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UniProtKB - Q92879 (CELF1_HUMAN)

Entry version 198 (10 Feb 2021)
Sequence version 2 (18 Oct 2001)
Previous versions | rss
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Protein

CUGBP Elav-like family member 1

Gene

CELF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233).By similarity9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92879

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CUGBP Elav-like family member 1
Short name:
CELF-1
Alternative name(s):
50 kDa nuclear polyadenylated RNA-binding protein
Bruno-like protein 2
CUG triplet repeat RNA-binding protein 1
Short name:
CUG-BP1
CUG-BP- and ETR-3-like factor 1
Deadenylation factor CUG-BP
Embryo deadenylation element-binding protein homolog
Short name:
EDEN-BP homolog
RNA-binding protein BRUNOL-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CELF1
Synonyms:BRUNOL2, CUGBP, CUGBP1, NAB50
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2549, CELF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601074, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92879

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000149187.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi63F → L: Does not reduce RNA-binding; when associated with D-331 and F-472. Abolishes ARE/EDEN-dependent deadenylation; when associated with D-331 and F-472. 1 Publication1
Mutagenesisi331G → D: Does not reduce RNA-binding; when associated with L-63 and F-472. Abolishes ARE/EDEN-dependent deadenylation; when associated with D-331 and F-472. 1 Publication1
Mutagenesisi472L → F: Does not reduce RNA-binding; when associated with L-63 and D-331. Abolishes ARE/EDEN-dependent deadenylation; when associated with D-331 and F-472. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10658

NIAGADS Genomics Database

More...NIAGADSi		ENSG00000149187

Open Targets

More...OpenTargetsi		ENSG00000149187

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27045

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92879, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CELF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		17374605

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000815381 – 486CUGBP Elav-like family member 1Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei4PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei179PhosphoserineCombined sources1
Modified residuei302PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Its phosphorylation status increases in senescent cells.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92879

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92879

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92879

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92879

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92879

PeptideAtlas

More...PeptideAtlasi		Q92879

PRoteomics IDEntifications database

More...PRIDEi		Q92879

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		30255
75565 [Q92879-1]
75566 [Q92879-2]
75567 [Q92879-3]
75568 [Q92879-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92879

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q92879

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92879

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q92879

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in myotonic dystrophy pathophysiology (DM).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000149187, Expressed in forebrain and 260 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92879, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92879, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000149187, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Associates with polysomes (By similarity).

Interacts with HNRNPH1; the interaction in RNA-dependent.

Interacts with PARN.

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115901, 75 interactors

Protein interaction database and analysis system

More...IntActi		Q92879, 35 interactors

Molecular INTeraction database

More...MINTi		Q92879

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000435926

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92879, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1486
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92879

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q92879

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 99RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini108 – 188RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini401 – 479RRM 3PROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi287 – 308Ser-richAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

RRM1 and RRM2 domains preferentially target UGU(U/G)-rich mRNA elements.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CELF/BRUNOL family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0144, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158970

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015367_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92879

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92879

TreeFam database of animal gene trees

More...TreeFami		TF314924

Family and domain databases

Conserved Domains Database

More...CDDi		cd12631, RRM1_CELF1_2_Bruno, 1 hit
cd12634, RRM2_CELF1_2, 1 hit
cd12638, RRM3_CELF1_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 3 hits

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00490

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034196, CELF1/2_RRM1
IPR034198, CELF1/2_RRM2
IPR034199, CELF1/2_RRM3
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076, RRM_1, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92879-1) [UniParc]FASTAAdd to basket
Also known as: LYLQ

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNGTLDHPDQ PDLDAIKMFV GQVPRTWSEK DLRELFEQYG AVYEINVLRD 
        60         70         80         90        100
RSQNPPQSKG CCFVTFYTRK AALEAQNALH NMKVLPGMHH PIQMKPADSE 
       110        120        130        140        150
KNNAVEDRKL FIGMISKKCT ENDIRVMFSS FGQIEECRIL RGPDGLSRGC 
       160        170        180        190        200
AFVTFTTRAM AQTAIKAMHQ AQTMEGCSSP MVVKFADTQK DKEQKRMAQQ 
       210        220        230        240        250
LQQQMQQISA ASVWGNLAGL NTLGPQYLAL YLQLLQQTAS SGNLNTLSSL 
       260        270        280        290        300
HPMGGLNAMQ LQNLAALAAA ASAAQNTPSG TNALTTSSSP LSVLTSSGSS 
       310        320        330        340        350
PSSSSSNSVN PIASLGALQT LAGATAGLNV GSLAGMAALN GGLGSSGLSN 
       360        370        380        390        400
GTGSTMEALT QAYSGIQQYA AAALPTLYNQ NLLTQQSIGA AGSQKEGPEG 
       410        420        430        440        450
ANLFIYHLPQ EFGDQDLLQM FMPFGNVVSA KVFIDKQTNL SKCFGFVSYD 
       460        470        480 
NPVSAQAAIQ SMNGFQIGMK RLKVQLKRSK NDSKPY
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:486
Mass (Da):52,063
Last modified:October 18, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC4C13D772273A01D
GO
Isoform 2 (identifier: Q92879-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-234: Missing.

