DAZL

Functionⁱ

RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).By similarity

GO - Molecular functionⁱ

identical protein binding Source: Ensembl
mRNA 3'-UTR binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA binding
Source: ProtInc
Traceable author statementⁱ
- 8968755
translation activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16001084

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

female meiosis II Source: Ensembl
germ cell development
Source: ProtInc
Traceable author statementⁱ
- 9288969
multicellular organism development Source: UniProtKB-KW
oocyte maturation Source: Ensembl
positive regulation of meiotic nuclear division Source: Ensembl
positive regulation of translational initiation
Source: UniProtKB
Inferred from direct assayⁱ
- 16001084
spermatogenesis Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, RNA-binding
Biological process	Differentiation, Spermatogenesis, Translation regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Deleted in azoospermia-like Alternative name(s): DAZ homolog DAZ-like autosomal Deleted in azoospermia-like 1 SPGY-like-autosomal
Gene namesⁱ	Name:DAZL Synonyms:DAZH, DAZL1, DAZLA, SPGYLA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000092345.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2685 DAZL
MIMⁱ	601486 gene
neXtProtⁱ	NX_Q92904

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1618
Open Targets More...OpenTargetsⁱ	ENSG00000092345
PharmGKBⁱ	PA27155

Polymorphism and mutation databases

BioMutaⁱ	DAZL
DMDMⁱ	27805453

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081559	1 – 295	Deleted in azoospermia-likeAdd BLAST		295

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	276	PhosphotyrosineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q92904
PaxDbⁱ	Q92904
PeptideAtlas More...PeptideAtlasⁱ	Q92904
PRIDEⁱ	Q92904
ProteomicsDBⁱ	75589 75590 [Q92904-2]

PTM databases

iPTMnetⁱ	Q92904
PhosphoSitePlusⁱ	Q92904

Expressionⁱ

Tissue specificityⁱ

Testis specific.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000092345 Expressed in 36 organ(s), highest expression level in oocyte
CleanExⁱ	HS_DAZL
ExpressionAtlasⁱ	Q92904 baseline and differential
Genevisibleⁱ	Q92904 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019593 HPA019777 HPA047113

HPAⁱ

HPA019593
HPA019777
HPA047113

Interactionⁱ

Subunit structureⁱ

Homodimer and heterodimer. Multiple DAZL RRMs can bind to a single RNA containing multiple GUU triplets (By similarity). Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2.By similarity3 Publications

GO - Molecular functionⁱ

identical protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107987, 6 interactors
IntActⁱ	Q92904, 1 interactor
STRINGⁱ	9606.ENSP00000250863

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92904
SMRⁱ	Q92904
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	40 – 115	RRMPROSITE-ProRule annotationAdd BLAST		76
Domainⁱ	167 – 190	DAZ-likeAdd BLAST		24

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	80 – 132	HomodimerizationBy similarityAdd BLAST		53

Domainⁱ

The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2.1 Publication

Sequence similaritiesⁱ

Belongs to the RRM DAZ family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0118 Eukaryota COG0724 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063480
HOGENOMⁱ	HOG000246400
HOVERGENⁱ	HBG000573
InParanoidⁱ	Q92904
OMAⁱ	RSYVIPP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02CS
PhylomeDBⁱ	Q92904
TreeFamⁱ	TF324396

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12672 RRM_DAZL, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR037366 BOULE/DAZ IPR037551 DAZ_RRM_vert IPR034779 DAZL IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
PANTHERⁱ	PTHR11176 PTHR11176, 1 hit PTHR11176:SF4 PTHR11176:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q92904-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTANPETPN STISREASTQ SSSAATSQGY ILPEGKIMPN TVFVGGIDVR 
        60         70         80         90        100
MDETEIRSFF ARYGSVKEVK IITDRTGVSK GYGFVSFFND VDVQKIVESQ 
       110        120        130        140        150
INFHGKKLKL GPAIRKQNLC AYHVQPRPLV FNHPPPPQFQ NVWTNPNTET 
       160        170        180        190        200
YMQPTTTMNP ITQYVQAYPT YPNSPVQVIT GYQLPVYNYQ MPPQWPVGEQ 
       210        220        230        240        250
RSYVVPPAYS AVNYHCNEVD PGAEVVPNEC SVHEATPPSG NGPQKKSVDR 
       260        270        280        290 
SIQTVVSCLF NPENRLRNSV VTQDDYFKDK RVHHFRRSRA MLKSV

