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UniProtKB - Q92876 (KLK6_HUMAN)

Entry version 183 (07 Apr 2021)
Sequence version 1 (01 Feb 1997)
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Protein

Kallikrein-6

Gene

KLK6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by a range of serine protease inhibitors including soybean trypsin inhibitor, benzamidine and serpins. Activated by a range of glycosaminoglycans including chondroitin sulfate, dermatan sulfate, heparan sulfate and heparin.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1562 µM for Tosyl-Gly-Pro-Arg-AMC2 Publications
  2. KM=777 µM for Tosyl-Gly-Pro-Lys-AMC2 Publications
  3. KM=0.410 mM for Phe-Ser-Arg-AMC2 Publications
  4. KM=0.455 mM for Gly-Gly-Arg-AMC2 Publications
  5. KM=0.335 mM for Asp-Pro-Arg-AMC2 Publications
  6. KM=0.758 mM for Gln-Gly-Arg-AMC2 Publications
  7. KM=0.625 mM for Pro-Phe-Arg-AMC2 Publications
  8. KM=0.271 mM for Val-Pro-Arg-AMC2 Publications
  9. KM=1.72 mM for Val-Leu-Lys-AMC2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei62Charge relay system1 Publication1
    Active sitei106Charge relay system1 Publication1
    Active sitei197Charge relay system1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		3.4.21.104, 2681
    3.4.21.34, 2681
    3.4.21.B10, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q92876

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q92876

    Protein family/group databases

    MEROPS protease database

    More...    MEROPSi    		S01.236

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Kallikrein-6 (EC:3.4.21.-)
    Alternative name(s):
    Neurosin
    Protease M
    SP59
    Serine protease 18
    Serine protease 9
    Zyme
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:KLK6
    Synonyms:PRSS18, PRSS9
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:6367, KLK6

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		602652, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q92876

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000167755.13

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Microsome, Mitochondrion, Nucleus, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		5653

    Open Targets

    More...    OpenTargetsi    		ENSG00000167755

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA30156

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q92876, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL4448

    Drug and drug target database

    More...    DrugBanki    		DB03127, Benzamidine

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...    GuidetoPHARMACOLOGYi    		2376

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		KLK6

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		3914480

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002794017 – 21Activation peptideSequence analysis5
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002794122 – 244Kallikrein-6Add BLAST223

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 157
    Disulfide bondi47 ↔ 63
    Disulfide bondi131 ↔ 231
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi138 ↔ 203
    Disulfide bondi168 ↔ 182
    Disulfide bondi193 ↔ 218

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Inactivated by autolytic cleavage after Arg-80.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei80 – 81Cleavage; by autolysis2

    Keywords - PTMi

    Autocatalytic cleavage, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q92876

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q92876

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q92876

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q92876

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q92876

    PeptideAtlas

    More...    PeptideAtlasi    		Q92876

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q92876

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		75559 [Q92876-1]
    75560 [Q92876-2]
    75561 [Q92876-3]

    PTM databases

    GlyConnect protein glycosylation platform

    More...    GlyConnecti    		2937, 2 N-Linked glycans (1 site)

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...    GlyGeni    		Q92876, 1 site, 15 N-linked glycans (1 site)

