UniProtKB - Q92870 (APBB2_HUMAN)

BLAST

>sp|Q92870|APBB2_HUMAN Amyloid-beta A4 precursor protein-binding family B member 2 OS=Homo sapiens OX=9606 GN=APBB2 PE=1 SV=3
MSEVLPADSGVDTLAVFMASSGTTDVTNRNSPATPPNTLNLRSSHNELLNAEIKHTETKN
STPPKCRKKYALTNIQAAMGLSDPAAQPLLGNGSANIKLVKNGENQLRKAAEQGQQDPNK
NLSPTAVINITSEKLEGKEPHPQDSSSCEILPSQPRRTKSFLNYYADLETSARELEQNRG
NHHGTAEEKSQPVQGQASTIIGNGDLLLQKPNRPQSSPEDGQVATVSSSPETKKDHPKTG
AKTDCALHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVS
DIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEKQPWSDFAVLNGG
KINSDIWKDLHAATVNPDPSLKEFEGATLRYASLKLRNAPHPDDDDSCSINSDPEAKCFA
VRSLGWVEMAEEDLAPGKSSVAVNNCIRQLSYCKNDIRDTVGIWGEGKDMYLILENDMLS
LVDPMDRSVLHSQPIVSIRVWGVGRDNGRDFAYVARDKDTRILKCHVFRCDTPAKAIATS
LHEICSKIMAERKNAKALACSSLQERANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPV
DKPVGMDILNSAIENLMTSSNKEDWLSVNMNVADATVTVISEKNEEEVLVECRVRFLSFM
GVGKDVHTFAFIMDTGNQRFECHVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQKVR
PPPPPADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP

Align

Format
Add to basket Added to basket
History
Entry version 161 (07 Nov 2018)
Sequence version 3 (11 Jan 2011)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Amyloid-beta A4 precursor protein-binding family B member 2

Gene

APBB2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May modulate the internalization of amyloid-beta precursor protein.

GO - Molecular functionⁱ

amyloid-beta binding Source: UniProtKB
transcription factor binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon guidance Source: Ensembl
cell cycle arrest Source: UniProtKB
extracellular matrix organization Source: Ensembl
intracellular signal transduction
Source: UniProtKB
Non-traceable author statementⁱ
- 8855266
negative regulation of apoptotic process Source: Ensembl
negative regulation of cell growth Source: UniProtKB
neuron migration Source: Ensembl
positive regulation of apoptotic process Source: Ensembl
regulation of transcription, DNA-templated Source: UniProtKB

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SignaLinkⁱ	Q92870

SignaLinkⁱ

Q92870

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Amyloid-beta A4 precursor protein-binding family B member 2 Alternative name(s): Protein Fe65-like 1
Gene namesⁱ	Name:APBB2 Synonyms:FE65L, FE65L1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163697.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:582 APBB2
MIMⁱ	602710 gene
neXtProtⁱ	NX_Q92870

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	323
MalaCards human disease database More...MalaCardsⁱ	APBB2
Open Targets More...OpenTargetsⁱ	ENSG00000163697
PharmGKBⁱ	PA24874

Polymorphism and mutation databases

BioMutaⁱ	APBB2
DMDMⁱ	317373476

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076052	1 – 758	Amyloid-beta A4 precursor protein-binding family B member 2Add BLAST		758

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	123	PhosphoserineCombined sources	1
Modified residueⁱ	160	PhosphoserineCombined sources	1
Modified residueⁱ	334	PhosphoserineCombined sources	1
Modified residueⁱ	409	PhosphoserineBy similarity	1
Modified residueⁱ	412	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q92870
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92870
PaxDbⁱ	Q92870
PeptideAtlas More...PeptideAtlasⁱ	Q92870
PRIDEⁱ	Q92870
ProteomicsDBⁱ	75555 75556 [Q92870-2]

