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UniProtKB - Q92876 (KLK6_HUMAN)

Entry version 185 (29 Sep 2021)
Sequence version 1 (01 Feb 1997)
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Protein

Kallikrein-6

Gene

KLK6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by a range of serine protease inhibitors including soybean trypsin inhibitor, benzamidine and serpins. Activated by a range of glycosaminoglycans including chondroitin sulfate, dermatan sulfate, heparan sulfate and heparin.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1562 µM for Tosyl-Gly-Pro-Arg-AMC2 Publications
  2. KM=777 µM for Tosyl-Gly-Pro-Lys-AMC2 Publications
  3. KM=0.410 mM for Phe-Ser-Arg-AMC2 Publications
  4. KM=0.455 mM for Gly-Gly-Arg-AMC2 Publications
  5. KM=0.335 mM for Asp-Pro-Arg-AMC2 Publications
  6. KM=0.758 mM for Gln-Gly-Arg-AMC2 Publications
  7. KM=0.625 mM for Pro-Phe-Arg-AMC2 Publications
  8. KM=0.271 mM for Val-Pro-Arg-AMC2 Publications
  9. KM=1.72 mM for Val-Leu-Lys-AMC2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei62Charge relay system1 Publication1
Active sitei106Charge relay system1 Publication1
Active sitei197Charge relay system1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.21.104, 2681
3.4.21.34, 2681
3.4.21.B10, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92876

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q92876

Protein family/group databases

MEROPS protease database

More...MEROPSi		S01.236

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kallikrein-6 (EC:3.4.21.-)
Alternative name(s):
Neurosin
Protease M
SP59
Serine protease 18
Serine protease 9
Zyme
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLK6
Synonyms:PRSS18, PRSS9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6367, KLK6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602652, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92876

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000167755

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Mitochondrion, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5653

Open Targets

More...OpenTargetsi		ENSG00000167755

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30156

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92876, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4448

Drug and drug target database

More...DrugBanki		DB03127, Benzamidine

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2376

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KLK6

Domain mapping of disease mutations (DMDM)

More...DMDMi		3914480

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002794017 – 21Activation peptideSequence analysis5
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002794122 – 244Kallikrein-6Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 157
Disulfide bondi47 ↔ 63
Disulfide bondi131 ↔ 231
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi138 ↔ 203
Disulfide bondi168 ↔ 182
Disulfide bondi193 ↔ 218

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Inactivated by autolytic cleavage after Arg-80.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei80 – 81Cleavage; by autolysis2

Keywords - PTMi

Autocatalytic cleavage, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92876

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92876

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92876

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92876

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92876

PeptideAtlas

More...PeptideAtlasi		Q92876

PRoteomics IDEntifications database

More...PRIDEi		Q92876

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75559 [Q92876-1]
75560 [Q92876-2]
75561 [Q92876-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2937, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q92876, 1 site, 15 N-linked glycans (1 site)

