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Entry version 170 (02 Dec 2020)
Sequence version 1 (01 Feb 1997)
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Protein

Deoxyribonuclease-1-like 2

Gene

DNASE1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei99By similarity1
Active sitei170By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q92874

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Deoxyribonuclease-1-like 2 (EC:3.1.21.-)
Alternative name(s):
DNase I homolog protein DHP1
Deoxyribonuclease I-like 2
Short name:
DNase I-like 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNASE1L2
Synonyms:DHP1, DNAS1L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000167968.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2958, DNASE1L2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602622, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92874

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1775

Open Targets

More...
OpenTargetsi
ENSG00000167968

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27429

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92874, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DNASE1L2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2494172

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000728621 – 299Deoxyribonuclease-1-like 2Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi209 ↔ 245Essential for enzymatic activityBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92874

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92874

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92874

PeptideAtlas

More...
PeptideAtlasi
Q92874

PRoteomics IDEntifications database

More...
PRIDEi
Q92874

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66528
75558 [Q92874-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92874

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92874

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Preferentially expressed in the skin and up-regulated during keratinocytes differentiation. Highly abundant (at protein level) in the stratum granulosum.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by inflammatory cytokines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167968, Expressed in skin of leg and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92874, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92874, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167968, Tissue enhanced (salivary gland, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
108114, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q92874, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000454562

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q92874, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92874

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNase I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SGB6, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182846

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_043335_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92874

Identification of Orthologs from Complete Genome Data

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OMAi
CNYVRAQ

Database of Orthologous Groups

More...
OrthoDBi
1282784at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92874

TreeFam database of animal gene trees

More...
TreeFami
TF329541

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018057, Deoxyribonuclease-1_AS
IPR016202, DNase_I
IPR033125, DNASE_I_2
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03372, Exo_endo_phos, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000988, DNase_I_euk, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00130, DNASEI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00476, DNaseIc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219, SSF56219, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00919, DNASE_I_1, 1 hit
PS00918, DNASE_I_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92874-1) [UniParc]FASTAAdd to basket
Also known as: DNAS1L2-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGPRALLAA LWALEAAGTA ALRIGAFNIQ SFGDSKVSDP ACGSIIAKIL
60 70 80 90 100
AGYDLALVQE VRDPDLSAVS ALMEQINSVS EHEYSFVSSQ PLGRDQYKEM
110 120 130 140 150
YLFVYRKDAV SVVDTYLYPD PEDVFSREPF VVKFSAPGTG ERAPPLPSRR
160 170 180 190 200
ALTPPPLPAA AQNLVLIPLH AAPHQAVAEI DALYDVYLDV IDKWGTDDML
210 220 230 240 250
FLGDFNADCS YVRAQDWAAI RLRSSEVFKW LIPDSADTTV GNSDCAYDRI
260 270 280 290
VACGARLRRS LKPQSATVHD FQEEFGLDQT QALAISDHFP VEVTLKFHR
Length:299
Mass (Da):32,853
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B66A5590D33D0A6
GO
Isoform 2 (identifier: Q92874-2) [UniParc]FASTAAdd to basket
Also known as: DNAS1L2-S

The sequence of this isoform differs from the canonical sequence as follows:
     140-160: Missing.

Note: Specifically expressed in peripheral blood leukocytes.Curated
Show »
Length:278
Mass (Da):30,707
Checksum:i076B44856A08D0BE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPU8H3BPU8_HUMAN
Deoxyribonuclease-1-like 2
DNASE1L2
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053879140 – 160Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U62647 mRNA Translation: AAB63981.1
AY298957 mRNA Translation: AAQ73759.1
AY298958 Genomic DNA Translation: AAQ73760.1
AY298958 Genomic DNA Translation: AAQ73761.1
AK098028 mRNA Translation: BAG53566.1
AC009065 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85526.1
CH471112 Genomic DNA Translation: EAW85527.1
CH471112 Genomic DNA Translation: EAW85528.1
CH471112 Genomic DNA Translation: EAW85529.1
BC035205 mRNA Translation: AAH35205.1
BC063710 mRNA Translation: AAH63710.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42105.1 [Q92874-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001288609.1, NM_001301680.1 [Q92874-1]
NP_001365.1, NM_001374.2 [Q92874-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000320700; ENSP00000316938; ENSG00000167968 [Q92874-1]
ENST00000382437; ENSP00000371874; ENSG00000167968 [Q92874-2]
ENST00000564065; ENSP00000454562; ENSG00000167968 [Q92874-1]
ENST00000567494; ENSP00000455358; ENSG00000167968 [Q92874-1]
ENST00000613572; ENSP00000482627; ENSG00000167968 [Q92874-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1775

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1775

UCSC genome browser

More...
UCSCi
uc002cpn.4, human [Q92874-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62647 mRNA Translation: AAB63981.1
AY298957 mRNA Translation: AAQ73759.1
AY298958 Genomic DNA Translation: AAQ73760.1
AY298958 Genomic DNA Translation: AAQ73761.1
AK098028 mRNA Translation: BAG53566.1
AC009065 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85526.1
CH471112 Genomic DNA Translation: EAW85527.1
CH471112 Genomic DNA Translation: EAW85528.1
CH471112 Genomic DNA Translation: EAW85529.1
BC035205 mRNA Translation: AAH35205.1
BC063710 mRNA Translation: AAH63710.1
CCDSiCCDS42105.1 [Q92874-1]
RefSeqiNP_001288609.1, NM_001301680.1 [Q92874-1]
NP_001365.1, NM_001374.2 [Q92874-1]

3D structure databases

SMRiQ92874
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108114, 12 interactors
IntActiQ92874, 11 interactors
STRINGi9606.ENSP00000454562

PTM databases

iPTMnetiQ92874
PhosphoSitePlusiQ92874

Polymorphism and mutation databases

BioMutaiDNASE1L2
DMDMi2494172

Proteomic databases

jPOSTiQ92874
MassIVEiQ92874
PaxDbiQ92874
PeptideAtlasiQ92874
PRIDEiQ92874
ProteomicsDBi66528
75558 [Q92874-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51835, 59 antibodies

Genome annotation databases

EnsembliENST00000320700; ENSP00000316938; ENSG00000167968 [Q92874-1]
ENST00000382437; ENSP00000371874; ENSG00000167968 [Q92874-2]
ENST00000564065; ENSP00000454562; ENSG00000167968 [Q92874-1]
ENST00000567494; ENSP00000455358; ENSG00000167968 [Q92874-1]
ENST00000613572; ENSP00000482627; ENSG00000167968 [Q92874-2]
GeneIDi1775
KEGGihsa:1775
UCSCiuc002cpn.4, human [Q92874-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1775
DisGeNETi1775
EuPathDBiHostDB:ENSG00000167968.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DNASE1L2
HGNCiHGNC:2958, DNASE1L2
HPAiENSG00000167968, Tissue enhanced (salivary gland, skin)
MIMi602622, gene
neXtProtiNX_Q92874
OpenTargetsiENSG00000167968
PharmGKBiPA27429

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SGB6, Eukaryota
GeneTreeiENSGT00950000182846
HOGENOMiCLU_043335_2_1_1
InParanoidiQ92874
OMAiCNYVRAQ
OrthoDBi1282784at2759
PhylomeDBiQ92874
TreeFamiTF329541

Enzyme and pathway databases

PathwayCommonsiQ92874

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1775, 2 hits in 840 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DNASE1L2, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DNASE1L2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1775
PharosiQ92874, Tbio

Protein Ontology

More...
PROi
PR:Q92874
RNActiQ92874, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000167968, Expressed in skin of leg and 114 other tissues
ExpressionAtlasiQ92874, baseline and differential
GenevisibleiQ92874, HS

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR018057, Deoxyribonuclease-1_AS
IPR016202, DNase_I
IPR033125, DNASE_I_2
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
PfamiView protein in Pfam
PF03372, Exo_endo_phos, 1 hit
PIRSFiPIRSF000988, DNase_I_euk, 1 hit
PRINTSiPR00130, DNASEI
SMARTiView protein in SMART
SM00476, DNaseIc, 1 hit
SUPFAMiSSF56219, SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS00919, DNASE_I_1, 1 hit
PS00918, DNASE_I_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNSL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92874
Secondary accession number(s): E9PBY4, Q6JVM2, Q6JVM3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: December 2, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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