PTM databases

iPTMnetⁱ	Q92870
PhosphoSitePlusⁱ	Q92870

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163697 Expressed in 227 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_APBB2
ExpressionAtlasⁱ	Q92870 baseline and differential
Genevisibleⁱ	Q92870 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023542

HPAⁱ

HPA023542

Interactionⁱ

Subunit structureⁱ

Binds to the intracellular domain of the amyloid-beta precursor protein.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
APP	P05067	2	EBI-79277,EBI-77613
EGFR	P00533	6	EBI-79277,EBI-297353

GO - Molecular functionⁱ

transcription factor binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106820, 32 interactors
IntActⁱ	Q92870, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q92870
STRINGⁱ	9606.ENSP00000427211

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92870
SMRⁱ	Q92870
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	290 – 322	WWPROSITE-ProRule annotationAdd BLAST	33
Domainⁱ	413 – 578	PID 1PROSITE-ProRule annotationAdd BLAST	166
Domainⁱ	584 – 736	PID 2PROSITE-ProRule annotationAdd BLAST	153

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IEKA Eukaryota ENOG410YEVS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000002
HOGENOMⁱ	HOG000070081
HOVERGENⁱ	HBG050524
InParanoidⁱ	Q92870
KEGG Orthology (KO) More...KOⁱ	K04530
OMAⁱ	EKSQPGQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04HV
PhylomeDBⁱ	Q92870
TreeFamⁱ	TF314331

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00201 WW, 1 hit
Gene3Dⁱ	2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR039576 Fe65 IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom IPR001202 WW_dom IPR036020 WW_dom_sf
PANTHERⁱ	PTHR14058 PTHR14058, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00640 PID, 2 hits PF00397 WW, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 2 hits SM00456 WW, 1 hit
SUPFAMⁱ	SSF51045 SSF51045, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 2 hits PS01159 WW_DOMAIN_1, 1 hit PS50020 WW_DOMAIN_2, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 13 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q92870-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN 
        60         70         80         90        100
AEIKHTETKN STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV 
       110        120        130        140        150
KNGENQLRKA AEQGQQDPNK NLSPTAVINI TSEKLEGKEP HPQDSSSCEI 
       160        170        180        190        200
LPSQPRRTKS FLNYYADLET SARELEQNRG NHHGTAEEKS QPVQGQASTI 
       210        220        230        240        250
IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI 
       260        270        280        290        300
QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS 
       310        320        330        340        350
DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEKQP 
       360        370        380        390        400
WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP 
       410        420        430        440        450
HPDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL 
       460        470        480        490        500
SYCKNDIRDT VGIWGEGKDM YLILENDMLS LVDPMDRSVL HSQPIVSIRV 
       510        520        530        540        550
WGVGRDNGRD FAYVARDKDT RILKCHVFRC DTPAKAIATS LHEICSKIMA 
       560        570        580        590        600
ERKNAKALAC SSLQERANVN LDVPLQVDFP TPKTELVQKF HVQYLGMLPV 
       610        620        630        640        650
DKPVGMDILN SAIENLMTSS NKEDWLSVNM NVADATVTVI SEKNEEEVLV 
       660        670        680        690        700
ECRVRFLSFM GVGKDVHTFA FIMDTGNQRF ECHVFWCEPN AGNVSEAVQA 
       710        720        730        740        750
ACMLRYQKCL VARPPSQKVR PPPPPADSVT RRVTTNVKRG VLSLIDTLKQ 

KRPVTEMP

Length:758

Mass (Da):83,374

Last modified:January 11, 2011 - v3

Checksum:ⁱ453521022CD548D5

Isoform 2 (identifier: Q92870-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
348-368: Missing.
577-577: Missing.

