Rho guanine nucleotide exchange factor 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• G-protein coupled receptor binding Source: InterPro
• GTPase activator activity Source: UniProtKB-KW
• guanyl-nucleotide exchange factor activity Source: Reactome
• Rho guanyl-nucleotide exchange factor activity Source: Reactome
• RNA binding Source: UniProtKBInferred from high throughput direct assayⁱ
  • 22658674

GO - Biological processⁱ

• cell proliferation Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 8810315
• G-protein coupled receptor signaling pathway Source: Reactome
• positive regulation of apoptotic process Source: Reactome
• regulation of Rho protein signal transduction Source: InterPro
• regulation of small GTPase mediated signal transduction Source: Reactome
• Rho protein signal transduction Source: ProtIncTraceable author statementⁱ
  • 10747909

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• G-protein coupled receptor binding Source: InterPro
• guanyl-nucleotide exchange factor activity Source: Reactome
• Rho guanyl-nucleotide exchange factor activity Source: Reactome

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 8 potential isoforms that are <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>computationally mapped.ⁱShow all

        10         20         30         40         50
MEDFARGAAS PGPSRPGLVP VSIIGAEDED FENELETNSE EQNSQFQSLE 
        60         70         80         90        100
QVKRRPAHLM ALLQHVALQF EPGPLLCCLH ADMLGSLGPK EAKKAFLDFY 
       110        120        130        140        150
HSFLEKTAVL RVPVPPNVAF ELDRTRADLI SEDVQRRFVQ EVVQSQQVAV 
       160        170        180        190        200
GRQLEDFRSK RLMGMTPWEQ ELAQLEAWVG RDRASYEARE RHVAERLLMH 
       210        220        230        240        250
LEEMQHTIST DEEKSAAVVN AIGLYMRHLG VRTKSGDKKS GRNFFRKKVM 
       260        270        280        290        300
GNRRSDEPAK TKKGLSSILD AARWNRGEPQ VPDFRHLKAE VDAEKPGATD 
       310        320        330        340        350
RKGGVGMPSR DRNIGAPGQD TPGVSLHPLS LDSPDREPGA DAPLELGDSS 
       360        370        380        390        400
PQGPMSLESL APPESTDEGA ETESPEPGDE GEPGRSGLEL EPEEPPGWRE 
       410        420        430        440        450
LVPPDTLHSL PKSQVKRQEV ISELLVTEAA HVRMLRVLHD LFFQPMAECL 
       460        470        480        490        500
FFPLEELQNI FPSLDELIEV HSLFLDRLMK RRQESGYLIE EIGDVLLARF 
       510        520        530        540        550
DGAEGSWFQK ISSRFCSRQS FALEQLKAKQ RKDPRFCAFV QEAESRPRCR 
       560        570        580        590        600
RLQLKDMIPT EMQRLTKYPL LLQSIGQNTE EPTEREKVEL AAECCREILH 
       610        620        630        640        650
HVNQAVRDME DLLRLKDYQR RLDLSHLRQS SDPMLSEFKN LDITKKKLVH 
       660        670        680        690        700
EGPLTWRVTK DKAVEVHVLL LDDLLLLLQR QDERLLLKSH SRTLTPTPDG 
       710        720        730        740        750
KTMLRPVLRL TSAMTREVAT DHKAFYVLFT WDQEAQIYEL VAQTVSERKN 
       760        770        780        790        800
WCALITETAG SLKVPAPASR PKPRPSPSST REPLLSSSEN GNGGRETSPA 
       810        820        830        840        850
DARTERILSD LLPFCRPGPE GQLAATALRK VLSLKQLLFP AEEDNGAGPP 
       860        870        880        890        900
RDGDGVPGGG PLSPARTQEI QENLLSLEET MKQLEELEEE FCRLRPLLSQ 
       910 
LGGNSVPQPG CT                                          

