UniProtKB - Q92889 (XPF_HUMAN)
Protein
DNA repair endonuclease XPF
Gene
ERCC4
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.1 Publication
Cofactori
GO - Molecular functioni
- damaged DNA binding Source: UniProtKB
- endodeoxyribonuclease activity Source: UniProtKB
- identical protein binding Source: IntAct
- promoter-specific chromatin binding Source: Ensembl
- protein C-terminus binding Source: UniProtKB
- protein N-terminus binding Source: UniProtKB
- single-stranded DNA binding Source: UniProtKB
- single-stranded DNA endodeoxyribonuclease activity Source: GO_Central
- TFIID-class transcription factor complex binding Source: Ensembl
GO - Biological processi
- cellular response to UV Source: BHF-UCL
- DNA repair Source: UniProtKB
- double-strand break repair via homologous recombination Source: UniProtKB
- double-strand break repair via nonhomologous end joining Source: BHF-UCL
- global genome nucleotide-excision repair Source: Reactome
- interstrand cross-link repair Source: Reactome
- negative regulation of double-stranded telomeric DNA binding Source: BHF-UCL
- negative regulation of protection from non-homologous end joining at telomere Source: BHF-UCL
- negative regulation of telomerase activity Source: GOC
- negative regulation of telomere maintenance Source: UniProtKB
- negative regulation of telomere maintenance via telomere lengthening Source: BHF-UCL
- nucleotide-excision repair Source: MGI
- nucleotide-excision repair, DNA incision Source: UniProtKB
- nucleotide-excision repair, DNA incision, 3'-to lesion Source: UniProtKB
- nucleotide-excision repair, DNA incision, 5'-to lesion Source: UniProtKB
- nucleotide-excision repair, preincision complex stabilization Source: Reactome
- nucleotide-excision repair involved in interstrand cross-link repair Source: GO_Central
- regulation of autophagy Source: Ensembl
- resolution of meiotic recombination intermediates Source: GO_Central
- response to UV Source: UniProtKB
- telomere maintenance Source: BHF-UCL
- telomeric DNA-containing double minutes formation Source: BHF-UCL
- transcription-coupled nucleotide-excision repair Source: Reactome
- UV protection Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Endonuclease, Hydrolase, Nuclease |
Biological process | DNA damage, DNA repair |
Ligand | Magnesium |
Enzyme and pathway databases
PathwayCommonsi | Q92889 |
Reactomei | R-HSA-5685938, HDR through Single Strand Annealing (SSA) R-HSA-5696395, Formation of Incision Complex in GG-NER R-HSA-5696400, Dual Incision in GG-NER R-HSA-6782135, Dual incision in TC-NER R-HSA-6783310, Fanconi Anemia Pathway |
SIGNORi | Q92889 |
Names & Taxonomyi
Protein namesi | Recommended name: DNA repair endonuclease XPF (EC:3.1.-.-)Alternative name(s): DNA excision repair protein ERCC-4 DNA repair protein complementing XP-F cells Xeroderma pigmentosum group F-complementing protein |
Gene namesi | Name:ERCC4 Synonyms:ERCC11, XPF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3436, ERCC4 |
MIMi | 133520, gene |
neXtProti | NX_Q92889 |
VEuPathDBi | HostDB:ENSG00000175595.14 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- ERCC4-ERCC1 complex Source: BHF-UCL
- nucleoplasm Source: Reactome
- nucleotide-excision repair complex Source: MGI
- nucleotide-excision repair factor 1 complex Source: UniProtKB
- nucleus Source: UniProtKB
Other locations
- chromosome, telomeric region Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Xeroderma pigmentosum complementation group F (XP-F)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. XP-F patients show a mild phenotype.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_008200 | 225 | I → M in XP-F. 1 PublicationCorresponds to variant dbSNP:rs764731249Ensembl. | 1 | |
Natural variantiVAR_008201 | 454 | R → W in XP-F. 1 Publication | 1 | |
Natural variantiVAR_008202 | 490 | R → Q in XP-F. 1 PublicationCorresponds to variant dbSNP:rs912480692Ensembl. | 1 | |
Natural variantiVAR_008203 | 502 | E → K in XP-F. 1 Publication | 1 | |
Natural variantiVAR_008204 | 513 | G → R in XP-F. 1 PublicationCorresponds to variant dbSNP:rs769679311Ensembl. | 1 | |