« Hide

        10         20         30         40         50
MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN 
        60         70         80         90        100
AEIKHTETKN STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV 
       110        120        130        140        150
KNGENQLRKA AEQGQQDPNK NLSPTAVINI TSEKLEGKEP HPQDSSSCEI 
       160        170        180        190        200
LPSQPRRTKS FLNYYADLET SARELEQNRG NHHGTAEEKS QPVQGQASTI 
       210        220        230        240        250
IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI 
       260        270        280        290        300
QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS 
       310        320        330        340        350
DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEDLH 
       360        370        380        390        400
AATVNPDPSL KEFEGATLRY ASLKLRNAPH PDDDDSCSIN SDPEAKCFAV 
       410        420        430        440        450
RSLGWVEMAE EDLAPGKSSV AVNNCIRQLS YCKNDIRDTV GIWGEGKDMY 
       460        470        480        490        500
LILENDMLSL VDPMDRSVLH SQPIVSIRVW GVGRDNGRDF AYVARDKDTR 
       510        520        530        540        550
ILKCHVFRCD TPAKAIATSL HEICSKIMAE RKNAKALACS SLQERANVNL 
       560        570        580        590        600
DVPLQDFPTP KTELVQKFHV QYLGMLPVDK PVGMDILNSA IENLMTSSNK 
       610        620        630        640        650
EDWLSVNMNV ADATVTVISE KNEEEVLVEC RVRFLSFMGV GKDVHTFAFI 
       660        670        680        690        700
MDTGNQRFEC HVFWCEPNAG NVSEAVQAAC MLRYQKCLVA RPPSQKVRPP 
       710        720        730 
PPPADSVTRR VTTNVKRGVL SLIDTLKQKR PVTEMP

Show »

Length:736

Mass (Da):80,889

Checksum:ⁱ6D64F31F4772DB3B

Isoform 3 (identifier: Q92870-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-548: Missing.

« Hide

        10         20         30         40         50
MAERKNAKAL ACSSLQERAN VNLDVPLQVD FPTPKTELVQ KFHVQYLGML 
        60         70         80         90        100
PVDKPVGMDI LNSAIENLMT SSNKEDWLSV NMNVADATVT VISEKNEEEV 
       110        120        130        140        150
LVECRVRFLS FMGVGKDVHT FAFIMDTGNQ RFECHVFWCE PNAGNVSEAV 
       160        170        180        190        200
QAACMLRYQK CLVARPPSQK VRPPPPPADS VTRRVTTNVK RGVLSLIDTL 
       210
KQKRPVTEMP

Show »

Length:210

Mass (Da):23,488

Checksum:ⁱ22E24FCE3101AB83

Isoform 4 (identifier: Q92870-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
278-278: T → TA

« Hide

        10         20         30         40         50
MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN 
        60         70         80         90        100
AEIKHTETKN STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV 
       110        120        130        140        150
KNGENQLRKA AEQGQQDPNK NLSPTAVINI TSEKLEGKEP HPQDSSSCEI 
       160        170        180        190        200
LPSQPRRTKS FLNYYADLET SARELEQNRG NHHGTAEEKS QPVQGQASTI 
       210        220        230        240        250
IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI 
       260        270        280        290        300
QNLAPSDEES SWTTLSQDSA SPSSPDETAD IWSDHSFQTD PDLPPGWKRV 
       310        320        330        340        350
SDIAGTYYWH IPTGTTQWER PVSIPADLQG SRKGSLSSVT PSPTPENEKQ 
       360        370        380        390        400
PWSDFAVLNG GKINSDIWKD LHAATVNPDP SLKEFEGATL RYASLKLRNA 
       410        420        430        440        450
PHPDDDDSCS INSDPEAKCF AVRSLGWVEM AEEDLAPGKS SVAVNNCIRQ 
       460        470        480        490        500
LSYCKNDIRD TVGIWGEGKD MYLILENDML SLVDPMDRSV LHSQPIVSIR 
       510        520        530        540        550
VWGVGRDNGR DFAYVARDKD TRILKCHVFR CDTPAKAIAT SLHEICSKIM 
       560        570        580        590        600
AERKNAKALA CSSLQERANV NLDVPLQVDF PTPKTELVQK FHVQYLGMLP 
       610        620        630        640        650
VDKPVGMDIL NSAIENLMTS SNKEDWLSVN MNVADATVTV ISEKNEEEVL 
       660        670        680        690        700
VECRVRFLSF MGVGKDVHTF AFIMDTGNQR FECHVFWCEP NAGNVSEAVQ 
       710        720        730        740        750
AACMLRYQKC LVARPPSQKV RPPPPPADSV TRRVTTNVKR GVLSLIDTLK 

QKRPVTEMP

Note: No experimental confirmation available.

