UniProtKB - Q92900 (RENT1_HUMAN)
Regulator of nonsense transcripts 1
UPF1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 486 | ATP | 1 | |
Binding sitei | 676 | ATP | 1 | |
Binding sitei | 713 | ATP | 1 | |
Binding sitei | 844 | ATP | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 121 – 272 | UPF1-typeAdd BLAST | 152 | |
Nucleotide bindingi | 506 – 510 | ATP | 5 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- chromatin binding Source: HGNC-UCL
- helicase activity Source: UniProtKB
- RNA binding Source: UniProtKB
- RNA helicase activity Source: UniProtKB
- telomeric DNA binding Source: BHF-UCL
- zinc ion binding Source: InterPro
GO - Biological processi
- 3'-UTR-mediated mRNA destabilization Source: UniProtKB
- cell cycle phase transition Source: UniProtKB
- cellular response to interleukin-1 Source: UniProtKB
- cellular response to lipopolysaccharide Source: UniProtKB
- DNA repair Source: HGNC-UCL
- DNA replication Source: HGNC-UCL
- dosage compensation by inactivation of X chromosome Source: Ensembl
- histone mRNA catabolic process Source: UniProtKB
- mRNA export from nucleus Source: HGNC-UCL
- nuclear-transcribed mRNA catabolic process Source: UniProtKB
- nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay Source: UniProtKB
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
- positive regulation of mRNA catabolic process Source: UniProtKB
- regulation of telomere maintenance Source: BHF-UCL
- regulation of translational termination Source: UniProtKB
- telomere maintenance via semi-conservative replication Source: BHF-UCL
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Helicase, Hydrolase, RNA-binding |
Biological process | Host-virus interaction, Nonsense-mediated mRNA decay |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q92900 |
Reactomei | R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | Q92900 |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of nonsense transcripts 1 (EC:3.6.4.-)Alternative name(s): ATP-dependent helicase RENT1 Nonsense mRNA reducing factor 1 Short name: NORF1 Up-frameshift suppressor 1 homolog Short name: hUpf1 |
Gene namesi | Name:UPF1 Synonyms:KIAA0221, RENT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9962, UPF1 |
MIMi | 601430, gene |
neXtProti | NX_Q92900 |
VEuPathDBi | HostDB:ENSG00000005007.12 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- exon-exon junction complex Source: UniProtKB
- nuclear chromosome, telomeric region Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- supraspliceosomal complex Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 126 | C → S: Abolishes ability to interact with UPF2/RENT2 and copurifies with greater amounts of SMG1, SMG8 and SMG9. 2 Publications | 1 | |
Mutagenesisi | 506 – 508 | GTG → RTE: Prevents dephosphorylation and targets the protein to the P-body. 1 Publication | 3 | |
Mutagenesisi | 509 | K → A: Inhibits histone mRNA degradation, ATPase activity and ATP binding. 3 Publications | 1 | |
Mutagenesisi | 610 – 611 | KR → AA: Impairs RNA binding. | 2 | |
Mutagenesisi | 615 | R → A: Impairs RNA binding. 1 Publication | 1 | |
Mutagenesisi | 647 – 648 | DE → AA: Loss of ATPase activity and helicase activity. 2 Publications | 2 | |
Mutagenesisi | 647 – 648 | DE → AA: Loss of ATPase activity and helicase activity. Inhibits ZC3H12A-mediated IL6 mRNA degradation. 3 Publications | 2 | |
Mutagenesisi | 676 | Q → A: Impairs ATPase activity, no effect on ATP binding. 1 Publication | 1 | |
Mutagenesisi | 714 | R → A: Impairs ATPase activity and ATP binding. 1 Publication | 1 | |
Mutagenesisi | 843 | R → A: Inhibits histone mRNA degradation. 2 Publications | 1 | |
Mutagenesisi | 843 | R → C: Abolishes NMD. 2 Publications | 1 | |
Mutagenesisi | 876 | R → A: Impairs ATPase activity and ATP binding. 1 Publication | 1 | |
