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Protein

Canalicular multispecific organic anion transporter 1

Gene

ABCC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi671 – 678ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1334 – 1341ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-5679001 Defective ABCC2 causes Dubin-Johnson syndrome

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q92887

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q92887

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.208.2 the atp-binding cassette (abc) superfamily

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001599

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Canalicular multispecific organic anion transporter 1
Alternative name(s):
ATP-binding cassette sub-family C member 2
Canalicular multidrug resistance protein
Multidrug resistance-associated protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCC2
Synonyms:CMOAT, CMOAT1, CMRP, MRP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000023839.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:53 ABCC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601107 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92887

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27ExtracellularBy similarityAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 48Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini49 – 68CytoplasmicBy similarityAdd BLAST20
Transmembranei69 – 89Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini90 – 93ExtracellularBy similarity4
Transmembranei94 – 114Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini115 – 126CytoplasmicBy similarityAdd BLAST12
Transmembranei127 – 147Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini148 – 165ExtracellularBy similarityAdd BLAST18
Transmembranei166 – 186Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini187 – 313CytoplasmicBy similarityAdd BLAST127
Transmembranei314 – 334Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini335 – 360ExtracellularBy similarityAdd BLAST26
Transmembranei361 – 381Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini382 – 437CytoplasmicBy similarityAdd BLAST56
Transmembranei438 – 458Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini459 – 461ExtracellularBy similarity3
Transmembranei462 – 482Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini483 – 544CytoplasmicBy similarityAdd BLAST62
Transmembranei545 – 565Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini566 – 587ExtracellularBy similarityAdd BLAST22
Transmembranei588 – 608Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini609 – 971CytoplasmicBy similarityAdd BLAST363
Transmembranei972 – 992Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini993 – 1033ExtracellularBy similarityAdd BLAST41
Transmembranei1034 – 1054Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1055 – 1097CytoplasmicBy similarityAdd BLAST43
Transmembranei1098 – 1118Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1119ExtracellularBy similarity1
Transmembranei1120 – 1140Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1141 – 1211CytoplasmicBy similarityAdd BLAST71
Transmembranei1212 – 1232Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1233 – 1234ExtracellularBy similarity2
Transmembranei1235 – 1255Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1256 – 1545CytoplasmicBy similarityAdd BLAST290

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dubin-Johnson syndrome (DJS)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
See also OMIM:237500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_000099768R → W in DJS. 4 PublicationsCorresponds to variant dbSNP:rs56199535EnsemblClinVar.1
Natural variantiVAR_0133271150R → H in DJS; protein is properly localized at the plasma membrane, but transporter activity is impaired. 1 PublicationCorresponds to variant dbSNP:rs72558200EnsemblClinVar.1
Natural variantiVAR_0133281173I → F in DJS; decreased expression and mislocation to the endoplasmic reticulum. 2 PublicationsCorresponds to variant dbSNP:rs72558201EnsemblClinVar.1
Natural variantiVAR_0107561382Q → R in DJS. 1 PublicationCorresponds to variant dbSNP:rs72558202EnsemblClinVar.1
Natural variantiVAR_0133291392 – 1393Missing in DJS; impaired transport from the endoplasmic reticulum to the apical plasma membrane associated with impaired maturation. 2 Publications2

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1254W → A or C: Fails to transport methotrexate, leukotriene C4 and estradiol glucuronide. 1 Publication1
Mutagenesisi1254W → F: Fails to transport methotrexate and leukotriene C4. Does not affect estradiol glucuronide transport. 1 Publication1
Mutagenesisi1254W → Y: Fails to transport methotrexate; reduces leukotriene C4 transport. Does not affect estradiol glucuronide transport. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1244

MalaCards human disease database

More...
MalaCardsi
ABCC2
MIMi237500 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000023839

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
234 Dubin-Johnson syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA116

