UniProtKB - Q92900 (RENT1_HUMAN)

BLAST

>sp|Q92900|RENT1_HUMAN Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2
MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAG
GPGGAGAGAAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPI
HACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETV
LECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLS
WLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAY
QYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGNEDLVII
WLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNF
QVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLP
DLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQ
LTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSS
ADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVP
VVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALS
AFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTE
AANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAF
QGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLL
NYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAIIPGSVYDR
SSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAGRG
TPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQMSQ
PGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY

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History
Entry version 191 (07 Nov 2018)
Sequence version 2 (18 Oct 2001)
Previous versions | rss
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Protein

Regulator of nonsense transcripts 1

Gene

UPF1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability.5 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	486	ATP	1
Binding siteⁱ	676	ATP	1
Binding siteⁱ	713	ATP	1
Binding siteⁱ	844	ATP	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	121 – 272	UPF1-typeAdd BLAST		152
Nucleotide bindingⁱ	506 – 510	ATP		5

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
ATP-dependent RNA helicase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21419344
chromatin binding
Source: HGNC
Inferred from direct assayⁱ
- 16488880
helicase activity
Source: UniProtKB
Non-traceable author statementⁱ
- 9064659
RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24726324
telomeric DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17916692
- 21829167
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

3'-UTR-mediated mRNA destabilization
Source: UniProtKB
Inferred from direct assayⁱ
- 24726324
cell cycle phase transition
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16488880
cellular response to interleukin-1
Source: UniProtKB
Inferred from direct assayⁱ
- 26255671
cellular response to lipopolysaccharide
Source: UniProtKB
Inferred from direct assayⁱ
- 26255671
DNA repair
Source: HGNC
Inferred from direct assayⁱ
- 16488880
DNA replication
Source: HGNC
Inferred from mutant phenotypeⁱ
- 16488880
dosage compensation by inactivation of X chromosome Source: Ensembl
histone mRNA catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16086026
mRNA export from nucleus
Source: HGNC
Traceable author statementⁱ
- 16488880
nuclear-transcribed mRNA catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23828042
nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26255671
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Source: UniProtKB
Inferred from direct assayⁱ
- 17468741
positive regulation of mRNA catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 24726324
regulation of telomere maintenance
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17916692
regulation of translational termination
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9620853
telomere maintenance via semi-conservative replication
Source: BHF-UCL
Inferred from direct assayⁱ
- 21829167
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Helicase, Hydrolase, RNA-binding
Biological process	Host-virus interaction, Nonsense-mediated mRNA decay
Ligand	ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORⁱ	Q92900

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of nonsense transcripts 1 (EC:3.6.4.-) Alternative name(s): ATP-dependent helicase RENT1 Nonsense mRNA reducing factor 1 Short name: NORF1 Up-frameshift suppressor 1 homolog Short name: hUpf1
Gene namesⁱ	Name:UPF1 Synonyms:KIAA0221, RENT1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000005007.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9962 UPF1
MIMⁱ	601430 gene
neXtProtⁱ	NX_Q92900