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q92876

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.5 Publications

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By spinal cord injury. This effect is particularly prominent in macrophages, microglia and reactive astrocytes.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000167755, Expressed in C1 segment of cervical spinal cord and 154 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q92876, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q92876, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000167755, Tissue enhanced (brain, esophagus)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Q92876
    With#Exp.IntAct
    ACBD4 - isoform 3 [Q8NC06-3]3EBI-2432309,EBI-12811089
    ACP2 [P11117]3EBI-2432309,EBI-2907070
    ACSM3 - isoform 2 [Q53FZ2-2]3EBI-2432309,EBI-25887341
    ALKBH8 - isoform 2 [Q96BT7-2]3EBI-2432309,EBI-13329511
    APP [P05067]4EBI-2432309,EBI-77613
    ARFGAP3 [Q9NP61]3EBI-2432309,EBI-2875816
    ARMCX4 - isoform 2 [Q5H9R4-2]3EBI-2432309,EBI-21899904
    ASB13 - isoform 2 [Q8WXK3-2]3EBI-2432309,EBI-12015080
    ASPH - isoform 6 [Q12797-6]3EBI-2432309,EBI-12092171
    ATP23 [Q9Y6H3]3EBI-2432309,EBI-12811889
    ATP6V0C [P27449]3EBI-2432309,EBI-721179
    BAG3 [O95817]3EBI-2432309,EBI-747185
    BAHD1 [Q8TBE0]3EBI-2432309,EBI-742750
    BAIAP2 - isoform 3 [Q9UQB8-3]3EBI-2432309,EBI-9091996
    BAIAP2 - isoform 6 [Q9UQB8-6]3EBI-2432309,EBI-9092016
    BCAP31 [P51572]3EBI-2432309,EBI-77683
    BET1 - isoform 2 [O15155-2]3EBI-2432309,EBI-25846497
    BEX2 [Q9BXY8]3EBI-2432309,EBI-745073
    BZW1 - isoform 2 [Q7L1Q6-2]3EBI-2432309,EBI-21557060
    C11orf54 - isoform 3 [Q9H0W9-3]3EBI-2432309,EBI-12108466
    CARD9 - isoform 2 [Q9H257-2]3EBI-2432309,EBI-11530605
    CATSPERD [Q86XM0]3EBI-2432309,EBI-10260328
    CDH16 [O75309]3EBI-2432309,EBI-2837263
    CDK8 - isoform 2 [P49336-2]3EBI-2432309,EBI-11039720
    CFL2 [Q9Y281]3EBI-2432309,EBI-351218
    CHDH [Q8NE62]3EBI-2432309,EBI-7127986
    CLDN11 [O75508]3EBI-2432309,EBI-12820543
    CNPY3 [Q9BT09]3EBI-2432309,EBI-2835965
    COL9A1 [P20849]3EBI-2432309,EBI-2528238
    COX4I1 [Q86WV2]3EBI-2432309,EBI-10260134
    CSNK2A1 [P68400]3EBI-2432309,EBI-347804
    CTSH [P09668]3EBI-2432309,EBI-6189940
    DBH [P09172]3EBI-2432309,EBI-8589586
    DCAF7 [P61962]3EBI-2432309,EBI-359808
    DCUN1D5 [Q9BTE7]3EBI-2432309,EBI-3924013
    DPY19L3 - isoform 2 [Q6ZPD9-2]3EBI-2432309,EBI-25888224
    DYNLL1 [P63167]3EBI-2432309,EBI-349105
    EEF1AKNMT [Q8N6R0]3EBI-2432309,EBI-1053295
    EIF2B5 [Q13144]3EBI-2432309,EBI-4401110