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5748

Drug and drug target database

More...
DrugBanki
DB04789 5-methyltetrahydrofolic acid
DB00171 Adenosine triphosphate
DB00345 Aminohippuric acid
DB01169 Arsenic trioxide
DB01076 Atorvastatin
DB09060 Avibactam
DB08907 Canagliflozin
DB00564 Carbamazepine
DB00958 Carboplatin
DB00439 Cerivastatin
DB02659 Cholic Acid
DB00515 Cisplatin
DB00257 Clotrimazole
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB00694 Daunorubicin
DB01234 Dexamethasone
DB01248 Docetaxel
DB00997 Doxorubicin
DB09272 Eluxadoline
DB00876 Eprosartan
DB00977 Ethinyl Estradiol
DB00773 Etoposide
DB00973 Ezetimibe
DB00695 Furosemide
DB02703 Fusidic Acid
DB08884 Gadoxetic acid
DB00143 Glutathione
DB01016 Glyburide
DB00365 Grepafloxacin
DB01892 Hyperforin
DB00224 Indinavir
DB09374 Indocyanine green
DB00328 Indomethacin
DB00762 Irinotecan
DB00602 Ivermectin
DB00709 Lamivudine
DB01202 Levetiracetam
DB11256 Levomefolic acid
DB00978 Lomefloxacin
DB00227 Lovastatin
DB00563 Methotrexate
DB00688 Mycophenolate mofetil
DB01115 Nifedipine
DB00957 Norgestimate
DB01165 Ofloxacin
DB00275 Olmesartan
DB00526 Oxaliplatin
DB01229 Paclitaxel
DB01174 Phenobarbital
DB00252 Phenytoin
DB08860 Pitavastatin
DB01411 Pranlukast
DB00175 Pravastatin
DB01032 Probenecid
DB04216 Quercetin
DB00908 Quinidine
DB00206 Reserpine
DB01045 Rifampicin
DB00503 Ritonavir
DB01232 Saquinavir
DB00641 Simvastatin
DB00398 Sorafenib
DB01208 Sparfloxacin
DB00421 Spironolactone
DB00795 Sulfasalazine
DB01138 Sulfinpyrazone
DB01268 Sunitinib
DB00675 Tamoxifen
DB04348 Taurocholic Acid
DB00966 Telmisartan
DB00300 Tenofovir
DB00116 Tetrahydrofolic acid
DB01586 Ursodeoxycholic acid
DB00067 Vasopressin
DB00661 Verapamil
DB00570 Vinblastine
DB00541 Vincristine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
780

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153583

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933561 – 1545Canalicular multispecific organic anion transporter 1Add BLAST1545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei281PhosphoserineBy similarity1
Modified residuei283PhosphoserineCombined sources1
Modified residuei878PhosphoserineCombined sources1
Modified residuei926PhosphoserineCombined sources1
Modified residuei930PhosphoserineCombined sources1
Modified residuei938PhosphoserineCombined sources1
Glycosylationi1011N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1438PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92887

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92887

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92887

PeptideAtlas

More...
PeptideAtlasi
Q92887

PRoteomics IDEntifications database

More...
PRIDEi
Q92887

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75571

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92887

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92887

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000023839 Expressed in 94 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_ABCC2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92887 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92887 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037271
HPA004860

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NFKB1P198383EBI-3916193,EBI-300010

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107647, 48 interactors

Protein interaction database and analysis system

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IntActi
Q92887, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359478

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q92887

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q92887

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92887

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini322 – 605ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini637 – 861ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini979 – 1264ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST286
Domaini1300 – 1534ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161741

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108314

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92887

KEGG Orthology (KO)

More...
KOi
K05666

Identification of Orthologs from Complete Genome Data

More...
OMAi
NMKNKDK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00IN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92887