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	126	C → S: Abolishes ability to interact with UPF2/RENT2 and copurifies with greater amounts of SMG1, SMG8 and SMG9. 2 Publications	1
Mutagenesisⁱ	506 – 508	GTG → RTE: Prevents dephosphorylation and targets the protein to the P-body. 1 Publication	3
Mutagenesisⁱ	509	K → A: Inhibits histone mRNA degradation, ATPase activity and ATP binding. 3 Publications	1
Mutagenesisⁱ	610 – 611	KR → AA: Impairs RNA binding.	2
Mutagenesisⁱ	615	R → A: Impairs RNA binding. 1 Publication	1
Mutagenesisⁱ	647 – 648	DE → AA: Loss of ATPase activity and helicase activity. 2 Publications	2
Mutagenesisⁱ	647 – 648	DE → AA: Loss of ATPase activity and helicase activity. Inhibits ZC3H12A-mediated IL6 mRNA degradation. 3 Publications	2
Mutagenesisⁱ	676	Q → A: Impairs ATPase activity, no effect on ATP binding. 1 Publication	1
Mutagenesisⁱ	714	R → A: Impairs ATPase activity and ATP binding. 1 Publication	1
Mutagenesisⁱ	843	R → A: Inhibits histone mRNA degradation. 2 Publications	1
Mutagenesisⁱ	843	R → C: Abolishes NMD. 2 Publications	1
Mutagenesisⁱ	876	R → A: Impairs ATPase activity and ATP binding. 1 Publication	1
Mutagenesisⁱ	1084	S → A: Impairs association with UPF2, SMG1 and SMG7 and impairs phosphorylation; when associated with A-1089, A-1107 and A-1127. 1 Publication	1
Mutagenesisⁱ	1089	S → A: Impairs association with UPF2, SMG1 and SMG7 and impairs phosphorylation; when associated with A-1084, A-1107 and A-1127. 2 Publications	1
Mutagenesisⁱ	1089	S → A: Still phosphorylated but with less efficiency. 2 Publications	1
Mutagenesisⁱ	1107	S → A: Impairs association with UPF2, SMG1 and SMG7 and impairs phosphorylation; when associated with A-1084, A-1089 and A-1127. 2 Publications	1
Mutagenesisⁱ	1107	S → A: Impairs phosphorylation. 2 Publications	1
Mutagenesisⁱ	1108	Q → N: Impairs phosphorylation. 1 Publication	1
Mutagenesisⁱ	1127	S → A: Impairs association with UPF2, SMG1 and SMG7 and impairs phosphorylation; when associated with A-1084, A-1089 and A-1107. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5976
Open Targets More...OpenTargetsⁱ	ENSG00000005007
PharmGKBⁱ	PA34328

Polymorphism and mutation databases

BioMutaⁱ	UPF1
DMDMⁱ	17380291

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080716	1 – 1129	Regulator of nonsense transcripts 1Add BLAST		1129

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	10	PhosphoserineCombined sources	1
Modified residueⁱ	31	PhosphoserineCombined sources	1
Modified residueⁱ	565	PhosphoserineCombined sources	1
Modified residueⁱ	956	PhosphoserineCombined sources	1
Modified residueⁱ	1019	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	1089	Phosphoserine2 Publications	1
Modified residueⁱ	1107	PhosphoserineCombined sources2 Publications	1
Modified residueⁱ	1110	PhosphoserineCombined sources	1
Modified residueⁱ	1127	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by SMG1; required for formation of mRNA surveillance complexes.5 Publications

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q92900
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92900
PaxDbⁱ	Q92900
PeptideAtlas More...PeptideAtlasⁱ	Q92900
PRIDEⁱ	Q92900
ProteomicsDBⁱ	75581 75582 [Q92900-2]

PTM databases

iPTMnetⁱ	Q92900
PhosphoSitePlusⁱ	Q92900
SwissPalmⁱ	Q92900

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000005007 Expressed in 210 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_UPF1
ExpressionAtlasⁱ	Q92900 baseline and differential
Genevisibleⁱ	Q92900 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019587 HPA020857

HPAⁱ

HPA019587
HPA020857

Interactionⁱ

Subunit structureⁱ

Found in a post-splicing messenger ribonucleoprotein (mRNP) complex (PubMed:21419344). Associates with the exon junction complex (EJC) (PubMed:11546874, PubMed:16452507). Associates with the SGM1C complex; is phosphorylated by the complex kinase component SGM1 (PubMed:19417104). Interacts with UPF2 (PubMed:11163187, PubMed:11073994, PubMed:11113196, PubMed:19556969). Interacts with UPF3A and UPF3B (PubMed:11163187). Interacts with EST1A (PubMed:12554878). Interacts with SLBP (PubMed:16086026). Interacts (when hyperphosphorylated) with PNRC2 (PubMed:19150429). Interacts with AGO1 and AGO2 (PubMed:17932509). Interacts with GSPT2 (PubMed:18447585). Interacts with isoform 1 and isoform 5 of ADAR/ADAR1 (PubMed:18362360). Interacts with SMG7 (PubMed:15721257). Interacts with ZC3H12A; this interaction occurs in a mRNA translationally active- and termination-dependent manner and is essential for ZC3H12A-mediated degradation of target mRNAs (PubMed:26000482). Interacts with CPSF6 (PubMed:19864460).17 Publications

(Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein Tax; this interaction inhibits the host nonsense-mediated mRNA decay (NMD).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ACD	Q96AP0	3	EBI-373471,EBI-717666
ADAR	P55265	3	EBI-373471,EBI-2462104
DCP1A	Q9NPI6	13	EBI-373471,EBI-374238
DCP2	Q8IU60	3	EBI-373471,EBI-521577
EIF3A	Q14152	5	EBI-373492,EBI-366617
GSPT1	P15170	2	EBI-373471,EBI-948993
GSPT2	Q8IYD1	3	EBI-373471,EBI-3869637
L1RE1	Q9UN81	6	EBI-373471,EBI-722458
PNRC2	Q9NPJ4	9	EBI-373471,EBI-726549
SKI7	Q08491	2	EBI-373471,EBI-1389	From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SLBP	Q14493	3	EBI-373471,EBI-2696402
SMG5	Q9UPR3	2	EBI-373492,EBI-3400861
SMG6	Q86US8	2	EBI-373492,EBI-3232100
SMG7	Q92540	3	EBI-373471,EBI-719830
STAU1	O95793	5	EBI-373471,EBI-358174
TERT	O14746	3	EBI-373471,EBI-1772203
UPF2	Q9HAU5	29	EBI-373471,EBI-372073
UPF3A	Q9H1J1	4	EBI-373471,EBI-521530
UPF3B	Q9BZI7	10	EBI-373471,EBI-372780

Protein-protein interaction databases

BioGridⁱ	111908, 250 interactors
CORUMⁱ	Q92900
Database of interacting proteins More...DIPⁱ	DIP-29875N
IntActⁱ	Q92900, 123 interactors
Molecular INTeraction database More...MINTⁱ	Q92900
STRINGⁱ	9606.ENSP00000262803