Show »
Length:482
Mass (Da):51,546
Checksum:iAC0863DB01A22163
GO
Isoform 3 (identifier: Q92879-3) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     231-234: Missing.
     297-297: S → SA

Show »
Length:483
Mass (Da):51,617
Checksum:i0C8D6B707E157FD1
GO
Isoform 4 (identifier: Q92879-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAAFKLDFLPEMMVDHCSLNSSPVSKKM
     104-104: Missing.

Show »
Length:512
Mass (Da):55,001
Checksum:i2A099A7F4E0F5358
GO
Isoform 5 (identifier: Q92879-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.
     104-104: Missing.

Show »
Length:468
Mass (Da):50,130
Checksum:i7CD2C6BFBE344830
GO
Isoform 6 (identifier: Q92879-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-104: Missing.

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Length:485
Mass (Da):51,992
Checksum:i37B0006E19EC012A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EA30G5EA30_HUMAN
CUG triplet repeat, RNA binding pro...
CELF1 CUGBP1, hCG_25183
514Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSH0E9PSH0_HUMAN
CUGBP Elav-like family member 1
CELF1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQK4E9PQK4_HUMAN
CUGBP Elav-like family member 1
CELF1
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0D8F5H0D8_HUMAN
CUGBP Elav-like family member 1
CELF1
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKA1E9PKA1_HUMAN
CUGBP Elav-like family member 1
CELF1
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKU1E9PKU1_HUMAN
CUGBP Elav-like family member 1
CELF1
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4Y5F5H4Y5_HUMAN
CUGBP Elav-like family member 1
CELF1
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3J7F5H3J7_HUMAN
CUGBP Elav-like family member 1
CELF1
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7M7F5H7M7_HUMAN
CUGBP Elav-like family member 1
CELF1
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE06101 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0450431 – 17Missing in isoform 5. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0267871M → MAAFKLDFLPEMMVDHCSLN SSPVSKKM in isoform 4. 1 Publication1
Alternative sequenceiVSP_026788104Missing in isoform 4, isoform 5 and isoform 6. 2 Publications1
Alternative sequenceiVSP_005784231 – 234Missing in isoform 2 and isoform 3. 3 Publications4
Alternative sequenceiVSP_005785297S → SA in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U63289 mRNA Translation: AAC50895.1
AF248648 mRNA Translation: AAF86230.1
AF267533 mRNA Translation: AAF78955.1
AF267534 mRNA Translation: AAF78956.1
AJ007988 mRNA Translation: CAC20566.1
AK304430 mRNA Translation: BAG65257.1
AB210019 mRNA Translation: BAE06101.1 Different initiation.
AC090559 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW67909.1
CH471064 Genomic DNA Translation: EAW67912.1
BC031079 mRNA Translation: AAH31079.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31482.1 [Q92879-1]
CCDS53622.1 [Q92879-6]
CCDS53623.1 [Q92879-4]
CCDS7938.1 [Q92879-2]
CCDS7939.1 [Q92879-3]

NCBI Reference Sequences

More...RefSeqi		NP_001020767.1, NM_001025596.2 [Q92879-1]
NP_001166110.1, NM_001172639.1 [Q92879-4]
NP_001166111.1, NM_001172640.1 [Q92879-6]
NP_006551.1, NM_006560.3 [Q92879-2]
NP_941989.1, NM_198700.2 [Q92879-3]
XP_011518161.1, XM_011519859.1 [Q92879-3]
XP_016872613.1, XM_017017124.1
XP_016872614.1, XM_017017125.1
XP_016872615.1, XM_017017126.1
XP_016872616.1, XM_017017127.1
XP_016872617.1, XM_017017128.1
XP_016872618.1, XM_017017129.1
XP_016872619.1, XM_017017130.1
XP_016872620.1, XM_017017131.1
XP_016872621.1, XM_017017132.1
XP_016872622.1, XM_017017133.1
XP_016872623.1, XM_017017134.1
XP_016872624.1, XM_017017135.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000310513; ENSP00000308386; ENSG00000149187 [Q92879-2]
ENST00000358597; ENSP00000351409; ENSG00000149187 [Q92879-1]
ENST00000361904; ENSP00000354639; ENSG00000149187 [Q92879-3]
ENST00000395290; ENSP00000378705; ENSG00000149187 [Q92879-6]
ENST00000395292; ENSP00000378706; ENSG00000149187 [Q92879-3]
ENST00000532048; ENSP00000435926; ENSG00000149187 [Q92879-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10658