        10         20         30         40         50
MEDFARGAAS PGPSRPGLVP VSIIGAEDED FENELETNSE EQNSQFQSLE 
        60         70         80         90        100
QVKRRPAHLM ALLQHVALQF EPGPLVLRVP VPPNVAFELD RTRADLISED 
       110        120        130        140        150
VQRRFVQEVV QSQQVAVGRQ LEDFRSKRLM GMTPWEQELA QLEAWVGRDR 
       160        170        180        190        200
ASYEARERHV AERLLMHLEE MQHTISTDEE KSAAVVNAIG LYMRHLGVRT 
       210        220        230        240        250
KSGDKKSGRN FFRKKVMGNR RSDEPAKTKK GLSSILDAAR WNRGEPQVPD 
       260        270        280        290        300
FRHLKAEVDA EKPGATDRKG GVGMPSRDRN IGAPGQDTPG VSLHPLSLDS 
       310        320        330        340        350
PDREPGADAP LELGDSSPQG PMSLESLAPP ESTDEGAETE SPEPGDEGEP 
       360        370        380        390        400
GRSGLELEPE EPPGWRELVP PDTLHSLPKS QVKRQEVISE LLVTEAAHVR 
       410        420        430        440        450
MLRVLHDLFF QPMAECLFFP LEELQNIFPS LDELIEVHSL FLDRLMKRRQ 
       460        470        480        490        500
ESGYLIEEIG DVLLARFDGA EGSWFQKISS RFCSRQSFAL EQLKAKQRKD 
       510        520        530        540        550
PRFCAFVQEA ESRPRCRRLQ LKDMIPTEMQ RLTKYPLLLQ SIGQNTEEPT 
       560        570        580        590        600
EREKVELAAE CCREILHHVN QAVRDMEDLL RLKDYQRRLD LSHLRQSSDP 
       610        620        630        640        650
MLSEFKNLDI TKKKLVHEGP LTWRVTKDKA VEVHVLLLDD LLLLLQRQDE 
       660        670        680        690        700
RLLLKSHSRT LTPTPDGKTM LRPVLRLTSA MTREVATDHK AFYVLFTWDQ 
       710        720        730        740        750
EAQIYELVAQ TVSERKNWCA LITETAGSLK VPAPASRPKP RPSPSSTREP 
       760        770        780        790        800
LLSSSENGNG GRETSPADAR TERILSDLLP FCRPGPEGQL AATALRKVLS 
       810        820        830        840        850
LKQLLFPAEE DNGAGPPRDG DGVPGGGPLS PARTQEIQEN LLSLEETMKQ 
       860        870 
LEELEEEFCR LRPLLSQLGG NSVPQPGCT                        

        10         20         30         40         50
MASLSTWSSP AEPREMEDFA RGAASPGPSR PGLVPVSIIG AEDEDFENEL 
        60         70         80         90        100
ETNSEEQNSQ FQSLEQVKRR PAHLMALLQH VALQFEPGPL LCCLHADMLG 
       110        120        130        140        150
SLGPKEAKKA FLDFYHSFLE KTAVLRVPVP PNVAFELDRT RADLISEDVQ 
       160        170        180        190        200
RRFVQEVVQS QQVAVGRQLE DFRSKRLMGM TPWEQELAQL EAWVGRDRAS 
       210        220        230        240        250
YEARERHVAE RLLMHLEEMQ HTISTDEEKS AAVVNAIGLY MRHLGVRTKS 
       260        270        280        290        300
GDKKSGRNFF RKKVMGNRRS DEPAKTKKGL SSILDAARWN RGEPQVPDFR 
       310        320        330        340        350
HLKAEVDAEK PGATDRKGGV GMPSRDRNIG APGQDTPGVS LHPLSLDSPD 
       360        370        380        390        400
REPGADAPLE LGDSSPQGPM SLESLAPPES TDEGAETESP EPGDEGEPGR 
       410        420        430        440        450
SGLELEPEEP PGWRELVPPD TLHSLPKSQV KRQEVISELL VTEAAHVRML 
       460        470        480        490        500
RVLHDLFFQP MAECLFFPLE ELQNIFPSLD ELIEVHSLFL DRLMKRRQES 
       510        520        530        540        550
GYLIEEIGDV LLARFDGAEG SWFQKISSRF CSRQSFALEQ LKAKQRKDPR 
       560        570        580        590        600
FCAFVQEAES RPRCRRLQLK DMIPTEMQRL TKYPLLLQSI GQNTEEPTER 
       610        620        630        640        650
EKVELAAECC REILHHVNQA VRDMEDLLRL KDYQRRLDLS HLRQSSDPML 
       660        670        680        690        700
SEFKNLDITK KKLVHEGPLT WRVTKDKAVE VHVLLLDDLL LLLQRQDERL 
       710        720        730        740        750
LLKSHSRTLT PTPDGKTMLR PVLRLTSAMT REVATDHKAF YVLFTWDQEA 
       760        770        780        790        800
QIYELVAQTV SERKNWCALI TETAGSLKVP APASRPKPRP SPSSTREPLL 
       810        820        830        840        850
SSSENGNGGR ETSPADARTE RILSDLLPFC RPGPEGQLAA TALRKVLSLK 
       860        870        880        890        900
QLLFPAEEDN GAGPPRDGDG VPGGGPLSPA RTQEIQENLL SLEETMKQLE 
       910        920 
ELEEEFCRLR PLLSQLGGNS VPQPGCT                          