Natural variantiVAR_008205 | 529 | I → T in XP-F. 1 Publication | 1 | |
Natural variantiVAR_008206 | 567 | T → A in XP-F. 1 Publication | 1 | |
Natural variantiVAR_008207 | 605 – 611 | Missing in XP-F. 1 Publication | 7 | |
Natural variantiVAR_013398 | 608 | L → P in XP-F. 1 Publication | 1 | |
Natural variantiVAR_005850 | 799 | R → W in XP-F; mild; significant residual repair activity. 2 PublicationsCorresponds to variant dbSNP:rs121913049EnsemblClinVar. | 1 |
XFE progeroid syndrome (XFEPS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by aged bird-like facies, lack of subcutaneous fat, dwarfism, cachexia and microcephaly. Additional features include sun-sensitivity from birth, learning disabilities, hearing loss, and visual impairment.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034802 | 153 | R → P in XFEPS. 1 PublicationCorresponds to variant dbSNP:rs121913050EnsemblClinVar. | 1 |
Xeroderma pigmentosum type F/Cockayne syndrome (XPF/CS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA variant form of Cockayne syndrome, a disorder characterized by growth retardation, microcephaly, impairment of nervous system development, pigmentary retinopathy, peculiar facies, and progeria together with abnormal skin photosensitivity. Cockayne syndrome dermatological features are milder than those in xeroderma pigmentosum and skin cancers are not found in affected individuals. XPF/CS patients, however, present with severe skin phenotypes, including severe photosensitivity, abnormal skin pigmentation, and skin cancer predisposition.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070087 | 236 | C → R in XPF/CS. 1 PublicationCorresponds to variant dbSNP:rs397509403EnsemblClinVar. | 1 | |
Natural variantiVAR_070088 | 589 | R → W in XPF/CS. 1 PublicationCorresponds to variant dbSNP:rs147105770EnsemblClinVar. | 1 |
Fanconi anemia complementation group Q (FANCQ)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070086 | 230 | L → P in FANCQ. 1 PublicationCorresponds to variant dbSNP:rs397509402EnsemblClinVar. | 1 | |
Natural variantiVAR_070089 | 689 | R → S in FANCQ; disruption of interstrand cross-link repair activity; no effect on protein stability. 2 PublicationsCorresponds to variant dbSNP:rs149364215EnsemblClinVar. | 1 | |
Natural variantiVAR_072087 | 786 | S → F in FANCQ; disruption of interstrand cross-link repair activity; no effect on protein stability. 1 PublicationCorresponds to variant dbSNP:rs1451008479Ensembl. | 1 |
Keywords - Diseasei
Cockayne syndrome, Disease variant, Dwarfism, Fanconi anemia, Xeroderma pigmentosumOrganism-specific databases
DisGeNETi | 2072 |
GeneReviewsi | ERCC4 |
MalaCardsi | ERCC4 |
MIMi | 278760, phenotype 610965, phenotype 615272, phenotype |
OpenTargetsi | ENSG00000175595 |
Orphaneti | 90321, Cockayne syndrome type 1 84, Fanconi anemia 910, Xeroderma pigmentosum 220295, Xeroderma pigmentosum-Cockayne syndrome complex |
PharmGKBi | PA27850 |
Miscellaneous databases
Pharosi | Q92889, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3883316 |
Genetic variation databases
BioMutai | ERCC4 |
DMDMi | 229463004 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000198853 | 1 – 916 | DNA repair endonuclease XPFAdd BLAST | 916 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 289 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 500 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 521 | PhosphoserineBy similarity | 1 | |
Modified residuei | 764 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q92889 |
jPOSTi | Q92889 |
MassIVEi | Q92889 |
MaxQBi | Q92889 |
PaxDbi | Q92889 |
PeptideAtlasi | Q92889 |
PRIDEi | Q92889 |
ProteomicsDBi | 722 75575 [Q92889-1] |
PTM databases
iPTMneti | Q92889 |
MetOSitei | Q92889 |
PhosphoSitePlusi | Q92889 |
Expressioni
Gene expression databases
Bgeei | ENSG00000175595, Expressed in adrenal tissue and 199 other tissues |
ExpressionAtlasi | Q92889, baseline and differential |
Genevisiblei | Q92889, HS |
Organism-specific databases
HPAi | ENSG00000175595, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer composed of ERCC1 and ERCC4/XPF.