Mutagenesisi | 1084 | S → A: Impairs association with UPF2, SMG1 and SMG7 and impairs phosphorylation; when associated with A-1089, A-1107 and A-1127. 1 Publication | 1 | |
Mutagenesisi | 1089 | S → A: Impairs association with UPF2, SMG1 and SMG7 and impairs phosphorylation; when associated with A-1084, A-1107 and A-1127. 2 Publications | 1 | |
Mutagenesisi | 1089 | S → A: Still phosphorylated but with less efficiency. 2 Publications | 1 | |
Mutagenesisi | 1107 | S → A: Impairs association with UPF2, SMG1 and SMG7 and impairs phosphorylation; when associated with A-1084, A-1089 and A-1127. 2 Publications | 1 | |
Mutagenesisi | 1107 | S → A: Impairs phosphorylation. 2 Publications | 1 | |
Mutagenesisi | 1108 | Q → N: Impairs phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 1127 | S → A: Impairs association with UPF2, SMG1 and SMG7 and impairs phosphorylation; when associated with A-1084, A-1089 and A-1107. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5976 |
OpenTargetsi | ENSG00000005007 |
PharmGKBi | PA34328 |
Miscellaneous databases
Pharosi | Q92900, Tbio |
Genetic variation databases
BioMutai | UPF1 |
DMDMi | 17380291 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080716 | 1 – 1129 | Regulator of nonsense transcripts 1Add BLAST | 1129 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | PhosphoserineCombined sources | 1 | |
Modified residuei | 31 | PhosphoserineCombined sources | 1 | |
Modified residuei | 565 | PhosphoserineCombined sources | 1 | |
Modified residuei | 956 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1019 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 1089 | Phosphoserine2 Publications | 1 | |
Modified residuei | 1107 | PhosphoserineCombined sources2 Publications | 1 | |
Modified residuei | 1110 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1127 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q92900 |
jPOSTi | Q92900 |
MassIVEi | Q92900 |
MaxQBi | Q92900 |
PaxDbi | Q92900 |
PeptideAtlasi | Q92900 |
PRIDEi | Q92900 |
ProteomicsDBi | 75581 [Q92900-1] 75582 [Q92900-2] |
PTM databases
iPTMneti | Q92900 |
MetOSitei | Q92900 |
PhosphoSitePlusi | Q92900 |
SwissPalmi | Q92900 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000005007, Expressed in stomach and 222 other tissues |
ExpressionAtlasi | Q92900, baseline and differential |
Genevisiblei | Q92900, HS |
Organism-specific databases
HPAi | ENSG00000005007, Low tissue specificity |
Interactioni
Subunit structurei
Found in a post-splicing messenger ribonucleoprotein (mRNP) complex (PubMed:21419344). Associates with the exon junction complex (EJC) (PubMed:11546874, PubMed:16452507). Associates with the SGM1C complex; is phosphorylated by the complex kinase component SGM1 (PubMed:19417104).
Interacts with UPF2 (PubMed:11163187, PubMed:11073994, PubMed:11113196, PubMed:19556969).
Interacts with UPF3A and UPF3B (PubMed:11163187).
Interacts with EST1A (PubMed:12554878).
Interacts with SLBP (PubMed:16086026).
Interacts (when hyperphosphorylated) with PNRC2 (PubMed:19150429).
Interacts with AGO1 and AGO2 (PubMed:17932509).
Interacts with GSPT2 (PubMed:18447585).
Interacts with isoform 1 and isoform 5 of ADAR/ADAR1 (PubMed:18362360).
Interacts with SMG7 (PubMed:15721257).
Interacts with ZC3H12A; this interaction occurs in a mRNA translationally active- and termination-dependent manner and is essential for ZC3H12A-mediated degradation of target mRNAs (PubMed:26000482).
Interacts with CPSF6 (PubMed:19864460).
Interacts with MOV10; the interaction is direct and RNA-dependent (PubMed:24726324).
Interacts with SHFL; the interaction increases in the presence of RNA (PubMed:27974568).
Interacts with UPF2 and DDX4; interactions are mediated by TDRD6 (By similarity).
