Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q92889 (XPF_HUMAN)

Protein

DNA repair endonuclease XPF

Gene

ERCC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.1 Publication

Cofactori

Mg2+

GO - Molecular functioni

  • damaged DNA binding Source: UniProtKB
  • endodeoxyribonuclease activity Source: UniProtKB
  • identical protein binding Source: IntAct
  • protein C-terminus binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB
  • single-stranded DNA binding Source: UniProtKB
  • single-stranded DNA endodeoxyribonuclease activity Source: GO_Central
  • TFIID-class transcription factor complex binding Source: Ensembl
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandMagnesium

Enzyme and pathway databases

ReactomeiR-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6783310 Fanconi Anemia Pathway
SIGNORiQ92889

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair endonuclease XPF (EC:3.1.-.-)
Alternative name(s):
DNA excision repair protein ERCC-4
DNA repair protein complementing XP-F cells
Xeroderma pigmentosum group F-complementing protein
Gene namesi
Name:ERCC4
Synonyms:ERCC11, XPF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000175595.14
HGNCiHGNC:3436 ERCC4
MIMi133520 gene
neXtProtiNX_Q92889

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Xeroderma pigmentosum complementation group F (XP-F)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. XP-F patients show a mild phenotype.
See also OMIM:278760
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_008200225I → M in XP-F. 1 PublicationCorresponds to variant dbSNP:rs764731249Ensembl.1
Natural variantiVAR_008201454R → W in XP-F. 1 Publication1
Natural variantiVAR_008202490R → Q in XP-F. 1 PublicationCorresponds to variant dbSNP:rs912480692Ensembl.1
Natural variantiVAR_008203502E → K in XP-F. 1 Publication1
Natural variantiVAR_008204513G → R in XP-F. 1 PublicationCorresponds to variant dbSNP:rs769679311Ensembl.1
Natural variantiVAR_008205529I → T in XP-F. 1 Publication1
Natural variantiVAR_008206567T → A in XP-F. 1 Publication1
Natural variantiVAR_008207605 – 611Missing in XP-F. 1 Publication7
Natural variantiVAR_013398608L → P in XP-F. 1 Publication1
Natural variantiVAR_005850799R → W in XP-F; mild; significant residual repair activity. 2 PublicationsCorresponds to variant dbSNP:rs121913049EnsemblClinVar.1
XFE progeroid syndrome (XFEPS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by aged bird-like facies, lack of subcutaneous fat, dwarfism, cachexia and microcephaly. Additional features include sun-sensitivity from birth, learning disabilities, hearing loss, and visual impairment.
See also OMIM:610965
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034802153R → P in XFEPS. 1 PublicationCorresponds to variant dbSNP:rs121913050EnsemblClinVar.1
Xeroderma pigmentosum type F/Cockayne syndrome (XPF/CS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA variant form of Cockayne syndrome, a disorder characterized by growth retardation, microcephaly, impairment of nervous system development, pigmentary retinopathy, peculiar facies, and progeria together with abnormal skin photosensitivity. Cockayne syndrome dermatological features are milder than those in xeroderma pigmentosum and skin cancers are not found in affected individuals. XPF/CS patients, however, present with severe skin phenotypes, including severe photosensitivity, abnormal skin pigmentation, and skin cancer predisposition.
See also OMIM:278760
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070087236C → R in XPF/CS. 1 PublicationCorresponds to variant dbSNP:rs397509403EnsemblClinVar.1
Natural variantiVAR_070088589R → W in XPF/CS. 1 PublicationCorresponds to variant dbSNP:rs147105770EnsemblClinVar.1
Fanconi anemia complementation group Q (FANCQ)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
See also OMIM:615272
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070086230L → P in FANCQ. 1 PublicationCorresponds to variant dbSNP:rs397509402EnsemblClinVar.1
Natural variantiVAR_070089689R → S in FANCQ; disruption of interstrand cross-link repair activity; no effect on protein stability. 2 PublicationsCorresponds to variant dbSNP:rs149364215EnsemblClinVar.1
Natural variantiVAR_072087786S → F in FANCQ; disruption of interstrand cross-link repair activity; no effect on protein stability. 1 Publication1

