Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q92911 (SC5A5_HUMAN)

Entry version 174 (05 Jun 2019)
Sequence version 1 (01 Feb 1997)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Sodium/iodide cotransporter

Gene

SLC5A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates iodide uptake in the thyroid gland.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-209968 Thyroxine biosynthesis
R-HSA-428643 Organic anion transporters
R-HSA-5619096 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92911

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.21.5.1 the solute:sodium symporter (sss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/iodide cotransporter
Short name:
Na(+)/I(-) cotransporter
Alternative name(s):
Sodium-iodide symporter
Short name:
Na(+)/I(-) symporter
Solute carrier family 5 member 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC5A5
Synonyms:NIS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11040 SLC5A5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601843 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92911

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 53CytoplasmicSequence analysisAdd BLAST16
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 88ExtracellularSequence analysisAdd BLAST14
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 136CytoplasmicSequence analysisAdd BLAST27
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 163ExtracellularSequence analysis6
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 186CytoplasmicSequence analysis2
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 241ExtracellularSequence analysisAdd BLAST34
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 286CytoplasmicSequence analysisAdd BLAST24
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 326ExtracellularSequence analysisAdd BLAST19
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 391CytoplasmicSequence analysisAdd BLAST44
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Topological domaini413 – 416ExtracellularSequence analysis4
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 444CytoplasmicSequence analysis7
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Topological domaini466 – 525ExtracellularSequence analysisAdd BLAST60
Transmembranei526 – 546HelicalSequence analysisAdd BLAST21
Topological domaini547 – 643CytoplasmicSequence analysisAdd BLAST97

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Thyroid dyshormonogenesis 1 (TDH1)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01026393G → R in TDH1. 1 PublicationCorresponds to variant dbSNP:rs121909178EnsemblClinVar.1
Natural variantiVAR_010265267Q → E in TDH1. 1 PublicationCorresponds to variant dbSNP:rs121909176EnsemblClinVar.1
Natural variantiVAR_010266354T → P in TDH1. 2 PublicationsCorresponds to variant dbSNP:rs121909174EnsemblClinVar.1
Natural variantiVAR_010267395G → R in TDH1. 1 PublicationCorresponds to variant dbSNP:rs121909180EnsemblClinVar.1
Natural variantiVAR_010269543G → E in TDH1. 1 PublicationCorresponds to variant dbSNP:rs121909179EnsemblClinVar.1

Keywords - Diseasei

Congenital hypothyroidism, Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		6528

MalaCards human disease database

More...MalaCardsi		SLC5A5
MIMi274400 phenotype

Open Targets

More...OpenTargetsi		ENSG00000105641

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		95716 Familial thyroid dyshormonogenesis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35905

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC5A5

Domain mapping of disease mutations (DMDM)

More...DMDMi		12643359

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001053831 – 643Sodium/iodide cotransporterAdd BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi489N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi502N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei556Phosphoserine; by PKASequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92911

PeptideAtlas

More...PeptideAtlasi		Q92911

PRoteomics IDEntifications database

More...PRIDEi		Q92911

ProteomicsDB human proteome resource

More...ProteomicsDBi		75594

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92911

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92911

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105641 Expressed in 84 organ(s), highest expression level in thyroid gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92911 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB022364
HPA049055

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112419, 19 interactors

Protein interaction database and analysis system

More...IntActi		Q92911, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000222248

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2349 Eukaryota
COG0591 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159489

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000261662

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92911

KEGG Orthology (KO)

More...KOi		K14385

Identification of Orthologs from Complete Genome Data

More...OMAi		GMFLPAC

Database of Orthologous Groups

More...OrthoDBi		1180002at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92911

TreeFam database of animal gene trees

More...TreeFami		TF316728

Family and domain databases

Conserved Domains Database

More...CDDi		cd11503 SLC5sbd_NIS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
IPR035689 SLC5A5