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92876

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.5 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By spinal cord injury. This effect is particularly prominent in macrophages, microglia and reactive astrocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167755, Expressed in C1 segment of cervical spinal cord and 155 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92876, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92876, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000167755, Tissue enhanced (brain, esophagus)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q92876
With#Exp.IntAct
ACBD4 - isoform 3 [Q8NC06-3]3EBI-2432309,EBI-12811089
ACP2 [P11117]3EBI-2432309,EBI-2907070
ACSM3 - isoform 2 [Q53FZ2-2]3EBI-2432309,EBI-25887341
ALKBH8 - isoform 2 [Q96BT7-2]3EBI-2432309,EBI-13329511
APP [P05067]4EBI-2432309,EBI-77613
ARFGAP3 [Q9NP61]3EBI-2432309,EBI-2875816
ARMCX4 - isoform 2 [Q5H9R4-2]3EBI-2432309,EBI-21899904
ASB13 - isoform 2 [Q8WXK3-2]3EBI-2432309,EBI-12015080
ASPH - isoform 6 [Q12797-6]3EBI-2432309,EBI-12092171
ATP23 [Q9Y6H3]3EBI-2432309,EBI-12811889
ATP6V0C [P27449]3EBI-2432309,EBI-721179
BAG3 [O95817]3EBI-2432309,EBI-747185
BAHD1 [Q8TBE0]3EBI-2432309,EBI-742750
BAIAP2 - isoform 3 [Q9UQB8-3]3EBI-2432309,EBI-9091996
BAIAP2 - isoform 6 [Q9UQB8-6]3EBI-2432309,EBI-9092016
BCAP31 [P51572]3EBI-2432309,EBI-77683
BET1 - isoform 2 [O15155-2]3EBI-2432309,EBI-25846497
BEX2 [Q9BXY8]3EBI-2432309,EBI-745073
BZW1 - isoform 2 [Q7L1Q6-2]3EBI-2432309,EBI-21557060
C11orf54 - isoform 3 [Q9H0W9-3]3EBI-2432309,EBI-12108466
CARD9 - isoform 2 [Q9H257-2]3EBI-2432309,EBI-11530605
CATSPERD [Q86XM0]3EBI-2432309,EBI-10260328
CDH16 [O75309]3EBI-2432309,EBI-2837263
CDK8 - isoform 2 [P49336-2]3EBI-2432309,EBI-11039720
CFL2 [Q9Y281]3EBI-2432309,EBI-351218
CHDH [Q8NE62]3EBI-2432309,EBI-7127986
CLDN11 [O75508]3EBI-2432309,EBI-12820543
CNPY3 [Q9BT09]3EBI-2432309,EBI-2835965
COL9A1 [P20849]3EBI-2432309,EBI-2528238
COX4I1 [Q86WV2]3EBI-2432309,EBI-10260134
CSNK2A1 [P68400]3EBI-2432309,EBI-347804
CTSH [P09668]3EBI-2432309,EBI-6189940
DBH [P09172]3EBI-2432309,EBI-8589586
DCAF7 [P61962]3EBI-2432309,EBI-359808
DCUN1D5 [Q9BTE7]3EBI-2432309,EBI-3924013
DPY19L3 - isoform 2 [Q6ZPD9-2]3EBI-2432309,EBI-25888224
DYNLL1 [P63167]3EBI-2432309,EBI-349105
EEF1AKNMT [Q8N6R0]3EBI-2432309,EBI-1053295
EIF2B5 [Q13144]3EBI-2432309,EBI-4401110
EIF4B [P23588]3EBI-2432309,EBI-970310
EPB42 [P16452]3EBI-2432309,EBI-1182496
ERICH3 - isoform 3 [Q5RHP9-3]3EBI-2432309,EBI-20839496
ESRP1 [Q6NXG1]3EBI-2432309,EBI-10213520
ESRP1 - isoform 3 [Q6NXG1-3]3EBI-2432309,EBI-21567429
FA2H [Q7L5A8]3EBI-2432309,EBI-11337888
FAAP20 - isoform 4 [Q6NZ36-4]3EBI-2432309,EBI-12013806
FASTK [Q14296]3EBI-2432309,EBI-1754067
FCGR2B [P31994]3EBI-2432309,EBI-724784
G2E3 [Q7L622]3EBI-2432309,EBI-751757
GADD45A [P24522]3EBI-2432309,EBI-448167
GATA1 - isoform 2 [P15976-2]3EBI-2432309,EBI-9090198
GFOD1 [Q9NXC2]3EBI-2432309,EBI-8799578
hCG_1818547 [B2RAF7]3EBI-2432309,EBI-25844370
HK3 [P52790]3EBI-2432309,EBI-2965780
HMG20B [Q9P0W2]3EBI-2432309,EBI-713401
HOXB1 [Q4VB01]3EBI-2432309,EBI-17494170
HS2ST1 - isoform 3 [Q7LGA3-3]3EBI-2432309,EBI-25887463
HVCN1 - isoform 2 [Q96D96-2]3EBI-2432309,EBI-25888137
IHO1 [Q8IYA8]3EBI-2432309,EBI-8638439
IL16 - isoform 2 [Q14005-2]3EBI-2432309,EBI-17178971
INCA1 [Q0VD86]3EBI-2432309,EBI-6509505
INPP5K [Q9BT40]3EBI-2432309,EBI-749162
INVS - isoform 3 [Q9Y283-3]3EBI-2432309,EBI-11944909
KLF3 [P57682]3EBI-2432309,EBI-8472267
KLHL20 [Q9Y2M5]3EBI-2432309,EBI-714379
KLK8 [O60259]3EBI-2432309,EBI-3915857