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	124 – 126	Combined sources	3
Helixⁱ	131 – 133	Combined sources	3
Beta strandⁱ	134 – 137	Combined sources	4
Turnⁱ	138 – 141	Combined sources	4
Beta strandⁱ	142 – 146	Combined sources	5
Beta strandⁱ	151 – 153	Combined sources	3
Helixⁱ	155 – 163	Combined sources	9
Beta strandⁱ	168 – 170	Combined sources	3
Beta strandⁱ	174 – 176	Combined sources	3
Turnⁱ	184 – 186	Combined sources	3
Turnⁱ	191 – 193	Combined sources	3
Beta strandⁱ	195 – 197	Combined sources	3
Beta strandⁱ	200 – 202	Combined sources	3
Beta strandⁱ	204 – 209	Combined sources	6
Turnⁱ	210 – 213	Combined sources	4
Turnⁱ	216 – 218	Combined sources	3
Turnⁱ	220 – 222	Combined sources	3
Helixⁱ	226 – 228	Combined sources	3
Beta strandⁱ	230 – 233	Combined sources	4
Beta strandⁱ	235 – 238	Combined sources	4
Turnⁱ	240 – 242	Combined sources	3
Helixⁱ	248 – 253	Combined sources	6
Helixⁱ	259 – 269	Combined sources	11
Helixⁱ	299 – 321	Combined sources	23
Beta strandⁱ	326 – 329	Combined sources	4
Beta strandⁱ	332 – 335	Combined sources	4
Turnⁱ	337 – 339	Combined sources	3
Beta strandⁱ	341 – 345	Combined sources	5
Helixⁱ	364 – 366	Combined sources	3
Beta strandⁱ	372 – 377	Combined sources	6
Beta strandⁱ	379 – 382	Combined sources	4
Beta strandⁱ	385 – 393	Combined sources	9
Beta strandⁱ	396 – 398	Combined sources	3
Beta strandⁱ	402 – 407	Combined sources	6
Beta strandⁱ	410 – 412	Combined sources	3
Beta strandⁱ	418 – 425	Combined sources	8
Helixⁱ	429 – 443	Combined sources	15
Beta strandⁱ	445 – 448	Combined sources	4
Helixⁱ	450 – 456	Combined sources	7
Helixⁱ	484 – 493	Combined sources	10
Beta strandⁱ	497 – 502	Combined sources	6
Helixⁱ	509 – 522	Combined sources	14
Beta strandⁱ	523 – 525	Combined sources	3
Beta strandⁱ	528 – 534	Combined sources	7
Helixⁱ	535 – 547	Combined sources	13
Beta strandⁱ	552 – 554	Combined sources	3
Helixⁱ	558 – 560	Combined sources	3
Helixⁱ	568 – 570	Combined sources	3
Helixⁱ	572 – 577	Combined sources	6
Helixⁱ	582 – 591	Combined sources	10
Turnⁱ	593 – 595	Combined sources	3
Helixⁱ	600 – 620	Combined sources	21
Beta strandⁱ	622 – 627	Combined sources	6
Helixⁱ	630 – 632	Combined sources	3
Helixⁱ	634 – 636	Combined sources	3
Beta strandⁱ	642 – 646	Combined sources	5
Helixⁱ	649 – 651	Combined sources	3
Helixⁱ	654 – 661	Combined sources	8
Turnⁱ	662 – 664	Combined sources	3
Beta strandⁱ	665 – 672	Combined sources	8
Beta strandⁱ	674 – 676	Combined sources	3
Helixⁱ	684 – 688	Combined sources	5
Turnⁱ	689 – 692	Combined sources	4
Helixⁱ	695 – 702	Combined sources	8
Helixⁱ	717 – 727	Combined sources	11
Beta strandⁱ	733 – 736	Combined sources	4
Helixⁱ	739 – 741	Combined sources	3
Beta strandⁱ	751 – 754	Combined sources	4
Beta strandⁱ	757 – 761	Combined sources	5
Beta strandⁱ	766 – 768	Combined sources	3
Beta strandⁱ	770 – 773	Combined sources	4
Beta strandⁱ	775 – 777	Combined sources	3
Helixⁱ	778 – 794	Combined sources	17
Helixⁱ	798 – 800	Combined sources	3
Beta strandⁱ	801 – 806	Combined sources	6
Helixⁱ	808 – 819	Combined sources	12
Helixⁱ	826 – 830	Combined sources	5
Beta strandⁱ	832 – 836	Combined sources	5
Turnⁱ	837 – 842	Combined sources	6
Beta strandⁱ	845 – 851	Combined sources	7
Beta strandⁱ	857 – 859	Combined sources	3
Helixⁱ	862 – 865	Combined sources	4
Helixⁱ	867 – 874	Combined sources	8
Beta strandⁱ	875 – 885	Combined sources	11
Helixⁱ	887 – 890	Combined sources	4
Helixⁱ	894 – 905	Combined sources	12
Beta strandⁱ	909 – 912	Combined sources	4
Helixⁱ	914 – 916	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q92900
SMRⁱ	Q92900
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q92900

EvolutionaryTraceⁱ

Q92900

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 415	Sufficient for interaction with RENT2Add BLAST		415

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	1089 – 1090	[ST]-Q motif 1		2
Motifⁱ	1107 – 1108	[ST]-Q motif 2		2

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	47 – 80	Ala/Gly/Pro-richAdd BLAST		34
Compositional biasⁱ	1042 – 1129	Gln/Ser-richAdd BLAST		88

Domainⁱ

The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.

