Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Deleted in azoospermia-like

Gene

DAZL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: Ensembl
  • mRNA 3'-UTR binding Source: GO_Central
  • RNA binding Source: ProtInc
  • translation activator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Spermatogenesis, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Deleted in azoospermia-like
Alternative name(s):
DAZ homolog
DAZ-like autosomal
Deleted in azoospermia-like 1
SPGY-like-autosomal
Gene namesi
Name:DAZL
Synonyms:DAZH, DAZL1, DAZLA, SPGYLA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000092345.13
HGNCiHGNC:2685 DAZL
MIMi601486 gene
neXtProtiNX_Q92904

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1618
OpenTargetsiENSG00000092345
PharmGKBiPA27155

Polymorphism and mutation databases

BioMutaiDAZL
DMDMi27805453

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815591 – 295Deleted in azoospermia-likeAdd BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei276PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92904
PaxDbiQ92904
PeptideAtlasiQ92904
PRIDEiQ92904
ProteomicsDBi75589
75590 [Q92904-2]

PTM databases

iPTMnetiQ92904
PhosphoSitePlusiQ92904

Expressioni

Tissue specificityi

Testis specific.3 Publications

Gene expression databases

BgeeiENSG00000092345 Expressed in 36 organ(s), highest expression level in oocyte
CleanExiHS_DAZL
ExpressionAtlasiQ92904 baseline and differential
GenevisibleiQ92904 HS

Organism-specific databases

HPAiHPA019593
HPA019777
HPA047113

Interactioni

Subunit structurei

Homodimer and heterodimer. Multiple DAZL RRMs can bind to a single RNA containing multiple GUU triplets (By similarity). Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2.By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107987, 6 interactors
IntActiQ92904, 1 interactor
STRINGi9606.ENSP00000250863

Structurei

3D structure databases

ProteinModelPortaliQ92904
SMRiQ92904
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 115RRMPROSITE-ProRule annotationAdd BLAST76
Domaini167 – 190DAZ-likeAdd BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 132HomodimerizationBy similarityAdd BLAST53

Domaini

The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2.1 Publication

Sequence similaritiesi

Belongs to the RRM DAZ family.Curated

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00530000063480
HOGENOMiHOG000246400
HOVERGENiHBG000573
InParanoidiQ92904
OMAiRSYVIPP
OrthoDBiEOG091G02CS
PhylomeDBiQ92904
TreeFamiTF324396

Family and domain databases

CDDicd12672 RRM_DAZL, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR037366 BOULE/DAZ
IPR037551 DAZ_RRM_vert
IPR034779 DAZL
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR11176 PTHR11176, 1 hit
PTHR11176:SF4 PTHR11176:SF4, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92904-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTANPETPN STISREASTQ SSSAATSQGY ILPEGKIMPN TVFVGGIDVR
60 70 80 90 100
MDETEIRSFF ARYGSVKEVK IITDRTGVSK GYGFVSFFND VDVQKIVESQ
110 120 130 140 150
INFHGKKLKL GPAIRKQNLC AYHVQPRPLV FNHPPPPQFQ NVWTNPNTET
160 170 180 190 200
YMQPTTTMNP ITQYVQAYPT YPNSPVQVIT GYQLPVYNYQ MPPQWPVGEQ
210 220 230 240 250
RSYVVPPAYS AVNYHCNEVD PGAEVVPNEC SVHEATPPSG NGPQKKSVDR
260 270 280 290
SIQTVVSCLF NPENRLRNSV VTQDDYFKDK RVHHFRRSRA MLKSV
Length:295
Mass (Da):33,178
Last modified:February 1, 1997 - v1
Checksum:i21B360739B35B95F
GO
Isoform 2 (identifier: Q92904-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAAPSCGGDRKARLTPSLPHE

Show »
Length:315
Mass (Da):35,224
Checksum:iF4380E654EFB350D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EV40E7EV40_HUMAN
Deleted in azoospermia-like
DAZL
204Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3T → I in AAB63596 (PubMed:8968756).Curated1
Sequence conflicti253Q → R in AAB84361 (PubMed:9294855).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01778012T → A Common polymorphism. 1 PublicationCorresponds to variant dbSNP:rs11710967Ensembl.1
Natural variantiVAR_01778154T → A May be associated with susceptibility to spermatogenic failure in Asian individuals; this substitution may lead to affect the DAZL transcript stability and prevent its translation. 1 PublicationCorresponds to variant dbSNP:rs121918346EnsemblClinVar.1
Natural variantiVAR_069231115R → G Severely impaired RNA-binding. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0432081M → MAAPSCGGDRKARLTPSLPH E in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65918 mRNA Translation: AAC50813.1
U66726 mRNA Translation: AAB39935.1
U66078 mRNA Translation: AAB63596.1
U77476
, U77467, U77468, U77469, U77470, U77471, U77472, U77473, U77474, U77475 Genomic DNA Translation: AAB84361.1
AK303026 mRNA Translation: BAG64152.1
BX648638 mRNA Translation: CAI45996.1
AC010139 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64279.1
BC027595 mRNA Translation: AAH27595.1
CCDSiCCDS43059.1 [Q92904-1]
CCDS54556.1 [Q92904-2]
RefSeqiNP_001177740.1, NM_001190811.1 [Q92904-2]
NP_001342.2, NM_001351.3 [Q92904-1]
UniGeneiHs.131179

Genome annotation databases

EnsembliENST00000250863; ENSP00000250863; ENSG00000092345 [Q92904-2]
ENST00000399444; ENSP00000382373; ENSG00000092345 [Q92904-1]
GeneIDi1618
KEGGihsa:1618
UCSCiuc003cba.4 human [Q92904-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65918 mRNA Translation: AAC50813.1
U66726 mRNA Translation: AAB39935.1
U66078 mRNA Translation: AAB63596.1
U77476
, U77467, U77468, U77469, U77470, U77471, U77472, U77473, U77474, U77475 Genomic DNA Translation: AAB84361.1
AK303026 mRNA Translation: BAG64152.1
BX648638 mRNA Translation: CAI45996.1
AC010139 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64279.1
BC027595 mRNA Translation: AAH27595.1
CCDSiCCDS43059.1 [Q92904-1]
CCDS54556.1 [Q92904-2]
RefSeqiNP_001177740.1, NM_001190811.1 [Q92904-2]
NP_001342.2, NM_001351.3 [Q92904-1]
UniGeneiHs.131179

3D structure databases

ProteinModelPortaliQ92904
SMRiQ92904
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107987, 6 interactors
IntActiQ92904, 1 interactor
STRINGi9606.ENSP00000250863

PTM databases

iPTMnetiQ92904
PhosphoSitePlusiQ92904

Polymorphism and mutation databases

BioMutaiDAZL
DMDMi27805453

Proteomic databases

EPDiQ92904
PaxDbiQ92904
PeptideAtlasiQ92904
PRIDEiQ92904
ProteomicsDBi75589
75590 [Q92904-2]

Protocols and materials databases

DNASUi1618
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250863; ENSP00000250863; ENSG00000092345 [Q92904-2]
ENST00000399444; ENSP00000382373; ENSG00000092345 [Q92904-1]
GeneIDi1618
KEGGihsa:1618
UCSCiuc003cba.4 human [Q92904-1]

Organism-specific databases

CTDi1618
DisGeNETi1618
EuPathDBiHostDB:ENSG00000092345.13
GeneCardsiDAZL
HGNCiHGNC:2685 DAZL
HPAiHPA019593
HPA019777
HPA047113
MIMi601486 gene
neXtProtiNX_Q92904
OpenTargetsiENSG00000092345
PharmGKBiPA27155
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00530000063480
HOGENOMiHOG000246400
HOVERGENiHBG000573
InParanoidiQ92904
OMAiRSYVIPP
OrthoDBiEOG091G02CS
PhylomeDBiQ92904
TreeFamiTF324396

Miscellaneous databases

GeneWikiiDAZL
GenomeRNAii1618
PROiPR:Q92904
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000092345 Expressed in 36 organ(s), highest expression level in oocyte
CleanExiHS_DAZL
ExpressionAtlasiQ92904 baseline and differential
GenevisibleiQ92904 HS

Family and domain databases

CDDicd12672 RRM_DAZL, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR037366 BOULE/DAZ
IPR037551 DAZ_RRM_vert
IPR034779 DAZL
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR11176 PTHR11176, 1 hit
PTHR11176:SF4 PTHR11176:SF4, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAZL_HUMAN
AccessioniPrimary (citable) accession number: Q92904
Secondary accession number(s): O15396, Q5HYB4, Q92909
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again