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00474 SSF, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00813 sss, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q92911-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAVETGERP TFGAWDYGVF ALMLLVSTGI GLWVGLARGG QRSAEDFFTG 
        60         70         80         90        100
GRRLAALPVG LSLSASFMSA VQVLGVPSEA YRYGLKFLWM CLGQLLNSVL 
       110        120        130        140        150
TALLFMPVFY RLGLTSTYEY LEMRFSRAVR LCGTLQYIVA TMLYTGIVIY 
       160        170        180        190        200
APALILNQVT GLDIWASLLS TGIICTFYTA VGGMKAVVWT DVFQVVVMLS 
       210        220        230        240        250
GFWVVLARGV MLVGGPRQVL TLAQNHSRIN LMDFNPDPRS RYTFWTFVVG 
       260        270        280        290        300
GTLVWLSMYG VNQAQVQRYV ACRTEKQAKL ALLINQVGLF LIVSSAACCG 
       310        320        330        340        350
IVMFVFYTDC DPLLLGRISA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG 
       360        370        380        390        400
TLSTASTSIN AMAAVTVEDL IKPRLRSLAP RKLVIISKGL SLIYGSACLT 
       410        420        430        440        450
VAALSSLLGG GVLQGSFTVM GVISGPLLGA FILGMFLPAC NTPGVLAGLG 
       460        470        480        490        500
AGLALSLWVA LGATLYPPSE QTMRVLPSSA ARCVALSVNA SGLLDPALLP 
       510        520        530        540        550
ANDSSRAPSS GMDASRPALA DSFYAISYLY YGALGTLTTV LCGALISCLT 
       560        570        580        590        600
GPTKRSTLAP GLLWWDLARQ TASVAPKEEV AILDDNLVKG PEELPTGNKK 
       610        620        630        640 
PPGFLPTNED RLFFLGQKEL EGAGSWTPCV GHDGGRDQQE TNL
Length:643
Mass (Da):68,666
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02D361A27B2FDA43
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01026393G → R in TDH1. 1 PublicationCorresponds to variant dbSNP:rs121909178EnsemblClinVar.1
Natural variantiVAR_010264102A → P1 Publication1
Natural variantiVAR_010265267Q → E in TDH1. 1 PublicationCorresponds to variant dbSNP:rs121909176EnsemblClinVar.1
Natural variantiVAR_052490298C → G. Corresponds to variant dbSNP:rs8108188Ensembl.1
Natural variantiVAR_010266354T → P in TDH1. 2 PublicationsCorresponds to variant dbSNP:rs121909174EnsemblClinVar.1
Natural variantiVAR_010267395G → R in TDH1. 1 PublicationCorresponds to variant dbSNP:rs121909180EnsemblClinVar.1
Natural variantiVAR_010268536T → Q Requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_010269543G → E in TDH1. 1 PublicationCorresponds to variant dbSNP:rs121909179EnsemblClinVar.1
Natural variantiVAR_010270556S → Q Requires 2 nucleotide substitutions. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U66088 mRNA Translation: AAB17378.1
AC005796 Genomic DNA Translation: AAC62827.1
D87920 mRNA Translation: BAA24835.1
BC105047 mRNA Translation: AAI05048.1
BC105049 mRNA Translation: AAI05050.1
AF260700 mRNA Translation: AAF70339.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12368.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC4974

NCBI Reference Sequences

More...RefSeqi		NP_000444.1, NM_000453.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000222248; ENSP00000222248; ENSG00000105641

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6528

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6528

UCSC genome browser

More...UCSCi		uc002nhr.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66088 mRNA Translation: AAB17378.1
AC005796 Genomic DNA Translation: AAC62827.1
D87920 mRNA Translation: BAA24835.1
BC105047 mRNA Translation: AAI05048.1
BC105049 mRNA Translation: AAI05050.1
AF260700 mRNA Translation: AAF70339.1
CCDSiCCDS12368.1
PIRiJC4974
RefSeqiNP_000444.1, NM_000453.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi112419, 19 interactors
IntActiQ92911, 2 interactors
STRINGi9606.ENSP00000222248

Protein family/group databases

TCDBi2.A.21.5.1 the solute:sodium symporter (sss) family

PTM databases

iPTMnetiQ92911
PhosphoSitePlusiQ92911

Polymorphism and mutation databases

BioMutaiSLC5A5
DMDMi12643359

Proteomic databases

PaxDbiQ92911
PeptideAtlasiQ92911
PRIDEiQ92911
ProteomicsDBi75594

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222248; ENSP00000222248; ENSG00000105641
GeneIDi6528
KEGGihsa:6528
UCSCiuc002nhr.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6528
DisGeNETi6528

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC5A5
HGNCiHGNC:11040 SLC5A5
HPAiCAB022364
HPA049055
MalaCardsiSLC5A5
MIMi274400 phenotype
601843 gene
neXtProtiNX_Q92911
OpenTargetsiENSG00000105641
Orphaneti95716 Familial thyroid dyshormonogenesis
PharmGKBiPA35905

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2349 Eukaryota
COG0591 LUCA
GeneTreeiENSGT00940000159489
HOGENOMiHOG000261662
InParanoidiQ92911
KOiK14385
OMAiGMFLPAC
OrthoDBi1180002at2759
PhylomeDBiQ92911
TreeFamiTF316728

Enzyme and pathway databases

ReactomeiR-HSA-209968 Thyroxine biosynthesis
R-HSA-428643 Organic anion transporters
R-HSA-5619096 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
SIGNORiQ92911

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC5A5 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Sodium-iodide_symporter

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6528

Protein Ontology

More...PROi		PR:Q92911

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105641 Expressed in 84 organ(s), highest expression level in thyroid gland
GenevisibleiQ92911 HS

Family and domain databases

CDDicd11503 SLC5sbd_NIS, 1 hit
Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
IPR035689 SLC5A5
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC5A5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92911
Secondary accession number(s): O43702, Q2M335, Q9NYB6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: February 1, 1997
Last modified: June 5, 2019
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again