    EIF4B [P23588]3EBI-2432309,EBI-970310
    EPB42 [P16452]3EBI-2432309,EBI-1182496
    ERICH3 - isoform 3 [Q5RHP9-3]3EBI-2432309,EBI-20839496
    ESRP1 [Q6NXG1]3EBI-2432309,EBI-10213520
    ESRP1 - isoform 3 [Q6NXG1-3]3EBI-2432309,EBI-21567429
    FA2H [Q7L5A8]3EBI-2432309,EBI-11337888
    FAAP20 - isoform 4 [Q6NZ36-4]3EBI-2432309,EBI-12013806
    FAM122C - isoform 2 [Q6P4D5-2]3EBI-2432309,EBI-9091052
    FASTK [Q14296]3EBI-2432309,EBI-1754067
    FCGR2B [P31994]3EBI-2432309,EBI-724784
    G2E3 [Q7L622]3EBI-2432309,EBI-751757
    GADD45A [P24522]3EBI-2432309,EBI-448167
    GATA1 - isoform 2 [P15976-2]3EBI-2432309,EBI-9090198
    GFOD1 [Q9NXC2]3EBI-2432309,EBI-8799578
    hCG_1818547 [B2RAF7]3EBI-2432309,EBI-25844370
    HK3 [P52790]3EBI-2432309,EBI-2965780
    HMG20B [Q9P0W2]3EBI-2432309,EBI-713401
    HOXB1 [Q4VB01]3EBI-2432309,EBI-17494170
    HS2ST1 - isoform 3 [Q7LGA3-3]3EBI-2432309,EBI-25887463
    HVCN1 - isoform 2 [Q96D96-2]3EBI-2432309,EBI-25888137
    IHO1 [Q8IYA8]3EBI-2432309,EBI-8638439
    IL16 - isoform 2 [Q14005-2]3EBI-2432309,EBI-17178971
    INCA1 [Q0VD86]3EBI-2432309,EBI-6509505
    INPP5K [Q9BT40]3EBI-2432309,EBI-749162
    INVS - isoform 3 [Q9Y283-3]3EBI-2432309,EBI-11944909
    KLF3 [P57682]3EBI-2432309,EBI-8472267
    KLHL20 [Q9Y2M5]3EBI-2432309,EBI-714379
    KLK8 [O60259]3EBI-2432309,EBI-3915857
    KRT19 [P08727]3EBI-2432309,EBI-742756
    KRT81 [Q14533]3EBI-2432309,EBI-739648
    KRTAP19-5 [Q3LI72]3EBI-2432309,EBI-1048945
    KRTAP19-7 [Q3SYF9]3EBI-2432309,EBI-10241353
    KRTAP8-1 [Q8IUC2]3EBI-2432309,EBI-10261141
    LARP4B [Q92615]3EBI-2432309,EBI-1052558
    LASP1 - isoform 2 [Q14847-2]3EBI-2432309,EBI-9088686
    LGALS9C [Q6DKI2]3EBI-2432309,EBI-9088829
    LMX1A - isoform LMX1A-4AB [Q8TE12-2]3EBI-2432309,EBI-25846312
    LOC57228 [O95332]3EBI-2432309,EBI-25846778
    LOXL4 [Q96JB6]3EBI-2432309,EBI-749562
    MAP3K5 [Q99683]3EBI-2432309,EBI-476263
    MAPK11 [Q15759]3EBI-2432309,EBI-298304
    MATK [P42679]3EBI-2432309,EBI-751664
    MFSD10 [Q14728]3EBI-2432309,EBI-11337904
    MLST8 [A0A0A0MR05]3EBI-2432309,EBI-25835557
    NAA38 [Q9BRA0]3EBI-2432309,EBI-9106509
    NEUROG1 [Q92886]3EBI-2432309,EBI-10279647
    NMU [P48645]3EBI-2432309,EBI-10210351
    NOD1 [Q9Y239]3EBI-2432309,EBI-1051262
    NPM1 [P06748]3EBI-2432309,EBI-78579
    PCNP [Q8WW12]3EBI-2432309,EBI-10972020
    PCSK7 [Q16549]3EBI-2432309,EBI-8059854
    PDCL [Q13371]3EBI-2432309,EBI-5772890
    PODXL2 - isoform 2 [Q9NZ53-2]3EBI-2432309,EBI-25887738
    POLR1E [Q9GZS1]3EBI-2432309,EBI-359458
    POLR2E [P19388]3EBI-2432309,EBI-395189