Show »

Length:759

Mass (Da):83,445

Checksum:ⁱ5D32E0D35D43756E

Computationally mapped potential isoform sequencesⁱ

There are 13 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	G5E9Y1	G5E9Y1_HUMAN	Amyloid beta (A4) protein-binding, ... Amyloid beta (A4) protein-binding, family B, member 2 (Fe65-like), isoform CRA_c (Amyloid-beta A4 precursor protein-binding family B member 2)	APBB2 hCG_33089	737	Annotation score:
	H0YAJ5	H0YAJ5_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 2	APBB2	728	Annotation score:
	H0Y9U9	H0Y9U9_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 2	APBB2	142	Annotation score:
	D6RD19	D6RD19_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 2	APBB2	102	Annotation score:
	H0YA92	H0YA92_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 2	APBB2	179	Annotation score:
	D6RGD4	D6RGD4_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 2	APBB2	87	Annotation score:
	D6RAJ4	D6RAJ4_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 2	APBB2	95	Annotation score:
	D6RB55	D6RB55_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 2	APBB2	140	Annotation score:
	D6RB00	D6RB00_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 2	APBB2	68	Annotation score:
	D6RDY3	D6RDY3_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 2	APBB2	26	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAC50805 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	490	L → W in AAC50805 (PubMed:8855266).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_069029	179	R → Q2 PublicationsCorresponds to variant dbSNP:rs4861358Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_044232	1 – 548	Missing in isoform 3. 1 PublicationAdd BLAST	548
Alternative sequenceⁱVSP_045042	278	T → TA in isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_040354	348 – 368	Missing in isoform 2. 1 PublicationAdd BLAST	21
Alternative sequenceⁱVSP_040355	577	Missing in isoform 2. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK299800 mRNA Translation: BAG61676.1 AK226179 mRNA No translation available. AC093804 Genomic DNA No translation available. AC096712 Genomic DNA No translation available. AC108937 Genomic DNA No translation available. AC131953 Genomic DNA No translation available. BC027946 mRNA Translation: AAH27946.2 U62325 mRNA Translation: AAC50805.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43224.1 [Q92870-2] CCDS54760.1 [Q92870-3] CCDS54761.1 [Q92870-1] CCDS54762.1 [Q92870-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001159522.1, NM_001166050.1 [Q92870-1] NP_001159523.1, NM_001166051.1 [Q92870-3] NP_001159524.1, NM_001166052.1 [Q92870-3] NP_001159525.1, NM_001166053.1 [Q92870-3] NP_001159526.1, NM_001166054.1 [Q92870-3] NP_001317585.1, NM_001330656.1 NP_001317587.1, NM_001330658.1 NP_775098.2, NM_173075.4 [Q92870-2] XP_016863634.1, XM_017008145.1 [Q92870-4]
UniGeneⁱ	Hs.479602

Genome annotation databases

Ensemblⁱ	ENST00000295974; ENSP00000295974; ENSG00000163697 [Q92870-1] ENST00000502841; ENSP00000425802; ENSG00000163697 [Q92870-3] ENST00000504305; ENSP00000423765; ENSG00000163697 [Q92870-3] ENST00000508593; ENSP00000427211; ENSG00000163697 [Q92870-4] ENST00000513140; ENSP00000426018; ENSG00000163697 [Q92870-2] ENST00000543538; ENSP00000439357; ENSG00000163697 [Q92870-3]
GeneIDⁱ	323
KEGGⁱ	hsa:323
UCSC genome browser More...UCSCⁱ	uc003gvk.4 human [Q92870-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q92870	amyloid beta A4 precursor protein-binding family B member 2 isoform X1		DELLE		768	UniRef90_Q92870
amyloid-beta A4 precursor protein-binding family B member 2 isoform X7		Yangtze finless porpoise		210
Amyloid beta precursor protein binding family B member 2		MACNE		768
Uncharacterized protein		FELCA		768
Amyloid beta precursor protein binding family B member 2		SAIBB		768
+196
Q92870-2	amyloid beta A4 precursor protein-binding family B member 2 isoform X5		DELLE		747	UniRef90_Q92870-2
Uncharacterized protein		FELCA		747
Uncharacterized protein		AOTNA		747
Uncharacterized protein		MACNE		747
amyloid beta A4 precursor protein-binding family B member 2 isoform X15		BALAS		740
+191
Q92870-3	APBB2 isoform 16		PANTR		830	UniRef90_A0A2J8PGN4
Amyloid-beta A4 precursor protein-binding family B member 2 (Fragment)		HUMAN		26
APBB2 isoform 22 (Fragment)		PONAB		68
APBB2 isoform 11 (Fragment)		PANTR		140
APBB2 isoform 27		PANTR		210
+13
Q92870-4	Amyloid beta precursor protein binding family B member 2		SARHA		765	UniRef90_Q92870-4
Amyloid beta A4 protein-binding family B member 2 isoform a		CALJA		761
Amyloid beta precursor protein binding family B member 2		SAIBB		759
Uncharacterized protein		RHIRO		759
Amyloid beta A4 protein-binding family B member 2 isoform a		MACMU		759
+87

Protein	Similar proteins		Species	Score	Length	Source
Q92870	Amyloid-beta A4 precursor protein-binding family B member 2	)	MOUSE		760	UniRef50_Q92870
Uncharacterized protein		AOTNA		768
Uncharacterized protein		FELCA		768
Amyloid beta precursor protein binding family B member 2		SAIBB		768
Uncharacterized protein		Cebus capucinus imitator		210
+1045
Q92870-3	Isoform 4 of Amyloid-beta A4 precursor protein-binding family B member 2		HUMAN		759	UniRef50_Q92870-4
Amyloid beta precursor protein binding family B member 2		SARHA		765
Amyloid beta A4 protein-binding family B member 2 isoform a		CALJA		761
Uncharacterized protein		COLAP		759
Uncharacterized protein		PAPAN		759
+357
Q92870-4	Amyloid beta precursor protein binding family B member 2		SARHA		765	UniRef50_Q92870-4
Amyloid beta A4 protein-binding family B member 2 isoform a		CALJA		761
Uncharacterized protein		COLAP		759
Uncharacterized protein		PAPAN		759
Uncharacterized protein		Cebus capucinus imitator		759
+357

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK299800 mRNA Translation: BAG61676.1 AK226179 mRNA No translation available. AC093804 Genomic DNA No translation available. AC096712 Genomic DNA No translation available. AC108937 Genomic DNA No translation available. AC131953 Genomic DNA No translation available. BC027946 mRNA Translation: AAH27946.2 U62325 mRNA Translation: AAC50805.1 Sequence problems.
CCDSⁱ	CCDS43224.1 [Q92870-2] CCDS54760.1 [Q92870-3] CCDS54761.1 [Q92870-1] CCDS54762.1 [Q92870-4]
RefSeqⁱ	NP_001159522.1, NM_001166050.1 [Q92870-1] NP_001159523.1, NM_001166051.1 [Q92870-3] NP_001159524.1, NM_001166052.1 [Q92870-3] NP_001159525.1, NM_001166053.1 [Q92870-3] NP_001159526.1, NM_001166054.1 [Q92870-3] NP_001317585.1, NM_001330656.1 NP_001317587.1, NM_001330658.1 NP_775098.2, NM_173075.4 [Q92870-2] XP_016863634.1, XM_017008145.1 [Q92870-4]
UniGeneⁱ	Hs.479602