Sequence similaritiesⁱ

Belongs to the DNA2/NAM7 helicase family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	121 – 272	UPF1-typeAdd BLAST		152

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1802 Eukaryota COG1112 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00800000124068
HOGENOMⁱ	HOG000205990
HOVERGENⁱ	HBG061556
InParanoidⁱ	Q92900
KEGG Orthology (KO) More...KOⁱ	K14326
OMAⁱ	QPCAAQN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01B6
PhylomeDBⁱ	Q92900
TreeFamⁱ	TF300554

Family and domain databases

InterProⁱ	View protein in InterPro IPR006935 Helicase/UvrB_N IPR027417 P-loop_NTPase IPR018999 RNA-helicase_UPF1_UPF2-interct
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04851 ResIII, 1 hit PF09416 UPF1_Zn_bind, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q92900-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTPPGG 
        60         70         80         90        100
PGGPGGGGAG GPGGAGAGAA AGQLDAQVGP EGILQNGAVD DSVAKTSQLL 
       110        120        130        140        150
AELNFEEDEE DTYYTKDLPI HACSYCGIHD PACVVYCNTS KKWFCNGRGN 
       160        170        180        190        200
TSGSHIVNHL VRAKCKEVTL HKDGPLGETV LECYNCGCRN VFLLGFIPAK 
       210        220        230        240        250
ADSVVVLLCR QPCASQSSLK DINWDSSQWQ PLIQDRCFLS WLVKIPSEQE 
       260        270        280        290        300
QLRARQITAQ QINKLEELWK ENPSATLEDL EKPGVDEEPQ HVLLRYEDAY 
       310        320        330        340        350
QYQNIFGPLV KLEADYDKKL KESQTQDNIT VRWDLGLNKK RIAYFTLPKT 
       360        370        380        390        400
DSGNEDLVII WLRDMRLMQG DEICLRYKGD LAPLWKGIGH VIKVPDNYGD 
       410        420        430        440        450
EIAIELRSSV GAPVEVTHNF QVDFVWKSTS FDRMQSALKT FAVDETSVSG 
       460        470        480        490        500
YIYHKLLGHE VEDVIIKCQL PKRFTAQGLP DLNHSQVYAV KTVLQRPLSL 
       510        520        530        540        550
IQGPPGTGKT VTSATIVYHL ARQGNGPVLV CAPSNIAVDQ LTEKIHQTGL 
       560        570        580        590        600
KVVRLCAKSR EAIDSPVSFL ALHNQIRNMD SMPELQKLQQ LKDETGELSS 
       610        620        630        640        650
ADEKRYRALK RTAERELLMN ADVICCTCVG AGDPRLAKMQ FRSILIDEST 
       660        670        680        690        700
QATEPECMVP VVLGAKQLIL VGDHCQLGPV VMCKKAAKAG LSQSLFERLV 
       710        720        730        740        750
VLGIRPIRLQ VQYRMHPALS AFPSNIFYEG SLQNGVTAAD RVKKGFDFQW 
       760        770        780        790        800
PQPDKPMFFY VTQGQEEIAS SGTSYLNRTE AANVEKITTK LLKAGAKPDQ 
       810        820        830        840        850
IGIITPYEGQ RSYLVQYMQF SGSLHTKLYQ EVEIASVDAF QGREKDFIIL 
       860        870        880        890        900
SCVRANEHQG IGFLNDPRRL NVALTRARYG VIIVGNPKAL SKQPLWNHLL 
       910        920        930        940        950
NYYKEQKVLV EGPLNNLRES LMQFSKPRKL VNTINPGARF MTTAMYDARE 
       960        970        980        990       1000
AIIPGSVYDR SSQGRPSSMY FQTHDQIGMI SAGPSHVAAM NIPIPFNLVM 
      1010       1020       1030       1040       1050
PPMPPPGYFG QANGPAAGRG TPKGKTGRGG RQKNRFGLPG PSQTNLPNSQ 
      1060       1070       1080       1090       1100
ASQDVASQPF SQGALTQGYI SMSQPSQMSQ PGLSQPELSQ DSYLGDEFKS 
      1110       1120 
QIDVALSQDS TYQGERAYQH GGVTGLSQY

Length:1,129

Mass (Da):124,345

Last modified:October 18, 2001 - v2

Checksum:ⁱ6CCA6FE42B15BA28

Isoform 2 (identifier: Q92900-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
353-363: Missing.