TreeFam database of animal gene trees

More...
TreeFami
TF105199

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030247 ABCC2
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24223:SF176 PTHR24223:SF176, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00957 MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q92887-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEKFCNSTF WNSSFLDSPE ADLPLCFEQT VLVWIPLGYL WLLAPWQLLH
60 70 80 90 100
VYKSRTKRSS TTKLYLAKQV FVGFLLILAA IELALVLTED SGQATVPAVR
110 120 130 140 150
YTNPSLYLGT WLLVLLIQYS RQWCVQKNSW FLSLFWILSI LCGTFQFQTL
160 170 180 190 200
IRTLLQGDNS NLAYSCLFFI SYGFQILILI FSAFSENNES SNNPSSIASF
210 220 230 240 250
LSSITYSWYD SIILKGYKRP LTLEDVWEVD EEMKTKTLVS KFETHMKREL
260 270 280 290 300
QKARRALQRR QEKSSQQNSG ARLPGLNKNQ SQSQDALVLE DVEKKKKKSG
310 320 330 340 350
TKKDVPKSWL MKALFKTFYM VLLKSFLLKL VNDIFTFVSP QLLKLLISFA
360 370 380 390 400
SDRDTYLWIG YLCAILLFTA ALIQSFCLQC YFQLCFKLGV KVRTAIMASV
410 420 430 440 450
YKKALTLSNL ARKEYTVGET VNLMSVDAQK LMDVTNFMHM LWSSVLQIVL
460 470 480 490 500
SIFFLWRELG PSVLAGVGVM VLVIPINAIL STKSKTIQVK NMKNKDKRLK
510 520 530 540 550
IMNEILSGIK ILKYFAWEPS FRDQVQNLRK KELKNLLAFS QLQCVVIFVF
560 570 580 590 600
QLTPVLVSVV TFSVYVLVDS NNILDAQKAF TSITLFNILR FPLSMLPMMI
610 620 630 640 650
SSMLQASVST ERLEKYLGGD DLDTSAIRHD CNFDKAMQFS EASFTWEHDS
660 670 680 690 700
EATVRDVNLD IMAGQLVAVI GPVGSGKSSL ISAMLGEMEN VHGHITIKGT
710 720 730 740 750
TAYVPQQSWI QNGTIKDNIL FGTEFNEKRY QQVLEACALL PDLEMLPGGD
760 770 780 790 800
LAEIGEKGIN LSGGQKQRIS LARATYQNLD IYLLDDPLSA VDAHVGKHIF
810 820 830 840 850
NKVLGPNGLL KGKTRLLVTH SMHFLPQVDE IVVLGNGTIV EKGSYSALLA
860 870 880 890 900
KKGEFAKNLK TFLRHTGPEE EATVHDGSEE EDDDYGLISS VEEIPEDAAS
910 920 930 940 950
ITMRRENSFR RTLSRSSRSN GRHLKSLRNS LKTRNVNSLK EDEELVKGQK
960 970 980 990 1000
LIKKEFIETG KVKFSIYLEY LQAIGLFSIF FIILAFVMNS VAFIGSNLWL
1010 1020 1030 1040 1050
SAWTSDSKIF NSTDYPASQR DMRVGVYGAL GLAQGIFVFI AHFWSAFGFV
1060 1070 1080 1090 1100
HASNILHKQL LNNILRAPMR FFDTTPTGRI VNRFAGDIST VDDTLPQSLR
1110 1120 1130 1140 1150
SWITCFLGII STLVMICMAT PVFTIIVIPL GIIYVSVQMF YVSTSRQLRR
1160 1170 1180 1190 1200
LDSVTRSPIY SHFSETVSGL PVIRAFEHQQ RFLKHNEVRI DTNQKCVFSW
1210 1220 1230 1240 1250
ITSNRWLAIR LELVGNLTVF FSALMMVIYR DTLSGDTVGF VLSNALNITQ
1260 1270 1280 1290 1300
TLNWLVRMTS EIETNIVAVE RITEYTKVEN EAPWVTDKRP PPDWPSKGKI
1310 1320 1330 1340 1350
QFNNYQVRYR PELDLVLRGI TCDIGSMEKI GVVGRTGAGK SSLTNCLFRI
1360 1370 1380 1390 1400
LEAAGGQIII DGVDIASIGL HDLREKLTII PQDPILFSGS LRMNLDPFNN
1410 1420 1430 1440 1450
YSDEEIWKAL ELAHLKSFVA SLQLGLSHEV TEAGGNLSIG QRQLLCLGRA
1460 1470 1480 1490 1500
LLRKSKILVL DEATAAVDLE TDNLIQTTIQ NEFAHCTVIT IAHRLHTIMD
1510 1520 1530 1540
SDKVMVLDNG KIIECGSPEE LLQIPGPFYF MAKEAGIENV NSTKF
Length:1,545
Mass (Da):174,207
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5F8984FFCDF9799
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1430V → G in CAB45309 (PubMed:10464142).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04715239Y → F7 PublicationsCorresponds to variant dbSNP:rs927344Ensembl.1
Natural variantiVAR_029113246M → L. Corresponds to variant dbSNP:rs17222744EnsemblClinVar.1
Natural variantiVAR_013324281S → N1 PublicationCorresponds to variant dbSNP:rs56131651EnsemblClinVar.1
Natural variantiVAR_020226333D → G Decreased expression; altered subcellular localization; altered transporter activity. 1 PublicationCorresponds to variant dbSNP:rs17222674EnsemblClinVar.1
Natural variantiVAR_020227353R → H Altered transporter activity. 1 PublicationCorresponds to variant dbSNP:rs7080681EnsemblClinVar.1
Natural variantiVAR_013325417V → I3 PublicationsCorresponds to variant dbSNP:rs2273697EnsemblClinVar.1