Length:295

Mass (Da):33,178

Last modified:February 1, 1997 - v1

Checksum:ⁱ21B360739B35B95F

GO

Isoform 2 (identifier: Q92904-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MAAPSCGGDRKARLTPSLPHE

« Hide

        10         20         30         40         50
MAAPSCGGDR KARLTPSLPH ESTANPETPN STISREASTQ SSSAATSQGY 
        60         70         80         90        100
ILPEGKIMPN TVFVGGIDVR MDETEIRSFF ARYGSVKEVK IITDRTGVSK 
       110        120        130        140        150
GYGFVSFFND VDVQKIVESQ INFHGKKLKL GPAIRKQNLC AYHVQPRPLV 
       160        170        180        190        200
FNHPPPPQFQ NVWTNPNTET YMQPTTTMNP ITQYVQAYPT YPNSPVQVIT 
       210        220        230        240        250
GYQLPVYNYQ MPPQWPVGEQ RSYVVPPAYS AVNYHCNEVD PGAEVVPNEC 
       260        270        280        290        300
SVHEATPPSG NGPQKKSVDR SIQTVVSCLF NPENRLRNSV VTQDDYFKDK 
       310 
RVHHFRRSRA MLKSV

Show »

Length:315

Mass (Da):35,224

Checksum:ⁱF4380E654EFB350D

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E7EV40	E7EV40_HUMAN		Deleted in azoospermia-like Deleted in azoospermia-like	DAZL	204	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	3	T → I in AAB63596 (PubMed:8968756).Curated		1
Sequence conflictⁱ	253	Q → R in AAB84361 (PubMed:9294855).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_017780	12	T → A Common polymorphism. 1 PublicationCorresponds to variant dbSNP:rs11710967Ensembl.	1
Natural variantⁱVAR_017781	54	T → A May be associated with susceptibility to spermatogenic failure in Asian individuals; this substitution may lead to affect the DAZL transcript stability and prevent its translation. 1 PublicationCorresponds to variant dbSNP:rs121918346EnsemblClinVar.	1
Natural variantⁱVAR_069231	115	R → G Severely impaired RNA-binding. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043208	1	M → MAAPSCGGDRKARLTPSLPH E in isoform 2. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U65918 mRNA Translation: AAC50813.1 U66726 mRNA Translation: AAB39935.1 U66078 mRNA Translation: AAB63596.1 U77476 U77475 Genomic DNA Translation: AAB84361.1 AK303026 mRNA Translation: BAG64152.1 BX648638 mRNA Translation: CAI45996.1 AC010139 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64279.1 BC027595 mRNA Translation: AAH27595.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43059.1 [Q92904-1] CCDS54556.1 [Q92904-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001177740.1, NM_001190811.1 [Q92904-2] NP_001342.2, NM_001351.3 [Q92904-1]
UniGeneⁱ	Hs.131179

Genome annotation databases

Ensemblⁱ	ENST00000250863; ENSP00000250863; ENSG00000092345 [Q92904-2] ENST00000399444; ENSP00000382373; ENSG00000092345 [Q92904-1]
GeneIDⁱ	1618
KEGGⁱ	hsa:1618
UCSC genome browser More...UCSCⁱ	uc003cba.4 human [Q92904-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92904	Deleted in azoospermia-like, isoform CRA_a		HUMAN		295	UniRef100_Q92904
Deleted in azoospermia like		GORGO		295
Q92904-2	Deleted in azoospermia like		GORGO		315	UniRef100_G3S8R9

Protein	Similar proteins		Species	Score	Length	Source
Q92904	Deleted in azoospermia-like		MACFA		295	UniRef90_Q92904
Deleted in azoospermia-like, isoform CRA_a		HUMAN		295
Deleted in azoospermia like		GORGO		295
deleted in azoospermia-like		Enhydra lutris kenyoni		295
Uncharacterized protein		CANLF		295
+45
Q92904-2	Deleted in azoospermia like		PANTR		315	UniRef90_A0A2I3TTQ5
Uncharacterized protein		PANPA		294
deleted in azoospermia-like		URSMA		383
Uncharacterized protein		FELCA		316
Uncharacterized protein		MACNE		315
+26