« Hide

        10         20         30         40         50
MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTPPGG 
        60         70         80         90        100
PGGPGGGGAG GPGGAGAGAA AGQLDAQVGP EGILQNGAVD DSVAKTSQLL 
       110        120        130        140        150
AELNFEEDEE DTYYTKDLPI HACSYCGIHD PACVVYCNTS KKWFCNGRGN 
       160        170        180        190        200
TSGSHIVNHL VRAKCKEVTL HKDGPLGETV LECYNCGCRN VFLLGFIPAK 
       210        220        230        240        250
ADSVVVLLCR QPCASQSSLK DINWDSSQWQ PLIQDRCFLS WLVKIPSEQE 
       260        270        280        290        300
QLRARQITAQ QINKLEELWK ENPSATLEDL EKPGVDEEPQ HVLLRYEDAY 
       310        320        330        340        350
QYQNIFGPLV KLEADYDKKL KESQTQDNIT VRWDLGLNKK RIAYFTLPKT 
       360        370        380        390        400
DSDMRLMQGD EICLRYKGDL APLWKGIGHV IKVPDNYGDE IAIELRSSVG 
       410        420        430        440        450
APVEVTHNFQ VDFVWKSTSF DRMQSALKTF AVDETSVSGY IYHKLLGHEV 
       460        470        480        490        500
EDVIIKCQLP KRFTAQGLPD LNHSQVYAVK TVLQRPLSLI QGPPGTGKTV 
       510        520        530        540        550
TSATIVYHLA RQGNGPVLVC APSNIAVDQL TEKIHQTGLK VVRLCAKSRE 
       560        570        580        590        600
AIDSPVSFLA LHNQIRNMDS MPELQKLQQL KDETGELSSA DEKRYRALKR 
       610        620        630        640        650
TAERELLMNA DVICCTCVGA GDPRLAKMQF RSILIDESTQ ATEPECMVPV 
       660        670        680        690        700
VLGAKQLILV GDHCQLGPVV MCKKAAKAGL SQSLFERLVV LGIRPIRLQV 
       710        720        730        740        750
QYRMHPALSA FPSNIFYEGS LQNGVTAADR VKKGFDFQWP QPDKPMFFYV 
       760        770        780        790        800
TQGQEEIASS GTSYLNRTEA ANVEKITTKL LKAGAKPDQI GIITPYEGQR 
       810        820        830        840        850
SYLVQYMQFS GSLHTKLYQE VEIASVDAFQ GREKDFIILS CVRANEHQGI 
       860        870        880        890        900
GFLNDPRRLN VALTRARYGV IIVGNPKALS KQPLWNHLLN YYKEQKVLVE 
       910        920        930        940        950
GPLNNLRESL MQFSKPRKLV NTINPGARFM TTAMYDAREA IIPGSVYDRS 
       960        970        980        990       1000
SQGRPSSMYF QTHDQIGMIS AGPSHVAAMN IPIPFNLVMP PMPPPGYFGQ 
      1010       1020       1030       1040       1050
ANGPAAGRGT PKGKTGRGGR QKNRFGLPGP SQTNLPNSQA SQDVASQPFS 
      1060       1070       1080       1090       1100
QGALTQGYIS MSQPSQMSQP GLSQPELSQD SYLGDEFKSQ IDVALSQDST 
      1110 
YQGERAYQHG GVTGLSQY

Show »