Natural variantiVAR_070607486T → I Altered transporter activity. 1 PublicationCorresponds to variant dbSNP:rs17222589EnsemblClinVar.1
Natural variantiVAR_029115495K → E. Corresponds to variant dbSNP:rs17222561EnsemblClinVar.1
Natural variantiVAR_029116562F → L. Corresponds to variant dbSNP:rs17216233Ensembl.1
Natural variantiVAR_020228670I → T1 PublicationCorresponds to variant dbSNP:rs17222632Ensembl.1
Natural variantiVAR_000099768R → W in DJS. 4 PublicationsCorresponds to variant dbSNP:rs56199535EnsemblClinVar.1
Natural variantiVAR_013326789S → F1 PublicationCorresponds to variant dbSNP:rs56220353Ensembl.1
Natural variantiVAR_020229849L → R. Corresponds to variant dbSNP:rs17222617EnsemblClinVar.1
Natural variantiVAR_070608921G → S Altered transporter activity. 1 PublicationCorresponds to variant dbSNP:rs41318029Ensembl.1
Natural variantiVAR_029117982I → V. Corresponds to variant dbSNP:rs17222554EnsemblClinVar.1
Natural variantiVAR_0202301036I → T Polymorphism; no effect on transporter activity. 1 PublicationCorresponds to variant dbSNP:rs45441199EnsemblClinVar.1
Natural variantiVAR_0291181063N → S. Corresponds to variant dbSNP:rs17222540EnsemblClinVar.1
Natural variantiVAR_0133271150R → H in DJS; protein is properly localized at the plasma membrane, but transporter activity is impaired. 1 PublicationCorresponds to variant dbSNP:rs72558200EnsemblClinVar.1
Natural variantiVAR_0133281173I → F in DJS; decreased expression and mislocation to the endoplasmic reticulum. 2 PublicationsCorresponds to variant dbSNP:rs72558201EnsemblClinVar.1
Natural variantiVAR_0706091174R → H Decreased expression; altered subcellular localization; decreased transporter activity. 1 PublicationCorresponds to variant dbSNP:rs139188247EnsemblClinVar.1
Natural variantiVAR_0202311181R → L Decreased expression. 1 PublicationCorresponds to variant dbSNP:rs8187692EnsemblClinVar.1
Natural variantiVAR_0202321188V → E2 PublicationsCorresponds to variant dbSNP:rs17222723EnsemblClinVar.1
Natural variantiVAR_0706101244N → K Decreased transporter activity. 1 PublicationCorresponds to variant dbSNP:rs757141905Ensembl.1
Natural variantiVAR_0243601273T → A. Corresponds to variant dbSNP:rs8187699Ensembl.1
Natural variantiVAR_0202331291P → L Altered transporter activity. 1 PublicationCorresponds to variant dbSNP:rs17216317EnsemblClinVar.1
Natural variantiVAR_0107561382Q → R in DJS. 1 PublicationCorresponds to variant dbSNP:rs72558202EnsemblClinVar.1
Natural variantiVAR_0133291392 – 1393Missing in DJS; impaired transport from the endoplasmic reticulum to the apical plasma membrane associated with impaired maturation. 2 Publications2
Natural variantiVAR_0133301450A → T1 PublicationCorresponds to variant dbSNP:rs56296335Ensembl.1
Natural variantiVAR_0202341515C → Y2 PublicationsCorresponds to variant dbSNP:rs8187710EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U63970 mRNA Translation: AAB39892.1
U49248 mRNA Translation: AAB09422.1
X96395 mRNA Translation: CAA65259.2
AJ132244
, AJ132287, AJ245625, AJ132288, AJ132289, AJ132290, AJ132291, AJ132292, AJ132293, AJ132294, AJ132295, AJ132296, AJ132297, AJ132298, AJ132299, AJ132300, AJ132301, AJ132302, AJ132303, AJ245626, AJ132304, AJ132305, AJ132306, AJ132307, AJ132308, AJ245627, AJ132309, AJ132310, AJ132311, AJ132312, AJ132313, AJ132314 Genomic DNA Translation: CAB45309.1
AL392107 Genomic DNA No translation available.
AL133353 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49853.1
BC136419 mRNA Translation: AAI36420.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7484.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S71841

