UniProtKB - Q92888 (ARHG1_HUMAN)
Rho guanine nucleotide exchange factor 1
ARHGEF1
Functioni
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916).
Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:9641915, PubMed:9641916, PubMed:8810315, PubMed:30521495).
Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916).
This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916).
Mediates angiotensin-2-induced RhoA activation (PubMed:20098430).
5 PublicationsGO - Molecular functioni
- G protein-coupled receptor binding Source: InterPro
- GTPase activator activity Source: UniProtKB-KW
- guanyl-nucleotide exchange factor activity Source: Reactome
- RNA binding Source: UniProtKB
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: InterPro
- regulation of small GTPase mediated signal transduction Source: Reactome
- Rho protein signal transduction Source: ProtInc
Keywordsi
Molecular function | GTPase activation, Guanine-nucleotide releasing factor |
Enzyme and pathway databases
PathwayCommonsi | Q92888 |
Reactomei | R-HSA-193648, NRAGE signals death through JNK R-HSA-416482, G alpha (12/13) signalling events R-HSA-8980692, RHOA GTPase cycle R-HSA-9013026, RHOB GTPase cycle R-HSA-9013106, RHOC GTPase cycle |
SignaLinki | Q92888 |
SIGNORi | Q92888 |
Names & Taxonomyi
Protein namesi | Recommended name: Rho guanine nucleotide exchange factor 1Alternative name(s): 115 kDa guanine nucleotide exchange factor Short name: p115-RhoGEF Short name: p115RhoGEF Sub1.5 |
Gene namesi | Name:ARHGEF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:681, ARHGEF1 |
MIMi | 601855, gene |
neXtProti | NX_Q92888 |
VEuPathDBi | HostDB:ENSG00000076928 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: ProtInc
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Immunodeficiency 62 (IMD62)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_082652 | 285 – 912 | Missing in IMD62; impairs RhoA GTPase activation and GNA12- and GNA13-mediated signaling; reduces actin polymerization. 1 PublicationCorresponds to variant dbSNP:rs1568815169Add BLAST | 628 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 487 | Y → F: No effect. 1 Publication | 1 | |
Mutagenesisi | 738 | Y → F: Lowers the exchange activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9138 |
MalaCardsi | ARHGEF1 |
MIMi | 618459, phenotype |
OpenTargetsi | ENSG00000076928 |
PharmGKBi | PA24966 |
Miscellaneous databases
Pharosi | Q92888, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295918 |
Genetic variation databases
BioMutai | ARHGEF1 |
DMDMi | 34395524 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080906 | 1 – 912 | Rho guanine nucleotide exchange factor 1Add BLAST | 912 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 374 | PhosphoserineCombined sources | 1 | |
Modified residuei | 409 | PhosphoserineCombined sources | 1 | |
Modified residuei | 695 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 738 | Phosphotyrosine; by JAK21 Publication | 1 | |
Modified residuei | 863 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-1231 |
EPDi | Q92888 |
jPOSTi | Q92888 |
MassIVEi | Q92888 |
MaxQBi | Q92888 |
PaxDbi | Q92888 |
PeptideAtlasi | Q92888 |
PRIDEi | Q92888 |
ProteomicsDBi | 66748 75572 [Q92888-1] 75573 [Q92888-2] 75574 [Q92888-3] |
PTM databases
GlyGeni | Q92888, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q92888 |
MetOSitei | Q92888 |
PhosphoSitePlusi | Q92888 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000076928, Expressed in granulocyte and 228 other tissues |
ExpressionAtlasi | Q92888, baseline and differential |
Genevisiblei | Q92888, HS |
Organism-specific databases
HPAi | ENSG00000076928, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1 (By similarity).
Interacts with CTNNAL1.