        10         20         30         40         50
MASLSTWSSP AEPREMEDFA RGAASPGPSR PGLVPVSIIG AEDEDFENEL 
        60         70         80         90        100
ETNSEEQNSQ FQSLEQVKRR PAHLMALLQH VALQFEPGPL VLRVPVPPNV 
       110        120        130        140        150
AFELDRTRAD LISEDVQRRF VQEVVQSQQV AVGRQLEDFR SKRLMGMTPW 
       160        170        180        190        200
EQELAQLEAW VGRDRASYEA RERHVAERLL MHLEEMQHTI STDEEKSAAV 
       210        220        230        240        250
VNAIGLYMRH LGVRTKSGDK KSGRNFFRKK VMGNRRSDEP AKTKKGLSSI 
       260        270        280        290        300
LDAARWNRGE PQVPDFRHLK AEVDAEKPGA TDRKGGVGMP SRDRNIGAPG 
       310        320        330        340        350
QDTPGVSLHP LSLDSPDREP GADAPLELGD SSPQGPMSLE SLAPPESTDE 
       360        370        380        390        400
GAETESPEPG DEGEPGRSGL ELEPEEPPGW RELVPPDTLH SLPKSQVKRQ 
       410        420        430        440        450
EVISELLVTE AAHVRMLRVL HDLFFQPMAE CLFFPLEELQ NIFPSLDELI 
       460        470        480        490        500
EVHSLFLDRL MKRRQESGYL IEEIGDVLLA RFDGAEGSWF QKISSRFCSR 
       510        520        530        540        550
QSFALEQLKA KQRKDPRFCA FVQEAESRPR CRRLQLKDMI PTEMQRLTKY 
       560        570        580        590        600
PLLLQSIGQN TEEPTEREKV ELAAECCREI LHHVNQAVRD MEDLLRLKDY 
       610        620        630        640        650
QRRLDLSHLR QSSDPMLSEF KNLDITKKKL VHEGPLTWRV TKDKAVEVHV 
       660        670        680        690        700
LLLDDLLLLL QRQDERLLLK SHSRTLTPTP DGKTMLRPVL RLTSAMTREV 
       710        720        730        740        750
ATDHKAFYVL FTWDQEAQIY ELVAQTVSER KNWCALITET AGSLKVPAPA 
       760        770        780        790        800
SRPKPRPSPS STREPLLSSS ENGNGGRETS PADARTERIL SDLLPFCRPG 
       810        820        830        840        850
PEGQLAATAL RKGVGGGILP PETPPVSAWG ELCPPAWLHL RFPPRKAFCK 
       860        870        880        890        900
KERNGGEDVR DHPHPHSCRS ISHPEGLRRG SCGPRLGGAQ LGLLAPHEPR 
       910        920        930        940 
PSLPPALCLG DSGLHSGGHH GDPGHLSIAC GGHPSTPTPK CLRSVFIP   

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