Interacts with SLX4/BTBD12; this interaction is direct and links the ERCC1-ERCC4/XPF complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair.
7 PublicationsBinary interactionsi
Hide detailsQ92889
With | #Exp. | IntAct |
---|---|---|
ERCC1 [P07992] | 13 | EBI-2370770,EBI-750962 |
itself | 2 | EBI-2370770,EBI-2370770 |
SLX4 [Q8IY92] | 10 | EBI-2370770,EBI-2370740 |
TACC1 - isoform 7 [O75410-7] | 3 | EBI-2370770,EBI-12007872 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein C-terminus binding Source: UniProtKB
- protein N-terminus binding Source: UniProtKB
- TFIID-class transcription factor complex binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108384, 56 interactors |
ComplexPortali | CPX-478, ERCC1-XPF endonuclease complex |
CORUMi | Q92889 |
DIPi | DIP-42006N |
IntActi | Q92889, 28 interactors |
MINTi | Q92889 |
STRINGi | 9606.ENSP00000310520 |
Miscellaneous databases
RNActi | Q92889, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q92889 |
SMRi | Q92889 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92889 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 683 – 763 | ERCC4Add BLAST | 81 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 457 | Helicase-likeAdd BLAST | 457 | |
Regioni | 233 – 254 | Leucine-zipper 1Add BLAST | 22 | |
Regioni | 270 – 298 | Leucine-zipper 2Add BLAST | 29 | |
Regioni | 658 – 813 | NucleaseAdd BLAST | 156 | |
Regioni | 837 – 905 | HhH2, dimerization with ERCC1Add BLAST | 69 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 486 – 491 | Nuclear localization signalSequence analysis | 6 |
Sequence similaritiesi
Belongs to the XPF family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0442, Eukaryota |
GeneTreei | ENSGT00390000004394 |
HOGENOMi | CLU_002265_0_0_1 |
InParanoidi | Q92889 |
OMAi | FHKILQA |
OrthoDBi | 324863at2759 |
PhylomeDBi | Q92889 |
TreeFami | TF101234 |
Family and domain databases
InterProi | View protein in InterPro IPR006166, ERCC4_domain IPR011335, Restrct_endonuc-II-like IPR010994, RuvA_2-like IPR006167, XPF |
Pfami | View protein in Pfam PF02732, ERCC4, 1 hit |
SMARTi | View protein in SMART SM00891, ERCC4, 1 hit |
SUPFAMi | SSF47781, SSF47781, 1 hit SSF52980, SSF52980, 1 hit |
TIGRFAMsi | TIGR00596, rad1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q92889-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESGQPARRI AMAPLLEYER QLVLELLDTD GLVVCARGLG ADRLLYHFLQ
60 70 80 90 100
LHCHPACLVL VLNTQPAEEE YFINQLKIEG VEHLPRRVTN EITSNSRYEV
110 120 130 140 150
YTQGGVIFAT SRILVVDFLT DRIPSDLITG ILVYRAHRII ESCQEAFILR
160 170 180 190 200
LFRQKNKRGF IKAFTDNAVA FDTGFCHVER VMRNLFVRKL YLWPRFHVAV
210 220 230 240 250
NSFLEQHKPE VVEIHVSMTP TMLAIQTAIL DILNACLKEL KCHNPSLEVE
260 270 280 290 300
DLSLENAIGK PFDKTIRHYL DPLWHQLGAK TKSLVQDLKI LRTLLQYLSQ
310 320 330 340 350
YDCVTFLNLL ESLRATEKAF GQNSGWLFLD SSTSMFINAR ARVYHLPDAK
360 370 380 390 400
MSKKEKISEK MEIKEGEETK KELVLESNPK WEALTEVLKE IEAENKESEA
410 420 430 440 450
LGGPGQVLIC ASDDRTCSQL RDYITLGAEA FLLRLYRKTF EKDSKAEEVW
460 470 480 490 500
MKFRKEDSSK RIRKSHKRPK DPQNKERAST KERTLKKKKR KLTLTQMVGK
510 520 530 540 550
PEELEEEGDV EEGYRREISS SPESCPEEIK HEEFDVNLSS DAAFGILKEP