KRT19 [P08727]3EBI-2432309,EBI-742756
KRT81 [Q14533]3EBI-2432309,EBI-739648
KRTAP19-5 [Q3LI72]3EBI-2432309,EBI-1048945
KRTAP19-7 [Q3SYF9]3EBI-2432309,EBI-10241353
KRTAP8-1 [Q8IUC2]3EBI-2432309,EBI-10261141
LARP4B [Q92615]3EBI-2432309,EBI-1052558
LASP1 - isoform 2 [Q14847-2]3EBI-2432309,EBI-9088686
LGALS9C [Q6DKI2]3EBI-2432309,EBI-9088829
LMX1A - isoform LMX1A-4AB [Q8TE12-2]3EBI-2432309,EBI-25846312
LOC57228 [O95332]3EBI-2432309,EBI-25846778
LOXL4 [Q96JB6]3EBI-2432309,EBI-749562
MAP3K5 [Q99683]3EBI-2432309,EBI-476263
MAPK11 [Q15759]3EBI-2432309,EBI-298304
MATK [P42679]3EBI-2432309,EBI-751664
MFSD10 [Q14728]3EBI-2432309,EBI-11337904
MLST8 [A0A0A0MR05]3EBI-2432309,EBI-25835557
NAA38 [Q9BRA0]3EBI-2432309,EBI-9106509
NEUROG1 [Q92886]3EBI-2432309,EBI-10279647
NMU [P48645]3EBI-2432309,EBI-10210351
NOD1 [Q9Y239]3EBI-2432309,EBI-1051262
NPM1 [P06748]3EBI-2432309,EBI-78579
PABIR3 - isoform 2 [Q6P4D5-2]3EBI-2432309,EBI-9091052
PCNP [Q8WW12]3EBI-2432309,EBI-10972020
PCSK7 [Q16549]3EBI-2432309,EBI-8059854
PDCL [Q13371]3EBI-2432309,EBI-5772890
PODXL2 - isoform 2 [Q9NZ53-2]3EBI-2432309,EBI-25887738
POLR1E [Q9GZS1]3EBI-2432309,EBI-359458
POLR2E [P19388]3EBI-2432309,EBI-395189
PPP1R21 - isoform 5 [Q6ZMI0-5]3EBI-2432309,EBI-25835994
PRAM1 [Q96QH2]3EBI-2432309,EBI-2860740
PRPF39 [Q86UA1]3EBI-2432309,EBI-2803203
PSME3 [P61289]3EBI-2432309,EBI-355546
PTN [P21246]3EBI-2432309,EBI-473725
PTTG1IP [P53801]3EBI-2432309,EBI-3906138
RBFOX1 - isoform 5 [Q9NWB1-5]3EBI-2432309,EBI-12123390
RBM4 [Q9BWF3]3EBI-2432309,EBI-2856454
RBM5 [P52756]3EBI-2432309,EBI-714003
RGR - isoform 3 [P47804-3]3EBI-2432309,EBI-25834767
RNF208 [Q9H0X6]3EBI-2432309,EBI-751555
RNF34 [Q969K3]3EBI-2432309,EBI-2340642
SCAPER - isoform 3 [Q9BY12-3]3EBI-2432309,EBI-25837959
SDCCAG8 - isoform 2 [Q86SQ7-2]3EBI-2432309,EBI-10696955
SEMA4G - isoform 3 [Q9NTN9-3]3EBI-2432309,EBI-9089805
SIAH1 - isoform 2 [Q8IUQ4-2]3EBI-2432309,EBI-11522811
SLC26A1 - isoform 2 [Q9H2B4-2]3EBI-2432309,EBI-12908340
SMAD5 [Q99717]3EBI-2432309,EBI-6391136
SNCA [P37840]3EBI-2432309,EBI-985879
SPATA46 [Q5T0L3]3EBI-2432309,EBI-750105
SPATS1 [Q496A3]3EBI-2432309,EBI-3923692
SPON2 [Q9BUD6]3EBI-2432309,EBI-10298801
SPRY4 [Q9C004]3EBI-2432309,EBI-354861
STAC [Q99469]3EBI-2432309,EBI-2652799
STX11 [O75558]3EBI-2432309,EBI-714135
SUFU [Q9UMX1]3EBI-2432309,EBI-740595
SUV39H1 [O43463]3EBI-2432309,EBI-349968
SYNCRIP - isoform 4 [O60506-4]3EBI-2432309,EBI-11123832
TCP10L [Q8TDR4]3EBI-2432309,EBI-3923210
TENT5B [Q96A09]3EBI-2432309,EBI-752030
TFAP4 [Q01664]3EBI-2432309,EBI-2514218
THADA [Q6YHU6]3EBI-2432309,EBI-2824523
TLE6 [Q9H808]3EBI-2432309,EBI-3921684
TMPRSS6 - isoform 3 [Q8IU80-2]3EBI-2432309,EBI-25839648
TMTC1 - isoform 4 [Q8IUR5-4]3EBI-2432309,EBI-9089156
TNFAIP8L1 [Q8WVP5]3EBI-2432309,EBI-752102
TNIP3 [Q96KP6]3EBI-2432309,EBI-2509913
TNPO2 - isoform 2 [O14787-2]3EBI-2432309,EBI-12076664
TOX [O94900]3EBI-2432309,EBI-9088321
TPM3 - isoform 2 [P06753-2]3EBI-2432309,EBI-10977875
TRNAU1AP [Q9NX07]3EBI-2432309,EBI-12581310
TSPAN2 [O60636]3EBI-2432309,EBI-3914288
TSPAN33 [Q86UF1]3EBI-2432309,EBI-12045841
TUT7 - isoform 5 [Q5VYS8-5]3EBI-2432309,EBI-9088812
TWSG1 [Q9GZX9]3EBI-2432309,EBI-10304067
UBE2V1 [Q13404]3EBI-2432309,EBI-1050671
UNKL - isoform 5 [Q9H9P5-5]3EBI-2432309,EBI-12817837
UQCC1 [Q9NVA1]3EBI-2432309,EBI-11911675
WDR5 [P61964]3EBI-2432309,EBI-540834
WWOX - isoform 5 [Q9NZC7-5]3EBI-2432309,EBI-12040603
WWP2 [O00308]3EBI-2432309,EBI-743923
XPO5 [Q9HAV4]3EBI-2432309,EBI-517949
ZNF444 - isoform 2 [Q8N0Y2-2]3EBI-2432309,EBI-12010736
Q7Z7833EBI-2432309,EBI-9088990
Q96EJ43EBI-2432309,EBI-750454