    PPP1R21 - isoform 5 [Q6ZMI0-5]3EBI-2432309,EBI-25835994
    PRAM1 [Q96QH2]3EBI-2432309,EBI-2860740
    PRPF39 [Q86UA1]3EBI-2432309,EBI-2803203
    PSME3 [P61289]3EBI-2432309,EBI-355546
    PTN [P21246]3EBI-2432309,EBI-473725
    PTTG1IP [P53801]3EBI-2432309,EBI-3906138
    RBFOX1 - isoform 5 [Q9NWB1-5]3EBI-2432309,EBI-12123390
    RBM4 [Q9BWF3]3EBI-2432309,EBI-2856454
    RBM5 [P52756]3EBI-2432309,EBI-714003
    RGR - isoform 3 [P47804-3]3EBI-2432309,EBI-25834767
    RNF208 [Q9H0X6]3EBI-2432309,EBI-751555
    RNF34 [Q969K3]3EBI-2432309,EBI-2340642
    SCAPER - isoform 3 [Q9BY12-3]3EBI-2432309,EBI-25837959
    SDCCAG8 - isoform 2 [Q86SQ7-2]3EBI-2432309,EBI-10696955
    SEMA4G - isoform 3 [Q9NTN9-3]3EBI-2432309,EBI-9089805
    SIAH1 - isoform 2 [Q8IUQ4-2]3EBI-2432309,EBI-11522811
    SLC26A1 - isoform 2 [Q9H2B4-2]3EBI-2432309,EBI-12908340
    SMAD5 [Q99717]3EBI-2432309,EBI-6391136
    SNCA [P37840]3EBI-2432309,EBI-985879
    SPATA46 [Q5T0L3]3EBI-2432309,EBI-750105
    SPATS1 [Q496A3]3EBI-2432309,EBI-3923692
    SPON2 [Q9BUD6]3EBI-2432309,EBI-10298801
    SPRY4 [Q9C004]3EBI-2432309,EBI-354861
    STAC [Q99469]3EBI-2432309,EBI-2652799
    STX11 [O75558]3EBI-2432309,EBI-714135
    SUFU [Q9UMX1]3EBI-2432309,EBI-740595
    SUV39H1 [O43463]3EBI-2432309,EBI-349968
    SYNCRIP - isoform 4 [O60506-4]3EBI-2432309,EBI-11123832
    TCP10L [Q8TDR4]3EBI-2432309,EBI-3923210
    TENT5B [Q96A09]3EBI-2432309,EBI-752030
    TFAP4 [Q01664]3EBI-2432309,EBI-2514218
    THADA [Q6YHU6]3EBI-2432309,EBI-2824523
    TLE6 [Q9H808]3EBI-2432309,EBI-3921684
    TMPRSS6 - isoform 3 [Q8IU80-2]3EBI-2432309,EBI-25839648
    TMTC1 - isoform 4 [Q8IUR5-4]3EBI-2432309,EBI-9089156
    TNFAIP8L1 [Q8WVP5]3EBI-2432309,EBI-752102
    TNIP3 [Q96KP6]3EBI-2432309,EBI-2509913
    TNPO2 - isoform 2 [O14787-2]3EBI-2432309,EBI-12076664
    TOX [O94900]3EBI-2432309,EBI-9088321
    TPM3 - isoform 2 [P06753-2]3EBI-2432309,EBI-10977875
    TRNAU1AP [Q9NX07]3EBI-2432309,EBI-12581310
    TSPAN2 [O60636]3EBI-2432309,EBI-3914288
    TSPAN33 [Q86UF1]3EBI-2432309,EBI-12045841
    TUT7 - isoform 5 [Q5VYS8-5]3EBI-2432309,EBI-9088812
    TWSG1 [Q9GZX9]3EBI-2432309,EBI-10304067
    UBE2V1 [Q13404]3EBI-2432309,EBI-1050671
    UNKL - isoform 5 [Q9H9P5-5]3EBI-2432309,EBI-12817837
    UQCC1 [Q9NVA1]3EBI-2432309,EBI-11911675
    WDR5 [P61964]3EBI-2432309,EBI-540834
    WWOX - isoform 5 [Q9NZC7-5]3EBI-2432309,EBI-12040603
    WWP2 [O00308]3EBI-2432309,EBI-743923
    XPO5 [Q9HAV4]3EBI-2432309,EBI-517949
    ZNF444 - isoform 2 [Q8N0Y2-2]3EBI-2432309,EBI-12010736
    Q7Z7833EBI-2432309,EBI-9088990
    Q96EJ43EBI-2432309,EBI-750454

