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Entry version 175 (08 May 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Receptor-type tyrosine-protein phosphatase N2

Gene

PTPRN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550).By similarity1 Publication

Caution

Has no tyrosine-protein phosphatase activity at mild acidic conditions (pH 5.5). The in vivo relevance of the low PPase activity at acidic conditions (pH 4.5) is questioned. This catalytic activity seems to be affected by the replacement of a highly conserved residue in the tyrosine-protein phosphatase domain.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 4.5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei913SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei945Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei990SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor
Biological processLipid metabolism, Phospholipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.48 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase N2 (EC:3.1.3.-, EC:3.1.3.481 Publication)
Short name:
R-PTP-N2
Alternative name(s):
Islet cell autoantigen-related protein1 Publication
Short name:
IAR1 Publication
Short name:
ICAAR1 Publication
Phogrin2 Publications
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPRN2
Synonyms:KIAA0387
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9677 PTPRN2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601698 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92932

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 615ExtracellularSequence analysisAdd BLAST594
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei616 – 636HelicalSequence analysisAdd BLAST21
Topological domaini637 – 1015CytoplasmicSequence analysisAdd BLAST379

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Autoantigen in insulin-dependent diabetes mellitus (IDDM).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi945C → A: No effect to increase invasion, migration, and metastatic lung colonization in mice breast cancer model. 1 Publication1
Mutagenesisi945C → S: Loss of activity. 1

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNET

More...
DisGeNETi
5799

Open Targets

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OpenTargetsi
ENSG00000155093

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34022

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTPRN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242738

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002545422 – 1015Receptor-type tyrosine-protein phosphatase N2Add BLAST994
ChainiPRO_0000438088502 – 1015IA-2beta60By similarityAdd BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei436PhosphoserineBy similarity1
Modified residuei437PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei692PhosphoserineBy similarity1
Modified residuei698PhosphoserineBy similarity1
Modified residuei970N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Subject to proteolytic cleavage at multiple sites.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei427 – 428CleavageSequence analysis2

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q92932

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q92932

PeptideAtlas

More...
PeptideAtlasi
Q92932

PRoteomics IDEntifications database

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PRIDEi
Q92932

ProteomicsDB human proteome resource

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ProteomicsDBi
75611
75612 [Q92932-2]
75613 [Q92932-3]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q92932

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q92932

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q92932

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in brain and pancreas (PubMed:8954911, PubMed:8798755). Lower levels in trachea, prostate, stomach and spinal chord (PubMed:8798755).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000155093 Expressed in 210 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q92932 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92932 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006900
HPA026656

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates. Interacts (via cytoplasmic domain) with PTPRN (via cytoplasmic domain). Interacts (precursor form) with CPE. Interacts with HAP1. Interacts with AP2A1 or AP2A2 and AP1G1; indicative for an association with adaptor protein complex 2 (AP-2) and adaptor protein complex 1 (AP-1) (By similarity). Interacts with AP2M1; indicative for an association with adaptor protein complex 2 (AP-2). Interacts with MYO5A (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111763, 27 interactors

Protein interaction database and analysis system

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IntActi
Q92932, 7 interactors

Molecular INTeraction database

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MINTi
Q92932

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000374069

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11015
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92932

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q92932

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini745 – 1005Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 421Involved in localization to secretory granules; interaction with CPEBy similarityAdd BLAST421
Regioni945 – 951Substrate bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi666 – 675Tyrosine-based internalization motifBy similarity10
Motifi1004 – 1010Leucine-based sorting signalBy similarity7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic domain appears to contain the autoantigenic epitopes.2 Publications
The leucine-based sorting signal is proposed to function in trafficking at the plasma membrane.By similarity
The tyrosine-based internalization signal is proposed to function at the level of clathrin-mediated endocytosis and recycling.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0793 Eukaryota
COG5599 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154095

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000243992

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92932

KEGG Orthology (KO)

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KOi
K07817

Identification of Orthologs from Complete Genome Data

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OMAi
FEDDLCR

Database of Orthologous Groups

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OrthoDBi
411281at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q92932

TreeFam database of animal gene trees

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TreeFami
TF351976

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.2470, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033522 IA-2/IA-2_beta
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR021613 Receptor_IA-2_dom
IPR038112 Receptor_IA-2_ectodomain_sf
IPR029403 RESP18_dom
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

