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UniProtKB - Q92876 (KLK6_HUMAN)

Protein

Kallikrein-6

Gene

KLK6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.6 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by a range of serine protease inhibitors including soybean trypsin inhibitor, benzamidine and serpins. Activated by a range of glycosaminoglycans including chondroitin sulfate, dermatan sulfate, heparan sulfate and heparin.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1562 µM for Tosyl-Gly-Pro-Arg-AMC2 Publications
  2. KM=777 µM for Tosyl-Gly-Pro-Lys-AMC2 Publications
  3. KM=0.410 mM for Phe-Ser-Arg-AMC2 Publications
  4. KM=0.455 mM for Gly-Gly-Arg-AMC2 Publications
  5. KM=0.335 mM for Asp-Pro-Arg-AMC2 Publications
  6. KM=0.758 mM for Gln-Gly-Arg-AMC2 Publications
  7. KM=0.625 mM for Pro-Phe-Arg-AMC2 Publications
  8. KM=0.271 mM for Val-Pro-Arg-AMC2 Publications
  9. KM=1.72 mM for Val-Leu-Lys-AMC2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei62Charge relay system1 Publication1
    Active sitei106Charge relay system1 Publication1
    Active sitei197Charge relay system1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • serine-type endopeptidase activity Source: UniProtKB
    View the complete GO annotation on QuickGO ...

    GO - Biological processi

    View the complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		3.4.21.104 2681
    3.4.21.34 2681
    3.4.21.B10 2681

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q92876

    Protein family/group databases

    MEROPS protease database

    More...    MEROPSi    		S01.236

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Kallikrein-6 (EC:3.4.21.-)
    Alternative name(s):
    Neurosin
    Protease M
    SP59
    Serine protease 18
    Serine protease 9
    Zyme
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:KLK6
    Synonyms:PRSS18, PRSS9
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000167755.13

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:6367 KLK6

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		602652 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q92876

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Microsome, Mitochondrion, Nucleus, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		5653

    Open Targets

    More...    OpenTargetsi    		ENSG00000167755

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA30156

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL4448

    Drug and drug target database

    More...    DrugBanki    		DB03127 Benzamidine

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...    GuidetoPHARMACOLOGYi    		2376

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		KLK6

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		3914480

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002794017 – 21Activation peptideSequence analysis5
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002794122 – 244Kallikrein-6Add BLAST223

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 157
    Disulfide bondi47 ↔ 63
    Disulfide bondi131 ↔ 231
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi138 ↔ 203
    Disulfide bondi168 ↔ 182
    Disulfide bondi193 ↔ 218

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Inactivated by autolytic cleavage after Arg-80.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei80 – 81Cleavage; by autolysis2

    Keywords - PTMi

    Autocatalytic cleavage, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q92876

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q92876

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q92876

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q92876

    PeptideAtlas

    More...    PeptideAtlasi    		Q92876

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q92876

    ProteomicsDB human proteome resource

    More...    ProteomicsDBi    		75559
    75560 [Q92876-2]
    75561 [Q92876-3]

    PTM databases

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q92876

    UniCarbKB; an annotated and curated database of glycan structures

    More...    UniCarbKBi    		Q92876

    Miscellaneous databases

    CutDB - Proteolytic event database

    More...    PMAP-CutDBi    		Q92876

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.5 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By spinal cord injury. This effect is particularly prominent in macrophages, microglia and reactive astrocytes.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000167755 Expressed in 133 organ(s), highest expression level in C1 segment of cervical spinal cord

    CleanEx database of gene expression profiles

    More...    CleanExi    		HS_KLK6

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q92876 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q92876 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		HPA051837

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		111634, 12 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q92876, 16 interactors

    Molecular INTeraction database

    More...    MINTi    		Q92876

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000309148

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q92876

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1244
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1GVLX-ray1.80A21-243[»]
    1L2EX-ray1.75A22-244[»]
    1LO6X-ray1.56A22-244[»]
    3VFEX-ray1.88A22-244[»]
    4D8NX-ray1.68A22-244[»]
    5NX1X-ray1.85A22-244[»]
    5NX3X-ray2.30A22-244[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...    ProteinModelPortali    		Q92876

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q92876

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		Q92876

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 242Peptidase S1PROSITE-ProRule annotationAdd BLAST221

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG3627 Eukaryota
    COG5640 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000153358

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		HOG000251820

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...    HOVERGENi    		HBG013304

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q92876

    KEGG Orthology (KO)

    More...    KOi    		K08667

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		WIRKTIQ

    Database of Orthologous Groups

    More...    OrthoDBi    		1314811at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q92876

    TreeFam database of animal gene trees

    More...    TreeFami    		TF331065

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd00190 Tryp_SPc, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR009003 Peptidase_S1_PA
    IPR001314 Peptidase_S1A
    IPR001254 Trypsin_dom
    IPR018114 TRYPSIN_HIS
    IPR033116 TRYPSIN_SER

