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UniProtKB - Q92870 (APBB2_HUMAN)

Entry version 179 (23 Feb 2022)
Sequence version 3 (11 Jan 2011)
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Protein

Amyloid beta precursor protein binding family B member 2

Gene

APBB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity).

Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity).

Activates transcription of APP (PubMed:14527950).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • amyloid-beta binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92870

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q92870

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amyloid beta precursor protein binding family B member 2Imported
Alternative name(s):
Amyloid-beta (A4) precursor protein-binding family B member 2By similarity
Protein Fe65-like 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APBB2Imported
Synonyms:FE65LImported, FE65L11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:582, APBB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602710, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92870

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163697

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi702C → V: Abolishes interaction with APP and gamma-secretase-dependent processing of the APP membrane-anchored C-terminal fragment C83. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		323

Open Targets

More...OpenTargetsi		ENSG00000163697

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24874

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92870, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		APBB2

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373476

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760521 – 758Amyloid beta precursor protein binding family B member 2Add BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei123PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei409PhosphoserineBy similarity1
Modified residuei412PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92870

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92870

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92870

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92870

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92870

PeptideAtlas

More...PeptideAtlasi		Q92870

PRoteomics IDEntifications database

More...PRIDEi		Q92870

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20267
5034
75555 [Q92870-1]
75556 [Q92870-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92870

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92870

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163697, Expressed in amniotic fluid and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92870, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92870, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163697, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with APP (via C-terminus) (PubMed:8855266, PubMed:14527950).

Interacts with APLP2 (via cytoplasmic domain) (PubMed:8855266).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q92870
With#Exp.IntAct
APP [P05067]3EBI-79277,EBI-77613
EGFR [P00533]7EBI-79277,EBI-297353
Isoform 2 [Q92870-2]
With#Exp.IntAct
ABHD17C [Q6PCB6]3EBI-21535880,EBI-22011868
AKR7A2 [O43488]3EBI-21535880,EBI-748855
AP2B1 - isoform 2 [P63010-2]3EBI-21535880,EBI-11529439
APLN [D3DTF8]3EBI-21535880,EBI-22002556
APP [P05067]3EBI-21535880,EBI-77613
ARFGAP1 - isoform 3 [Q8N6T3-3]3EBI-21535880,EBI-10694449
ARL16 [Q0P5N6]3EBI-21535880,EBI-10186132
ASCL4 [Q6XD76]3EBI-21535880,EBI-10254793
ASIC4 - isoform 3 [Q96FT7-4]3EBI-21535880,EBI-9089489
ATF3 [P18847]3EBI-21535880,EBI-712767
BBLN [Q9BUW7]3EBI-21535880,EBI-752084
BIRC5 [O15392]3EBI-21535880,EBI-518823
BMF [Q96LC9]3EBI-21535880,EBI-3919268
C12orf74 [Q32Q52]3EBI-21535880,EBI-12891828
C7orf31 [Q8N865]3EBI-21535880,EBI-10174456
CAMK2A [Q9UQM7]3EBI-21535880,EBI-1383687
CBWD3 [Q5JTY5]3EBI-21535880,EBI-723434
CCNC [P24863]3EBI-21535880,EBI-395261
CDS2 [O95674]3EBI-21535880,EBI-3913685
DAXX [Q9UER7]3EBI-21535880,EBI-77321
DLX3 [O60479]3EBI-21535880,EBI-3908248
DPF1 - isoform 2 [Q92782-2]3EBI-21535880,EBI-23669343
E2F8 [A0AVK6]3EBI-21535880,EBI-7779316
ELL2 [O00472]3EBI-21535880,EBI-395274
ENKUR [Q8TC29]3EBI-21535880,EBI-9246952
ESRP1 - isoform 3 [Q6NXG1-3]3EBI-21535880,EBI-21567429
EYA3 [Q99504]3EBI-21535880,EBI-9089567
FAM104B - isoform 2 [Q5XKR9-2]3EBI-21535880,EBI-19946114
FANCG [O15287]3EBI-21535880,EBI-81610
FOXR1 [Q6PIV2]3EBI-21535880,EBI-10253815
FYN [P06241]3EBI-21535880,EBI-515315
HDAC10 [Q969S8]3EBI-21535880,EBI-301762
HK3 [P52790]3EBI-21535880,EBI-2965780
HOXA5 [P20719]3EBI-21535880,EBI-8470697
IQSEC1 - isoform 2 [Q6DN90-2]3EBI-21535880,EBI-21911304
KCTD15 - isoform 2 [Q96SI1-2]3EBI-21535880,EBI-12382297
KCTD17 [Q8N5Z5]3EBI-21535880,EBI-743960
KLC3 [Q6P597]3EBI-21535880,EBI-1643885
KRTAP19-1 [Q8IUB9]3EBI-21535880,EBI-12811111
KRTAP8-1 [Q8IUC2]3EBI-21535880,EBI-10261141
LINC00518 [Q8N0U6]3EBI-21535880,EBI-10264791
LOC642947 [Q6ZP95]3EBI-21535880,EBI-25831954
MECOM - isoform 9 [Q03112-9]3EBI-21535880,EBI-23820194
MEOX1 [P50221]3EBI-21535880,EBI-2864512
MGARP [Q8TDB4]3EBI-21535880,EBI-4397720
MKL1 [A4FUJ8]3EBI-21535880,EBI-21250407
MKRN3 [Q13064]3EBI-21535880,EBI-2340269
MRFAP1 [Q9Y605]3EBI-21535880,EBI-995714
MSRB2 [Q9Y3D2]3EBI-21535880,EBI-9092052
MYLIP [Q8WY64]3EBI-21535880,EBI-6952711
NAIF1 - isoform 2 [Q69YI7-2]3EBI-21535880,EBI-18040878
NCKAP1 [Q9Y2A7]3EBI-21535880,EBI-389845
NR2C2 [Q6PHZ7]3EBI-21535880,EBI-2802743
NRF1 - isoform 4 [Q16656-4]3EBI-21535880,EBI-11742836
NXT2 - isoform 3 [Q9NPJ8-3]3EBI-21535880,EBI-10698339
OIP5 [O43482]3EBI-21535880,EBI-536879
OPTN - isoform 2 [Q96CV9-2]3EBI-21535880,EBI-9091423
PACS1 [Q6VY07]3EBI-21535880,EBI-2555014
PCMT1 - isoform 2 [P22061-2]3EBI-21535880,EBI-12386584
PER1 [O15534]3EBI-21535880,EBI-2557276
PIAS1 [O75925]3EBI-21535880,EBI-629434
PITX1 [P78337]3EBI-21535880,EBI-748265
POLR3F [Q9H1D9]3EBI-21535880,EBI-710067
PPP1R16A [Q96I34]3EBI-21535880,EBI-710402
PRKACA [P17612]3EBI-21535880,EBI-476586
PRUNE2 [A0A0C4DFM3]3EBI-21535880,EBI-25830870
RAB6C [Q9H0N0]3EBI-21535880,EBI-2856714
RNF183 [Q96D59]3EBI-21535880,EBI-743938
SAP30 [O75446]3EBI-21535880,EBI-632609
SASS6 [Q6UVJ0]3EBI-21535880,EBI-1570153
SHLD1 [Q8IYI0]3EBI-21535880,EBI-2560428
SLC6A13 - isoform 3 [Q9NSD5-3]3EBI-21535880,EBI-25831241
SOX7 [Q9BT81]3EBI-21535880,EBI-7239117
SPATA12 [Q7Z6I5]3EBI-21535880,EBI-10696971
SPATA2L [Q8IUW3]3EBI-21535880,EBI-2510414
SPRED2 [Q7Z698]3EBI-21535880,EBI-7082156
STAM2 [O75886]3EBI-21535880,EBI-373258
SULT4A1 - isoform 2 [Q9BR01-2]3EBI-21535880,EBI-25831443
SUMF2 [Q8NBJ7]3EBI-21535880,EBI-723091
TDG [Q13569]3EBI-21535880,EBI-348333
TIGD1 [Q96MW7]3EBI-21535880,EBI-9091586
tmp_locus_54 [Q53NU3]3EBI-21535880,EBI-10242677
TMUB2 - isoform 4 [Q71RG4-4]3EBI-21535880,EBI-25831574
UBE2V1 [Q13404]3EBI-21535880,EBI-1050671
VDAC2 [P45880]3EBI-21535880,EBI-354022
VSX2 [P58304]3EBI-21535880,EBI-6427899
ZBTB17 [Q13105]3EBI-21535880,EBI-372156
ZFYVE19 [Q96K21]3EBI-21535880,EBI-6448240
ZHX1-C8orf76 [Q96EF9]3EBI-21535880,EBI-25830993
ZMAT2 [Q96NC0]3EBI-21535880,EBI-2682299
ZNF366 [Q8N895]3EBI-21535880,EBI-2813661
ZNF488 - isoform 2 [Q96MN9-2]3EBI-21535880,EBI-25831733
ZNHIT1 [O43257]3EBI-21535880,EBI-347522
A8K8783EBI-21535880,EBI-25831303
B7Z3E83EBI-21535880,EBI-25831617
Q7L8T73EBI-21535880,EBI-25831943
Q7Z6373EBI-21535880,EBI-25831475
Q9H6693EBI-21535880,EBI-10307430

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106820, 72 interactors

Protein interaction database and analysis system

More...IntActi		Q92870, 124 interactors

Molecular INTeraction database

More...MINTi		Q92870

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000427211

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92870, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92870

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini290 – 322WWPROSITE-ProRule annotationAdd BLAST33
Domaini413 – 578PID 1PROSITE-ProRule annotationAdd BLAST166
Domaini584 – 736PID 2PROSITE-ProRule annotationAdd BLAST153

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni134 – 154DisorderedSequence analysisAdd BLAST21
Regioni176 – 195DisorderedSequence analysisAdd BLAST20
Regioni206 – 295DisorderedSequence analysisAdd BLAST90
Regioni326 – 351DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi206 – 230Polar residuesSequence analysisAdd BLAST25
Compositional biasi254 – 281Polar residuesSequence analysisAdd BLAST28
Compositional biasi329 – 348Polar residuesSequence analysisAdd BLAST20

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QT08, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000002

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_092267_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92870

Identification of Orthologs from Complete Genome Data

More...OMAi		NVPHADD

Database of Orthologous Groups

More...OrthoDBi		437627at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92870

TreeFam database of animal gene trees

More...TreeFami		TF314331

Family and domain databases

Conserved Domains Database

More...CDDi		cd00201, WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039576, Fe65
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR001202, WW_dom
IPR036020, WW_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR14058, PTHR14058, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00640, PID, 2 hits
PF00397, WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00462, PTB, 2 hits
SM00456, WW, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51045, SSF51045, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01179, PID, 2 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92870-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN 
        60         70         80         90        100
AEIKHTETKN STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV 
       110        120        130        140        150
KNGENQLRKA AEQGQQDPNK NLSPTAVINI TSEKLEGKEP HPQDSSSCEI 
       160        170        180        190        200
LPSQPRRTKS FLNYYADLET SARELEQNRG NHHGTAEEKS QPVQGQASTI 
       210        220        230        240        250
IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI 
       260        270        280        290        300
QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS 
       310        320        330        340        350
DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEKQP 
       360        370        380        390        400
WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP 
       410        420        430        440        450
HPDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL 
       460        470        480        490        500
SYCKNDIRDT VGIWGEGKDM YLILENDMLS LVDPMDRSVL HSQPIVSIRV 
       510        520        530        540        550
WGVGRDNGRD FAYVARDKDT RILKCHVFRC DTPAKAIATS LHEICSKIMA 
       560        570        580        590        600
ERKNAKALAC SSLQERANVN LDVPLQVDFP TPKTELVQKF HVQYLGMLPV 
       610        620        630        640        650
DKPVGMDILN SAIENLMTSS NKEDWLSVNM NVADATVTVI SEKNEEEVLV 
       660        670        680        690        700
ECRVRFLSFM GVGKDVHTFA FIMDTGNQRF ECHVFWCEPN AGNVSEAVQA 
       710        720        730        740        750
ACMLRYQKCL VARPPSQKVR PPPPPADSVT RRVTTNVKRG VLSLIDTLKQ 

KRPVTEMP
Length:758
Mass (Da):83,374
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i453521022CD548D5
GO
Isoform 2 (identifier: Q92870-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
     577-577: Missing.

Show »
Length:736
Mass (Da):80,889
Checksum:i6D64F31F4772DB3B
GO
Isoform 3 (identifier: Q92870-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-548: Missing.

Show »
Length:210
Mass (Da):23,488
Checksum:i22E24FCE3101AB83
GO
Isoform 4 (identifier: Q92870-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-278: T → TA

Show »
Length:759
Mass (Da):83,445
Checksum:i5D32E0D35D43756E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9Y1G5E9Y1_HUMAN
Amyloid beta (A4) protein-binding, ...
APBB2 hCG_33089
737Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAJ5H0YAJ5_HUMAN
Amyloid beta precursor protein-bind...
APBB2
728Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB55D6RB55_HUMAN
Amyloid beta precursor protein-bind...
APBB2
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9U9H0Y9U9_HUMAN
Amyloid beta precursor protein-bind...
APBB2
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA92H0YA92_HUMAN
Amyloid beta precursor protein-bind...
APBB2
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAJ4D6RAJ4_HUMAN
Amyloid beta precursor protein-bind...
APBB2
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RD19D6RD19_HUMAN
Amyloid beta precursor protein-bind...
APBB2
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGD4D6RGD4_HUMAN
Amyloid beta precursor protein-bind...
APBB2
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB00D6RB00_HUMAN
Amyloid beta precursor protein-bind...
APBB2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDY3D6RDY3_HUMAN
Amyloid beta precursor protein-bind...
APBB2
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50805 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti490L → W in AAC50805 (PubMed:8855266).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069029179R → Q2 PublicationsCorresponds to variant dbSNP:rs4861358Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0442321 – 548Missing in isoform 3. 1 PublicationAdd BLAST548
Alternative sequenceiVSP_045042278T → TA in isoform 4. 1 Publication1
Alternative sequenceiVSP_040354348 – 368Missing in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_040355577Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK299800 mRNA Translation: BAG61676.1
AK226179 mRNA No translation available.
AC093804 Genomic DNA No translation available.
AC096712 Genomic DNA No translation available.
AC108937 Genomic DNA No translation available.
AC131953 Genomic DNA No translation available.
BC027946 mRNA Translation: AAH27946.2
U62325 mRNA Translation: AAC50805.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43224.1 [Q92870-2]
CCDS54760.1 [Q92870-3]
CCDS54761.1 [Q92870-1]
CCDS54762.1 [Q92870-4]

NCBI Reference Sequences

More...RefSeqi		NP_001159522.1, NM_001166050.1 [Q92870-1]
NP_001159523.1, NM_001166051.1 [Q92870-3]
NP_001159524.1, NM_001166052.1 [Q92870-3]
NP_001159525.1, NM_001166053.1 [Q92870-3]
NP_001159526.1, NM_001166054.1 [Q92870-3]
NP_001317585.1, NM_001330656.1
NP_001317587.1, NM_001330658.1
NP_775098.2, NM_173075.4 [Q92870-2]
XP_016863634.1, XM_017008145.1 [Q92870-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295974; ENSP00000295974; ENSG00000163697
ENST00000502841; ENSP00000425802; ENSG00000163697 [Q92870-3]
ENST00000504305; ENSP00000423765; ENSG00000163697 [Q92870-3]
ENST00000508593; ENSP00000427211; ENSG00000163697 [Q92870-4]
ENST00000513140; ENSP00000426018; ENSG00000163697 [Q92870-2]
ENST00000543538; ENSP00000439357; ENSG00000163697 [Q92870-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		323

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:323

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000508593.6; ENSP00000427211.1; NM_004307.2; NP_004298.1 [Q92870-4]

UCSC genome browser

More...UCSCi		uc003gvk.4, human [Q92870-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299800 mRNA Translation: BAG61676.1
AK226179 mRNA No translation available.
AC093804 Genomic DNA No translation available.
AC096712 Genomic DNA No translation available.
AC108937 Genomic DNA No translation available.
AC131953 Genomic DNA No translation available.
BC027946 mRNA Translation: AAH27946.2
U62325 mRNA Translation: AAC50805.1 Sequence problems.
CCDSiCCDS43224.1 [Q92870-2]
CCDS54760.1 [Q92870-3]
CCDS54761.1 [Q92870-1]
CCDS54762.1 [Q92870-4]
RefSeqiNP_001159522.1, NM_001166050.1 [Q92870-1]
NP_001159523.1, NM_001166051.1 [Q92870-3]
NP_001159524.1, NM_001166052.1 [Q92870-3]
NP_001159525.1, NM_001166053.1 [Q92870-3]
NP_001159526.1, NM_001166054.1 [Q92870-3]
NP_001317585.1, NM_001330656.1
NP_001317587.1, NM_001330658.1
NP_775098.2, NM_173075.4 [Q92870-2]
XP_016863634.1, XM_017008145.1 [Q92870-4]

3D structure databases

SMRiQ92870
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106820, 72 interactors
IntActiQ92870, 124 interactors
MINTiQ92870
STRINGi9606.ENSP00000427211

PTM databases

iPTMnetiQ92870
PhosphoSitePlusiQ92870

Genetic variation databases

BioMutaiAPBB2
DMDMi317373476

Proteomic databases

EPDiQ92870
jPOSTiQ92870
MassIVEiQ92870
MaxQBiQ92870
PaxDbiQ92870
PeptideAtlasiQ92870
PRIDEiQ92870
ProteomicsDBi20267
5034
75555 [Q92870-1]
75556 [Q92870-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		5811, 174 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		323

Genome annotation databases

EnsembliENST00000295974; ENSP00000295974; ENSG00000163697
ENST00000502841; ENSP00000425802; ENSG00000163697 [Q92870-3]
ENST00000504305; ENSP00000423765; ENSG00000163697 [Q92870-3]
ENST00000508593; ENSP00000427211; ENSG00000163697 [Q92870-4]
ENST00000513140; ENSP00000426018; ENSG00000163697 [Q92870-2]
ENST00000543538; ENSP00000439357; ENSG00000163697 [Q92870-3]
GeneIDi323
KEGGihsa:323
MANE-SelectiENST00000508593.6; ENSP00000427211.1; NM_004307.2; NP_004298.1 [Q92870-4]
UCSCiuc003gvk.4, human [Q92870-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		323
DisGeNETi323

GeneCards: human genes, protein and diseases

More...GeneCardsi		APBB2
HGNCiHGNC:582, APBB2
HPAiENSG00000163697, Tissue enhanced (brain)
MIMi602710, gene
neXtProtiNX_Q92870
OpenTargetsiENSG00000163697
PharmGKBiPA24874
VEuPathDBiHostDB:ENSG00000163697

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QT08, Eukaryota
GeneTreeiENSGT00390000000002
HOGENOMiCLU_092267_0_0_1
InParanoidiQ92870
OMAiNVPHADD
OrthoDBi437627at2759
PhylomeDBiQ92870
TreeFamiTF314331

Enzyme and pathway databases

PathwayCommonsiQ92870
SignaLinkiQ92870

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		323, 3 hits in 1039 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		APBB2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		APBB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		323
PharosiQ92870, Tbio

Protein Ontology

More...PROi		PR:Q92870
RNActiQ92870, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163697, Expressed in amniotic fluid and 234 other tissues
ExpressionAtlasiQ92870, baseline and differential
GenevisibleiQ92870, HS

Family and domain databases

CDDicd00201, WW, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039576, Fe65
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR001202, WW_dom
IPR036020, WW_dom_sf
PANTHERiPTHR14058, PTHR14058, 1 hit
PfamiView protein in Pfam
PF00640, PID, 2 hits
PF00397, WW, 1 hit
SMARTiView protein in SMART
SM00462, PTB, 2 hits
SM00456, WW, 1 hit
SUPFAMiSSF51045, SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01179, PID, 2 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPBB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92870
Secondary accession number(s): B4DSL4, E9PG87, Q8IUI6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2011
Last modified: February 23, 2022
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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