By similarity19 Publications(Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein Tax; this interaction inhibits the host nonsense-mediated mRNA decay (NMD).
1 PublicationBinary interactionsi
Hide detailsQ92900
Isoform 2 [Q92900-2]
With | #Exp. | IntAct |
---|---|---|
EIF3A [Q14152] | 5 | EBI-373492,EBI-366617 |
SMG5 [Q9UPR3] | 2 | EBI-373492,EBI-3400861 |
SMG6 [Q86US8] | 2 | EBI-373492,EBI-3232100 |
UPF2 [Q9HAU5] | 9 | EBI-373492,EBI-372073 |
Protein-protein interaction databases
BioGRIDi | 111908, 302 interactors |
CORUMi | Q92900 |
DIPi | DIP-29875N |
IntActi | Q92900, 169 interactors |
MINTi | Q92900 |
STRINGi | 9606.ENSP00000470142 |
Miscellaneous databases
RNActi | Q92900, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q92900 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92900 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 415 | Sufficient for interaction with RENT2Add BLAST | 415 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1089 – 1090 | [ST]-Q motif 1 | 2 | |
Motifi | 1107 – 1108 | [ST]-Q motif 2 | 2 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 47 – 80 | Ala/Gly/Pro-richAdd BLAST | 34 | |
Compositional biasi | 1042 – 1129 | Gln/Ser-richAdd BLAST | 88 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 121 – 272 | UPF1-typeAdd BLAST | 152 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1802, Eukaryota |
GeneTreei | ENSGT00940000157413 |
HOGENOMi | CLU_001666_4_3_1 |
InParanoidi | Q92900 |
OMAi | DMKLMHG |
OrthoDBi | 62494at2759 |
PhylomeDBi | Q92900 |
TreeFami | TF300554 |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
IDEALi | IID00325 |
InterProi | View protein in InterPro IPR041679, DNA2/NAM7-like_C IPR041677, DNA2/NAM7_AAA_11 IPR040812, DUF5599 IPR006935, Helicase/UvrB_N IPR027417, P-loop_NTPase IPR018999, RNA-helicase_UPF1_UPF2-interct |
Pfami | View protein in Pfam PF13086, AAA_11, 1 hit PF13087, AAA_12, 1 hit PF18141, DUF5599, 1 hit PF04851, ResIII, 1 hit PF09416, UPF1_Zn_bind, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTPPGG
60 70 80 90 100
PGGPGGGGAG GPGGAGAGAA AGQLDAQVGP EGILQNGAVD DSVAKTSQLL
110 120 130 140 150
AELNFEEDEE DTYYTKDLPI HACSYCGIHD PACVVYCNTS KKWFCNGRGN
160 170 180 190 200
TSGSHIVNHL VRAKCKEVTL HKDGPLGETV LECYNCGCRN VFLLGFIPAK
210 220 230 240 250
ADSVVVLLCR QPCASQSSLK DINWDSSQWQ PLIQDRCFLS WLVKIPSEQE
260 270 280 290 300
QLRARQITAQ QINKLEELWK ENPSATLEDL EKPGVDEEPQ HVLLRYEDAY
310 320 330 340 350
QYQNIFGPLV KLEADYDKKL KESQTQDNIT VRWDLGLNKK RIAYFTLPKT
360 370 380 390 400
DSGNEDLVII WLRDMRLMQG DEICLRYKGD LAPLWKGIGH VIKVPDNYGD
410 420 430 440 450
EIAIELRSSV GAPVEVTHNF QVDFVWKSTS FDRMQSALKT FAVDETSVSG
460 470 480 490 500
YIYHKLLGHE VEDVIIKCQL PKRFTAQGLP DLNHSQVYAV KTVLQRPLSL
510 520 530 540 550
IQGPPGTGKT VTSATIVYHL ARQGNGPVLV CAPSNIAVDQ LTEKIHQTGL
560 570 580 590 600
KVVRLCAKSR EAIDSPVSFL ALHNQIRNMD SMPELQKLQQ LKDETGELSS
610 620 630 640 650
ADEKRYRALK RTAERELLMN ADVICCTCVG AGDPRLAKMQ FRSILIDEST
660 670 680 690 700