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00089 Trypsin, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00722 CHYMOTRYPSIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00020 Tryp_SPc, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF50494 SSF50494, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS50240 TRYPSIN_DOM, 1 hit
    PS00134 TRYPSIN_HIS, 1 hit
    PS00135 TRYPSIN_SER, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q92876-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKKLMVVLSL IAAAWAEEQN KLVHGGPCDK TSHPYQAALY TSGHLLCGGV 
            60         70         80         90        100
    LIHPLWVLTA AHCKKPNLQV FLGKHNLRQR ESSQEQSSVV RAVIHPDYDA 
           110        120        130        140        150
    ASHDQDIMLL RLARPAKLSE LIQPLPLERD CSANTTSCHI LGWGKTADGD 
           160        170        180        190        200
    FPDTIQCAYI HLVSREECEH AYPGQITQNM LCAGDEKYGK DSCQGDSGGP 
           210        220        230        240 
    LVCGDHLRGL VSWGNIPCGS KEKPGVYTNV CRYTNWIQKT IQAK
    Length:244
    Mass (Da):26,856
    Last modified:February 1, 1997 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEA03F9145D87AAB
    GO
    Isoform 2 (identifier: Q92876-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-107: Missing.

    Show »
    Length:137
    Mass (Da):15,055
    Checksum:i25A421C212869BEA
    GO
    Isoform 3 (identifier: Q92876-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         14-40: AWAEEQNKLVHGGPCDKTSHPYQAALY → GIFRSSWGSITFGKGRVPRSRVLLSGL
         41-244: Missing.

    Show »
    Length:40
    Mass (Da):4,333
    Checksum:i323721E6AE557378
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    M0QYA5M0QYA5_HUMAN
    Kallikrein-6
    KLK6
    		69Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

    Molecular mass is 25866 Da from positions 22 - 244. Determined by MALDI. 1 Publication

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06177678R → W. Corresponds to variant dbSNP:rs61469141Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0344031 – 107Missing in isoform 2. 1 PublicationAdd BLAST107
    Alternative sequenceiVSP_03440414 – 40AWAEE…QAALY → GIFRSSWGSITFGKGRVPRS RVLLSGL in isoform 3. 1 PublicationAdd BLAST27
    Alternative sequenceiVSP_03440541 – 244Missing in isoform 3. 1 PublicationAdd BLAST204

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		U62801 mRNA Translation: AAB07113.1
    D78203 mRNA Translation: BAA11306.1
    AF013988 mRNA Translation: AAB66483.1
    AF149289 Genomic DNA Translation: AAD51475.1
    AF243527 Genomic DNA Translation: AAG33359.1
    AY318867 mRNA Translation: AAP82446.1
    AY318868 mRNA No translation available.
    AY318869 mRNA Translation: AAP82448.1
    AY318870 mRNA No translation available.
    DQ223012 mRNA Translation: ABB04464.1
    AK314897 mRNA Translation: BAG37411.1
    BT006852 mRNA Translation: AAP35498.1
    AC011483 Genomic DNA No translation available.
    CH471135 Genomic DNA Translation: EAW71953.1
    CH471135 Genomic DNA Translation: EAW71954.1
    BC015525 mRNA Translation: AAH15525.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS12811.1 [Q92876-1]
    CCDS42599.1 [Q92876-2]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001012982.1, NM_001012964.2 [Q92876-1]
    NP_001012983.1, NM_001012965.2 [Q92876-2]
    NP_001306877.1, NM_001319948.1 [Q92876-2]
    NP_001306878.1, NM_001319949.1 [Q92876-2]
    NP_002765.1, NM_002774.3 [Q92876-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...    UniGenei    		Hs.79361

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000310157; ENSP00000309148; ENSG00000167755 [Q92876-1]
    ENST00000376851; ENSP00000366047; ENSG00000167755 [Q92876-1]
    ENST00000391808; ENSP00000375684; ENSG00000167755 [Q92876-2]
    ENST00000594641; ENSP00000470482; ENSG00000167755 [Q92876-1]
    ENST00000597379; ENSP00000469630; ENSG00000167755 [Q92876-3]
    ENST00000599881; ENSP00000471948; ENSG00000167755 [Q92876-3]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		5653

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:5653

    UCSC genome browser

    More...    UCSCi    		uc002pui.4 human [Q92876-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		U62801 mRNA Translation: AAB07113.1
    D78203 mRNA Translation: BAA11306.1
    AF013988 mRNA Translation: AAB66483.1
    AF149289 Genomic DNA Translation: AAD51475.1
    AF243527 Genomic DNA Translation: AAG33359.1
    AY318867 mRNA Translation: AAP82446.1
    AY318868 mRNA No translation available.
    AY318869 mRNA Translation: AAP82448.1
    AY318870 mRNA No translation available.
    DQ223012 mRNA Translation: ABB04464.1
    AK314897 mRNA Translation: BAG37411.1
    BT006852 mRNA Translation: AAP35498.1
    AC011483 Genomic DNA No translation available.
    CH471135 Genomic DNA Translation: EAW71953.1
    CH471135 Genomic DNA Translation: EAW71954.1
    BC015525 mRNA Translation: AAH15525.1
    CCDSiCCDS12811.1 [Q92876-1]
    CCDS42599.1 [Q92876-2]
    RefSeqiNP_001012982.1, NM_001012964.2 [Q92876-1]
    NP_001012983.1, NM_001012965.2 [Q92876-2]
    NP_001306877.1, NM_001319948.1 [Q92876-2]
    NP_001306878.1, NM_001319949.1 [Q92876-2]
    NP_002765.1, NM_002774.3 [Q92876-1]
    UniGeneiHs.79361