The PANTHER Classification System

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PANTHERi
PTHR46106:SF5 PTHR46106:SF5, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF11548 Receptor_IA-2, 1 hit
PF14948 RESP18, 1 hit
PF00102 Y_phosphatase, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92932-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE
60 70 80 90 100
ACVNDGVFGR CQKVPAMDFY RYEVSPVALQ RLRVALQKLS GTGFTWQDDY
110 120 130 140 150
TQYVMDQELA DLPKTYLRRP EASSPARPSK HSVGSERRYS REGGAALANA
160 170 180 190 200
LRRHLPFLEA LSQAPASDVL ARTHTAQDRP PAEGDDRFSE SILTYVAHTS
210 220 230 240 250
ALTYPPGSRT QLREDLLPRT LGQLQPDELS PKVDSGVDRH HLMAALSAYA
260 270 280 290 300
AQRPPAPPGE GSLEPQYLLR APSRMPRPLL APAAPQKWPS PLGDSEDPSS
310 320 330 340 350
TGDGARIHTL LKDLQRQPAE VRGLSGLELD GMAELMAGLM QGVDHGVARG
360 370 380 390 400
SPGRAALGES GEQADGPKAT LRGDSFPDDG VQDDDDRLYQ EVHRLSATLG
410 420 430 440 450
GLLQDHGSRL LPGALPFARP LDMERKKSEH PESSLSSEEE TAGVENVKSQ
460 470 480 490 500
TYSKDLLGQQ PHSEPGAAAF GELQNQMPGP SKEEQSLPAG AQEALSDGLQ
510 520 530 540 550
LEVQPSEEEA RGYIVTDRDP LRPEEGRRLV EDVARLLQVP SSAFADVEVL
560 570 580 590 600
GPAVTFKVSA NVQNVTTEDV EKATVDNKDK LEETSGLKIL QTGVGSKSKL
610 620 630 640 650
KFLPPQAEQE DSTKFIALTL VSLACILGVL LASGLIYCLR HSSQHRLKEK
660 670 680 690 700
LSGLGGDPGA DATAAYQELC RQRMATRPPD RPEGPHTSRI SSVSSQFSDG
710 720 730 740 750
PIPSPSARSS ASSWSEEPVQ SNMDISTGHM ILSYMEDHLK NKNRLEKEWE
760 770 780 790 800
ALCAYQAEPN SSFVAQREEN VPKNRSLAVL TYDHSRVLLK AENSHSHSDY
810 820 830 840 850
INASPIMDHD PRNPAYIATQ GPLPATVADF WQMVWESGCV VIVMLTPLAE
860 870 880 890 900
NGVRQCYHYW PDEGSNLYHI YEVNLVSEHI WCEDFLVRSF YLKNLQTNET
910 920 930 940 950
RTVTQFHFLS WYDRGVPSSS RSLLDFRRKV NKCYRGRSCP IIVHCSDGAG
960 970 980 990 1000
RSGTYVLIDM VLNKMAKGAK EIDIAATLEH LRDQRPGMVQ TKEQFEFALT
1010
AVAEEVNAIL KALPQ
Length:1,015
Mass (Da):111,271
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i950C15CA89DBC029
GO
Isoform 2 (identifier: Q92932-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     519-547: Missing.

Note: No experimental confirmation available.
Show »
Length:986
Mass (Da):108,054
Checksum:i6AECE2238F5E1DAE
GO
Isoform 3 (identifier: Q92932-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MGPPLPLLLL...PRGRQLPGRL → MAVESEYSLL...RWQCLVQMWA

Note: No experimental confirmation available.
Show »
Length:1,038
Mass (Da):114,360
Checksum:iDB2F9170755B08A6
GO
Isoform 4 (identifier: Q92932-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-54: Missing.

Note: No experimental confirmation available.
Show »
Length:998
Mass (Da):109,622
Checksum:iDD03BB2583397566
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EM83E7EM83_HUMAN
Receptor-type tyrosine-protein phos...
PTPRN2
977Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSD7A0A0A0MSD7_HUMAN
Receptor-type tyrosine-protein phos...
PTPRN2
457Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU41A0A3B3IU41_HUMAN
Receptor-type tyrosine-protein phos...
PTPRN2
293Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWV3A0A0J9YWV3_HUMAN
Receptor-type tyrosine-protein phos...
PTPRN2
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20841 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti160A → D in AAB68603 (Ref. 4) Curated1
Sequence conflicti247S → G in CAA69880 (PubMed:8954911).Curated1
Sequence conflicti323G → R in CAA69880 (PubMed:8954911).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027955140S → T1 PublicationCorresponds to variant dbSNP:rs3800855Ensembl.1
Natural variantiVAR_046301208S → P4 PublicationsCorresponds to variant dbSNP:rs1130495Ensembl.1
Natural variantiVAR_027956213R → H1 PublicationCorresponds to variant dbSNP:rs1130496Ensembl.1
Natural variantiVAR_020302325S → N2 PublicationsCorresponds to variant dbSNP:rs1130499Ensembl.1
Natural variantiVAR_022015343V → M. Corresponds to variant dbSNP:rs3752368Ensembl.1
Natural variantiVAR_046302388L → H. Corresponds to variant dbSNP:rs7456452Ensembl.1
Natural variantiVAR_035648716E → K in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs577236042Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0352641 – 37MGPPL…LPGRL → MAVESEYSLLRTEASFPTMK MFCVSHTLPRVEVMFVSGPQ TRERTEPVDPRWQCLVQMWA in isoform 3. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_04503238 – 54Missing in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_007779519 – 547Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U66702 mRNA Translation: AAC50742.1
Y08569 Genomic DNA Translation: CAA69880.1
AF007555 mRNA Translation: AAB63600.1
U81561 mRNA Translation: AAB68603.1
AB002385 mRNA Translation: BAA20841.2 Different initiation.
AC005481 Genomic DNA No translation available.
AC006003 Genomic DNA No translation available.
AC006372 Genomic DNA No translation available.
AC011899 Genomic DNA No translation available.
AC019043 Genomic DNA No translation available.
AC078942 Genomic DNA No translation available.
AC093662 Genomic DNA No translation available.
AC093856 Genomic DNA No translation available.
AC125243 Genomic DNA No translation available.
BC034040 mRNA Translation: AAH34040.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5947.1 [Q92932-1]
CCDS5948.1 [Q92932-4]
CCDS5949.1 [Q92932-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5062
JC5263