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		111634, 12 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q92876, 169 interactors

    Molecular INTeraction database

    More...    MINTi    		Q92876

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000366047

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q92876

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q92876, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1244
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q92876

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		Q92876

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 242Peptidase S1PROSITE-ProRule annotationAdd BLAST221

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG3627, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT01020000230469

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_006842_1_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q92876

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		HTSCHIL

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q92876

    TreeFam database of animal gene trees

    More...    TreeFami    		TF331065

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd00190, Tryp_SPc, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		2.40.10.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR009003, Peptidase_S1_PA
    IPR043504, Peptidase_S1_PA_chymotrypsin
    IPR001314, Peptidase_S1A
    IPR001254, Trypsin_dom
    IPR018114, TRYPSIN_HIS
    IPR033116, TRYPSIN_SER

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00089, Trypsin, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00722, CHYMOTRYPSIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00020, Tryp_SPc, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF50494, SSF50494, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS50240, TRYPSIN_DOM, 1 hit
    PS00134, TRYPSIN_HIS, 1 hit
    PS00135, TRYPSIN_SER, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q92876-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKKLMVVLSL IAAAWAEEQN KLVHGGPCDK TSHPYQAALY TSGHLLCGGV 
            60         70         80         90        100
    LIHPLWVLTA AHCKKPNLQV FLGKHNLRQR ESSQEQSSVV RAVIHPDYDA 
           110        120        130        140        150
    ASHDQDIMLL RLARPAKLSE LIQPLPLERD CSANTTSCHI LGWGKTADGD 
           160        170        180        190        200
    FPDTIQCAYI HLVSREECEH AYPGQITQNM LCAGDEKYGK DSCQGDSGGP 
           210        220        230        240 
    LVCGDHLRGL VSWGNIPCGS KEKPGVYTNV CRYTNWIQKT IQAK
    Length:244
    Mass (Da):26,856
    Last modified:February 1, 1997 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEA03F9145D87AAB
    GO
    Isoform 2 (identifier: Q92876-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-107: Missing.

    Show »
    Length:137
    Mass (Da):15,055
    Checksum:i25A421C212869BEA
    GO
    Isoform 3 (identifier: Q92876-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         14-40: AWAEEQNKLVHGGPCDKTSHPYQAALY → GIFRSSWGSITFGKGRVPRSRVLLSGL
         41-244: Missing.

    Show »
    Length:40
    Mass (Da):4,333
    Checksum:i323721E6AE557378
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    M0QYA5M0QYA5_HUMAN
    Kallikrein-6
    KLK6
    		69Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

    Molecular mass is 25866 Da. Determined by MALDI. 1 Publication

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06177678R → W. Corresponds to variant dbSNP:rs61469141EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0344031 – 107Missing in isoform 2. 1 PublicationAdd BLAST107
    Alternative sequenceiVSP_03440414 – 40AWAEE…QAALY → GIFRSSWGSITFGKGRVPRS RVLLSGL in isoform 3. 1 PublicationAdd BLAST27
    Alternative sequenceiVSP_03440541 – 244Missing in isoform 3. 1 PublicationAdd BLAST204