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1GVLX-ray1.80A21-243[»]
    1L2EX-ray1.75A22-244[»]
    1LO6X-ray1.56A22-244[»]
    3VFEX-ray1.88A22-244[»]
    4D8NX-ray1.68A22-244[»]
    5NX1X-ray1.85A22-244[»]
    5NX3X-ray2.30A22-244[»]
    ProteinModelPortaliQ92876
    SMRiQ92876
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi111634, 12 interactors
    IntActiQ92876, 16 interactors
    MINTiQ92876
    STRINGi9606.ENSP00000309148

    Chemistry databases

    BindingDBiQ92876
    ChEMBLiCHEMBL4448
    DrugBankiDB03127 Benzamidine
    GuidetoPHARMACOLOGYi2376

    Protein family/group databases

    MEROPSiS01.236

    PTM databases

    PhosphoSitePlusiQ92876
    UniCarbKBiQ92876

    Polymorphism and mutation databases

    BioMutaiKLK6
    DMDMi3914480

    Proteomic databases

    EPDiQ92876
    jPOSTiQ92876
    MaxQBiQ92876
    PaxDbiQ92876
    PeptideAtlasiQ92876
    PRIDEiQ92876
    ProteomicsDBi75559
    75560 [Q92876-2]
    75561 [Q92876-3]

    Protocols and materials databases

    The DNASU plasmid repository

    More...    DNASUi    		5653
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000310157; ENSP00000309148; ENSG00000167755 [Q92876-1]
    ENST00000376851; ENSP00000366047; ENSG00000167755 [Q92876-1]
    ENST00000391808; ENSP00000375684; ENSG00000167755 [Q92876-2]
    ENST00000594641; ENSP00000470482; ENSG00000167755 [Q92876-1]
    ENST00000597379; ENSP00000469630; ENSG00000167755 [Q92876-3]
    ENST00000599881; ENSP00000471948; ENSG00000167755 [Q92876-3]
    GeneIDi5653
    KEGGihsa:5653
    UCSCiuc002pui.4 human [Q92876-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		5653
    DisGeNETi5653
    EuPathDBiHostDB:ENSG00000167755.13

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		KLK6
    HGNCiHGNC:6367 KLK6
    HPAiHPA051837
    MIMi602652 gene
    neXtProtiNX_Q92876
    OpenTargetsiENSG00000167755
    PharmGKBiPA30156

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG3627 Eukaryota
    COG5640 LUCA
    GeneTreeiENSGT00940000153358
    HOGENOMiHOG000251820
    HOVERGENiHBG013304
    InParanoidiQ92876
    KOiK08667
    OMAiWIRKTIQ
    OrthoDBi1314811at2759
    PhylomeDBiQ92876
    TreeFamiTF331065

    Enzyme and pathway databases

    BRENDAi3.4.21.104 2681
    3.4.21.34 2681
    3.4.21.B10 2681
    SABIO-RKiQ92876

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		KLK6 human
    EvolutionaryTraceiQ92876

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		KLK6

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		5653
    PMAP-CutDBiQ92876

    Protein Ontology

    More...    PROi    		PR:Q92876

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000167755 Expressed in 133 organ(s), highest expression level in C1 segment of cervical spinal cord
    CleanExiHS_KLK6
    ExpressionAtlasiQ92876 baseline and differential
    GenevisibleiQ92876 HS

    Family and domain databases

    CDDicd00190 Tryp_SPc, 1 hit
    InterProiView protein in InterPro
    IPR009003 Peptidase_S1_PA
    IPR001314 Peptidase_S1A
    IPR001254 Trypsin_dom
    IPR018114 TRYPSIN_HIS
    IPR033116 TRYPSIN_SER
    PfamiView protein in Pfam
    PF00089 Trypsin, 1 hit
    PRINTSiPR00722 CHYMOTRYPSIN
    SMARTiView protein in SMART
    SM00020 Tryp_SPc, 1 hit
    SUPFAMiSSF50494 SSF50494, 1 hit
    PROSITEiView protein in PROSITE
    PS50240 TRYPSIN_DOM, 1 hit
    PS00134 TRYPSIN_HIS, 1 hit
    PS00135 TRYPSIN_SER, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLK6_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92876
    Secondary accession number(s): A6NJA1, A8MW09, Q6H301
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 1, 1997
    Last modified: January 16, 2019
    This is version 167 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
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