560 570 580 590 600
LTIIHPLLGC SDPYALTRVL HEVEPRYVVL YDAELTFVRQ LEIYRASRPG
610 620 630 640 650
KPLRVYFLIY GGSTEEQRYL TALRKEKEAF EKLIREKASM VVPEEREGRD
660 670 680 690 700
ETNLDLVRGT ASADVSTDTR KAGGQEQNGT QQSIVVDMRE FRSELPSLIH
710 720 730 740 750
RRGIDIEPVT LEVGDYILTP EMCVERKSIS DLIGSLNNGR LYSQCISMSR
760 770 780 790 800
YYKRPVLLIE FDPSKPFSLT SRGALFQEIS SNDISSKLTL LTLHFPRLRI
810 820 830 840 850
LWCPSPHATA ELFEELKQSK PQPDAATALA ITADSETLPE SEKYNPGPQD
860 870 880 890 900
FLLKMPGVNA KNCRSLMHHV KNIAELAALS QDELTSILGN AANAKQLYDF
910
IHTSFAEVVS KGKGKK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3NI48 | I3NI48_HUMAN | DNA repair endonuclease XPF | ERCC4 | 75 | Annotation score: | ||
I3L4K0 | I3L4K0_HUMAN | DNA repair endonuclease XPF | ERCC4 | 35 | Annotation score: |
Sequence cautioni
The sequence AAB07689 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057477 | 33 | V → L. Corresponds to variant dbSNP:rs34205098Ensembl. | 1 | |
Natural variantiVAR_072084 | 150 | R → C Rare functional variant; causes mild disruption of interstrand cross-link repair activity; partial loss of protein stability. 1 PublicationCorresponds to variant dbSNP:rs145402255Ensembl. | 1 | |
Natural variantiVAR_034802 | 153 | R → P in XFEPS. 1 PublicationCorresponds to variant dbSNP:rs121913050EnsemblClinVar. | 1 | |
Natural variantiVAR_014769 | 168 | A → V1 PublicationCorresponds to variant dbSNP:rs2020961EnsemblClinVar. | 1 | |
Natural variantiVAR_008200 | 225 | I → M in XP-F. 1 PublicationCorresponds to variant dbSNP:rs764731249Ensembl. | 1 | |
Natural variantiVAR_070086 | 230 | L → P in FANCQ. 1 PublicationCorresponds to variant dbSNP:rs397509402EnsemblClinVar. | 1 | |
Natural variantiVAR_070087 | 236 | C → R in XPF/CS. 1 PublicationCorresponds to variant dbSNP:rs397509403EnsemblClinVar. | 1 | |
Natural variantiVAR_072085 | 267 | R → H1 PublicationCorresponds to variant dbSNP:rs143479220Ensembl. | 1 | |
Natural variantiVAR_013395 | 379 | P → S2 PublicationsCorresponds to variant dbSNP:rs1799802EnsemblClinVar. | 1 | |
Natural variantiVAR_013396 | 415 | R → Q3 PublicationsCorresponds to variant dbSNP:rs1800067EnsemblClinVar. | 1 | |
Natural variantiVAR_008201 | 454 | R → W in XP-F. 1 Publication | 1 | |
Natural variantiVAR_008202 | 490 | R → Q in XP-F. 1 PublicationCorresponds to variant dbSNP:rs912480692Ensembl. | 1 | |
Natural variantiVAR_008203 | 502 | E → K in XP-F. 1 Publication | 1 | |
Natural variantiVAR_008204 | 513 | G → R in XP-F. 1 PublicationCorresponds to variant dbSNP:rs769679311Ensembl. | 1 | |
Natural variantiVAR_008205 | 529 | I → T in XP-F. 1 Publication | 1 | |
Natural variantiVAR_008206 | 567 | T → A in XP-F. 1 Publication | 1 | |
Natural variantiVAR_013397 | 576 | R → T1 PublicationCorresponds to variant dbSNP:rs1800068EnsemblClinVar. | 1 | |
Natural variantiVAR_070088 | 589 | R → W in XPF/CS. 1 PublicationCorresponds to variant dbSNP:rs147105770EnsemblClinVar. | 1 | |
Natural variantiVAR_008207 | 605 – 611 | Missing in XP-F. 1 Publication | 7 | |
Natural variantiVAR_013398 | 608 | L → P in XP-F. 1 Publication | 1 | |
Natural variantiVAR_072086 | 621 | T → A1 Publication | 1 | |