3D structure databases

ProteinModelPortalⁱ	Q92870
SMRⁱ	Q92870
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106820, 32 interactors
IntActⁱ	Q92870, 5 interactors
MINTⁱ	Q92870
STRINGⁱ	9606.ENSP00000427211

PTM databases

iPTMnetⁱ	Q92870
PhosphoSitePlusⁱ	Q92870

Polymorphism and mutation databases

BioMutaⁱ	APBB2
DMDMⁱ	317373476

Proteomic databases

EPDⁱ	Q92870
MaxQBⁱ	Q92870
PaxDbⁱ	Q92870
PeptideAtlasⁱ	Q92870
PRIDEⁱ	Q92870
ProteomicsDBⁱ	75555 75556 [Q92870-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	323
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000295974; ENSP00000295974; ENSG00000163697 [Q92870-1] ENST00000502841; ENSP00000425802; ENSG00000163697 [Q92870-3] ENST00000504305; ENSP00000423765; ENSG00000163697 [Q92870-3] ENST00000508593; ENSP00000427211; ENSG00000163697 [Q92870-4] ENST00000513140; ENSP00000426018; ENSG00000163697 [Q92870-2] ENST00000543538; ENSP00000439357; ENSG00000163697 [Q92870-3]
GeneIDⁱ	323
KEGGⁱ	hsa:323
UCSCⁱ	uc003gvk.4 human [Q92870-1]

Organism-specific databases

CTDⁱ	323
DisGeNETⁱ	323
EuPathDBⁱ	HostDB:ENSG00000163697.16
GeneCardsⁱ	APBB2
HGNCⁱ	HGNC:582 APBB2
HPAⁱ	HPA023542
MalaCardsⁱ	APBB2
MIMⁱ	602710 gene
neXtProtⁱ	NX_Q92870
OpenTargetsⁱ	ENSG00000163697
PharmGKBⁱ	PA24874
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEKA Eukaryota ENOG410YEVS LUCA
GeneTreeⁱ	ENSGT00390000000002
HOGENOMⁱ	HOG000070081
HOVERGENⁱ	HBG050524
InParanoidⁱ	Q92870
KOⁱ	K04530
OMAⁱ	EKSQPGQ
OrthoDBⁱ	EOG091G04HV
PhylomeDBⁱ	Q92870
TreeFamⁱ	TF314331

Enzyme and pathway databases

SignaLinkⁱ	Q92870

SignaLinkⁱ

Q92870

Miscellaneous databases

ChiTaRSⁱ	APBB2 human
GeneWikiⁱ	APBB2
GenomeRNAiⁱ	323
Protein Ontology More...PROⁱ	PR:Q92870
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163697 Expressed in 227 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_APBB2
ExpressionAtlasⁱ	Q92870 baseline and differential
Genevisibleⁱ	Q92870 HS

Family and domain databases

CDDⁱ	cd00201 WW, 1 hit
Gene3Dⁱ	2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR039576 Fe65 IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom IPR001202 WW_dom IPR036020 WW_dom_sf
PANTHERⁱ	PTHR14058 PTHR14058, 1 hit
Pfamⁱ	View protein in Pfam PF00640 PID, 2 hits PF00397 WW, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 2 hits SM00456 WW, 1 hit
SUPFAMⁱ	SSF51045 SSF51045, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 2 hits PS01159 WW_DOMAIN_1, 1 hit PS50020 WW_DOMAIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	APBB2_HUMAN
Accessionⁱ	Q92870Primary (citable) accession number: Q92870 Secondary accession number(s): B4DSL4, E9PG87, Q8IUI6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q92870 (APBB2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Amyloid-beta A4 precursor protein-binding family B member 2

APBB2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