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Protein

Bcl2-associated agonist of cell death

Gene

BAD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.By similarity

Caution

The protein name 'Bcl2 antagonist of cell death' may be misleading. The protein antagonises Bcl2-mediated repression of cell death, hence it promotes apoptosis.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 14-3-3 protein binding Source: Ensembl
  • cysteine-type endopeptidase activator activity involved in apoptotic process Source: UniProtKB
  • lipid binding Source: UniProtKB
  • phospholipid binding Source: UniProtKB
  • protein heterodimerization activity Source: Ensembl
  • protein kinase B binding Source: Ensembl
  • protein kinase binding Source: UniProtKB
  • protein phosphatase 2B binding Source: Ensembl
  • protein phosphatase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-193648 NRAGE signals death through JNK
R-HSA-198323 AKT phosphorylates targets in the cytosol
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q92934

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bcl2-associated agonist of cell death
Short name:
BAD
Alternative name(s):
Bcl-2-binding component 6
Bcl-2-like protein 8
Short name:
Bcl2-L-8
Bcl-xL/Bcl-2-associated death promoter
Bcl2 antagonist of cell death
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BAD
Synonyms:BBC6, BCL2L8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000002330.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:936 BAD

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603167 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92934

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi94R → K: Decreased methylation; when associated with K-96. 1 Publication1
Mutagenesisi96R → K: Decreased methylation; when associated with K-94. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
572

Open Targets

More...
OpenTargetsi
ENSG00000002330

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25236

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3817

Drug and drug target database

More...
DrugBanki
DB05764 ABT-263

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BAD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17371773

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001431031 – 168Bcl2-associated agonist of cell deathAdd BLAST168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Modified residuei94Asymmetric dimethylarginine; by PRMT11 Publication1
Modified residuei96Asymmetric dimethylarginine; by PRMT11 Publication1
Modified residuei97PhosphoserineBy similarity1
Modified residuei99Phosphoserine; by PKA, PKB, PAK1, RPS6KA1, RPS6KB1 and PKC/PRKCQBy similarity1
Modified residuei99Phosphoserine; by PKB/AKT1Combined sources1 Publication1
Modified residuei118PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei161Omega-N-methylarginineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis.4 Publications
Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-99.2 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92934

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92934

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92934

PeptideAtlas

More...
PeptideAtlasi
Q92934

PRoteomics IDEntifications database

More...
PRIDEi
Q92934

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75614

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92934

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92934

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q92934

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a wide variety of tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000002330 Expressed in 172 organ(s), highest expression level in dorsolateral prefrontal cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_BAD

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92934 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92934 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004205
HPA028185
HPA062105

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins (By similarity). Interacts with AKT1 and PIM3. Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BAD with BCL2 (By similarity). Interacts with HIF3A (via C-terminus domain); the interaction reduces the binding between BAD and BAX (By similarity).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107048, 46 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1982 BAD:BCL-2 complex
CPX-1983 BAD:BCL-XL complex

Database of interacting proteins

More...
DIPi
DIP-29184N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q92934

Protein interaction database and analysis system

More...
IntActi
Q92934, 39 interactors

Molecular INTeraction database

More...
MINTi
Q92934

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309103

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q92934

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q92934

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92934

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q92934

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi110 – 124BH3Add BLAST15

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXUQ Eukaryota
ENOG410Y2J3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010740

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000095169

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001653

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92934

KEGG Orthology (KO)

More...
KOi
K02158

Identification of Orthologs from Complete Genome Data

More...
OMAi
AGHQQGQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0Z5T

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92934

TreeFam database of animal gene trees

More...
TreeFami
TF102001

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018868 BAD

The PANTHER Classification System

More...
PANTHERi
PTHR28540 PTHR28540, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10514 Bcl-2_BAD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q92934-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFQIPEFEPS EQEDSSSAER GLGPSPAGDG PSGSGKHHRQ APGLLWDASH
60 70 80 90 100
QQEQPTSSSH HGGAGAVEIR SRHSSYPAGT EDDEGMGEEP SPFRGRSRSA
110 120 130 140 150
PPNLWAAQRY GRELRRMSDE FVDSFKKGLP RPKSAGTATQ MRQSSSWTRV
160
FQSWWDRNLG RGSSAPSQ
Length:168
Mass (Da):18,392
Last modified:September 26, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69FD8D27DDEE3241
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H3B1F5H3B1_HUMAN
Bcl2-associated agonist of cell dea...
BAD
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MXU7A8MXU7_HUMAN
Bcl2-associated agonist of cell dea...
BAD
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYS3F5GYS3_HUMAN
Bcl2-associated agonist of cell dea...
BAD
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1R6F5H1R6_HUMAN
Bcl2-associated agonist of cell dea...
BAD
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB36516 differs from that shown. Reason: Frameshift at positions 64 and 91.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015380107A → S. Corresponds to variant dbSNP:rs3729933Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U66879 mRNA Translation: AAB36516.1 Frameshift.
AF021792 mRNA Translation: AAB72092.1
AF031523 mRNA Translation: AAB88124.1
AK291863 mRNA Translation: BAF84552.1
BT006678 mRNA Translation: AAP35324.1
CR541935 mRNA Translation: CAG46733.1
CR541959 mRNA Translation: CAG46757.1
AB451254 mRNA Translation: BAG70068.1
AB451378 mRNA Translation: BAG70192.1
CH471076 Genomic DNA Translation: EAW74235.1
BC001901 mRNA Translation: AAH01901.1
BC095431 mRNA Translation: AAH95431.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8065.1

