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Protein

Amyloid-beta A4 precursor protein-binding family B member 2

Gene

APBB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate the internalization of amyloid-beta precursor protein.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ92870

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-beta A4 precursor protein-binding family B member 2
Alternative name(s):
Protein Fe65-like 1
Gene namesi
Name:APBB2
Synonyms:FE65L, FE65L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163697.16
HGNCiHGNC:582 APBB2
MIMi602710 gene
neXtProtiNX_Q92870

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi323
MalaCardsiAPBB2
OpenTargetsiENSG00000163697
PharmGKBiPA24874

Polymorphism and mutation databases

BioMutaiAPBB2
DMDMi317373476

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760521 – 758Amyloid-beta A4 precursor protein-binding family B member 2Add BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei409PhosphoserineBy similarity1
Modified residuei412PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92870
MaxQBiQ92870
PaxDbiQ92870
PeptideAtlasiQ92870
PRIDEiQ92870
ProteomicsDBi75555
75556 [Q92870-2]

PTM databases

iPTMnetiQ92870
PhosphoSitePlusiQ92870

Expressioni

Gene expression databases

BgeeiENSG00000163697
CleanExiHS_APBB2
ExpressionAtlasiQ92870 baseline and differential
GenevisibleiQ92870 HS

Organism-specific databases

HPAiHPA023542

Interactioni

Subunit structurei

Binds to the intracellular domain of the amyloid-beta precursor protein.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106820, 31 interactors
IntActiQ92870, 5 interactors
MINTiQ92870
STRINGi9606.ENSP00000427211

Structurei

3D structure databases

ProteinModelPortaliQ92870
SMRiQ92870
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini290 – 322WWPROSITE-ProRule annotationAdd BLAST33
Domaini413 – 578PID 1PROSITE-ProRule annotationAdd BLAST166
Domaini584 – 736PID 2PROSITE-ProRule annotationAdd BLAST153

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKA Eukaryota
ENOG410YEVS LUCA
GeneTreeiENSGT00390000000002
HOGENOMiHOG000033983
HOVERGENiHBG050524
InParanoidiQ92870
KOiK04530
OMAiTKNSTPP
OrthoDBiEOG091G04HV
PhylomeDBiQ92870
TreeFamiTF314331

Family and domain databases

CDDicd00201 WW, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00640 PID, 2 hits
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 2 hits
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92870-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN
60 70 80 90 100
AEIKHTETKN STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV
110 120 130 140 150
KNGENQLRKA AEQGQQDPNK NLSPTAVINI TSEKLEGKEP HPQDSSSCEI
160 170 180 190 200
LPSQPRRTKS FLNYYADLET SARELEQNRG NHHGTAEEKS QPVQGQASTI
210 220 230 240 250
IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI
260 270 280 290 300
QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS
310 320 330 340 350
DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEKQP
360 370 380 390 400
WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP
410 420 430 440 450
HPDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL
460 470 480 490 500
SYCKNDIRDT VGIWGEGKDM YLILENDMLS LVDPMDRSVL HSQPIVSIRV
510 520 530 540 550
WGVGRDNGRD FAYVARDKDT RILKCHVFRC DTPAKAIATS LHEICSKIMA
560 570 580 590 600
ERKNAKALAC SSLQERANVN LDVPLQVDFP TPKTELVQKF HVQYLGMLPV
610 620 630 640 650
DKPVGMDILN SAIENLMTSS NKEDWLSVNM NVADATVTVI SEKNEEEVLV
660 670 680 690 700
ECRVRFLSFM GVGKDVHTFA FIMDTGNQRF ECHVFWCEPN AGNVSEAVQA
710 720 730 740 750
ACMLRYQKCL VARPPSQKVR PPPPPADSVT RRVTTNVKRG VLSLIDTLKQ

KRPVTEMP
Length:758
Mass (Da):83,374
Last modified:January 11, 2011 - v3
Checksum:i453521022CD548D5
GO
Isoform 2 (identifier: Q92870-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
     577-577: Missing.

Show »
Length:736
Mass (Da):80,889
Checksum:i6D64F31F4772DB3B
GO
Isoform 3 (identifier: Q92870-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-548: Missing.

Show »
Length:210
Mass (Da):23,488
Checksum:i22E24FCE3101AB83
GO
Isoform 4 (identifier: Q92870-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-278: T → TA

Note: No experimental confirmation available.
Show »
Length:759
Mass (Da):83,445
Checksum:i5D32E0D35D43756E
GO

Sequence cautioni

The sequence AAC50805 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti490L → W in AAC50805 (PubMed:8855266).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069029179R → Q2 PublicationsCorresponds to variant dbSNP:rs4861358Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442321 – 548Missing in isoform 3. 1 PublicationAdd BLAST548
Alternative sequenceiVSP_045042278T → TA in isoform 4. 1 Publication1
Alternative sequenceiVSP_040354348 – 368Missing in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_040355577Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299800 mRNA Translation: BAG61676.1
AK226179 mRNA No translation available.
AC093804 Genomic DNA No translation available.
AC096712 Genomic DNA No translation available.
AC108937 Genomic DNA No translation available.
AC131953 Genomic DNA No translation available.
BC027946 mRNA Translation: AAH27946.2
U62325 mRNA Translation: AAC50805.1 Sequence problems.
CCDSiCCDS43224.1 [Q92870-2]
CCDS54760.1 [Q92870-3]
CCDS54761.1 [Q92870-1]
CCDS54762.1 [Q92870-4]
RefSeqiNP_001159522.1, NM_001166050.1 [Q92870-1]
NP_001159523.1, NM_001166051.1 [Q92870-3]
NP_001159524.1, NM_001166052.1 [Q92870-3]
NP_001159525.1, NM_001166053.1 [Q92870-3]
NP_001159526.1, NM_001166054.1 [Q92870-3]
NP_001317585.1, NM_001330656.1
NP_001317587.1, NM_001330658.1
NP_775098.2, NM_173075.4 [Q92870-2]
XP_016863634.1, XM_017008145.1 [Q92870-4]
UniGeneiHs.479602

Genome annotation databases

EnsembliENST00000295974; ENSP00000295974; ENSG00000163697 [Q92870-1]
ENST00000502841; ENSP00000425802; ENSG00000163697 [Q92870-3]
ENST00000504305; ENSP00000423765; ENSG00000163697 [Q92870-3]
ENST00000508593; ENSP00000427211; ENSG00000163697 [Q92870-4]
ENST00000513140; ENSP00000426018; ENSG00000163697 [Q92870-2]
ENST00000543538; ENSP00000439357; ENSG00000163697 [Q92870-3]
GeneIDi323
KEGGihsa:323
UCSCiuc003gvk.4 human [Q92870-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAPBB2_HUMAN
AccessioniPrimary (citable) accession number: Q92870
Secondary accession number(s): B4DSL4, E9PG87, Q8IUI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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