Natural variantiVAR_014770 | 662 | S → P1 PublicationCorresponds to variant dbSNP:rs2020955EnsemblClinVar. | 1 | |
Natural variantiVAR_070089 | 689 | R → S in FANCQ; disruption of interstrand cross-link repair activity; no effect on protein stability. 2 PublicationsCorresponds to variant dbSNP:rs149364215EnsemblClinVar. | 1 | |
Natural variantiVAR_005849 | 703 | G → D1 Publication | 1 | |
Natural variantiVAR_014771 | 706 | I → T1 PublicationCorresponds to variant dbSNP:rs1800069EnsemblClinVar. | 1 | |
Natural variantiVAR_013399 | 717 | I → T1 Publication | 1 | |
Natural variantiVAR_057478 | 768 | S → F. Corresponds to variant dbSNP:rs12928650Ensembl. | 1 | |
Natural variantiVAR_072087 | 786 | S → F in FANCQ; disruption of interstrand cross-link repair activity; no effect on protein stability. 1 PublicationCorresponds to variant dbSNP:rs1451008479Ensembl. | 1 | |
Natural variantiVAR_005850 | 799 | R → W in XP-F; mild; significant residual repair activity. 2 PublicationsCorresponds to variant dbSNP:rs121913049EnsemblClinVar. | 1 | |
Natural variantiVAR_057479 | 860 | A → D. Corresponds to variant dbSNP:rs4986933EnsemblClinVar. | 1 | |
Natural variantiVAR_019201 | 873 | I → V1 PublicationCorresponds to variant dbSNP:rs2020957EnsemblClinVar. | 1 | |
Natural variantiVAR_013408 | 875 | E → G2 PublicationsCorresponds to variant dbSNP:rs1800124EnsemblClinVar. | 1 | |
Natural variantiVAR_014772 | 912 | G → E. Corresponds to variant dbSNP:rs2020956Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056341 | 368 – 372 | ETKKE → GILWG in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_056342 | 373 – 916 | Missing in isoform 2. 1 PublicationAdd BLAST | 544 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L77890 Genomic DNA Translation: AAB50174.1 AF491814 Genomic DNA Translation: AAL91593.1 AK289726 mRNA Translation: BAF82415.1 AC010401 Genomic DNA No translation available. BC142631 mRNA Translation: AAI42632.1 U64315 mRNA Translation: AAB07689.1 Different initiation. |
CCDSi | CCDS32390.1 [Q92889-1] |
RefSeqi | NP_005227.1, NM_005236.2 [Q92889-1] |
Genome annotation databases
Ensembli | ENST00000311895; ENSP00000310520; ENSG00000175595 [Q92889-1] ENST00000575156; ENSP00000459933; ENSG00000175595 [Q92889-2] |
GeneIDi | 2072 |
KEGGi | hsa:2072 |
UCSCi | uc002dce.3, human [Q92889-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L77890 Genomic DNA Translation: AAB50174.1 AF491814 Genomic DNA Translation: AAL91593.1 AK289726 mRNA Translation: BAF82415.1 AC010401 Genomic DNA No translation available. BC142631 mRNA Translation: AAI42632.1 U64315 mRNA Translation: AAB07689.1 Different initiation. |
CCDSi | CCDS32390.1 [Q92889-1] |
RefSeqi | NP_005227.1, NM_005236.2 [Q92889-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Z00 | NMR | - | B | 834-916 | [»] | |
2A1J | X-ray | 2.70 | A | 848-909 | [»] | |
2AQ0 | NMR | - | A/B | 834-916 | [»] | |
2KN7 | NMR | - | A/D | 842-908 | [»] | |
2MUT | NMR | - | B | 834-916 | [»] | |
6SXA | electron microscopy | 3.60 | F | 1-916 | [»] | |
6SXB | electron microscopy | 7.90 | F | 1-916 | [»] | |
BMRBi | Q92889 | |||||
SMRi | Q92889 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108384, 56 interactors |