NCBI Reference Sequences

More...
RefSeqi
NP_004313.1, NM_004322.3
NP_116784.1, NM_032989.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.370254

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309032; ENSP00000309103; ENSG00000002330
ENST00000394532; ENSP00000378040; ENSG00000002330

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
572

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:572

UCSC genome browser

More...
UCSCi
uc001nzc.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Bcl 2-associated death promoter entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66879 mRNA Translation: AAB36516.1 Frameshift.
AF021792 mRNA Translation: AAB72092.1
AF031523 mRNA Translation: AAB88124.1
AK291863 mRNA Translation: BAF84552.1
BT006678 mRNA Translation: AAP35324.1
CR541935 mRNA Translation: CAG46733.1
CR541959 mRNA Translation: CAG46757.1
AB451254 mRNA Translation: BAG70068.1
AB451378 mRNA Translation: BAG70192.1
CH471076 Genomic DNA Translation: EAW74235.1
BC001901 mRNA Translation: AAH01901.1
BC095431 mRNA Translation: AAH95431.1
CCDSiCCDS8065.1
RefSeqiNP_004313.1, NM_004322.3
NP_116784.1, NM_032989.2
UniGeneiHs.370254

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G5JNMR-B103-127[»]
ProteinModelPortaliQ92934
SMRiQ92934
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107048, 46 interactors
ComplexPortaliCPX-1982 BAD:BCL-2 complex
CPX-1983 BAD:BCL-XL complex
DIPiDIP-29184N
ELMiQ92934
IntActiQ92934, 39 interactors
MINTiQ92934
STRINGi9606.ENSP00000309103

Chemistry databases

BindingDBiQ92934
ChEMBLiCHEMBL3817
DrugBankiDB05764 ABT-263

PTM databases

iPTMnetiQ92934
PhosphoSitePlusiQ92934

Polymorphism and mutation databases

BioMutaiBAD
DMDMi17371773

Proteomic databases

EPDiQ92934
MaxQBiQ92934
PaxDbiQ92934
PeptideAtlasiQ92934
PRIDEiQ92934
ProteomicsDBi75614

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
572
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309032; ENSP00000309103; ENSG00000002330
ENST00000394532; ENSP00000378040; ENSG00000002330
GeneIDi572
KEGGihsa:572
UCSCiuc001nzc.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
572
DisGeNETi572
EuPathDBiHostDB:ENSG00000002330.13

GeneCards: human genes, protein and diseases

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GeneCardsi
BAD
HGNCiHGNC:936 BAD
HPAiCAB004205
HPA028185
HPA062105
MIMi603167 gene
neXtProtiNX_Q92934
OpenTargetsiENSG00000002330
PharmGKBiPA25236

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IXUQ Eukaryota
ENOG410Y2J3 LUCA
GeneTreeiENSGT00390000010740
HOGENOMiHOG000095169
HOVERGENiHBG001653
InParanoidiQ92934
KOiK02158
OMAiAGHQQGQ
OrthoDBiEOG091G0Z5T
PhylomeDBiQ92934
TreeFamiTF102001

Enzyme and pathway databases

ReactomeiR-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-193648 NRAGE signals death through JNK
R-HSA-198323 AKT phosphorylates targets in the cytosol
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
SIGNORiQ92934

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BAD human
EvolutionaryTraceiQ92934

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Bcl-2-associated_death_promoter

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
572
PMAP-CutDBiQ92934

Protein Ontology

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PROi
PR:Q92934

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000002330 Expressed in 172 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_BAD
ExpressionAtlasiQ92934 baseline and differential
GenevisibleiQ92934 HS

Family and domain databases

InterProiView protein in InterPro
IPR018868 BAD
PANTHERiPTHR28540 PTHR28540, 1 hit
PfamiView protein in Pfam
PF10514 Bcl-2_BAD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBAD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92934
Secondary accession number(s): O14803, Q6FH21
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 26, 2001
Last modified: December 5, 2018
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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