By similarity3 PublicationsBinary interactionsi
Q92888
With | #Exp. | IntAct |
---|---|---|
GNA13 [Q14344] | 3 | EBI-465400,EBI-465387 |
TCF4 [P15884] | 3 | EBI-465400,EBI-533224 |
espH [Q7DB74] from Escherichia coli O157:H7. | 7 | EBI-465400,EBI-7864788 |
GO - Molecular functioni
- G protein-coupled receptor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 114585, 118 interactors |
CORUMi | Q92888 |
IntActi | Q92888, 35 interactors |
MINTi | Q92888 |
STRINGi | 9606.ENSP00000337261 |
Chemistry databases
BindingDBi | Q92888 |
Miscellaneous databases
RNActi | Q92888, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q92888 |
SMRi | Q92888 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92888 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 232 | RGSLAdd BLAST | 192 | |
Domaini | 416 – 605 | DHPROSITE-ProRule annotationAdd BLAST | 190 | |
Domaini | 647 – 760 | PHPROSITE-ProRule annotationAdd BLAST | 114 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 248 – 413 | DisorderedSequence analysisAdd BLAST | 166 | |
Regioni | 763 – 802 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 841 – 865 | DisorderedSequence analysisAdd BLAST | 25 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 865 – 896 | Sequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 248 – 263 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 279 – 299 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 378 – 398 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 779 – 797 | Polar residuesSequence analysisAdd BLAST | 19 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3520, Eukaryota |
GeneTreei | ENSGT00940000161180 |
HOGENOMi | CLU_003962_2_0_1 |
InParanoidi | Q92888 |
OrthoDBi | 319635at2759 |
PhylomeDBi | Q92888 |
TreeFami | TF106495 |
Family and domain databases
CDDi | cd08755, RGS_p115RhoGEF, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.10.167.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR037887, p115RhoGEF_RGS IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR015212, RGS-like_dom IPR036305, RGS_sf IPR044926, RGS_subdomain_2 |
Pfami | View protein in Pfam PF17838, PH_16, 1 hit PF09128, RGS-like, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEDFARGAAS PGPSRPGLVP VSIIGAEDED FENELETNSE EQNSQFQSLE
60 70 80 90 100
QVKRRPAHLM ALLQHVALQF EPGPLLCCLH ADMLGSLGPK EAKKAFLDFY
110 120 130 140 150
HSFLEKTAVL RVPVPPNVAF ELDRTRADLI SEDVQRRFVQ EVVQSQQVAV
160 170 180 190 200
GRQLEDFRSK RLMGMTPWEQ ELAQLEAWVG RDRASYEARE RHVAERLLMH
210 220 230 240 250
LEEMQHTIST DEEKSAAVVN AIGLYMRHLG VRTKSGDKKS GRNFFRKKVM
260 270 280 290 300
GNRRSDEPAK TKKGLSSILD AARWNRGEPQ VPDFRHLKAE VDAEKPGATD
310 320 330 340 350
RKGGVGMPSR DRNIGAPGQD TPGVSLHPLS LDSPDREPGA DAPLELGDSS
360 370 380 390 400
PQGPMSLESL APPESTDEGA ETESPEPGDE GEPGRSGLEL EPEEPPGWRE
410 420 430 440 450
LVPPDTLHSL PKSQVKRQEV ISELLVTEAA HVRMLRVLHD LFFQPMAECL
460 470 480 490 500
FFPLEELQNI FPSLDELIEV HSLFLDRLMK RRQESGYLIE EIGDVLLARF
510 520 530 540 550
DGAEGSWFQK ISSRFCSRQS FALEQLKAKQ RKDPRFCAFV QEAESRPRCR
560 570 580 590 600
RLQLKDMIPT EMQRLTKYPL LLQSIGQNTE EPTEREKVEL AAECCREILH
610 620 630 640 650
HVNQAVRDME DLLRLKDYQR RLDLSHLRQS SDPMLSEFKN LDITKKKLVH
660 670 680 690 700
EGPLTWRVTK DKAVEVHVLL LDDLLLLLQR QDERLLLKSH SRTLTPTPDG
710 720 730 740 750
KTMLRPVLRL TSAMTREVAT DHKAFYVLFT WDQEAQIYEL VAQTVSERKN
760 770 780 790 800
WCALITETAG SLKVPAPASR PKPRPSPSST REPLLSSSEN GNGGRETSPA
810 820 830 840 850
DARTERILSD LLPFCRPGPE GQLAATALRK VLSLKQLLFP AEEDNGAGPP
860 870 880 890 900
RDGDGVPGGG PLSPARTQEI QENLLSLEET MKQLEELEEE FCRLRPLLSQ
910
LGGNSVPQPG CT
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QZR4 | M0QZR4_HUMAN | Rho guanine nucleotide exchange fac... | ARHGEF1 | 968 | Annotation score: | ||
M0QYC1 | M0QYC1_HUMAN | Rho guanine nucleotide exchange fac... | ARHGEF1 | 702 | Annotation score: | ||
M0QYS3 | M0QYS3_HUMAN | Rho guanine nucleotide exchange fac... | ARHGEF1 | 307 | Annotation score: | ||
