPTMnetiQ92953
      PhosphoSitePlusiQ92953

      Polymorphism and mutation databases

      BioMutaiKCNB2
      DMDMi24418855

      Proteomic databases

      jPOSTiQ92953
      PaxDbiQ92953
      PeptideAtlasiQ92953
      PRIDEiQ92953
      ProteomicsDBi75623

      Protocols and materials databases

      The DNASU plasmid repository

      More...
      DNASUi
      9312
      Structural Biology KnowledgebaseSearch...

      Genome annotation databases

      EnsembliENST00000523207; ENSP00000430846; ENSG00000182674
      GeneIDi9312
      KEGGihsa:9312
      UCSCiuc003xzb.3 human

      Organism-specific databases

      Comparative Toxicogenomics Database

      More...
      CTDi
      9312
      DisGeNETi9312

      GeneCards: human genes, protein and diseases

      More...
      GeneCardsi
      KCNB2
      HGNCiHGNC:6232 KCNB2
      HPAiHPA065970
      MIMi607738 gene
      neXtProtiNX_Q92953
      OpenTargetsiENSG00000182674
      PharmGKBiPA30025

      GenAtlas: human gene database

      More...
      GenAtlasi
      Search...

      Phylogenomic databases

      eggNOGiKOG3713 Eukaryota
      COG1226 LUCA
      GeneTreeiENSGT00940000161902
      HOGENOMiHOG000113206
      InParanoidiQ92953
      KOiK04886
      OMAiSHNCRQD
      OrthoDBi203440at2759
      PhylomeDBiQ92953
      TreeFamiTF313103

      Enzyme and pathway databases

      ReactomeiR-HSA-1296072 Voltage gated Potassium channels

      Miscellaneous databases

      ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

      More...
      ChiTaRSi
      KCNB2 human

      The Gene Wiki collection of pages on human genes and proteins

      More...
      GeneWikii
      KCNB2

      Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

      More...
      GenomeRNAii
      9312

      Protein Ontology

      More...
      PROi
      PR:Q92953

      The Stanford Online Universal Resource for Clones and ESTs

      More...
      SOURCEi
      Search...

      Gene expression databases

      BgeeiENSG00000182674 Expressed in 69 organ(s), highest expression level in buccal mucosa cell
      GenevisibleiQ92953 HS

      Family and domain databases

      Gene3Di1.20.120.350, 1 hit
      InterProiView protein in InterPro
      IPR000210 BTB/POZ_dom
      IPR005821 Ion_trans_dom
      IPR003968 K_chnl_volt-dep_Kv
      IPR003973 K_chnl_volt-dep_Kv2
      IPR005826 K_chnl_volt-dep_Kv2.2
      IPR011333 SKP1/BTB/POZ_sf
      IPR003131 T1-type_BTB
      IPR028325 VG_K_chnl
      IPR027359 Volt_channel_dom_sf
      PANTHERiPTHR11537 PTHR11537, 1 hit
      PfamiView protein in Pfam
      PF02214 BTB_2, 1 hit
      PF00520 Ion_trans, 1 hit
      PF03521 Kv2channel, 1 hit
      PRINTSiPR01515 KV22CHANNEL
      PR01491 KVCHANNEL
      PR01495 SHABCHANNEL
      SMARTiView protein in SMART
      SM00225 BTB, 1 hit
      SUPFAMiSSF54695 SSF54695, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

      More...
      ProtoNeti
      Search...

      MobiDB: a database of protein disorder and mobility annotations

      More...
      MobiDBi
      Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNB2_HUMAN
      <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92953
      Secondary accession number(s): Q7Z7D0, Q9BXD3
      <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
      Last sequence update: October 25, 2002
      Last modified: July 3, 2019
      This is version 170 of the entry and version 2 of the sequence. See complete history.
      <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program
      DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

      <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      Complete proteome, Reference proteome

      Documents

      1. SIMILARITY comments
        Index of protein domains and families
      2. Human entries with polymorphisms or disease mutations
        List of human entries with polymorphisms or disease mutations
      3. Human polymorphisms and disease mutations
        Index of human polymorphisms and disease mutations
      4. MIM cross-references
        Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
      5. Human chromosome 8
        Human chromosome 8: entries, gene names and cross-references to MIM
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