Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 96 (29 Sep 2021)
Sequence version 2 (05 Jul 2004)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

BRCA1

Gene

BRCA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
BRCA1Imported
Submitted name:
BRCA1 proteinImported
Submitted name:
Breast cancer 1Imported
Submitted name:
Breast cancer type 1 susceptibility proteinImported
Submitted name:
Truncated breast and ovarian cancer susceptibility protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRCA1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q92897

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q92897-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
MDLSALRVEE VQNVINAMQK ILECPI
Length:26
Mass (Da):2,958
Last modified:July 5, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD9552E2FA0FCF38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei26Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U61268 Genomic DNA Translation: AAB40910.1
U37574 Genomic DNA Translation: AAC50330.1
MG494337 Genomic DNA Translation: AYD59804.1
MH046834 Genomic DNA Translation: AYD91265.1
MH046835 Genomic DNA Translation: AYD91266.1
MH046836 Genomic DNA Translation: AYD91267.1
MH043202 Genomic DNA Translation: AZL94785.1
MH043203 Genomic DNA Translation: AZL94786.1
MH043204 Genomic DNA Translation: AZL94787.1
MH043205 Genomic DNA Translation: AZL94788.1
MH043206 Genomic DNA Translation: AZL94789.1
MH043207 Genomic DNA Translation: AZL94790.1
MH043208 Genomic DNA Translation: AZL94791.1
MH043209 Genomic DNA Translation: AZL94792.1
MH043210 Genomic DNA Translation: AZL94793.1
MH043211 Genomic DNA Translation: AZL94794.1
MH043212 Genomic DNA Translation: AZL94795.1
MH043214 Genomic DNA Translation: AZL94797.1
MH043215 Genomic DNA Translation: AZL94798.1
MH043216 Genomic DNA Translation: AZL94799.1
MH043217 Genomic DNA Translation: AZL94800.1
MH043218 Genomic DNA Translation: AZL94801.1
MH043219 Genomic DNA Translation: AZL94802.1
MH043221 Genomic DNA Translation: AZL94803.1
MH043222 Genomic DNA Translation: AZL94804.1
MH043223 Genomic DNA Translation: AZL94805.1
MH043224 Genomic DNA Translation: AZL94806.1
MH043225 Genomic DNA Translation: AZL94807.1
MH043226 Genomic DNA Translation: AZL94808.1
MH043227 Genomic DNA Translation: AZL94809.1
MH043228 Genomic DNA Translation: AZL94810.1
MH043229 Genomic DNA Translation: AZL94811.1
MH043230 Genomic DNA Translation: AZL94812.1
MH043231 Genomic DNA Translation: AZL94813.1
MH043232 Genomic DNA Translation: AZL94814.1
MH043233 Genomic DNA Translation: AZL94815.1
MH043234 Genomic DNA Translation: AZL94816.1
MH043235 Genomic DNA Translation: AZL94817.1
MH043236 Genomic DNA Translation: AZL94818.1
MH043237 Genomic DNA Translation: AZL94819.1
MH043238 Genomic DNA Translation: AZL94820.1
MH043239 Genomic DNA Translation: AZL94821.1
MH043241 Genomic DNA Translation: AZL94822.1
MH043242 Genomic DNA Translation: AZL94823.1
MH043243 Genomic DNA Translation: AZL94824.1
MH043244 Genomic DNA Translation: AZL94825.1
MH043245 Genomic DNA Translation: AZL94826.1
MH043246 Genomic DNA Translation: AZL94827.1
MH043247 Genomic DNA Translation: AZL94828.1
MH043248 Genomic DNA Translation: AZL94829.1
MH043249 Genomic DNA Translation: AZL94830.1
MH043250 Genomic DNA Translation: AZL94831.1
MH043251 Genomic DNA Translation: AZL94832.1
MH043252 Genomic DNA Translation: AZL94833.1
MH043253 Genomic DNA Translation: AZL94834.1
MH043254 Genomic DNA Translation: AZL94835.1
MH043255 Genomic DNA Translation: AZL94836.1
MH043256 Genomic DNA Translation: AZL94837.1
MH043257 Genomic DNA Translation: AZL94838.1
MH043258 Genomic DNA Translation: AZL94839.1