ComplexPortali | CPX-478, ERCC1-XPF endonuclease complex |
CORUMi | Q92889 |
DIPi | DIP-42006N |
IntActi | Q92889, 28 interactors |
MINTi | Q92889 |
STRINGi | 9606.ENSP00000310520 |
Chemistry databases
ChEMBLi | CHEMBL3883316 |
PTM databases
iPTMneti | Q92889 |
MetOSitei | Q92889 |
PhosphoSitePlusi | Q92889 |
Genetic variation databases
BioMutai | ERCC4 |
DMDMi | 229463004 |
Proteomic databases
EPDi | Q92889 |
jPOSTi | Q92889 |
MassIVEi | Q92889 |
MaxQBi | Q92889 |
PaxDbi | Q92889 |
PeptideAtlasi | Q92889 |
PRIDEi | Q92889 |
ProteomicsDBi | 722 75575 [Q92889-1] |
Protocols and materials databases
Antibodypediai | 24811, 505 antibodies |
DNASUi | 2072 |
Genome annotation databases
Ensembli | ENST00000311895; ENSP00000310520; ENSG00000175595 [Q92889-1] ENST00000575156; ENSP00000459933; ENSG00000175595 [Q92889-2] |
GeneIDi | 2072 |
KEGGi | hsa:2072 |
UCSCi | uc002dce.3, human [Q92889-1] |
Organism-specific databases
CTDi | 2072 |
DisGeNETi | 2072 |
GeneCardsi | ERCC4 |
GeneReviewsi | ERCC4 |
HGNCi | HGNC:3436, ERCC4 |
HPAi | ENSG00000175595, Low tissue specificity |
MalaCardsi | ERCC4 |
MIMi | 133520, gene 278760, phenotype 610965, phenotype 615272, phenotype |
neXtProti | NX_Q92889 |
OpenTargetsi | ENSG00000175595 |
Orphaneti | 90321, Cockayne syndrome type 1 84, Fanconi anemia 910, Xeroderma pigmentosum 220295, Xeroderma pigmentosum-Cockayne syndrome complex |
PharmGKBi | PA27850 |
VEuPathDBi | HostDB:ENSG00000175595.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0442, Eukaryota |
GeneTreei | ENSGT00390000004394 |
HOGENOMi | CLU_002265_0_0_1 |
InParanoidi | Q92889 |
OMAi | FHKILQA |
OrthoDBi | 324863at2759 |
PhylomeDBi | Q92889 |
TreeFami | TF101234 |
Enzyme and pathway databases
PathwayCommonsi | Q92889 |
Reactomei | R-HSA-5685938, HDR through Single Strand Annealing (SSA) R-HSA-5696395, Formation of Incision Complex in GG-NER R-HSA-5696400, Dual Incision in GG-NER R-HSA-6782135, Dual incision in TC-NER R-HSA-6783310, Fanconi Anemia Pathway |
SIGNORi | Q92889 |
Miscellaneous databases
BioGRID-ORCSi | 2072, 110 hits in 996 CRISPR screens |
EvolutionaryTracei | Q92889 |
GeneWikii | ERCC4 |
GenomeRNAii | 2072 |
Pharosi | Q92889, Tbio |
PROi | PR:Q92889 |
RNActi | Q92889, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175595, Expressed in adrenal tissue and 199 other tissues |
ExpressionAtlasi | Q92889, baseline and differential |
Genevisiblei | Q92889, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006166, ERCC4_domain IPR011335, Restrct_endonuc-II-like IPR010994, RuvA_2-like IPR006167, XPF |
Pfami | View protein in Pfam PF02732, ERCC4, 1 hit |
SMARTi | View protein in SMART SM00891, ERCC4, 1 hit |
SUPFAMi | SSF47781, SSF47781, 1 hit SSF52980, SSF52980, 1 hit |
TIGRFAMsi | TIGR00596, rad1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | XPF_HUMAN | |
Accessioni | Q92889Primary (citable) accession number: Q92889 Secondary accession number(s): A5PKV6 Q8TD83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 5, 2009 | |
Last modified: | April 7, 2021 | |
This is version 211 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families