Keywords - Diseasei

Cockayne syndrome, Disease mutation, Dwarfism, Fanconi anemia, Xeroderma pigmentosum

Organism-specific databases

DisGeNETi2072
GeneReviewsiERCC4
MalaCardsiERCC4
MIMi278760 phenotype
610965 phenotype
615272 phenotype
OpenTargetsiENSG00000175595
Orphaneti90321 Cockayne syndrome type 1
84 Fanconi anemia
910 Xeroderma pigmentosum
220295 Xeroderma pigmentosum-Cockayne syndrome complex
PharmGKBiPA27850

Chemistry databases

ChEMBLiCHEMBL3883316

Polymorphism and mutation databases

BioMutaiERCC4
DMDMi229463004

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988531 – 916DNA repair endonuclease XPFAdd BLAST916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei289N6-acetyllysineCombined sources1
Cross-linki500Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei521PhosphoserineBy similarity1
Modified residuei764PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ92889
MaxQBiQ92889
PaxDbiQ92889
PeptideAtlasiQ92889
PRIDEiQ92889
ProteomicsDBi75575

PTM databases

iPTMnetiQ92889
PhosphoSitePlusiQ92889

Expressioni

Gene expression databases

BgeeiENSG00000175595 Expressed in 183 organ(s), highest expression level in adrenal tissue
CleanExiHS_ERCC4
ExpressionAtlasiQ92889 baseline and differential
GenevisibleiQ92889 HS

Organism-specific databases

HPAiCAB000156
HPA045828

Interactioni

Subunit structurei

Heterodimer composed of ERCC1 and XPF/ERCC4. Interacts with SLX4/BTBD12; this interaction is direct and links the ERCC1-XPF/ERCC1 complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair.6 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi108384, 38 interactors
ComplexPortaliCPX-478 ERCC1-XPF endonuclease complex
CORUMiQ92889
DIPiDIP-42006N
IntActiQ92889, 20 interactors
MINTiQ92889
STRINGi9606.ENSP00000310520

Structurei

Secondary structure

1916
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92889
SMRiQ92889
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92889

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini683 – 763ERCC4Add BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 457Helicase-likeAdd BLAST457
Regioni233 – 254Leucine-zipper 1Add BLAST22
Regioni270 – 298Leucine-zipper 2Add BLAST29
Regioni658 – 813NucleaseAdd BLAST156
Regioni837 – 905HhH2, dimerization with ERCC1Add BLAST69

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi486 – 491Nuclear localization signalSequence analysis6

Sequence similaritiesi

Belongs to the XPF family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0442 Eukaryota
COG1948 LUCA
GeneTreeiENSGT00390000004394
HOGENOMiHOG000202204
HOVERGENiHBG051500
InParanoidiQ92889
KOiK10848
OMAiVENCVTK
OrthoDBiEOG091G0554
PhylomeDBiQ92889
TreeFamiTF101234