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10658

UCSC genome browser

More...UCSCi		uc001nfk.3, human [Q92879-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63289 mRNA Translation: AAC50895.1
AF248648 mRNA Translation: AAF86230.1
AF267533 mRNA Translation: AAF78955.1
AF267534 mRNA Translation: AAF78956.1
AJ007988 mRNA Translation: CAC20566.1
AK304430 mRNA Translation: BAG65257.1
AB210019 mRNA Translation: BAE06101.1 Different initiation.
AC090559 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW67909.1
CH471064 Genomic DNA Translation: EAW67912.1
BC031079 mRNA Translation: AAH31079.1
CCDSiCCDS31482.1 [Q92879-1]
CCDS53622.1 [Q92879-6]
CCDS53623.1 [Q92879-4]
CCDS7938.1 [Q92879-2]
CCDS7939.1 [Q92879-3]
RefSeqiNP_001020767.1, NM_001025596.2 [Q92879-1]
NP_001166110.1, NM_001172639.1 [Q92879-4]
NP_001166111.1, NM_001172640.1 [Q92879-6]
NP_006551.1, NM_006560.3 [Q92879-2]
NP_941989.1, NM_198700.2 [Q92879-3]
XP_011518161.1, XM_011519859.1 [Q92879-3]
XP_016872613.1, XM_017017124.1
XP_016872614.1, XM_017017125.1
XP_016872615.1, XM_017017126.1
XP_016872616.1, XM_017017127.1
XP_016872617.1, XM_017017128.1
XP_016872618.1, XM_017017129.1
XP_016872619.1, XM_017017130.1
XP_016872620.1, XM_017017131.1
XP_016872621.1, XM_017017132.1
XP_016872622.1, XM_017017133.1
XP_016872623.1, XM_017017134.1
XP_016872624.1, XM_017017135.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPZNMR-A383-484[»]
2DHSNMR-A1-187[»]
2RQ4NMR-A383-484[»]
2RQCNMR-A383-484[»]
3NMRX-ray1.85A14-187[»]
3NNAX-ray1.90A14-187[»]
3NNCX-ray2.20A14-187[»]
3NNHX-ray2.75A/B/C/D14-100[»]
SMRiQ92879
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115901, 75 interactors
IntActiQ92879, 35 interactors
MINTiQ92879
STRINGi9606.ENSP00000435926

PTM databases

iPTMnetiQ92879
MetOSiteiQ92879
PhosphoSitePlusiQ92879
SwissPalmiQ92879

Genetic variation databases

BioMutaiCELF1
DMDMi17374605

Proteomic databases

EPDiQ92879
jPOSTiQ92879
MassIVEiQ92879
MaxQBiQ92879
PaxDbiQ92879
PeptideAtlasiQ92879
PRIDEiQ92879
ProteomicsDBi30255
75565 [Q92879-1]
75566 [Q92879-2]
75567 [Q92879-3]
75568 [Q92879-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4239, 377 antibodies

The DNASU plasmid repository

More...DNASUi		10658

Genome annotation databases

EnsembliENST00000310513; ENSP00000308386; ENSG00000149187 [Q92879-2]
ENST00000358597; ENSP00000351409; ENSG00000149187 [Q92879-1]
ENST00000361904; ENSP00000354639; ENSG00000149187 [Q92879-3]
ENST00000395290; ENSP00000378705; ENSG00000149187 [Q92879-6]
ENST00000395292; ENSP00000378706; ENSG00000149187 [Q92879-3]
ENST00000532048; ENSP00000435926; ENSG00000149187 [Q92879-4]
GeneIDi10658
KEGGihsa:10658
UCSCiuc001nfk.3, human [Q92879-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10658
DisGeNETi10658

GeneCards: human genes, protein and diseases

More...GeneCardsi		CELF1
HGNCiHGNC:2549, CELF1
HPAiENSG00000149187, Low tissue specificity
MIMi601074, gene
neXtProtiNX_Q92879
NIAGADSiENSG00000149187
OpenTargetsiENSG00000149187
PharmGKBiPA27045
VEuPathDBiHostDB:ENSG00000149187.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0144, Eukaryota
GeneTreeiENSGT00940000158970
HOGENOMiCLU_015367_0_2_1
InParanoidiQ92879
PhylomeDBiQ92879
TreeFamiTF314924

Enzyme and pathway databases

PathwayCommonsiQ92879

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10658, 24 hits in 885 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CELF1, human
EvolutionaryTraceiQ92879

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CUGBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10658
PharosiQ92879, Tbio

Protein Ontology

More...PROi		PR:Q92879
RNActiQ92879, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000149187, Expressed in forebrain and 260 other tissues
ExpressionAtlasiQ92879, baseline and differential
GenevisibleiQ92879, HS

Family and domain databases

CDDicd12631, RRM1_CELF1_2_Bruno, 1 hit
cd12634, RRM2_CELF1_2, 1 hit
cd12638, RRM3_CELF1_2, 1 hit
Gene3Di3.30.70.330, 3 hits
IDEALiIID00490
InterProiView protein in InterPro
IPR034196, CELF1/2_RRM1
IPR034198, CELF1/2_RRM2
IPR034199, CELF1/2_RRM3
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PfamiView protein in Pfam
PF00076, RRM_1, 3 hits
SMARTiView protein in SMART
SM00360, RRM, 3 hits
SUPFAMiSSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92879
Secondary accession number(s): B4E2U5
, D3DQS0, F8W940, Q4LE52, Q9NP83, Q9NR06
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: February 10, 2021
This is version 198 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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