MH043259 Genomic DNA Translation: AZL94840.1
MH043260 Genomic DNA Translation: AZL94841.1
MH043261 Genomic DNA Translation: AZL94842.1
MH043262 Genomic DNA Translation: AZL94843.1
MH043263 Genomic DNA Translation: AZL94844.1
MN968555 Genomic DNA Translation: QPB71858.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61268 Genomic DNA Translation: AAB40910.1
U37574 Genomic DNA Translation: AAC50330.1
MG494337 Genomic DNA Translation: AYD59804.1
MH046834 Genomic DNA Translation: AYD91265.1
MH046835 Genomic DNA Translation: AYD91266.1
MH046836 Genomic DNA Translation: AYD91267.1
MH043202 Genomic DNA Translation: AZL94785.1
MH043203 Genomic DNA Translation: AZL94786.1
MH043204 Genomic DNA Translation: AZL94787.1
MH043205 Genomic DNA Translation: AZL94788.1
MH043206 Genomic DNA Translation: AZL94789.1
MH043207 Genomic DNA Translation: AZL94790.1
MH043208 Genomic DNA Translation: AZL94791.1
MH043209 Genomic DNA Translation: AZL94792.1
MH043210 Genomic DNA Translation: AZL94793.1
MH043211 Genomic DNA Translation: AZL94794.1
MH043212 Genomic DNA Translation: AZL94795.1
MH043214 Genomic DNA Translation: AZL94797.1
MH043215 Genomic DNA Translation: AZL94798.1
MH043216 Genomic DNA Translation: AZL94799.1
MH043217 Genomic DNA Translation: AZL94800.1
MH043218 Genomic DNA Translation: AZL94801.1
MH043219 Genomic DNA Translation: AZL94802.1
MH043221 Genomic DNA Translation: AZL94803.1
MH043222 Genomic DNA Translation: AZL94804.1
MH043223 Genomic DNA Translation: AZL94805.1
MH043224 Genomic DNA Translation: AZL94806.1
MH043225 Genomic DNA Translation: AZL94807.1
MH043226 Genomic DNA Translation: AZL94808.1
MH043227 Genomic DNA Translation: AZL94809.1
MH043228 Genomic DNA Translation: AZL94810.1
MH043229 Genomic DNA Translation: AZL94811.1
MH043230 Genomic DNA Translation: AZL94812.1
MH043231 Genomic DNA Translation: AZL94813.1
MH043232 Genomic DNA Translation: AZL94814.1
MH043233 Genomic DNA Translation: AZL94815.1
MH043234 Genomic DNA Translation: AZL94816.1
MH043235 Genomic DNA Translation: AZL94817.1
MH043236 Genomic DNA Translation: AZL94818.1
MH043237 Genomic DNA Translation: AZL94819.1
MH043238 Genomic DNA Translation: AZL94820.1
MH043239 Genomic DNA Translation: AZL94821.1
MH043241 Genomic DNA Translation: AZL94822.1
MH043242 Genomic DNA Translation: AZL94823.1
MH043243 Genomic DNA Translation: AZL94824.1
MH043244 Genomic DNA Translation: AZL94825.1
MH043245 Genomic DNA Translation: AZL94826.1
MH043246 Genomic DNA Translation: AZL94827.1
MH043247 Genomic DNA Translation: AZL94828.1
MH043248 Genomic DNA Translation: AZL94829.1
MH043249 Genomic DNA Translation: AZL94830.1
MH043250 Genomic DNA Translation: AZL94831.1
MH043251 Genomic DNA Translation: AZL94832.1
MH043252 Genomic DNA Translation: AZL94833.1
MH043253 Genomic DNA Translation: AZL94834.1
MH043254 Genomic DNA Translation: AZL94835.1
MH043255 Genomic DNA Translation: AZL94836.1
MH043256 Genomic DNA Translation: AZL94837.1
MH043257 Genomic DNA Translation: AZL94838.1
MH043258 Genomic DNA Translation: AZL94839.1
MH043259 Genomic DNA Translation: AZL94840.1
MH043260 Genomic DNA Translation: AZL94841.1
MH043261 Genomic DNA Translation: AZL94842.1
MH043262 Genomic DNA Translation: AZL94843.1
MH043263 Genomic DNA Translation: AZL94844.1
MN968555 Genomic DNA Translation: QPB71858.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ92897

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BRCA1, human

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ92897_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92897
Secondary accession number(s): Q93056
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again