QATEPECMVP VVLGAKQLIL VGDHCQLGPV VMCKKAAKAG LSQSLFERLV
710 720 730 740 750
VLGIRPIRLQ VQYRMHPALS AFPSNIFYEG SLQNGVTAAD RVKKGFDFQW
760 770 780 790 800
PQPDKPMFFY VTQGQEEIAS SGTSYLNRTE AANVEKITTK LLKAGAKPDQ
810 820 830 840 850
IGIITPYEGQ RSYLVQYMQF SGSLHTKLYQ EVEIASVDAF QGREKDFIIL
860 870 880 890 900
SCVRANEHQG IGFLNDPRRL NVALTRARYG VIIVGNPKAL SKQPLWNHLL
910 920 930 940 950
NYYKEQKVLV EGPLNNLRES LMQFSKPRKL VNTINPGARF MTTAMYDARE
960 970 980 990 1000
AIIPGSVYDR SSQGRPSSMY FQTHDQIGMI SAGPSHVAAM NIPIPFNLVM
1010 1020 1030 1040 1050
PPMPPPGYFG QANGPAAGRG TPKGKTGRGG RQKNRFGLPG PSQTNLPNSQ
1060 1070 1080 1090 1100
ASQDVASQPF SQGALTQGYI SMSQPSQMSQ PGLSQPELSQ DSYLGDEFKS
1110 1120
QIDVALSQDS TYQGERAYQH GGVTGLSQY
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 | G → S in AAC51140 (PubMed:9064659).Curated | 1 | |
Sequence conflicti | 466 | I → T in AAC51140 (PubMed:9064659).Curated | 1 | |
Sequence conflicti | 478 | G → A in AAC50771 (PubMed:8855285).Curated | 1 | |
Sequence conflicti | 524 | G → D in AAC50771 (PubMed:8855285).Curated | 1 | |
Sequence conflicti | 557 | A → P in AAC50771 (PubMed:8855285).Curated | 1 | |
Sequence conflicti | 901 – 902 | NY → IF in AAC50771 (PubMed:8855285).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056207 | 69 | A → S1 PublicationCorresponds to variant dbSNP:rs17339451Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003393 | 353 – 363 | Missing in isoform 2. 4 PublicationsAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U65533 mRNA Translation: AAC50771.1 U59323 mRNA Translation: AAC51140.1 D86988 mRNA Translation: BAA19664.2 Different initiation. AF074016 mRNA Translation: AAC26788.1 AC003972 Genomic DNA Translation: AAB94785.1 BC039817 mRNA Translation: AAH39817.1 |
CCDSi | CCDS12386.1 [Q92900-2] CCDS74315.1 [Q92900-1] |
RefSeqi | NP_001284478.1, NM_001297549.1 [Q92900-1] NP_002902.2, NM_002911.3 [Q92900-2] |
Genome annotation databases
Ensembli | ENST00000262803; ENSP00000262803; ENSG00000005007 [Q92900-2] ENST00000599848; ENSP00000470142; ENSG00000005007 [Q92900-1] |
GeneIDi | 5976 |
KEGGi | hsa:5976 |
UCSCi | uc002nkf.4, human [Q92900-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U65533 mRNA Translation: AAC50771.1 U59323 mRNA Translation: AAC51140.1 D86988 mRNA Translation: BAA19664.2 Different initiation. AF074016 mRNA Translation: AAC26788.1 AC003972 Genomic DNA Translation: AAB94785.1 BC039817 mRNA Translation: AAH39817.1 |
CCDSi | CCDS12386.1 [Q92900-2] CCDS74315.1 [Q92900-1] |
RefSeqi | NP_001284478.1, NM_001297549.1 [Q92900-1] NP_002902.2, NM_002911.3 [Q92900-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2GJK | X-ray | 2.60 | A | 295-925 | [»] | |
2GK6 | X-ray | 2.40 | A/B | 295-925 | [»] | |
2GK7 | X-ray | 2.80 | A | 295-925 | [»] | |
2IYK | X-ray | 2.95 | A/B | 115-272 | [»] | |
2WJV | X-ray | 2.85 | A/B | 115-925 | [»] | |
2WJY | X-ray | 2.50 | A | 115-925 | [»] | |
2XZO | X-ray | 2.40 | A | 295-925 | [»] | |
