UniProtKB - Q92901 (RL3L_HUMAN)
Protein
60S ribosomal protein L3-like
Gene
RPL3L
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: GO_Central
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- ribosomal large subunit assembly Source: GO_Central
- translation Source: ProtInc
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | Q92901 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L3-likeAlternative name(s): Large ribosomal subunit protein uL3-like |
Gene namesi | Name:RPL3L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10351, RPL3L |
MIMi | 617416, gene |
neXtProti | NX_Q92901 |
VEuPathDBi | HostDB:ENSG00000140986.7 |
Subcellular locationi
Cytosol
- cytosolic large ribosomal subunit Source: UniProtKB
Other locations
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6123 |
OpenTargetsi | ENSG00000140986 |
PharmGKBi | PA34746 |
Miscellaneous databases
Pharosi | Q92901, Tdark |
Genetic variation databases
BioMutai | RPL3L |
DMDMi | 2500230 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000077233 | 1 – 407 | 60S ribosomal protein L3-likeAdd BLAST | 407 |
Proteomic databases
EPDi | Q92901 |
jPOSTi | Q92901 |
MassIVEi | Q92901 |
MaxQBi | Q92901 |
PaxDbi | Q92901 |
PeptideAtlasi | Q92901 |
PRIDEi | Q92901 |
ProteomicsDBi | 75583 |
PTM databases
iPTMneti | Q92901 |
PhosphoSitePlusi | Q92901 |
SwissPalmi | Q92901 |
Expressioni
Gene expression databases
Bgeei | ENSG00000140986, Expressed in skeletal muscle tissue and 106 other tissues |
ExpressionAtlasi | Q92901, baseline and differential |
Genevisiblei | Q92901, HS |
Organism-specific databases
HPAi | ENSG00000140986, Tissue enhanced (heart muscle, skeletal muscle, tongue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 112043, 47 interactors |
IntActi | Q92901, 4 interactors |
STRINGi | 9606.ENSP00000268661 |
Miscellaneous databases
RNActi | Q92901, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL3 family.Curated
Phylogenomic databases
eggNOGi | KOG0746, Eukaryota |
GeneTreei | ENSGT00390000017606 |
HOGENOMi | CLU_033361_1_0_1 |
InParanoidi | Q92901 |
OMAi | AQEKRVF |
OrthoDBi | 793191at2759 |
PhylomeDBi | Q92901 |
TreeFami | TF300555 |
Family and domain databases
InterProi | View protein in InterPro IPR000597, Ribosomal_L3 IPR019926, Ribosomal_L3_CS IPR009000, Transl_B-barrel_sf |
Pfami | View protein in Pfam PF00297, Ribosomal_L3, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit |
PROSITEi | View protein in PROSITE PS00474, RIBOSOMAL_L3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q92901-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHRKFSAPR HGHLGFLPHK RSHRHRGKVK TWPRDDPSQP VHLTAFLGYK
60 70 80 90 100
AGMTHTLREV HRPGLKISKR EEVEAVTIVE TPPLVVVGVV GYVATPRGLR
110 120 130 140 150
SFKTIFAEHL SDECRRRFYK DWHKSKKKAF TKACKRWRDT DGKKQLQKDF
160 170 180 190 200
AAMKKYCKVI RVIVHTQMKL LPFRQKKAHI MEIQLNGGTV AEKVAWAQAR
210 220 230 240 250
LEKQVPVHSV FSQSEVIDVI AVTKGRGVKG VTSRWHTKKL PRKTHKGLRK
260 270 280 290 300
VACIGAWHPA RVGCSIARAG QKGYHHRTEL NKKIFRIGRG PHMEDGKLVK
310 320 330 340 350
NNASTSYDVT AKSITPLGGF PHYGEVNNDF VMLKGCIAGT KKRVITLRKS
360 370 380 390 400
LLVHHSRQAV ENIELKFIDT TSKFGHGRFQ TAQEKRAFMG PQKKHLEKET
PETSGDL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BQN3 | H3BQN3_HUMAN | 60S ribosomal protein L3-like | RPL3L | 43 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034461 | 291 | P → L. Corresponds to variant dbSNP:rs34265469Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U65581 mRNA Translation: AAC50777.1 AE006640 Genomic DNA Translation: AAK61301.1 BC050413 mRNA Translation: AAH50413.1 |
CCDSi | CCDS10450.1 |
RefSeqi | NP_005052.1, NM_005061.2 |
Genome annotation databases
Ensembli | ENST00000268661; ENSP00000268661; ENSG00000140986 |
GeneIDi | 6123 |
KEGGi | hsa:6123 |
UCSCi | uc002cnh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U65581 mRNA Translation: AAC50777.1 AE006640 Genomic DNA Translation: AAK61301.1 BC050413 mRNA Translation: AAH50413.1 |
CCDSi | CCDS10450.1 |
RefSeqi | NP_005052.1, NM_005061.2 |
3D structure databases
SMRi | Q92901 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112043, 47 interactors |
IntActi | Q92901, 4 interactors |
STRINGi | 9606.ENSP00000268661 |
PTM databases
iPTMneti | Q92901 |
PhosphoSitePlusi | Q92901 |
SwissPalmi | Q92901 |
Genetic variation databases
BioMutai | RPL3L |
DMDMi | 2500230 |
Proteomic databases
EPDi | Q92901 |
jPOSTi | Q92901 |
MassIVEi | Q92901 |
MaxQBi | Q92901 |
PaxDbi | Q92901 |
PeptideAtlasi | Q92901 |
PRIDEi | Q92901 |
ProteomicsDBi | 75583 |
Protocols and materials databases
Antibodypediai | 23334, 62 antibodies |
Genome annotation databases
Ensembli | ENST00000268661; ENSP00000268661; ENSG00000140986 |
GeneIDi | 6123 |
KEGGi | hsa:6123 |
UCSCi | uc002cnh.4, human |
Organism-specific databases
CTDi | 6123 |
DisGeNETi | 6123 |
GeneCardsi | RPL3L |
HGNCi | HGNC:10351, RPL3L |
HPAi | ENSG00000140986, Tissue enhanced (heart muscle, skeletal muscle, tongue) |
MIMi | 617416, gene |
neXtProti | NX_Q92901 |
OpenTargetsi | ENSG00000140986 |
PharmGKBi | PA34746 |
VEuPathDBi | HostDB:ENSG00000140986.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0746, Eukaryota |
GeneTreei | ENSGT00390000017606 |
HOGENOMi | CLU_033361_1_0_1 |
InParanoidi | Q92901 |
OMAi | AQEKRVF |
OrthoDBi | 793191at2759 |
PhylomeDBi | Q92901 |
TreeFami | TF300555 |
Enzyme and pathway databases
PathwayCommonsi | Q92901 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 6123, 10 hits in 880 CRISPR screens |
GenomeRNAii | 6123 |
Pharosi | Q92901, Tdark |
PROi | PR:Q92901 |
RNActi | Q92901, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140986, Expressed in skeletal muscle tissue and 106 other tissues |
ExpressionAtlasi | Q92901, baseline and differential |
Genevisiblei | Q92901, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000597, Ribosomal_L3 IPR019926, Ribosomal_L3_CS IPR009000, Transl_B-barrel_sf |
Pfami | View protein in Pfam PF00297, Ribosomal_L3, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit |
PROSITEi | View protein in PROSITE PS00474, RIBOSOMAL_L3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL3L_HUMAN | |
Accessioni | Q92901Primary (citable) accession number: Q92901 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 159 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families