Family and domain databases

InterProiView protein in InterPro
IPR006166 ERCC4_domain
IPR011335 Restrct_endonuc-II-like
IPR010994 RuvA_2-like
IPR006167 XPF
PfamiView protein in Pfam
PF02732 ERCC4, 1 hit
SMARTiView protein in SMART
SM00891 ERCC4, 1 hit
SUPFAMiSSF47781 SSF47781, 1 hit
SSF52980 SSF52980, 1 hit
TIGRFAMsiTIGR00596 rad1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92889-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESGQPARRI AMAPLLEYER QLVLELLDTD GLVVCARGLG ADRLLYHFLQ 
        60         70         80         90        100
LHCHPACLVL VLNTQPAEEE YFINQLKIEG VEHLPRRVTN EITSNSRYEV 
       110        120        130        140        150
YTQGGVIFAT SRILVVDFLT DRIPSDLITG ILVYRAHRII ESCQEAFILR 
       160        170        180        190        200
LFRQKNKRGF IKAFTDNAVA FDTGFCHVER VMRNLFVRKL YLWPRFHVAV 
       210        220        230        240        250
NSFLEQHKPE VVEIHVSMTP TMLAIQTAIL DILNACLKEL KCHNPSLEVE 
       260        270        280        290        300
DLSLENAIGK PFDKTIRHYL DPLWHQLGAK TKSLVQDLKI LRTLLQYLSQ 
       310        320        330        340        350
YDCVTFLNLL ESLRATEKAF GQNSGWLFLD SSTSMFINAR ARVYHLPDAK 
       360        370        380        390        400
MSKKEKISEK MEIKEGEETK KELVLESNPK WEALTEVLKE IEAENKESEA 
       410        420        430        440        450
LGGPGQVLIC ASDDRTCSQL RDYITLGAEA FLLRLYRKTF EKDSKAEEVW 
       460        470        480        490        500
MKFRKEDSSK RIRKSHKRPK DPQNKERAST KERTLKKKKR KLTLTQMVGK 
       510        520        530        540        550
PEELEEEGDV EEGYRREISS SPESCPEEIK HEEFDVNLSS DAAFGILKEP 
       560        570        580        590        600
LTIIHPLLGC SDPYALTRVL HEVEPRYVVL YDAELTFVRQ LEIYRASRPG 
       610        620        630        640        650
KPLRVYFLIY GGSTEEQRYL TALRKEKEAF EKLIREKASM VVPEEREGRD 
       660        670        680        690        700
ETNLDLVRGT ASADVSTDTR KAGGQEQNGT QQSIVVDMRE FRSELPSLIH 
       710        720        730        740        750
RRGIDIEPVT LEVGDYILTP EMCVERKSIS DLIGSLNNGR LYSQCISMSR 
       760        770        780        790        800
YYKRPVLLIE FDPSKPFSLT SRGALFQEIS SNDISSKLTL LTLHFPRLRI 
       810        820        830        840        850
LWCPSPHATA ELFEELKQSK PQPDAATALA ITADSETLPE SEKYNPGPQD 
       860        870        880        890        900
FLLKMPGVNA KNCRSLMHHV KNIAELAALS QDELTSILGN AANAKQLYDF 
       910 
IHTSFAEVVS KGKGKK
Length:916
Mass (Da):104,486
Last modified:May 5, 2009 - v3
Checksum:iC58CDE900378CCA8
GO
Isoform 2 (identifier: Q92889-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-372: ETKKE → GILWG
     373-916: Missing.

Note: No experimental confirmation available.
Show »
Length:372
Mass (Da):42,745
Checksum:i98642E13DB2EAF52
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3NI48I3NI48_HUMAN
DNA repair endonuclease XPF
ERCC4
75Annotation score:
I3L4K0I3L4K0_HUMAN
DNA repair endonuclease XPF
ERCC4
35Annotation score:

