UniProtKB - Q92952 (KCNN1_HUMAN)
Protein
Small conductance calcium-activated potassium channel protein 1
Gene
KCNN1
Organism
Homo sapiens (Human)
Status
Functioni
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).By similarity
GO - Molecular functioni
- calcium-activated potassium channel activity Source: ProtInc
- calmodulin binding Source: GO_Central
- protein-containing complex binding Source: Ensembl
- small conductance calcium-activated potassium channel activity Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: ProtInc
- ion transport Source: GO_Central
- potassium ion transmembrane transport Source: GO_Central
- potassium ion transport Source: ProtInc
Keywordsi
Molecular function | Calmodulin-binding, Ion channel |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q92952 |
Reactomei | R-HSA-1296052, Ca2+ activated K+ channels |
SIGNORi | Q92952 |
Protein family/group databases
TCDBi | 1.A.1.16.6, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Small conductance calcium-activated potassium channel protein 1Short name: SK1 Short name: SKCa 1 Short name: SKCa1 Alternative name(s): KCa2.1 |
Gene namesi | Name:KCNN1 Synonyms:SK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6290, KCNN1 |
MIMi | 602982, gene |
neXtProti | NX_Q92952 |
VEuPathDBi | HostDB:ENSG00000105642.15 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: GO_Central
- voltage-gated potassium channel complex Source: ProtInc
Other locations
- neuron projection Source: GO_Central
- neuronal cell body Source: GO_Central
- synapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 111 – 131 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 140 – 160 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 179 – 199 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 228 – 248 | Helical; Name=Segment S4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 277 – 297 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Intramembranei | 317 – 337 | Pore-forming; Name=Segment H5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 346 – 366 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3780 |
OpenTargetsi | ENSG00000105642 |
PharmGKBi | PA30070 |
Miscellaneous databases
Pharosi | Q92952, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2369 |
DrugBanki | DB01110, Miconazole DB00721, Procaine DB09089, Trimebutine |
DrugCentrali | Q92952 |
GuidetoPHARMACOLOGYi | 381 |
Genetic variation databases
BioMutai | KCNN1 |
DMDMi | 124056468 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000155007 | 1 – 543 | Small conductance calcium-activated potassium channel protein 1Add BLAST | 543 |
Proteomic databases
MassIVEi | Q92952 |
PeptideAtlasi | Q92952 |
PRIDEi | Q92952 |
ProteomicsDBi | 75621 [Q92952-1] 75622 [Q92952-2] |
PTM databases
iPTMneti | Q92952 |
PhosphoSitePlusi | Q92952 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105642, Expressed in dorsolateral prefrontal cortex and 125 other tissues |
ExpressionAtlasi | Q92952, baseline and differential |
Genevisiblei | Q92952, HS |
Organism-specific databases
HPAi | ENSG00000105642, Tissue enriched (brain) |
Interactioni
Subunit structurei
Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).
By similarityGO - Molecular functioni
- calmodulin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 109981, 4 interactors |
IntActi | Q92952, 2 interactors |
STRINGi | 9606.ENSP00000476519 |
Chemistry databases
BindingDBi | Q92952 |
Miscellaneous databases
RNActi | Q92952, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 384 – 463 | Calmodulin-bindingBy similarityAdd BLAST | 80 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 509 – 518 | Poly-Pro | 10 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3684, Eukaryota |
GeneTreei | ENSGT00950000182904 |
HOGENOMi | CLU_014617_5_0_1 |
InParanoidi | Q92952 |
OMAi | PLFAIKC |
OrthoDBi | 907751at2759 |
PhylomeDBi | Q92952 |
TreeFami | TF315015 |
Family and domain databases
InterProi | View protein in InterPro IPR004178, CaM-bd_dom IPR036122, CaM-bd_dom_sf IPR015449, K_chnl_Ca-activ_SK IPR013099, K_chnl_dom |
PANTHERi | PTHR10153, PTHR10153, 1 hit |
Pfami | View protein in Pfam PF02888, CaMBD, 1 hit PF07885, Ion_trans_2, 1 hit PF03530, SK_channel, 1 hit |
PRINTSi | PR01451, SKCHANNEL |
SMARTi | View protein in SMART SM01053, CaMBD, 1 hit |
SUPFAMi | SSF81327, SSF81327, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q92952-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNSHSYNGSV GRPLGSGPGA LGRDPPDPEA GHPPQPPHSP GLQVVVAKSE
60 70 80 90 100
PARPSPGSPR GQPQDQDDDE DDEEDEAGRQ RASGKPSNVG HRLGHRRALF
110 120 130 140 150
EKRKRLSDYA LIFGMFGIVV MVTETELSWG VYTKESLYSF ALKCLISLST
160 170 180 190 200
