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Protein

Neurogenin-1

Gene

NEUROG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ92886

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-1
Short name:
NGN-1
Alternative name(s):
Class A basic helix-loop-helix protein 6
Short name:
bHLHa6
Neurogenic basic-helix-loop-helix protein
Neurogenic differentiation factor 3
Short name:
NeuroD3
Gene namesi
Name:NEUROG1
Synonyms:BHLHA6, NEUROD3, NGN, NGN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000181965.5
HGNCiHGNC:7764 NEUROG1
MIMi601726 gene
neXtProtiNX_Q92886

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4762
OpenTargetsiENSG00000181965
PharmGKBiPA31569

Polymorphism and mutation databases

BioMutaiNEUROG1
DMDMi37538313

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273961 – 237Neurogenin-1Add BLAST237

Proteomic databases

PaxDbiQ92886
PRIDEiQ92886
ProteomicsDBi75570

PTM databases

iPTMnetiQ92886
PhosphoSitePlusiQ92886

Expressioni

Tissue specificityi

Expression restricted to the embryonic nervous system.

Gene expression databases

BgeeiENSG00000181965 Expressed in 13 organ(s), highest expression level in vastus lateralis
CleanExiHS_NEUROG1
ExpressionAtlasiQ92886 baseline and differential
GenevisibleiQ92886 HS

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Binary interactionsi

WithEntry#Exp.IntActNotes
TCF4P158843EBI-10279647,EBI-533224

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110835, 7 interactors
IntActiQ92886, 2 interactors
STRINGi9606.ENSP00000317580

Structurei

3D structure databases

DisProtiDP00672
ProteinModelPortaliQ92886
SMRiQ92886
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 144bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG4111U26 LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000063655
HOVERGENiHBG101129
InParanoidiQ92886
KOiK09081
OMAiYIWALAE
OrthoDBiEOG091G0PNH
PhylomeDBiQ92886
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032653 Ngn1
PANTHERiPTHR19290:SF130 PTHR19290:SF130, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q92886-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR
60 70 80 90 100
GAPNISRASE VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR
110 120 130 140 150
ERNRMHNLNA ALDALRSVLP SFPDDTKLTK IETLRFAYNY IWALAETLRL
160 170 180 190 200
ADQGLPGGGA RERLLPPQCV PCLPGPPSPA SDAESWGSGA AAASPLSDPS
210 220 230
SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH
Length:237
Mass (Da):25,718
Last modified:October 3, 2003 - v2
Checksum:iE3702A0B3408D567
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51G → S in AAB37575 (PubMed:8816493).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63842 Genomic DNA Translation: AAB37575.1
BT019366 mRNA Translation: AAV38173.1
CH471062 Genomic DNA Translation: EAW62214.1
BC008687 mRNA Translation: AAH08687.1
BC028226 mRNA Translation: AAH28226.1
CCDSiCCDS4187.1
RefSeqiNP_006152.2, NM_006161.2
UniGeneiHs.248149

Genome annotation databases

EnsembliENST00000314744; ENSP00000317580; ENSG00000181965
GeneIDi4762
KEGGihsa:4762
UCSCiuc003lax.3 human

Similar proteinsi

Entry informationi

Entry nameiNGN1_HUMAN
AccessioniPrimary (citable) accession number: Q92886
Secondary accession number(s): Q5U0Q9, Q96HE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2003
Last modified: September 12, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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