NCBI Reference Sequences

More...
RefSeqi
NP_000383.1, NM_000392.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.368243

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370449; ENSP00000359478; ENSG00000023839
ENST00000647814; ENSP00000497274; ENSG00000023839

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1244

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1244

UCSC genome browser

More...
UCSCi
uc001kqf.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63970 mRNA Translation: AAB39892.1
U49248 mRNA Translation: AAB09422.1
X96395 mRNA Translation: CAA65259.2
AJ132244
, AJ132287, AJ245625, AJ132288, AJ132289, AJ132290, AJ132291, AJ132292, AJ132293, AJ132294, AJ132295, AJ132296, AJ132297, AJ132298, AJ132299, AJ132300, AJ132301, AJ132302, AJ132303, AJ245626, AJ132304, AJ132305, AJ132306, AJ132307, AJ132308, AJ245627, AJ132309, AJ132310, AJ132311, AJ132312, AJ132313, AJ132314 Genomic DNA Translation: CAB45309.1
AL392107 Genomic DNA No translation available.
AL133353 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49853.1
BC136419 mRNA Translation: AAI36420.1
CCDSiCCDS7484.1
PIRiS71841
RefSeqiNP_000383.1, NM_000392.4
UniGeneiHs.368243

3D structure databases

ProteinModelPortaliQ92887
SMRiQ92887
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107647, 48 interactors
IntActiQ92887, 5 interactors
STRINGi9606.ENSP00000359478