Protein	Similar proteins		Species	Score	Length	Source
Q92904	Deleted in azoospermia-like	)	MOUSE		298	UniRef50_Q64368
Deleted in azoospermia-like		MACFA		295
Uncharacterized protein		PANTR		304
Deleted in azoospermia-like		RAT		298
Deleted in azoospermia-like protein (Fragment)		wild yak		297
+122

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U65918 mRNA Translation: AAC50813.1 U66726 mRNA Translation: AAB39935.1 U66078 mRNA Translation: AAB63596.1 U77476 U77475 Genomic DNA Translation: AAB84361.1 AK303026 mRNA Translation: BAG64152.1 BX648638 mRNA Translation: CAI45996.1 AC010139 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64279.1 BC027595 mRNA Translation: AAH27595.1
CCDSⁱ	CCDS43059.1 [Q92904-1] CCDS54556.1 [Q92904-2]
RefSeqⁱ	NP_001177740.1, NM_001190811.1 [Q92904-2] NP_001342.2, NM_001351.3 [Q92904-1]
UniGeneⁱ	Hs.131179

3D structure databases

ProteinModelPortalⁱ	Q92904
SMRⁱ	Q92904
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107987, 6 interactors
IntActⁱ	Q92904, 1 interactor
STRINGⁱ	9606.ENSP00000250863

PTM databases

iPTMnetⁱ	Q92904
PhosphoSitePlusⁱ	Q92904

Polymorphism and mutation databases

BioMutaⁱ	DAZL
DMDMⁱ	27805453

Proteomic databases

EPDⁱ	Q92904
PaxDbⁱ	Q92904
PeptideAtlasⁱ	Q92904
PRIDEⁱ	Q92904
ProteomicsDBⁱ	75589 75590 [Q92904-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1618
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000250863; ENSP00000250863; ENSG00000092345 [Q92904-2] ENST00000399444; ENSP00000382373; ENSG00000092345 [Q92904-1]
GeneIDⁱ	1618
KEGGⁱ	hsa:1618
UCSCⁱ	uc003cba.4 human [Q92904-1]

Organism-specific databases

CTDⁱ	1618
DisGeNETⁱ	1618
EuPathDBⁱ	HostDB:ENSG00000092345.13
GeneCardsⁱ	DAZL
HGNCⁱ	HGNC:2685 DAZL
HPAⁱ	HPA019593 HPA019777 HPA047113
MIMⁱ	601486 gene
neXtProtⁱ	NX_Q92904
OpenTargetsⁱ	ENSG00000092345
PharmGKBⁱ	PA27155
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0118 Eukaryota COG0724 LUCA
GeneTreeⁱ	ENSGT00530000063480
HOGENOMⁱ	HOG000246400
HOVERGENⁱ	HBG000573
InParanoidⁱ	Q92904
OMAⁱ	RSYVIPP
OrthoDBⁱ	EOG091G02CS
PhylomeDBⁱ	Q92904
TreeFamⁱ	TF324396

Miscellaneous databases

GeneWikiⁱ	DAZL
GenomeRNAiⁱ	1618
Protein Ontology More...PROⁱ	PR:Q92904
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000092345 Expressed in 36 organ(s), highest expression level in oocyte
CleanExⁱ	HS_DAZL
ExpressionAtlasⁱ	Q92904 baseline and differential
Genevisibleⁱ	Q92904 HS

Family and domain databases

CDDⁱ	cd12672 RRM_DAZL, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR037366 BOULE/DAZ IPR037551 DAZ_RRM_vert IPR034779 DAZL IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
PANTHERⁱ	PTHR11176 PTHR11176, 1 hit PTHR11176:SF4 PTHR11176:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DAZL_HUMAN
Accessionⁱ	Q92904Primary (citable) accession number: Q92904 Secondary accession number(s): O15396, Q5HYB4, Q92909
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
	Last sequence update:	February 1, 1997
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q92904 (DAZL_HUMAN)

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Deleted in azoospermia-like

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