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		U62801 mRNA Translation: AAB07113.1
    D78203 mRNA Translation: BAA11306.1
    AF013988 mRNA Translation: AAB66483.1
    AF149289 Genomic DNA Translation: AAD51475.1
    AF243527 Genomic DNA Translation: AAG33359.1
    AY318867 mRNA Translation: AAP82446.1
    AY318868 mRNA No translation available.
    AY318869 mRNA Translation: AAP82448.1
    AY318870 mRNA No translation available.
    DQ223012 mRNA Translation: ABB04464.1
    AK314897 mRNA Translation: BAG37411.1
    BT006852 mRNA Translation: AAP35498.1
    AC011483 Genomic DNA No translation available.
    CH471135 Genomic DNA Translation: EAW71953.1
    CH471135 Genomic DNA Translation: EAW71954.1
    BC015525 mRNA Translation: AAH15525.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS12811.1 [Q92876-1]
    CCDS42599.1 [Q92876-2]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001012982.1, NM_001012964.2 [Q92876-1]
    NP_001012983.1, NM_001012965.2 [Q92876-2]
    NP_001306877.1, NM_001319948.1 [Q92876-2]
    NP_001306878.1, NM_001319949.1 [Q92876-2]
    NP_002765.1, NM_002774.3 [Q92876-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000310157; ENSP00000309148; ENSG00000167755 [Q92876-1]
    ENST00000376851; ENSP00000366047; ENSG00000167755 [Q92876-1]
    ENST00000391808; ENSP00000375684; ENSG00000167755 [Q92876-2]
    ENST00000594641; ENSP00000470482; ENSG00000167755 [Q92876-1]
    ENST00000597379; ENSP00000469630; ENSG00000167755 [Q92876-3]
    ENST00000599881; ENSP00000471948; ENSG00000167755 [Q92876-3]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		5653

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:5653

    UCSC genome browser

    More...    UCSCi    		uc002pui.4, human [Q92876-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		U62801 mRNA Translation: AAB07113.1
    D78203 mRNA Translation: BAA11306.1
    AF013988 mRNA Translation: AAB66483.1
    AF149289 Genomic DNA Translation: AAD51475.1
    AF243527 Genomic DNA Translation: AAG33359.1
    AY318867 mRNA Translation: AAP82446.1
    AY318868 mRNA No translation available.
    AY318869 mRNA Translation: AAP82448.1
    AY318870 mRNA No translation available.
    DQ223012 mRNA Translation: ABB04464.1
    AK314897 mRNA Translation: BAG37411.1
    BT006852 mRNA Translation: AAP35498.1
    AC011483 Genomic DNA No translation available.
    CH471135 Genomic DNA Translation: EAW71953.1
    CH471135 Genomic DNA Translation: EAW71954.1
    BC015525 mRNA Translation: AAH15525.1
    CCDSiCCDS12811.1 [Q92876-1]
    CCDS42599.1 [Q92876-2]
    RefSeqiNP_001012982.1, NM_001012964.2 [Q92876-1]
    NP_001012983.1, NM_001012965.2 [Q92876-2]
    NP_001306877.1, NM_001319948.1 [Q92876-2]
    NP_001306878.1, NM_001319949.1 [Q92876-2]
    NP_002765.1, NM_002774.3 [Q92876-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1GVLX-ray1.80A21-243[»]
    1L2EX-ray1.75A22-244[»]
    1LO6X-ray1.56A22-244[»]
    3VFEX-ray1.88A22-244[»]
    4D8NX-ray1.68A22-244[»]
    5NX1X-ray1.85A22-244[»]
    5NX3X-ray2.30A22-244[»]
    6QFFX-ray1.64A/B22-243[»]
    6QFGX-ray1.68A/B22-244[»]
    6QFHX-ray1.65A/B22-243[»]
    6QH9X-ray2.27A/B22-244[»]
    6QHAX-ray1.82A/B22-244[»]
    6QHBX-ray1.84A/B22-244[»]
    6QHCX-ray1.87A/B22-244[»]
    6SKBX-ray1.84A/B/C12-244[»]
    6SKCX-ray2.18A/B22-244[»]
    6SKDX-ray2.26A/B22-244[»]
    SMRiQ92876
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi111634, 12 interactors
    IntActiQ92876, 169 interactors
    MINTiQ92876
    STRINGi9606.ENSP00000366047

    Chemistry databases

    BindingDBiQ92876
    ChEMBLiCHEMBL4448
    DrugBankiDB03127, Benzamidine
    GuidetoPHARMACOLOGYi2376

