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Protein

Osteoclast-stimulating factor 1

Gene

OSTF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • neutrophil degranulation Source: Reactome
  • ossification Source: ProtInc
  • signal transduction Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast-stimulating factor 1
Gene namesi
Name:OSTF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000134996.11
HGNCiHGNC:8510 OSTF1
MIMi610180 gene
neXtProtiNX_Q92882

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi26578
OpenTargetsiENSG00000134996
PharmGKBiPA32839

Polymorphism and mutation databases

BioMutaiOSTF1
DMDMi108885279

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000670352 – 214Osteoclast-stimulating factor 1Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei200PhosphothreonineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92882
MaxQBiQ92882
PaxDbiQ92882
PeptideAtlasiQ92882
PRIDEiQ92882
ProteomicsDBi75569

PTM databases

iPTMnetiQ92882
PhosphoSitePlusiQ92882

Expressioni

Tissue specificityi

Ubiquitously expressed. Present in osteoclasts (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000134996 Expressed in 215 organ(s), highest expression level in blood
CleanExiHS_OSTF1
GenevisibleiQ92882 HS

Organism-specific databases

HPAiHPA020514

Interactioni

Subunit structurei

Interacts with SRC and SMN1. Interacts with FASLG.4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117747, 35 interactors
CORUMiQ92882
IntActiQ92882, 11 interactors
MINTiQ92882
STRINGi9606.ENSP00000340836

Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92882
SMRiQ92882
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92882

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 71SH3PROSITE-ProRule annotationAdd BLAST60
Repeati72 – 101ANK 1Add BLAST30
Repeati105 – 135ANK 2Add BLAST31
Repeati139 – 168ANK 3Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 11Pro-rich8

Domaini

The SH3 domain mediates interaction with SMN1.

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IIWQ Eukaryota
ENOG410XR45 LUCA
GeneTreeiENSGT00920000149159
HOGENOMiHOG000286040
HOVERGENiHBG053379
InParanoidiQ92882
OMAiFRALFTF
OrthoDBiEOG091G0HJ5
PhylomeDBiQ92882
TreeFamiTF314534

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR01415 ANKYRIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92882-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTNWW
60 70 80 90 100
KGTSKGRTGL IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN
110 120 130 140 150
GLDKAGSTAL YWACHGGHKD IVEMLFTQPN IELNQQNKLG DTALHAAAWK
160 170 180 190 200
GYADIVQLLL AKGARTDLRN IEKKLAFDMA TNAACASLLK KKQGTDAVRT
210
LSNAEDYLDD EDSD
Length:214
Mass (Da):23,787
Last modified:May 30, 2006 - v2
Checksum:i6C37F3D2B68578C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11P → PGEG in AAH07459 (PubMed:15489334).Curated1
Sequence conflicti144 – 145LH → FD in AAB06396 (PubMed:10092216).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04830948N → S. Corresponds to variant dbSNP:rs2295862Ensembl.1
Natural variantiVAR_026573159L → F1 PublicationCorresponds to variant dbSNP:rs17850197Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63717 mRNA Translation: AAB06396.1
AK222596 mRNA Translation: BAD96316.1
AL133548 Genomic DNA No translation available.
BC007459 mRNA Translation: AAH07459.1
CCDSiCCDS6651.1
RefSeqiNP_036515.4, NM_012383.4
UniGeneiHs.494192

Genome annotation databases

EnsembliENST00000346234; ENSP00000340836; ENSG00000134996
GeneIDi26578
KEGGihsa:26578
UCSCiuc004ajv.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63717 mRNA Translation: AAB06396.1
AK222596 mRNA Translation: BAD96316.1
AL133548 Genomic DNA No translation available.
BC007459 mRNA Translation: AAH07459.1
CCDSiCCDS6651.1
RefSeqiNP_036515.4, NM_012383.4
UniGeneiHs.494192

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X2KNMR-A15-69[»]
1ZLMX-ray1.07A12-69[»]
3EHQX-ray2.57A/B1-214[»]
3EHRX-ray1.95A/B1-214[»]
ProteinModelPortaliQ92882
SMRiQ92882
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117747, 35 interactors
CORUMiQ92882
IntActiQ92882, 11 interactors
MINTiQ92882
STRINGi9606.ENSP00000340836

PTM databases

iPTMnetiQ92882
PhosphoSitePlusiQ92882

Polymorphism and mutation databases

BioMutaiOSTF1
DMDMi108885279

Proteomic databases

EPDiQ92882
MaxQBiQ92882
PaxDbiQ92882
PeptideAtlasiQ92882
PRIDEiQ92882
ProteomicsDBi75569

Protocols and materials databases

DNASUi26578
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346234; ENSP00000340836; ENSG00000134996
GeneIDi26578
KEGGihsa:26578
UCSCiuc004ajv.5 human

Organism-specific databases

CTDi26578
DisGeNETi26578
EuPathDBiHostDB:ENSG00000134996.11
GeneCardsiOSTF1
HGNCiHGNC:8510 OSTF1
HPAiHPA020514
MIMi610180 gene
neXtProtiNX_Q92882
OpenTargetsiENSG00000134996
PharmGKBiPA32839
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIWQ Eukaryota
ENOG410XR45 LUCA
GeneTreeiENSGT00920000149159
HOGENOMiHOG000286040
HOVERGENiHBG053379
InParanoidiQ92882
OMAiFRALFTF
OrthoDBiEOG091G0HJ5
PhylomeDBiQ92882
TreeFamiTF314534

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiOSTF1 human
EvolutionaryTraceiQ92882
GeneWikiiOSTF1
GenomeRNAii26578
PROiPR:Q92882
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134996 Expressed in 215 organ(s), highest expression level in blood
CleanExiHS_OSTF1
GenevisibleiQ92882 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR01415 ANKYRIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSTF1_HUMAN
AccessioniPrimary (citable) accession number: Q92882
Secondary accession number(s): Q5W126, Q96IJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 30, 2006
Last modified: November 7, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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