Chemistry databases

BindingDBiQ92887
ChEMBLiCHEMBL5748
DrugBankiDB04789 5-methyltetrahydrofolic acid
DB00171 Adenosine triphosphate
DB00345 Aminohippuric acid
DB01169 Arsenic trioxide
DB01076 Atorvastatin
DB09060 Avibactam
DB08907 Canagliflozin
DB00564 Carbamazepine
DB00958 Carboplatin
DB00439 Cerivastatin
DB02659 Cholic Acid
DB00515 Cisplatin
DB00257 Clotrimazole
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB00694 Daunorubicin
DB01234 Dexamethasone
DB01248 Docetaxel
DB00997 Doxorubicin
DB09272 Eluxadoline
DB00876 Eprosartan
DB00977 Ethinyl Estradiol
DB00773 Etoposide
DB00973 Ezetimibe
DB00695 Furosemide
DB02703 Fusidic Acid
DB08884 Gadoxetic acid
DB00143 Glutathione
DB01016 Glyburide
DB00365 Grepafloxacin
DB01892 Hyperforin
DB00224 Indinavir
DB09374 Indocyanine green
DB00328 Indomethacin
DB00762 Irinotecan
DB00602 Ivermectin
DB00709 Lamivudine
DB01202 Levetiracetam
DB11256 Levomefolic acid
DB00978 Lomefloxacin
DB00227 Lovastatin
DB00563 Methotrexate
DB00688 Mycophenolate mofetil
DB01115 Nifedipine
DB00957 Norgestimate
DB01165 Ofloxacin
DB00275 Olmesartan
DB00526 Oxaliplatin
DB01229 Paclitaxel
DB01174 Phenobarbital
DB00252 Phenytoin
DB08860 Pitavastatin
DB01411 Pranlukast
DB00175 Pravastatin
DB01032 Probenecid
DB04216 Quercetin
DB00908 Quinidine
DB00206 Reserpine
DB01045 Rifampicin
DB00503 Ritonavir
DB01232 Saquinavir
DB00641 Simvastatin
DB00398 Sorafenib
DB01208 Sparfloxacin
DB00421 Spironolactone
DB00795 Sulfasalazine
DB01138 Sulfinpyrazone
DB01268 Sunitinib
DB00675 Tamoxifen
DB04348 Taurocholic Acid
DB00966 Telmisartan
DB00300 Tenofovir
DB00116 Tetrahydrofolic acid
DB01586 Ursodeoxycholic acid
DB00067 Vasopressin
DB00661 Verapamil
DB00570 Vinblastine
DB00541 Vincristine
GuidetoPHARMACOLOGYi780
SwissLipidsiSLP:000001599

Protein family/group databases

TCDBi3.A.1.208.2 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiQ92887
PhosphoSitePlusiQ92887

Polymorphism and mutation databases

BioMutaiABCC2
DMDMi308153583

Proteomic databases

EPDiQ92887
MaxQBiQ92887
PaxDbiQ92887
PeptideAtlasiQ92887
PRIDEiQ92887
ProteomicsDBi75571

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370449; ENSP00000359478; ENSG00000023839
ENST00000647814; ENSP00000497274; ENSG00000023839
GeneIDi1244
KEGGihsa:1244
UCSCiuc001kqf.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1244
DisGeNETi1244
EuPathDBiHostDB:ENSG00000023839.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABCC2
HGNCiHGNC:53 ABCC2
HPAiCAB037271
HPA004860
MalaCardsiABCC2
MIMi237500 phenotype
601107 gene
neXtProtiNX_Q92887
OpenTargetsiENSG00000023839
Orphaneti234 Dubin-Johnson syndrome
PharmGKBiPA116

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000161741
HOVERGENiHBG108314
InParanoidiQ92887
KOiK05666
OMAiNMKNKDK
OrthoDBiEOG091G00IN
PhylomeDBiQ92887
TreeFamiTF105199

Enzyme and pathway databases

ReactomeiR-HSA-382556 ABC-family proteins mediated transport
R-HSA-5679001 Defective ABCC2 causes Dubin-Johnson syndrome
SABIO-RKiQ92887
SIGNORiQ92887

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABCC2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Multidrug_resistance-associated_protein_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1244

Protein Ontology

More...
PROi
PR:Q92887

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000023839 Expressed in 94 organ(s), highest expression level in right lobe of liver
CleanExiHS_ABCC2
ExpressionAtlasiQ92887 baseline and differential
GenevisibleiQ92887 HS

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030247 ABCC2
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF176 PTHR24223:SF176, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92887
Secondary accession number(s): B2RMT8
, Q14022, Q5T2B1, Q92500, Q92798, Q99663, Q9UMS2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 5, 2010
Last modified: December 5, 2018
This is version 188 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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