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111634, 12 interactors

Protein interaction database and analysis system

More...IntActi		Q92876, 169 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366047

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q92876

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92876, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92876

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q92876

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 242Peptidase S1PROSITE-ProRule annotationAdd BLAST221

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3627, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234551

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006842_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92876

Identification of Orthologs from Complete Genome Data

More...OMAi		YNPATHD

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92876

TreeFam database of animal gene trees

More...TreeFami		TF331065

Family and domain databases

Conserved Domains Database

More...CDDi		cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00089, Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00722, CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00020, Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494, SSF50494, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92876-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKLMVVLSL IAAAWAEEQN KLVHGGPCDK TSHPYQAALY TSGHLLCGGV 
        60         70         80         90        100
LIHPLWVLTA AHCKKPNLQV FLGKHNLRQR ESSQEQSSVV RAVIHPDYDA 
       110        120        130        140        150
ASHDQDIMLL RLARPAKLSE LIQPLPLERD CSANTTSCHI LGWGKTADGD 
       160        170        180        190        200
FPDTIQCAYI HLVSREECEH AYPGQITQNM LCAGDEKYGK DSCQGDSGGP 
       210        220        230        240 
LVCGDHLRGL VSWGNIPCGS KEKPGVYTNV CRYTNWIQKT IQAK
Length:244
Mass (Da):26,856
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEA03F9145D87AAB
GO
Isoform 2 (identifier: Q92876-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Show »
Length:137
Mass (Da):15,055
Checksum:i25A421C212869BEA
GO
Isoform 3 (identifier: Q92876-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-40: AWAEEQNKLVHGGPCDKTSHPYQAALY → GIFRSSWGSITFGKGRVPRSRVLLSGL
     41-244: Missing.

Show »
Length:40
Mass (Da):4,333
Checksum:i323721E6AE557378
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYA5M0QYA5_HUMAN
Kallikrein-6
KLK6
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 25866 Da. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06177678R → W. Corresponds to variant dbSNP:rs61469141EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0344031 – 107Missing in isoform 2. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_03440414 – 40AWAEE…QAALY → GIFRSSWGSITFGKGRVPRS RVLLSGL in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_03440541 – 244Missing in isoform 3. 1 PublicationAdd BLAST204

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U62801 mRNA Translation: AAB07113.1
D78203 mRNA Translation: BAA11306.1
AF013988 mRNA Translation: AAB66483.1
AF149289 Genomic DNA Translation: AAD51475.1
AF243527 Genomic DNA Translation: AAG33359.1
AY318867 mRNA Translation: AAP82446.1
AY318868 mRNA No translation available.
AY318869 mRNA Translation: AAP82448.1
AY318870 mRNA No translation available.
DQ223012 mRNA Translation: ABB04464.1
AK314897 mRNA Translation: BAG37411.1
BT006852 mRNA Translation: AAP35498.1
AC011483 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW71953.1
CH471135 Genomic DNA Translation: EAW71954.1
BC015525 mRNA Translation: AAH15525.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12811.1 [Q92876-1]
CCDS42599.1 [Q92876-2]

NCBI Reference Sequences

More...RefSeqi		NP_001012982.1, NM_001012964.2 [Q92876-1]
NP_001012983.1, NM_001012965.2 [Q92876-2]
NP_001306877.1, NM_001319948.1 [Q92876-2]
NP_001306878.1, NM_001319949.1 [Q92876-2]
NP_002765.1, NM_002774.3 [Q92876-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000310157; ENSP00000309148; ENSG00000167755 [Q92876-1]
ENST00000376851; ENSP00000366047; ENSG00000167755 [Q92876-1]
ENST00000391808; ENSP00000375684; ENSG00000167755 [Q92876-2]
ENST00000594641; ENSP00000470482; ENSG00000167755 [Q92876-1]
ENST00000597379; ENSP00000469630; ENSG00000167755 [Q92876-3]
ENST00000599881; ENSP00000471948; ENSG00000167755 [Q92876-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5653

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5653

UCSC genome browser

More...UCSCi		uc002pui.4, human [Q92876-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62801 mRNA Translation: AAB07113.1
D78203 mRNA Translation: BAA11306.1
AF013988 mRNA Translation: AAB66483.1
AF149289 Genomic DNA Translation: AAD51475.1
AF243527 Genomic DNA Translation: AAG33359.1
AY318867 mRNA Translation: AAP82446.1
AY318868 mRNA No translation available.
AY318869 mRNA Translation: AAP82448.1
AY318870 mRNA No translation available.
DQ223012 mRNA Translation: ABB04464.1
AK314897 mRNA Translation: BAG37411.1
BT006852 mRNA Translation: AAP35498.1
AC011483 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW71953.1
CH471135 Genomic DNA Translation: EAW71954.1
BC015525 mRNA Translation: AAH15525.1
CCDSiCCDS12811.1 [Q92876-1]
CCDS42599.1 [Q92876-2]
RefSeqiNP_001012982.1, NM_001012964.2 [Q92876-1]
NP_001012983.1, NM_001012965.2 [Q92876-2]
NP_001306877.1, NM_001319948.1 [Q92876-2]
NP_001306878.1, NM_001319949.1 [Q92876-2]
NP_002765.1, NM_002774.3 [Q92876-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GVLX-ray1.80A21-243[»]
1L2EX-ray1.75A22-244[»]
1LO6X-ray1.56A22-244[»]
3VFEX-ray1.88A22-244[»]
4D8NX-ray1.68A22-244[»]
5NX1X-ray1.85A22-244[»]
5NX3X-ray2.30A22-244[»]
6QFFX-ray1.64A/B22-243[»]
6QFGX-ray1.68A/B22-244[»]
6QFHX-ray1.65A/B22-243[»]
6QH9X-ray2.27A/B22-244[»]
6QHAX-ray1.82A/B22-244[»]
6QHBX-ray1.84A/B22-244[»]
6QHCX-ray1.87A/B22-244[»]
6SKBX-ray1.84A/B/C12-244[»]
6SKCX-ray2.18A/B22-244[»]
6SKDX-ray2.26A/B22-244[»]
SMRiQ92876
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111634, 12 interactors
IntActiQ92876, 169 interactors
STRINGi9606.ENSP00000366047

Chemistry databases

BindingDBiQ92876
ChEMBLiCHEMBL4448
DrugBankiDB03127, Benzamidine
GuidetoPHARMACOLOGYi2376

Protein family/group databases

MEROPSiS01.236

PTM databases

GlyConnecti2937, 2 N-Linked glycans (1 site)
GlyGeniQ92876, 1 site, 15 N-linked glycans (1 site)
PhosphoSitePlusiQ92876

Genetic variation databases

BioMutaiKLK6
DMDMi3914480

Proteomic databases

EPDiQ92876
jPOSTiQ92876
MassIVEiQ92876
MaxQBiQ92876
PaxDbiQ92876
PeptideAtlasiQ92876
PRIDEiQ92876
ProteomicsDBi75559 [Q92876-1]
75560 [Q92876-2]
75561 [Q92876-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32402, 361 antibodies

The DNASU plasmid repository

More...DNASUi		5653

Genome annotation databases

EnsembliENST00000310157; ENSP00000309148; ENSG00000167755 [Q92876-1]
ENST00000376851; ENSP00000366047; ENSG00000167755 [Q92876-1]
ENST00000391808; ENSP00000375684; ENSG00000167755 [Q92876-2]
ENST00000594641; ENSP00000470482; ENSG00000167755 [Q92876-1]
ENST00000597379; ENSP00000469630; ENSG00000167755 [Q92876-3]
ENST00000599881; ENSP00000471948; ENSG00000167755 [Q92876-3]
GeneIDi5653
KEGGihsa:5653
UCSCiuc002pui.4, human [Q92876-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5653
DisGeNETi5653

GeneCards: human genes, protein and diseases

More...GeneCardsi		KLK6
HGNCiHGNC:6367, KLK6
HPAiENSG00000167755, Tissue enhanced (brain, esophagus)
MIMi602652, gene
neXtProtiNX_Q92876
OpenTargetsiENSG00000167755
PharmGKBiPA30156
VEuPathDBiHostDB:ENSG00000167755

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3627, Eukaryota
GeneTreeiENSGT01030000234551
HOGENOMiCLU_006842_1_1_1
InParanoidiQ92876
OMAiYNPATHD
PhylomeDBiQ92876
TreeFamiTF331065

Enzyme and pathway databases

BRENDAi3.4.21.104, 2681
3.4.21.34, 2681
3.4.21.B10, 2681
PathwayCommonsiQ92876
SABIO-RKiQ92876

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5653, 9 hits in 1014 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KLK6, human
EvolutionaryTraceiQ92876

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KLK6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5653
PharosiQ92876, Tchem

Protein Ontology

More...PROi		PR:Q92876
RNActiQ92876, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000167755, Expressed in C1 segment of cervical spinal cord and 155 other tissues
ExpressionAtlasiQ92876, baseline and differential
GenevisibleiQ92876, HS

Family and domain databases

CDDicd00190, Tryp_SPc, 1 hit
Gene3Di2.40.10.10, 2 hits
InterProiView protein in InterPro
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER
PfamiView protein in Pfam
PF00089, Trypsin, 1 hit
PRINTSiPR00722, CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020, Tryp_SPc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLK6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92876
Secondary accession number(s): A6NJA1, A8MW09, Q6H301
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: September 29, 2021
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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