Length:1,118

Mass (Da):123,036

Checksum:ⁱA485D3ED52C39D06

Sequence cautionⁱ

The sequence BAA19664 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	61	G → S in AAC51140 (PubMed:9064659).Curated	1
Sequence conflictⁱ	466	I → T in AAC51140 (PubMed:9064659).Curated	1
Sequence conflictⁱ	478	G → A in AAC50771 (PubMed:8855285).Curated	1
Sequence conflictⁱ	524	G → D in AAC50771 (PubMed:8855285).Curated	1
Sequence conflictⁱ	557	A → P in AAC50771 (PubMed:8855285).Curated	1
Sequence conflictⁱ	901 – 902	NY → IF in AAC50771 (PubMed:8855285).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_056207	69	A → S1 PublicationCorresponds to variant dbSNP:rs17339451Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003393	353 – 363	Missing in isoform 2. 4 PublicationsAdd BLAST		11

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U65533 mRNA Translation: AAC50771.1 U59323 mRNA Translation: AAC51140.1 D86988 mRNA Translation: BAA19664.2 Different initiation. AF074016 mRNA Translation: AAC26788.1 AC003972 Genomic DNA Translation: AAB94785.1 BC039817 mRNA Translation: AAH39817.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12386.1 [Q92900-2] CCDS74315.1 [Q92900-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001284478.1, NM_001297549.1 [Q92900-1] NP_002902.2, NM_002911.3 [Q92900-2]
UniGeneⁱ	Hs.515266

Genome annotation databases

Ensemblⁱ	ENST00000262803; ENSP00000262803; ENSG00000005007 [Q92900-2] ENST00000599848; ENSP00000470142; ENSG00000005007 [Q92900-1]
GeneIDⁱ	5976
KEGGⁱ	hsa:5976
UCSC genome browser More...UCSCⁱ	uc002nkf.4 human [Q92900-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92900	UPF1 regulator of nonsense transcripts homolog (Yeast), isoform CRA_a		HUMAN		1129	UniRef100_Q92900
UPF1 isoform 4		PANTR		1129
Uncharacterized protein		CALJA		1129
Uncharacterized protein		MACMU		1129
UPF1 isoform 2		PONAB		1129
+6
Q92900-2	UPF1 regulator of nonsense transcripts homolog (Yeast), isoform CRA_b		HUMAN		1118	UniRef100_A0A024R7L5
UPF1 isoform 1		PANTR		1118
Regulator of nonsense transcripts 1		CALJA		1118
Regulator of nonsense transcripts 1		MACMU		1118
Uncharacterized protein		Cebus capucinus imitator		1118
+2

Protein	Similar proteins		Species	Score	Length	Source
Q92900	Regulator of nonsense transcripts 1		MOUSE		1124	UniRef90_Q92900
UPF1 regulator of nonsense transcripts homolog (Yeast), isoform CRA_a		HUMAN		1129
UPF1 isoform 4		PANTR		1129
Uncharacterized protein		CALJA		1129
Uncharacterized protein		MACMU		1129
+490

Protein	Similar proteins		Species	Score	Length	Source
Q92900	Regulator of nonsense transcripts 1		MOUSE		1124	UniRef50_Q92900
UPF1 regulator of nonsense transcripts homolog (Yeast), isoform CRA_a		HUMAN		1129
UPF1 isoform 4		PANTR		1129
Uncharacterized protein		CALJA		1129
Uncharacterized protein		MACMU		1129
+523

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U65533 mRNA Translation: AAC50771.1 U59323 mRNA Translation: AAC51140.1 D86988 mRNA Translation: BAA19664.2 Different initiation. AF074016 mRNA Translation: AAC26788.1 AC003972 Genomic DNA Translation: AAB94785.1 BC039817 mRNA Translation: AAH39817.1
CCDSⁱ	CCDS12386.1 [Q92900-2] CCDS74315.1 [Q92900-1]
RefSeqⁱ	NP_001284478.1, NM_001297549.1 [Q92900-1] NP_002902.2, NM_002911.3 [Q92900-2]
UniGeneⁱ	Hs.515266

