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UniProtKB - Q92952 (KCNN1_HUMAN)

Entry version 172 (02 Jun 2021)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

Small conductance calcium-activated potassium channel protein 1

Gene

KCNN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Ion channel
Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92952

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1296052, Ca2+ activated K+ channels

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92952

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.1.16.6, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small conductance calcium-activated potassium channel protein 1
Short name:
SK1
Short name:
SKCa 1
Short name:
SKCa1
Alternative name(s):
KCa2.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNN1
Synonyms:SK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6290, KCNN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602982, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92952

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000105642.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei111 – 131Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=Segment S2Sequence analysisAdd BLAST21
Transmembranei179 – 199Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei228 – 248Helical; Name=Segment S4Sequence analysisAdd BLAST21
Transmembranei277 – 297Helical; Name=Segment S5Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei317 – 337Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei346 – 366Helical; Name=Segment S6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3780

Open Targets

More...OpenTargetsi		ENSG00000105642

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30070

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92952, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2369

Drug and drug target database

More...DrugBanki		DB01110, Miconazole
DB00721, Procaine
DB09089, Trimebutine

DrugCentral

More...DrugCentrali		Q92952

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		381

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCNN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		124056468

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001550071 – 543Small conductance calcium-activated potassium channel protein 1Add BLAST543

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92952

PeptideAtlas

More...PeptideAtlasi		Q92952

PRoteomics IDEntifications database

More...PRIDEi		Q92952

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75621 [Q92952-1]
75622 [Q92952-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92952

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92952

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105642, Expressed in dorsolateral prefrontal cortex and 127 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92952, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92952, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105642, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109981, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q92952, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000476519

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q92952

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92952, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92952

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 92DisorderedSequence analysisAdd BLAST92
Regioni384 – 463Calmodulin-bindingBy similarityAdd BLAST80
Regioni505 – 543DisorderedSequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi505 – 522Pro residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3684, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182904

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014617_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92952

Identification of Orthologs from Complete Genome Data

More...OMAi		PLFAIKC

Database of Orthologous Groups

More...OrthoDBi		907751at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92952

TreeFam database of animal gene trees

More...TreeFami		TF315015

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004178, CaM-bd_dom
IPR036122, CaM-bd_dom_sf
IPR015449, K_chnl_Ca-activ_SK
IPR013099, K_chnl_dom

The PANTHER Classification System

More...PANTHERi		PTHR10153, PTHR10153, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02888, CaMBD, 1 hit
PF07885, Ion_trans_2, 1 hit
PF03530, SK_channel, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01451, SKCHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01053, CaMBD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81327, SSF81327, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92952-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSHSYNGSV GRPLGSGPGA LGRDPPDPEA GHPPQPPHSP GLQVVVAKSE 
        60         70         80         90        100
PARPSPGSPR GQPQDQDDDE DDEEDEAGRQ RASGKPSNVG HRLGHRRALF 
       110        120        130        140        150
EKRKRLSDYA LIFGMFGIVV MVTETELSWG VYTKESLYSF ALKCLISLST 
       160        170        180        190        200
AILLGLVVLY HAREIQLFMV DNGADDWRIA MTCERVFLIS LELAVCAIHP 
       210        220        230        240        250
VPGHYRFTWT ARLAFTYAPS VAEADVDVLL SIPMFLRLYL LGRVMLLHSK 
       260        270        280        290        300
IFTDASSRSI GALNKITFNT RFVMKTLMTI CPGTVLLVFS ISSWIIAAWT 
       310        320        330        340        350
VRVCERYHDK QEVTSNFLGA MWLISITFLS IGYGDMVPHT YCGKGVCLLT 
       360        370        380        390        400
GIMGAGCTAL VVAVVARKLE LTKAEKHVHN FMMDTQLTKR VKNAAANVLR 
       410        420        430        440        450
ETWLIYKHTR LVKKPDQARV RKHQRKFLQA IHQAQKLRSV KIEQGKLNDQ 
       460        470        480        490        500
ANTLTDLAKT QTVMYDLVSE LHAQHEELEA RLATLESRLD ALGASLQALP 
       510        520        530        540 
GLIAQAIRPP PPPLPPRPGP GPQDQAARSS PCRWTPVAPS DCG
Length:543
Mass (Da):59,987
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13EFF47C263BCB11
GO
Isoform 2 (identifier: Q92952-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGPRAACSEPNPCTQVVM

