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Protein

Ras-related protein Rab-8B

Gene

RAB8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • signaling receptor binding Source: UniProtKB
  • TPR domain binding Source: Ensembl

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-8B
Gene namesi
Name:RAB8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166128.12
HGNCiHGNC:30273 RAB8B
MIMi613532 gene
neXtProtiNX_Q92930

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51762
OpenTargetsiENSG00000166128
PharmGKBiPA134944620

Chemistry databases

DrugBankiDB04315 Guanosine-5'-Diphosphate
DB02082 Phosphoaminophosphonic Acid Guanylate Ester

Polymorphism and mutation databases

BioMutaiRAB8B
DMDMi13638434

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211341 – 204Ras-related protein Rab-8BAdd BLAST204
PropeptideiPRO_0000370800205 – 207Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei180PhosphoserineBy similarity1
Modified residuei204Cysteine methyl esterSequence analysis1
Lipidationi204S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ92930
MaxQBiQ92930
PaxDbiQ92930
PeptideAtlasiQ92930
PRIDEiQ92930
ProteomicsDBi75610

PTM databases

iPTMnetiQ92930
PhosphoSitePlusiQ92930
SwissPalmiQ92930

Expressioni

Gene expression databases

BgeeiENSG00000166128 Expressed in 215 organ(s), highest expression level in bone marrow
CleanExiHS_RAB8B
ExpressionAtlasiQ92930 baseline and differential
GenevisibleiQ92930 HS

Organism-specific databases

HPAiHPA074534

Interactioni

Subunit structurei

Associated with actin, delta-catenin and alpha and beta tubulins (By similarity). Interacts with OTOF (By similarity). Interacts with PEX5R (By similarity). Interacts with RAB3IP. Interacts with VIM (By similarity). Interacts with CDH1 (By similarity). Interacts with MICALL2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119719, 49 interactors
IntActiQ92930, 4 interactors
MINTiQ92930
STRINGi9606.ENSP00000312734

Structurei

3D structure databases

ProteinModelPortaliQ92930
SMRiQ92930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0078 Eukaryota
ENOG410XPUI LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ92930
KOiK07902
OMAiNRKMNDG
OrthoDBiEOG091G0LA6
PhylomeDBiQ92930
TreeFamiTF314097

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q92930-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKTYDYLFK LLLIGDSGVG KTCLLFRFSE DAFNTTFIST IGIDFKIRTI
60 70 80 90 100
ELDGKKIKLQ IWDTAGQERF RTITTAYYRG AMGIMLVYDI TNEKSFDNIK
110 120 130 140 150
NWIRNIEEHA SSDVERMILG NKCDMNDKRQ VSKERGEKLA IDYGIKFLET
160 170 180 190 200
SAKSSANVEE AFFTLARDIM TKLNRKMNDS NSAGAGGPVK ITENRSKKTS

FFRCSLL
Length:207
Mass (Da):23,584
Last modified:April 27, 2001 - v2
Checksum:i5960993C0F87F944
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNE9H0YNE9_HUMAN
Ras-related protein Rab-8B
RAB8B
188Annotation score:
H0YMN7H0YMN7_HUMAN
Ras-related protein Rab-8B
RAB8B
92Annotation score:
H0YLJ8H0YLJ8_HUMAN
Ras-related protein Rab-8B
RAB8B
47Annotation score:
H0YL94H0YL94_HUMAN
Ras-related protein Rab-8B
RAB8B
48Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038995 mRNA Translation: BAA92249.1
AK001111 mRNA Translation: BAG50856.1
AL833365 mRNA Translation: CAI46143.1
AC016207 Genomic DNA No translation available.
BC020654 mRNA Translation: AAH20654.1
U66624 mRNA Translation: AAC51199.1
CCDSiCCDS10183.1
RefSeqiNP_057614.1, NM_016530.2
UniGeneiHs.389733

Genome annotation databases

EnsembliENST00000321437; ENSP00000312734; ENSG00000166128
GeneIDi51762
KEGGihsa:51762
UCSCiuc002alz.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038995 mRNA Translation: BAA92249.1
AK001111 mRNA Translation: BAG50856.1
AL833365 mRNA Translation: CAI46143.1
AC016207 Genomic DNA No translation available.
BC020654 mRNA Translation: AAH20654.1
U66624 mRNA Translation: AAC51199.1
CCDSiCCDS10183.1
RefSeqiNP_057614.1, NM_016530.2
UniGeneiHs.389733

3D structure databases

ProteinModelPortaliQ92930
SMRiQ92930
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119719, 49 interactors
IntActiQ92930, 4 interactors
MINTiQ92930
STRINGi9606.ENSP00000312734

Chemistry databases

DrugBankiDB04315 Guanosine-5'-Diphosphate
DB02082 Phosphoaminophosphonic Acid Guanylate Ester

PTM databases

iPTMnetiQ92930
PhosphoSitePlusiQ92930
SwissPalmiQ92930

Polymorphism and mutation databases

BioMutaiRAB8B
DMDMi13638434

Proteomic databases

EPDiQ92930
MaxQBiQ92930
PaxDbiQ92930
PeptideAtlasiQ92930
PRIDEiQ92930
ProteomicsDBi75610

Protocols and materials databases

DNASUi51762
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321437; ENSP00000312734; ENSG00000166128
GeneIDi51762
KEGGihsa:51762
UCSCiuc002alz.4 human

Organism-specific databases

CTDi51762
DisGeNETi51762
EuPathDBiHostDB:ENSG00000166128.12
GeneCardsiRAB8B
HGNCiHGNC:30273 RAB8B
HPAiHPA074534
MIMi613532 gene
neXtProtiNX_Q92930
OpenTargetsiENSG00000166128
PharmGKBiPA134944620
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0078 Eukaryota
ENOG410XPUI LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ92930
KOiK07902
OMAiNRKMNDG
OrthoDBiEOG091G0LA6
PhylomeDBiQ92930
TreeFamiTF314097

Enzyme and pathway databases

ReactomeiR-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiRAB8B human
GeneWikiiRAB8B
GenomeRNAii51762
PROiPR:Q92930
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166128 Expressed in 215 organ(s), highest expression level in bone marrow
CleanExiHS_RAB8B
ExpressionAtlasiQ92930 baseline and differential
GenevisibleiQ92930 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB8B_HUMAN
AccessioniPrimary (citable) accession number: Q92930
Secondary accession number(s): Q5JPC4, Q9P293
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 27, 2001
Last modified: September 12, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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