Sequence cautioni

The sequence AAB07689 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05747733V → L. Corresponds to variant dbSNP:rs34205098Ensembl.1
Natural variantiVAR_072084150R → C Rare functional polymorphism; causes mild disruption of interstrand cross-link repair activity; partial loss of protein stability. 1 PublicationCorresponds to variant dbSNP:rs145402255Ensembl.1
Natural variantiVAR_034802153R → P in XFEPS. 1 PublicationCorresponds to variant dbSNP:rs121913050EnsemblClinVar.1
Natural variantiVAR_014769168A → V1 PublicationCorresponds to variant dbSNP:rs2020961Ensembl.1
Natural variantiVAR_008200225I → M in XP-F. 1 PublicationCorresponds to variant dbSNP:rs764731249Ensembl.1
Natural variantiVAR_070086230L → P in FANCQ. 1 PublicationCorresponds to variant dbSNP:rs397509402EnsemblClinVar.1
Natural variantiVAR_070087236C → R in XPF/CS. 1 PublicationCorresponds to variant dbSNP:rs397509403EnsemblClinVar.1
Natural variantiVAR_072085267R → H1 PublicationCorresponds to variant dbSNP:rs143479220Ensembl.1
Natural variantiVAR_013395379P → S2 PublicationsCorresponds to variant dbSNP:rs1799802EnsemblClinVar.1
Natural variantiVAR_013396415R → Q3 PublicationsCorresponds to variant dbSNP:rs1800067EnsemblClinVar.1
Natural variantiVAR_008201454R → W in XP-F. 1 Publication1
Natural variantiVAR_008202490R → Q in XP-F. 1 PublicationCorresponds to variant dbSNP:rs912480692Ensembl.1
Natural variantiVAR_008203502E → K in XP-F. 1 Publication1
Natural variantiVAR_008204513G → R in XP-F. 1 PublicationCorresponds to variant dbSNP:rs769679311Ensembl.1
Natural variantiVAR_008205529I → T in XP-F. 1 Publication1
Natural variantiVAR_008206567T → A in XP-F. 1 Publication1
Natural variantiVAR_013397576R → T1 PublicationCorresponds to variant dbSNP:rs1800068EnsemblClinVar.1
Natural variantiVAR_070088589R → W in XPF/CS. 1 PublicationCorresponds to variant dbSNP:rs147105770EnsemblClinVar.1
Natural variantiVAR_008207605 – 611Missing in XP-F. 1 Publication7
Natural variantiVAR_013398608L → P in XP-F. 1 Publication1
Natural variantiVAR_072086621T → A1 Publication1
Natural variantiVAR_014770662S → P1 PublicationCorresponds to variant dbSNP:rs2020955EnsemblClinVar.1
Natural variantiVAR_070089689R → S in FANCQ; disruption of interstrand cross-link repair activity; no effect on protein stability. 2 PublicationsCorresponds to variant dbSNP:rs149364215EnsemblClinVar.1
Natural variantiVAR_005849703G → D1 Publication1
Natural variantiVAR_014771706I → T1 PublicationCorresponds to variant dbSNP:rs1800069EnsemblClinVar.1
Natural variantiVAR_013399717I → T1 Publication1
Natural variantiVAR_057478768S → F. Corresponds to variant dbSNP:rs12928650Ensembl.1
Natural variantiVAR_072087786S → F in FANCQ; disruption of interstrand cross-link repair activity; no effect on protein stability. 1 Publication1
Natural variantiVAR_005850799R → W in XP-F; mild; significant residual repair activity. 2 PublicationsCorresponds to variant dbSNP:rs121913049EnsemblClinVar.1
Natural variantiVAR_057479860A → D. Corresponds to variant dbSNP:rs4986933EnsemblClinVar.1
Natural variantiVAR_019201873I → V1 PublicationCorresponds to variant dbSNP:rs2020957EnsemblClinVar.1
Natural variantiVAR_013408875E → G2 PublicationsCorresponds to variant dbSNP:rs1800124EnsemblClinVar.1
Natural variantiVAR_014772912G → E. Corresponds to variant dbSNP:rs2020956Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056341368 – 372ETKKE → GILWG in isoform 2. 1 Publication5
Alternative sequenceiVSP_056342373 – 916Missing in isoform 2. 1 PublicationAdd BLAST544

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77890 Genomic DNA Translation: AAB50174.1
AF491814 Genomic DNA Translation: AAL91593.1
AK289726 mRNA Translation: BAF82415.1
AC010401 Genomic DNA No translation available.
BC142631 mRNA Translation: AAI42632.1
U64315 mRNA Translation: AAB07689.1 Different initiation.
CCDSiCCDS32390.1 [Q92889-1]
RefSeqiNP_005227.1, NM_005236.2 [Q92889-1]
UniGeneiHs.567265