Show »
Length:561
Mass (Da):61,827
Checksum:i66CA9A21C5FFDE74
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X2E7A0A087X2E7_HUMAN
Small conductance calcium-activated...
KCNN1
543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYV2V9GYV2_HUMAN
Small conductance calcium-activated...
KCNN1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti513 – 542PLPPR…APSDC → RLPRQRAGLDH in BAD86831 (Ref. 3) CuratedAdd BLAST30

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0225011M → MPGPRAACSEPNPCTQVVM in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U69883 mRNA Translation: AAB09562.1
AF131948 AF131947 Genomic DNA Translation: AAD37507.1
AB198191 mRNA Translation: BAD86831.1
BC075037 mRNA Translation: AAH75037.3

The Consensus CDS (CCDS) project

More...CCDSi		CCDS67611.1 [Q92952-1]

NCBI Reference Sequences

More...RefSeqi		NP_002239.2, NM_002248.4 [Q92952-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000222249; ENSP00000476519; ENSG00000105642 [Q92952-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3780

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3780

UCSC genome browser

More...UCSCi		uc002nht.4, human [Q92952-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69883 mRNA Translation: AAB09562.1
AF131948 AF131947 Genomic DNA Translation: AAD37507.1
AB198191 mRNA Translation: BAD86831.1
BC075037 mRNA Translation: AAH75037.3
CCDSiCCDS67611.1 [Q92952-1]
RefSeqiNP_002239.2, NM_002248.4 [Q92952-1]

3D structure databases

SMRiQ92952
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109981, 4 interactors
IntActiQ92952, 3 interactors
STRINGi9606.ENSP00000476519

Chemistry databases

BindingDBiQ92952
ChEMBLiCHEMBL2369
DrugBankiDB01110, Miconazole
DB00721, Procaine
DB09089, Trimebutine
DrugCentraliQ92952
GuidetoPHARMACOLOGYi381

Protein family/group databases

TCDBi1.A.1.16.6, the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiQ92952
PhosphoSitePlusiQ92952

Genetic variation databases

BioMutaiKCNN1
DMDMi124056468

Proteomic databases

MassIVEiQ92952
PeptideAtlasiQ92952
PRIDEiQ92952
ProteomicsDBi75621 [Q92952-1]
75622 [Q92952-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27885, 123 antibodies

The DNASU plasmid repository

More...DNASUi		3780

Genome annotation databases

EnsembliENST00000222249; ENSP00000476519; ENSG00000105642 [Q92952-1]
GeneIDi3780
KEGGihsa:3780
UCSCiuc002nht.4, human [Q92952-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3780
DisGeNETi3780

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCNN1
HGNCiHGNC:6290, KCNN1
HPAiENSG00000105642, Tissue enriched (brain)
MIMi602982, gene
neXtProtiNX_Q92952
OpenTargetsiENSG00000105642
PharmGKBiPA30070
VEuPathDBiHostDB:ENSG00000105642.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3684, Eukaryota
GeneTreeiENSGT00950000182904
HOGENOMiCLU_014617_5_0_1
InParanoidiQ92952
OMAiPLFAIKC
OrthoDBi907751at2759
PhylomeDBiQ92952
TreeFamiTF315015

Enzyme and pathway databases

PathwayCommonsiQ92952
ReactomeiR-HSA-1296052, Ca2+ activated K+ channels
SIGNORiQ92952

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3780, 6 hits in 933 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KCNN1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KCNN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3780
PharosiQ92952, Tchem

Protein Ontology

More...PROi		PR:Q92952
RNActiQ92952, protein

The Stanford Online Universal Resource for Clones and ESTs

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Gene expression databases

BgeeiENSG00000105642, Expressed in dorsolateral prefrontal cortex and 127 other tissues
ExpressionAtlasiQ92952, baseline and differential
GenevisibleiQ92952, HS

Family and domain databases

InterProiView protein in InterPro
IPR004178, CaM-bd_dom
IPR036122, CaM-bd_dom_sf
IPR015449, K_chnl_Ca-activ_SK
IPR013099, K_chnl_dom
PANTHERiPTHR10153, PTHR10153, 1 hit
PfamiView protein in Pfam
PF02888, CaMBD, 1 hit
PF07885, Ion_trans_2, 1 hit
PF03530, SK_channel, 1 hit
PRINTSiPR01451, SKCHANNEL
SMARTiView protein in SMART
SM01053, CaMBD, 1 hit
SUPFAMiSSF81327, SSF81327, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNN1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92952
Secondary accession number(s): Q5KR10, Q6DJU4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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