2XZP | X-ray | 2.72 | A | 295-925 | [»] | |
6EJ5 | X-ray | 3.34 | A | 295-925 | [»] | |
6Z3R | electron microscopy | 2.97 | E | 1085-1095 | [»] | |
SMRi | Q92900 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111908, 302 interactors |
CORUMi | Q92900 |
DIPi | DIP-29875N |
IntActi | Q92900, 169 interactors |
MINTi | Q92900 |
STRINGi | 9606.ENSP00000470142 |
PTM databases
iPTMneti | Q92900 |
MetOSitei | Q92900 |
PhosphoSitePlusi | Q92900 |
SwissPalmi | Q92900 |
Genetic variation databases
BioMutai | UPF1 |
DMDMi | 17380291 |
Proteomic databases
EPDi | Q92900 |
jPOSTi | Q92900 |
MassIVEi | Q92900 |
MaxQBi | Q92900 |
PaxDbi | Q92900 |
PeptideAtlasi | Q92900 |
PRIDEi | Q92900 |
ProteomicsDBi | 75581 [Q92900-1] 75582 [Q92900-2] |
Protocols and materials databases
Antibodypediai | 15175, 316 antibodies |
Genome annotation databases
Ensembli | ENST00000262803; ENSP00000262803; ENSG00000005007 [Q92900-2] ENST00000599848; ENSP00000470142; ENSG00000005007 [Q92900-1] |
GeneIDi | 5976 |
KEGGi | hsa:5976 |
UCSCi | uc002nkf.4, human [Q92900-1] |
Organism-specific databases
CTDi | 5976 |
DisGeNETi | 5976 |
GeneCardsi | UPF1 |
HGNCi | HGNC:9962, UPF1 |
HPAi | ENSG00000005007, Low tissue specificity |
MIMi | 601430, gene |
neXtProti | NX_Q92900 |
OpenTargetsi | ENSG00000005007 |
PharmGKBi | PA34328 |
VEuPathDBi | HostDB:ENSG00000005007.12 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1802, Eukaryota |
GeneTreei | ENSGT00940000157413 |
HOGENOMi | CLU_001666_4_3_1 |
InParanoidi | Q92900 |
OMAi | DMKLMHG |
OrthoDBi | 62494at2759 |
PhylomeDBi | Q92900 |
TreeFami | TF300554 |
Enzyme and pathway databases
PathwayCommonsi | Q92900 |
Reactomei | R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | Q92900 |
Miscellaneous databases
BioGRID-ORCSi | 5976, 744 hits in 886 CRISPR screens |
ChiTaRSi | UPF1, human |
EvolutionaryTracei | Q92900 |
GeneWikii | UPF1 |
GenomeRNAii | 5976 |
Pharosi | Q92900, Tbio |
PROi | PR:Q92900 |
RNActi | Q92900, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000005007, Expressed in stomach and 222 other tissues |
ExpressionAtlasi | Q92900, baseline and differential |
Genevisiblei | Q92900, HS |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
IDEALi | IID00325 |
InterProi | View protein in InterPro IPR041679, DNA2/NAM7-like_C IPR041677, DNA2/NAM7_AAA_11 IPR040812, DUF5599 IPR006935, Helicase/UvrB_N IPR027417, P-loop_NTPase IPR018999, RNA-helicase_UPF1_UPF2-interct |
Pfami | View protein in Pfam PF13086, AAA_11, 1 hit PF13087, AAA_12, 1 hit PF18141, DUF5599, 1 hit PF04851, ResIII, 1 hit PF09416, UPF1_Zn_bind, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RENT1_HUMAN | |
Accessioni | Q92900Primary (citable) accession number: Q92900 Secondary accession number(s): O00239 Q92842 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | October 18, 2001 | |
Last modified: | February 10, 2021 | |
This is version 210 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families