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2GJK	X-ray	2.60	A	295-925	[»]
	2GK6	X-ray	2.40	A/B	295-925	[»]
	2GK7	X-ray	2.80	A	295-925	[»]
	2IYK	X-ray	2.95	A/B	115-272	[»]
	2WJV	X-ray	2.85	A/B	115-925	[»]
	2WJY	X-ray	2.50	A	115-925	[»]
	2XZO	X-ray	2.40	A	295-925	[»]
	2XZP	X-ray	2.72	A	295-925	[»]
	6EJ5	X-ray	3.34	A	295-925	[»]
ProteinModelPortalⁱ	Q92900
SMRⁱ	Q92900
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111908, 250 interactors
CORUMⁱ	Q92900
DIPⁱ	DIP-29875N
IntActⁱ	Q92900, 123 interactors
MINTⁱ	Q92900
STRINGⁱ	9606.ENSP00000262803

PTM databases

iPTMnetⁱ	Q92900
PhosphoSitePlusⁱ	Q92900
SwissPalmⁱ	Q92900

Polymorphism and mutation databases

BioMutaⁱ	UPF1
DMDMⁱ	17380291

Proteomic databases

EPDⁱ	Q92900
MaxQBⁱ	Q92900
PaxDbⁱ	Q92900
PeptideAtlasⁱ	Q92900
PRIDEⁱ	Q92900
ProteomicsDBⁱ	75581 75582 [Q92900-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000262803; ENSP00000262803; ENSG00000005007 [Q92900-2] ENST00000599848; ENSP00000470142; ENSG00000005007 [Q92900-1]
GeneIDⁱ	5976
KEGGⁱ	hsa:5976
UCSCⁱ	uc002nkf.4 human [Q92900-1]

Organism-specific databases

CTDⁱ	5976
DisGeNETⁱ	5976
EuPathDBⁱ	HostDB:ENSG00000005007.12
GeneCardsⁱ	UPF1
HGNCⁱ	HGNC:9962 UPF1
HPAⁱ	HPA019587 HPA020857
MIMⁱ	601430 gene
neXtProtⁱ	NX_Q92900
OpenTargetsⁱ	ENSG00000005007
PharmGKBⁱ	PA34328
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1802 Eukaryota COG1112 LUCA
GeneTreeⁱ	ENSGT00800000124068
HOGENOMⁱ	HOG000205990
HOVERGENⁱ	HBG061556
InParanoidⁱ	Q92900
KOⁱ	K14326
OMAⁱ	QPCAAQN
OrthoDBⁱ	EOG091G01B6
PhylomeDBⁱ	Q92900
TreeFamⁱ	TF300554

Enzyme and pathway databases

Reactomeⁱ	R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORⁱ	Q92900

Miscellaneous databases

ChiTaRSⁱ	UPF1 human
EvolutionaryTraceⁱ	Q92900
GeneWikiⁱ	UPF1
GenomeRNAiⁱ	5976
Protein Ontology More...PROⁱ	PR:Q92900
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000005007 Expressed in 210 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_UPF1
ExpressionAtlasⁱ	Q92900 baseline and differential
Genevisibleⁱ	Q92900 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006935 Helicase/UvrB_N IPR027417 P-loop_NTPase IPR018999 RNA-helicase_UPF1_UPF2-interct
Pfamⁱ	View protein in Pfam PF04851 ResIII, 1 hit PF09416 UPF1_Zn_bind, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RENT1_HUMAN
Accessionⁱ	Q92900Primary (citable) accession number: Q92900 Secondary accession number(s): O00239 , O43343, Q86Z25, Q92842
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
	Last sequence update:	October 18, 2001
	Last modified:	November 7, 2018
	This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q92900 (RENT1_HUMAN)

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Regulator of nonsense transcripts 1

UPF1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