    Protein family/group databases

    MEROPSiS01.236

    PTM databases

    GlyConnecti2937, 2 N-Linked glycans (1 site)
    GlyGeniQ92876, 1 site, 15 N-linked glycans (1 site)
    PhosphoSitePlusiQ92876

    Genetic variation databases

    BioMutaiKLK6
    DMDMi3914480

    Proteomic databases

    EPDiQ92876
    jPOSTiQ92876
    MassIVEiQ92876
    MaxQBiQ92876
    PaxDbiQ92876
    PeptideAtlasiQ92876
    PRIDEiQ92876
    ProteomicsDBi75559 [Q92876-1]
    75560 [Q92876-2]
    75561 [Q92876-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		32402, 354 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		5653

    Genome annotation databases

    EnsembliENST00000310157; ENSP00000309148; ENSG00000167755 [Q92876-1]
    ENST00000376851; ENSP00000366047; ENSG00000167755 [Q92876-1]
    ENST00000391808; ENSP00000375684; ENSG00000167755 [Q92876-2]
    ENST00000594641; ENSP00000470482; ENSG00000167755 [Q92876-1]
    ENST00000597379; ENSP00000469630; ENSG00000167755 [Q92876-3]
    ENST00000599881; ENSP00000471948; ENSG00000167755 [Q92876-3]
    GeneIDi5653
    KEGGihsa:5653
    UCSCiuc002pui.4, human [Q92876-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		5653
    DisGeNETi5653

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		KLK6
    HGNCiHGNC:6367, KLK6
    HPAiENSG00000167755, Tissue enhanced (brain, esophagus)
    MIMi602652, gene
    neXtProtiNX_Q92876
    OpenTargetsiENSG00000167755
    PharmGKBiPA30156
    VEuPathDBiHostDB:ENSG00000167755.13

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG3627, Eukaryota
    GeneTreeiENSGT01020000230469
    HOGENOMiCLU_006842_1_1_1
    InParanoidiQ92876
    OMAiHTSCHIL
    PhylomeDBiQ92876
    TreeFamiTF331065

    Enzyme and pathway databases

    BRENDAi3.4.21.104, 2681
    3.4.21.34, 2681
    3.4.21.B10, 2681
    PathwayCommonsiQ92876
    SABIO-RKiQ92876

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		5653, 9 hits in 991 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		KLK6, human
    EvolutionaryTraceiQ92876

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		KLK6

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		5653
    PharosiQ92876, Tchem

    Protein Ontology

    More...    PROi    		PR:Q92876
    RNActiQ92876, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000167755, Expressed in C1 segment of cervical spinal cord and 154 other tissues
    ExpressionAtlasiQ92876, baseline and differential
    GenevisibleiQ92876, HS

    Family and domain databases

    CDDicd00190, Tryp_SPc, 1 hit
    Gene3Di2.40.10.10, 2 hits
    InterProiView protein in InterPro
    IPR009003, Peptidase_S1_PA
    IPR043504, Peptidase_S1_PA_chymotrypsin
    IPR001314, Peptidase_S1A
    IPR001254, Trypsin_dom
    IPR018114, TRYPSIN_HIS
    IPR033116, TRYPSIN_SER
    PfamiView protein in Pfam
    PF00089, Trypsin, 1 hit
    PRINTSiPR00722, CHYMOTRYPSIN
    SMARTiView protein in SMART
    SM00020, Tryp_SPc, 1 hit
    SUPFAMiSSF50494, SSF50494, 1 hit
    PROSITEiView protein in PROSITE
    PS50240, TRYPSIN_DOM, 1 hit
    PS00134, TRYPSIN_HIS, 1 hit
    PS00135, TRYPSIN_SER, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLK6_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92876
    Secondary accession number(s): A6NJA1, A8MW09, Q6H301
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 1, 1997
    Last modified: April 7, 2021
    This is version 183 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with genetic variants
      List of human entries with genetic variants
    4. Human variants curated from literature reports
      Index of human variants curated from literature reports
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families
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