AILLGLVVLY HAREIQLFMV DNGADDWRIA MTCERVFLIS LELAVCAIHP
210 220 230 240 250
VPGHYRFTWT ARLAFTYAPS VAEADVDVLL SIPMFLRLYL LGRVMLLHSK
260 270 280 290 300
IFTDASSRSI GALNKITFNT RFVMKTLMTI CPGTVLLVFS ISSWIIAAWT
310 320 330 340 350
VRVCERYHDK QEVTSNFLGA MWLISITFLS IGYGDMVPHT YCGKGVCLLT
360 370 380 390 400
GIMGAGCTAL VVAVVARKLE LTKAEKHVHN FMMDTQLTKR VKNAAANVLR
410 420 430 440 450
ETWLIYKHTR LVKKPDQARV RKHQRKFLQA IHQAQKLRSV KIEQGKLNDQ
460 470 480 490 500
ANTLTDLAKT QTVMYDLVSE LHAQHEELEA RLATLESRLD ALGASLQALP
510 520 530 540
GLIAQAIRPP PPPLPPRPGP GPQDQAARSS PCRWTPVAPS DCG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X2E7 | A0A087X2E7_HUMAN | Small conductance calcium-activated... | KCNN1 | 543 | Annotation score: | ||
V9GYV2 | V9GYV2_HUMAN | Small conductance calcium-activated... | KCNN1 | 158 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 513 – 542 | PLPPR…APSDC → RLPRQRAGLDH in BAD86831 (Ref. 3) CuratedAdd BLAST | 30 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022501 | 1 | M → MPGPRAACSEPNPCTQVVM in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U69883 mRNA Translation: AAB09562.1 AF131948 , AF131940, AF131941, AF131942, AF131943, AF131944, AF131945, AF131946, AF131947 Genomic DNA Translation: AAD37507.1 AB198191 mRNA Translation: BAD86831.1 BC075037 mRNA Translation: AAH75037.3 |
CCDSi | CCDS67611.1 [Q92952-1] |
RefSeqi | NP_002239.2, NM_002248.4 [Q92952-1] |
Genome annotation databases
Ensembli | ENST00000222249; ENSP00000476519; ENSG00000105642 [Q92952-1] |
GeneIDi | 3780 |
KEGGi | hsa:3780 |
UCSCi | uc002nht.4, human [Q92952-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U69883 mRNA Translation: AAB09562.1 AF131948 , AF131940, AF131941, AF131942, AF131943, AF131944, AF131945, AF131946, AF131947 Genomic DNA Translation: AAD37507.1 AB198191 mRNA Translation: BAD86831.1 BC075037 mRNA Translation: AAH75037.3 |
CCDSi | CCDS67611.1 [Q92952-1] |
RefSeqi | NP_002239.2, NM_002248.4 [Q92952-1] |
3D structure databases
SMRi | Q92952 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109981, 4 interactors |
IntActi | Q92952, 2 interactors |
STRINGi | 9606.ENSP00000476519 |
Chemistry databases
BindingDBi | Q92952 |
ChEMBLi | CHEMBL2369 |
DrugBanki | DB01110, Miconazole DB00721, Procaine DB09089, Trimebutine |
DrugCentrali | Q92952 |
GuidetoPHARMACOLOGYi | 381 |
Protein family/group databases
TCDBi | 1.A.1.16.6, the voltage-gated ion channel (vic) superfamily |
PTM databases
iPTMneti | Q92952 |
PhosphoSitePlusi | Q92952 |
Genetic variation databases
BioMutai | KCNN1 |
DMDMi | 124056468 |
Proteomic databases
MassIVEi | Q92952 |
PeptideAtlasi | Q92952 |
PRIDEi | Q92952 |
ProteomicsDBi | 75621 [Q92952-1] 75622 [Q92952-2] |
Protocols and materials databases
Antibodypediai | 27885, 117 antibodies |
Genome annotation databases
Ensembli | ENST00000222249; ENSP00000476519; ENSG00000105642 [Q92952-1] |
GeneIDi | 3780 |
KEGGi | hsa:3780 |
UCSCi | uc002nht.4, human [Q92952-1] |
Organism-specific databases
CTDi | 3780 |
DisGeNETi | 3780 |
GeneCardsi | KCNN1 |
HGNCi | HGNC:6290, KCNN1 |
HPAi | ENSG00000105642, Tissue enriched (brain) |
MIMi | 602982, gene |
neXtProti | NX_Q92952 |
OpenTargetsi | ENSG00000105642 |
PharmGKBi | PA30070 |
VEuPathDBi | HostDB:ENSG00000105642.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3684, Eukaryota |
GeneTreei | ENSGT00950000182904 |
HOGENOMi | CLU_014617_5_0_1 |
InParanoidi | Q92952 |
OMAi | PLFAIKC |
OrthoDBi | 907751at2759 |
PhylomeDBi | Q92952 |
TreeFami | TF315015 |
Enzyme and pathway databases
PathwayCommonsi | Q92952 |
Reactomei | R-HSA-1296052, Ca2+ activated K+ channels |
SIGNORi | Q92952 |
Miscellaneous databases
BioGRID-ORCSi | 3780, 5 hits in 832 CRISPR screens |
ChiTaRSi | KCNN1, human |
GeneWikii | KCNN1 |
GenomeRNAii | 3780 |
Pharosi | Q92952, Tchem |
PROi | PR:Q92952 |
RNActi | Q92952, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105642, Expressed in dorsolateral prefrontal cortex and 125 other tissues |
ExpressionAtlasi | Q92952, baseline and differential |
Genevisiblei | Q92952, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004178, CaM-bd_dom IPR036122, CaM-bd_dom_sf IPR015449, K_chnl_Ca-activ_SK IPR013099, K_chnl_dom |
PANTHERi | PTHR10153, PTHR10153, 1 hit |
Pfami | View protein in Pfam PF02888, CaMBD, 1 hit PF07885, Ion_trans_2, 1 hit PF03530, SK_channel, 1 hit |
PRINTSi | PR01451, SKCHANNEL |
SMARTi | View protein in SMART SM01053, CaMBD, 1 hit |
SUPFAMi | SSF81327, SSF81327, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNN1_HUMAN | |
Accessioni | Q92952Primary (citable) accession number: Q92952 Secondary accession number(s): Q5KR10, Q6DJU4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM