UniProtKB - Q92870 (APBB2_HUMAN)
Amyloid beta precursor protein binding family B member 2
APBB2
Functioni
Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity).
Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity).
Activates transcription of APP (PubMed:14527950).
By similarity1 PublicationGO - Molecular functioni
- amyloid-beta binding Source: GO_Central
GO - Biological processi
- intracellular signal transduction Source: UniProtKB
- maintenance of lens transparency Source: UniProtKB
- negative regulation of cell cycle phase transition Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
- smooth muscle contraction Source: UniProtKB
- synapse organization Source: ARUK-UCL
Enzyme and pathway databases
PathwayCommonsi | Q92870 |
SignaLinki | Q92870 |
Names & Taxonomyi
Protein namesi | Recommended name: Amyloid beta precursor protein binding family B member 2ImportedAlternative name(s): Amyloid-beta (A4) precursor protein-binding family B member 2By similarity Protein Fe65-like 1Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:582, APBB2 |
MIMi | 602710, gene |
neXtProti | NX_Q92870 |
VEuPathDBi | HostDB:ENSG00000163697 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Golgi apparatus
- Golgi apparatus 1 Publication
Endosome
- Early endosome 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Endosome
- early endosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- growth cone Source: UniProtKB
- lamellipodium Source: UniProtKB
- membrane Source: UniProtKB
- synapse Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulum, Endosome, Golgi apparatusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 702 | C → V: Abolishes interaction with APP and gamma-secretase-dependent processing of the APP membrane-anchored C-terminal fragment C83. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 323 |
OpenTargetsi | ENSG00000163697 |
PharmGKBi | PA24874 |
Miscellaneous databases
Pharosi | Q92870, Tbio |
Genetic variation databases
BioMutai | APBB2 |
DMDMi | 317373476 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076052 | 1 – 758 | Amyloid beta precursor protein binding family B member 2Add BLAST | 758 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 123 | PhosphoserineCombined sources | 1 | |
Modified residuei | 160 | PhosphoserineCombined sources | 1 | |
Modified residuei | 334 | PhosphoserineCombined sources | 1 | |
Modified residuei | 409 | PhosphoserineBy similarity | 1 | |
Modified residuei | 412 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q92870 |
jPOSTi | Q92870 |
MassIVEi | Q92870 |
MaxQBi | Q92870 |
PaxDbi | Q92870 |
PeptideAtlasi | Q92870 |
PRIDEi | Q92870 |
ProteomicsDBi | 20267 5034 75555 [Q92870-1] 75556 [Q92870-2] |
PTM databases
iPTMneti | Q92870 |
PhosphoSitePlusi | Q92870 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000163697, Expressed in amniotic fluid and 234 other tissues |
ExpressionAtlasi | Q92870, baseline and differential |
Genevisiblei | Q92870, HS |
Organism-specific databases
HPAi | ENSG00000163697, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Binary interactionsi
Q92870
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 3 | EBI-79277,EBI-77613 |
EGFR [P00533] | 7 | EBI-79277,EBI-297353 |
Isoform 2 [Q92870-2]
Protein-protein interaction databases
BioGRIDi | 106820, 72 interactors |
IntActi | Q92870, 124 interactors |
MINTi | Q92870 |
STRINGi | 9606.ENSP00000427211 |
Miscellaneous databases
RNActi | Q92870, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 290 – 322 | WWPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 413 – 578 | PID 1PROSITE-ProRule annotationAdd BLAST | 166 | |
Domaini | 584 – 736 | PID 2PROSITE-ProRule annotationAdd BLAST | 153 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 134 – 154 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 176 – 195 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 206 – 295 | DisorderedSequence analysisAdd BLAST | 90 | |
Regioni | 326 – 351 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 206 – 230 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 254 – 281 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 329 – 348 | Polar residuesSequence analysisAdd BLAST | 20 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QT08, Eukaryota |
GeneTreei | ENSGT00390000000002 |
HOGENOMi | CLU_092267_0_0_1 |
InParanoidi | Q92870 |
OMAi | NVPHADD |
OrthoDBi | 437627at2759 |
PhylomeDBi | Q92870 |
TreeFami | TF314331 |
Family and domain databases
CDDi | cd00201, WW, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR039576, Fe65 IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom IPR001202, WW_dom IPR036020, WW_dom_sf |
PANTHERi | PTHR14058, PTHR14058, 1 hit |
Pfami | View protein in Pfam PF00640, PID, 2 hits PF00397, WW, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 2 hits SM00456, WW, 1 hit |
SUPFAMi | SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 2 hits PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN
60 70 80 90 100
AEIKHTETKN STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV
110 120 130 140 150
KNGENQLRKA AEQGQQDPNK NLSPTAVINI TSEKLEGKEP HPQDSSSCEI
160 170 180 190 200
LPSQPRRTKS FLNYYADLET SARELEQNRG NHHGTAEEKS QPVQGQASTI
210 220 230 240 250
IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI
260 270 280 290 300
QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS
310 320 330 340 350
DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEKQP
360 370 380 390 400
WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP
410 420 430 440 450
HPDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL
460 470 480 490 500
SYCKNDIRDT VGIWGEGKDM YLILENDMLS LVDPMDRSVL HSQPIVSIRV
510 520 530 540 550
WGVGRDNGRD FAYVARDKDT RILKCHVFRC DTPAKAIATS LHEICSKIMA
560 570 580 590 600
ERKNAKALAC SSLQERANVN LDVPLQVDFP TPKTELVQKF HVQYLGMLPV
610 620 630 640 650
DKPVGMDILN SAIENLMTSS NKEDWLSVNM NVADATVTVI SEKNEEEVLV
660 670 680 690 700
ECRVRFLSFM GVGKDVHTFA FIMDTGNQRF ECHVFWCEPN AGNVSEAVQA
710 720 730 740 750
ACMLRYQKCL VARPPSQKVR PPPPPADSVT RRVTTNVKRG VLSLIDTLKQ
KRPVTEMP
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E9Y1 | G5E9Y1_HUMAN | Amyloid beta (A4) protein-binding, ... | APBB2 hCG_33089 | 737 | Annotation score: | ||
H0YAJ5 | H0YAJ5_HUMAN | Amyloid beta precursor protein-bind... | APBB2 | 728 | Annotation score: | ||
D6RB55 | D6RB55_HUMAN | Amyloid beta precursor protein-bind... | APBB2 | 140 | Annotation score: | ||
H0Y9U9 | H0Y9U9_HUMAN | Amyloid beta precursor protein-bind... | APBB2 | 142 | Annotation score: | ||
H0YA92 | H0YA92_HUMAN | Amyloid beta precursor protein-bind... | APBB2 | 179 | Annotation score: | ||
D6RAJ4 | D6RAJ4_HUMAN | Amyloid beta precursor protein-bind... | APBB2 | 95 | Annotation score: | ||
D6RD19 | D6RD19_HUMAN | Amyloid beta precursor protein-bind... | APBB2 | 102 | Annotation score: | ||
D6RGD4 | D6RGD4_HUMAN | Amyloid beta precursor protein-bind... | APBB2 | 87 | Annotation score: | ||
D6RB00 | D6RB00_HUMAN | Amyloid beta precursor protein-bind... | APBB2 | 68 | Annotation score: | ||
D6RDY3 | D6RDY3_HUMAN | Amyloid beta precursor protein-bind... | APBB2 | 26 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 490 | L → W in AAC50805 (PubMed:8855266).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069029 | 179 | R → Q2 PublicationsCorresponds to variant dbSNP:rs4861358Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044232 | 1 – 548 | Missing in isoform 3. 1 PublicationAdd BLAST | 548 | |
Alternative sequenceiVSP_045042 | 278 | T → TA in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_040354 | 348 – 368 | Missing in isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_040355 | 577 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK299800 mRNA Translation: BAG61676.1 AK226179 mRNA No translation available. AC093804 Genomic DNA No translation available. AC096712 Genomic DNA No translation available. AC108937 Genomic DNA No translation available. AC131953 Genomic DNA No translation available. BC027946 mRNA Translation: AAH27946.2 U62325 mRNA Translation: AAC50805.1 Sequence problems. |
CCDSi | CCDS43224.1 [Q92870-2] CCDS54760.1 [Q92870-3] CCDS54761.1 [Q92870-1] CCDS54762.1 [Q92870-4] |
RefSeqi | NP_001159522.1, NM_001166050.1 [Q92870-1] NP_001159523.1, NM_001166051.1 [Q92870-3] NP_001159524.1, NM_001166052.1 [Q92870-3] NP_001159525.1, NM_001166053.1 [Q92870-3] NP_001159526.1, NM_001166054.1 [Q92870-3] NP_001317585.1, NM_001330656.1 NP_001317587.1, NM_001330658.1 NP_775098.2, NM_173075.4 [Q92870-2] XP_016863634.1, XM_017008145.1 [Q92870-4] |
Genome annotation databases
Ensembli | ENST00000295974; ENSP00000295974; ENSG00000163697 ENST00000502841; ENSP00000425802; ENSG00000163697 [Q92870-3] ENST00000504305; ENSP00000423765; ENSG00000163697 [Q92870-3] ENST00000508593; ENSP00000427211; ENSG00000163697 [Q92870-4] ENST00000513140; ENSP00000426018; ENSG00000163697 [Q92870-2] ENST00000543538; ENSP00000439357; ENSG00000163697 [Q92870-3] |
GeneIDi | 323 |
KEGGi | hsa:323 |
MANE-Selecti | ENST00000508593.6; ENSP00000427211.1; NM_004307.2; NP_004298.1 [Q92870-4] |
UCSCi | uc003gvk.4, human [Q92870-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK299800 mRNA Translation: BAG61676.1 AK226179 mRNA No translation available. AC093804 Genomic DNA No translation available. AC096712 Genomic DNA No translation available. AC108937 Genomic DNA No translation available. AC131953 Genomic DNA No translation available. BC027946 mRNA Translation: AAH27946.2 U62325 mRNA Translation: AAC50805.1 Sequence problems. |
CCDSi | CCDS43224.1 [Q92870-2] CCDS54760.1 [Q92870-3] CCDS54761.1 [Q92870-1] CCDS54762.1 [Q92870-4] |
RefSeqi | NP_001159522.1, NM_001166050.1 [Q92870-1] NP_001159523.1, NM_001166051.1 [Q92870-3] NP_001159524.1, NM_001166052.1 [Q92870-3] NP_001159525.1, NM_001166053.1 [Q92870-3] NP_001159526.1, NM_001166054.1 [Q92870-3] NP_001317585.1, NM_001330656.1 NP_001317587.1, NM_001330658.1 NP_775098.2, NM_173075.4 [Q92870-2] XP_016863634.1, XM_017008145.1 [Q92870-4] |
3D structure databases
SMRi | Q92870 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106820, 72 interactors |
IntActi | Q92870, 124 interactors |
MINTi | Q92870 |
STRINGi | 9606.ENSP00000427211 |
PTM databases
iPTMneti | Q92870 |
PhosphoSitePlusi | Q92870 |
Genetic variation databases
BioMutai | APBB2 |
DMDMi | 317373476 |
Proteomic databases
EPDi | Q92870 |
jPOSTi | Q92870 |
MassIVEi | Q92870 |
MaxQBi | Q92870 |
PaxDbi | Q92870 |
PeptideAtlasi | Q92870 |
PRIDEi | Q92870 |
ProteomicsDBi | 20267 5034 75555 [Q92870-1] 75556 [Q92870-2] |
Protocols and materials databases
Antibodypediai | 5811, 174 antibodies from 30 providers |
DNASUi | 323 |
Genome annotation databases
Ensembli | ENST00000295974; ENSP00000295974; ENSG00000163697 ENST00000502841; ENSP00000425802; ENSG00000163697 [Q92870-3] ENST00000504305; ENSP00000423765; ENSG00000163697 [Q92870-3] ENST00000508593; ENSP00000427211; ENSG00000163697 [Q92870-4] ENST00000513140; ENSP00000426018; ENSG00000163697 [Q92870-2] ENST00000543538; ENSP00000439357; ENSG00000163697 [Q92870-3] |
GeneIDi | 323 |
KEGGi | hsa:323 |
MANE-Selecti | ENST00000508593.6; ENSP00000427211.1; NM_004307.2; NP_004298.1 [Q92870-4] |
UCSCi | uc003gvk.4, human [Q92870-1] |
Organism-specific databases
CTDi | 323 |
DisGeNETi | 323 |
GeneCardsi | APBB2 |
HGNCi | HGNC:582, APBB2 |
HPAi | ENSG00000163697, Tissue enhanced (brain) |
MIMi | 602710, gene |
neXtProti | NX_Q92870 |
OpenTargetsi | ENSG00000163697 |
PharmGKBi | PA24874 |
VEuPathDBi | HostDB:ENSG00000163697 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT08, Eukaryota |
GeneTreei | ENSGT00390000000002 |
HOGENOMi | CLU_092267_0_0_1 |
InParanoidi | Q92870 |
OMAi | NVPHADD |
OrthoDBi | 437627at2759 |
PhylomeDBi | Q92870 |
TreeFami | TF314331 |
Enzyme and pathway databases
PathwayCommonsi | Q92870 |
SignaLinki | Q92870 |
Miscellaneous databases
BioGRID-ORCSi | 323, 3 hits in 1039 CRISPR screens |
ChiTaRSi | APBB2, human |
GeneWikii | APBB2 |
GenomeRNAii | 323 |
Pharosi | Q92870, Tbio |
PROi | PR:Q92870 |
RNActi | Q92870, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163697, Expressed in amniotic fluid and 234 other tissues |
ExpressionAtlasi | Q92870, baseline and differential |
Genevisiblei | Q92870, HS |
Family and domain databases
CDDi | cd00201, WW, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR039576, Fe65 IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom IPR001202, WW_dom IPR036020, WW_dom_sf |
PANTHERi | PTHR14058, PTHR14058, 1 hit |
Pfami | View protein in Pfam PF00640, PID, 2 hits PF00397, WW, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 2 hits SM00456, WW, 1 hit |
SUPFAMi | SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 2 hits PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | APBB2_HUMAN | |
Accessioni | Q92870Primary (citable) accession number: Q92870 Secondary accession number(s): B4DSL4, E9PG87, Q8IUI6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 23, 2022 | |
This is version 179 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot