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Protein

Putative Ras-related protein Rab-1C

Gene

RAB1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Caution

Could be the product of a pseudogene.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23GTPBy similarity9
Nucleotide bindingi33 – 40GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4
Nucleotide bindingi151 – 153GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Ras-related protein Rab-1C
Short name:
hRab1c
Gene namesi
Name:RAB1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23683 RAB1C
neXtProtiNX_Q92928

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003435681 – 201Putative Ras-related protein Rab-1CAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76O-(2-cholinephosphoryl)serine2 Publications1
Lipidationi200S-geranylgeranyl cysteineBy similarity1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Phosphocholinated at Ser-76 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring accessibility to L.pneumophila GTPase effector LepB.2 Publications

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ92928
MaxQBiQ92928
PeptideAtlasiQ92928
PRIDEiQ92928
ProteomicsDBi75609

PTM databases

iPTMnetiQ92928
PhosphoSitePlusiQ92928
SwissPalmiQ92928

Expressioni

Organism-specific databases

HPAiHPA056141

Interactioni

Protein-protein interaction databases

IntActiQ92928, 4 interactors
MINTiQ92928

Structurei

3D structure databases

ProteinModelPortaliQ92928
SMRiQ92928
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0084 Eukaryota
ENOG410XQN5 LUCA
HOVERGENiHBG009351
InParanoidiQ92928
PhylomeDBiQ92928

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q92928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPGYDCLFK LLLIGDSGVG KSCLLLRFAD DPYTESYIST IGVDFKIQTI
60 70 80 90 100
ELDGKTIKLQ IWDTAGQERF WTITSSYYRG AHGFLVVYDV TDQESYANVK
110 120 130 140 150
QWLQEIDRHA SENVNKLLVG NKSDLTTKKV VDNTTAKEFA DSLGIPFLET
160 170 180 190 200
SAKNATNVEQ AFMTMAAEIK KQMGPGAASG GERPNLKIDS TPVKPAGGGC

C
Length:201
Mass (Da):22,017
Last modified:July 1, 2008 - v2
Checksum:iD6E22F1D13FBD22C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513165 Genomic DNA No translation available.
U66622 mRNA Translation: AAC51197.1
UniGeneiHs.651788

Similar proteinsi

Entry informationi

Entry nameiRAB1C_HUMAN
AccessioniPrimary (citable) accession number: Q92928
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: June 20, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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