M0QZH8 | M0QZH8_HUMAN | Rho guanine nucleotide exchange fac... | ARHGEF1 | 275 | Annotation score: | ||
M0R2C7 | M0R2C7_HUMAN | Rho guanine nucleotide exchange fac... | ARHGEF1 | 291 | Annotation score: | ||
M0R1K8 | M0R1K8_HUMAN | Rho guanine nucleotide exchange fac... | ARHGEF1 | 128 | Annotation score: | ||
M0R3H5 | M0R3H5_HUMAN | Rho guanine nucleotide exchange fac... | ARHGEF1 | 88 | Annotation score: | ||
M0QXV6 | M0QXV6_HUMAN | Rho guanine nucleotide exchange fac... | ARHGEF1 | 68 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 257 – 259 | EPA → DPP in AAB17896 (PubMed:8810315).Curated | 3 | |
Sequence conflicti | 305 – 308 | VGMP → GGDA in CAA70356 (PubMed:9135076).Curated | 4 | |
Sequence conflicti | 339 | Missing in CAA70356 (PubMed:9135076).Curated | 1 | |
Sequence conflicti | 346 – 352 | LGDSSPQ → PGGLIPA in CAA70356 (PubMed:9135076).Curated | 7 | |
Sequence conflicti | 549 | C → S in CAA70356 (PubMed:9135076).Curated | 1 | |
Sequence conflicti | 752 | C → S in CAA70356 (PubMed:9135076).Curated | 1 | |
Sequence conflicti | 776 | S → R in AAB17896 (PubMed:8810315).Curated | 1 | |
Sequence conflicti | 862 | L → R in CAA70356 (PubMed:9135076).Curated | 1 | |
Sequence conflicti | 876 | S → R in CAA70356 (PubMed:9135076).Curated | 1 | |
Sequence conflicti | 883 | Q → T in CAA70356 (PubMed:9135076).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035969 | 165 | M → V in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_082652 | 285 – 912 | Missing in IMD62; impairs RhoA GTPase activation and GNA12- and GNA13-mediated signaling; reduces actin polymerization. 1 PublicationCorresponds to variant dbSNP:rs1568815169Add BLAST | 628 | |
Natural variantiVAR_033521 | 375 | P → L. Corresponds to variant dbSNP:rs2303797EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037766 | 1 | M → MASLSTWSSPAEPREM in isoform 3 and isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_008125 | 76 – 108 | Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_057289 | 831 – 912 | VLSLK…QPGCT → GVGGGILPPETPPVSAWGEL CPPAWLHLRFPPRKAFCKKE RNGGEDVRDHPHPHSCRSIS HPEGLRRGSCGPRLGGAQLG LLAPHEPRPSLPPALCLGDS GLHSGGHHGDPGHLSIACGG HPSTPTPKCLRSVFIP in isoform 4. 1 PublicationAdd BLAST | 82 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U64105 mRNA Translation: AAB17896.1 AC010616 Genomic DNA No translation available. AC243967 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57084.1 BC005155 mRNA Translation: AAH05155.2 BC011726 mRNA Translation: AAH11726.1 BC015652 mRNA No translation available. BC034013 mRNA Translation: AAH34013.2 BC067262 mRNA Translation: AAH67262.1 Y09160 mRNA Translation: CAA70356.1 Sequence problems. BT007421 mRNA Translation: AAP36089.1 |
CCDSi | CCDS12590.1 [Q92888-3] CCDS12591.1 [Q92888-1] CCDS12592.1 [Q92888-2] |
RefSeqi | NP_004697.2, NM_004706.3 [Q92888-1] NP_945328.1, NM_198977.1 [Q92888-2] NP_945353.1, NM_199002.1 [Q92888-3] |
Genome annotation databases
Ensembli | ENST00000337665.8; ENSP00000337261.3; ENSG00000076928.18 [Q92888-3] ENST00000347545.8; ENSP00000344429.3; ENSG00000076928.18 [Q92888-2] ENST00000354532.8; ENSP00000346532.3; ENSG00000076928.18 ENST00000378152.8; ENSP00000367394.3; ENSG00000076928.18 [Q92888-4] |
GeneIDi | 9138 |
KEGGi | hsa:9138 |
MANE-Selecti | ENST00000354532.8; ENSP00000346532.3; NM_004706.4; NP_004697.2 |
UCSCi | uc002orx.4, human [Q92888-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U64105 mRNA Translation: AAB17896.1 AC010616 Genomic DNA No translation available. AC243967 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57084.1 BC005155 mRNA Translation: AAH05155.2 BC011726 mRNA Translation: AAH11726.1 BC015652 mRNA No translation available. BC034013 mRNA Translation: AAH34013.2 BC067262 mRNA Translation: AAH67262.1 Y09160 mRNA Translation: CAA70356.1 Sequence problems. BT007421 mRNA Translation: AAP36089.1 |
CCDSi | CCDS12590.1 [Q92888-3] CCDS12591.1 [Q92888-1] CCDS12592.1 [Q92888-2] |
RefSeqi | NP_004697.2, NM_004706.3 [Q92888-1] NP_945328.1, NM_198977.1 [Q92888-2] NP_945353.1, NM_199002.1 [Q92888-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IAP | X-ray | 1.90 | A | 42-252 | [»] | |
1SHZ | X-ray | 2.85 | C/F | 7-239 | [»] | |
3AB3 | X-ray | 2.40 | B/D | 1-233 | [»] | |
3ODO | X-ray | 2.90 | A/B | 395-766 | [»] | |
3ODW | X-ray | 3.20 | A/B | 240-766 | [»] | |
3ODX | X-ray | 3.20 | A/B | 353-766 | [»] | |
3P6A | X-ray | 2.50 | A/B | 395-766 | [»] | |
AlphaFoldDBi | Q92888 | |||||
SMRi | Q92888 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114585, 118 interactors |
CORUMi | Q92888 |
IntActi | Q92888, 35 interactors |
MINTi | Q92888 |
STRINGi | 9606.ENSP00000337261 |
Chemistry databases
BindingDBi | Q92888 |
ChEMBLi | CHEMBL4295918 |
PTM databases
GlyGeni | Q92888, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q92888 |
MetOSitei | Q92888 |
PhosphoSitePlusi | Q92888 |
Genetic variation databases
BioMutai | ARHGEF1 |
DMDMi | 34395524 |
Proteomic databases
CPTACi | CPTAC-1231 |
EPDi | Q92888 |
jPOSTi | Q92888 |
MassIVEi | Q92888 |
MaxQBi | Q92888 |
PaxDbi | Q92888 |
PeptideAtlasi | Q92888 |
PRIDEi | Q92888 |
ProteomicsDBi | 66748 75572 [Q92888-1] 75573 [Q92888-2] 75574 [Q92888-3] |
Protocols and materials databases
Antibodypediai | 2765, 276 antibodies from 34 providers |
DNASUi | 9138 |
Genome annotation databases
Ensembli | ENST00000337665.8; ENSP00000337261.3; ENSG00000076928.18 [Q92888-3] ENST00000347545.8; ENSP00000344429.3; ENSG00000076928.18 [Q92888-2] ENST00000354532.8; ENSP00000346532.3; ENSG00000076928.18 ENST00000378152.8; ENSP00000367394.3; ENSG00000076928.18 [Q92888-4] |
GeneIDi | 9138 |
KEGGi | hsa:9138 |
MANE-Selecti | ENST00000354532.8; ENSP00000346532.3; NM_004706.4; NP_004697.2 |
UCSCi | uc002orx.4, human [Q92888-1] |
Organism-specific databases
CTDi | 9138 |
DisGeNETi | 9138 |
GeneCardsi | ARHGEF1 |
HGNCi | HGNC:681, ARHGEF1 |
HPAi | ENSG00000076928, Tissue enhanced (lymphoid) |
MalaCardsi | ARHGEF1 |
MIMi | 601855, gene 618459, phenotype |
neXtProti | NX_Q92888 |
OpenTargetsi | ENSG00000076928 |
PharmGKBi | PA24966 |
VEuPathDBi | HostDB:ENSG00000076928 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3520, Eukaryota |
GeneTreei | ENSGT00940000161180 |
HOGENOMi | CLU_003962_2_0_1 |
InParanoidi | Q92888 |
OrthoDBi | 319635at2759 |
PhylomeDBi | Q92888 |
TreeFami | TF106495 |
Enzyme and pathway databases
PathwayCommonsi | Q92888 |
Reactomei | R-HSA-193648, NRAGE signals death through JNK R-HSA-416482, G alpha (12/13) signalling events R-HSA-8980692, RHOA GTPase cycle R-HSA-9013026, RHOB GTPase cycle R-HSA-9013106, RHOC GTPase cycle |
SignaLinki | Q92888 |
SIGNORi | Q92888 |
Miscellaneous databases
BioGRID-ORCSi | 9138, 18 hits in 1084 CRISPR screens |
ChiTaRSi | ARHGEF1, human |
EvolutionaryTracei | Q92888 |
GeneWikii | ARHGEF1 |
GenomeRNAii | 9138 |
Pharosi | Q92888, Tbio |
PROi | PR:Q92888 |
RNActi | Q92888, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000076928, Expressed in granulocyte and 228 other tissues |
ExpressionAtlasi | Q92888, baseline and differential |
Genevisiblei | Q92888, HS |
Family and domain databases
CDDi | cd08755, RGS_p115RhoGEF, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.10.167.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR037887, p115RhoGEF_RGS IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR015212, RGS-like_dom IPR036305, RGS_sf IPR044926, RGS_subdomain_2 |
Pfami | View protein in Pfam PF17838, PH_16, 1 hit PF09128, RGS-like, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARHG1_HUMAN | |
Accessioni | Q92888Primary (citable) accession number: Q92888 Secondary accession number(s): O00513 Q9BSB1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2003 |
Last sequence update: | August 29, 2003 | |
Last modified: | May 25, 2022 | |
This is version 199 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references