Genome annotation databases

EnsembliENST00000311895; ENSP00000310520; ENSG00000175595 [Q92889-1]
ENST00000575156; ENSP00000459933; ENSG00000175595 [Q92889-2]
GeneIDi2072
KEGGihsa:2072
UCSCiuc002dce.3 human [Q92889-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77890 Genomic DNA Translation: AAB50174.1
AF491814 Genomic DNA Translation: AAL91593.1
AK289726 mRNA Translation: BAF82415.1
AC010401 Genomic DNA No translation available.
BC142631 mRNA Translation: AAI42632.1
U64315 mRNA Translation: AAB07689.1 Different initiation.
CCDSiCCDS32390.1 [Q92889-1]
RefSeqiNP_005227.1, NM_005236.2 [Q92889-1]
UniGeneiHs.567265

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z00NMR-B834-916[»]
2A1JX-ray2.70A848-909[»]
2AQ0NMR-A/B834-916[»]
2KN7NMR-A/D842-908[»]
2MUTNMR-B834-916[»]
ProteinModelPortaliQ92889
SMRiQ92889
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108384, 38 interactors
ComplexPortaliCPX-478 ERCC1-XPF endonuclease complex
CORUMiQ92889
DIPiDIP-42006N
IntActiQ92889, 20 interactors
MINTiQ92889
STRINGi9606.ENSP00000310520

Chemistry databases

ChEMBLiCHEMBL3883316

PTM databases

iPTMnetiQ92889
PhosphoSitePlusiQ92889

Polymorphism and mutation databases

BioMutaiERCC4
DMDMi229463004

Proteomic databases

EPDiQ92889
MaxQBiQ92889
PaxDbiQ92889
PeptideAtlasiQ92889
PRIDEiQ92889
ProteomicsDBi75575

Protocols and materials databases

DNASUi2072
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311895; ENSP00000310520; ENSG00000175595 [Q92889-1]
ENST00000575156; ENSP00000459933; ENSG00000175595 [Q92889-2]
GeneIDi2072
KEGGihsa:2072
UCSCiuc002dce.3 human [Q92889-1]

Organism-specific databases

CTDi2072
DisGeNETi2072
EuPathDBiHostDB:ENSG00000175595.14
GeneCardsiERCC4
GeneReviewsiERCC4
H-InvDBiHIX0038603
HIX0173284
HGNCiHGNC:3436 ERCC4
HPAiCAB000156
HPA045828
MalaCardsiERCC4
MIMi133520 gene
278760 phenotype
610965 phenotype
615272 phenotype
neXtProtiNX_Q92889
OpenTargetsiENSG00000175595
Orphaneti90321 Cockayne syndrome type 1
84 Fanconi anemia
910 Xeroderma pigmentosum
220295 Xeroderma pigmentosum-Cockayne syndrome complex
PharmGKBiPA27850
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0442 Eukaryota
COG1948 LUCA
GeneTreeiENSGT00390000004394
HOGENOMiHOG000202204
HOVERGENiHBG051500
InParanoidiQ92889
KOiK10848
OMAiVENCVTK
OrthoDBiEOG091G0554
PhylomeDBiQ92889
TreeFamiTF101234

Enzyme and pathway databases

ReactomeiR-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6783310 Fanconi Anemia Pathway
SIGNORiQ92889

Miscellaneous databases

EvolutionaryTraceiQ92889
GeneWikiiERCC4
GenomeRNAii2072
PROiPR:Q92889
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175595 Expressed in 183 organ(s), highest expression level in adrenal tissue
CleanExiHS_ERCC4
ExpressionAtlasiQ92889 baseline and differential
GenevisibleiQ92889 HS

Family and domain databases

InterProiView protein in InterPro
IPR006166 ERCC4_domain
IPR011335 Restrct_endonuc-II-like
IPR010994 RuvA_2-like
IPR006167 XPF
PfamiView protein in Pfam
PF02732 ERCC4, 1 hit
SMARTiView protein in SMART
SM00891 ERCC4, 1 hit
SUPFAMiSSF47781 SSF47781, 1 hit
SSF52980 SSF52980, 1 hit
TIGRFAMsiTIGR00596 rad1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXPF_HUMAN
AccessioniPrimary (citable) accession number: Q92889
Secondary accession number(s): A5PKV6
, A8K111, O00140, Q8TD83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 194 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again