NCBI Reference Sequences

More...
RefSeqi
NP_001295196.1, NM_001308267.1
NP_001295197.1, NM_001308268.1 [Q92932-3]
NP_002838.2, NM_002847.4 [Q92932-1]
NP_570857.2, NM_130842.3 [Q92932-4]
NP_570858.2, NM_130843.3 [Q92932-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389413; ENSP00000374064; ENSG00000155093 [Q92932-2]
ENST00000389416; ENSP00000374067; ENSG00000155093 [Q92932-4]
ENST00000389418; ENSP00000374069; ENSG00000155093 [Q92932-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5799

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5799

UCSC genome browser

More...
UCSCi
uc003wno.4 human [Q92932-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66702 mRNA Translation: AAC50742.1
Y08569 Genomic DNA Translation: CAA69880.1
AF007555 mRNA Translation: AAB63600.1
U81561 mRNA Translation: AAB68603.1
AB002385 mRNA Translation: BAA20841.2 Different initiation.
AC005481 Genomic DNA No translation available.
AC006003 Genomic DNA No translation available.
AC006372 Genomic DNA No translation available.
AC011899 Genomic DNA No translation available.
AC019043 Genomic DNA No translation available.
AC078942 Genomic DNA No translation available.
AC093662 Genomic DNA No translation available.
AC093856 Genomic DNA No translation available.
AC125243 Genomic DNA No translation available.
BC034040 mRNA Translation: AAH34040.1
CCDSiCCDS5947.1 [Q92932-1]
CCDS5948.1 [Q92932-4]
CCDS5949.1 [Q92932-2]
PIRiJC5062
JC5263
RefSeqiNP_001295196.1, NM_001308267.1
NP_001295197.1, NM_001308268.1 [Q92932-3]
NP_002838.2, NM_002847.4 [Q92932-1]
NP_570857.2, NM_130842.3 [Q92932-4]
NP_570858.2, NM_130843.3 [Q92932-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QEPX-ray2.50A/B715-1010[»]
4HTIX-ray1.95A502-599[»]
4HTJX-ray2.01A502-599[»]
SMRiQ92932
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111763, 27 interactors
IntActiQ92932, 7 interactors
MINTiQ92932
STRINGi9606.ENSP00000374069

PTM databases

DEPODiQ92932
iPTMnetiQ92932
PhosphoSitePlusiQ92932

Polymorphism and mutation databases

BioMutaiPTPRN2
DMDMi116242738

Proteomic databases

jPOSTiQ92932
PaxDbiQ92932
PeptideAtlasiQ92932
PRIDEiQ92932
ProteomicsDBi75611
75612 [Q92932-2]
75613 [Q92932-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5799
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389413; ENSP00000374064; ENSG00000155093 [Q92932-2]
ENST00000389416; ENSP00000374067; ENSG00000155093 [Q92932-4]
ENST00000389418; ENSP00000374069; ENSG00000155093 [Q92932-1]
GeneIDi5799
KEGGihsa:5799
UCSCiuc003wno.4 human [Q92932-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5799
DisGeNETi5799

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTPRN2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0019047
HGNCiHGNC:9677 PTPRN2
HPAiHPA006900
HPA026656
MIMi601698 gene
neXtProtiNX_Q92932
OpenTargetsiENSG00000155093
PharmGKBiPA34022

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0793 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00940000154095
HOGENOMiHOG000243992
InParanoidiQ92932
KOiK07817
OMAiFEDDLCR
OrthoDBi411281at2759
PhylomeDBiQ92932
TreeFamiTF351976

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTPRN2 human
EvolutionaryTraceiQ92932

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PTPRN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5799

Protein Ontology

More...
PROi
PR:Q92932

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000155093 Expressed in 210 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ92932 baseline and differential
GenevisibleiQ92932 HS

Family and domain databases

Gene3Di3.30.70.2470, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR033522 IA-2/IA-2_beta
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR021613 Receptor_IA-2_dom
IPR038112 Receptor_IA-2_ectodomain_sf
IPR029403 RESP18_dom
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PANTHERiPTHR46106:SF5 PTHR46106:SF5, 1 hit
PfamiView protein in Pfam
PF11548 Receptor_IA-2, 1 hit
PF14948 RESP18, 1 hit
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92932
Secondary accession number(s): E9PC57
, Q8N4I5, Q92662, Q9Y4F8, Q9Y4I6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: May 8, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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