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Protein

Protein atonal homolog 1

Gene

ATOH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ92858

Names & Taxonomyi

Protein namesi
Recommended name:
Protein atonal homolog 1
Alternative name(s):
Class A basic helix-loop-helix protein 14
Short name:
bHLHa14
Helix-loop-helix protein hATH-1
Short name:
hATH1
Gene namesi
Name:ATOH1
Synonyms:ATH1, BHLHA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000172238.4
HGNCiHGNC:797 ATOH1
MIMi601461 gene
neXtProtiNX_Q92858

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi474
OpenTargetsiENSG00000172238
PharmGKBiPA25095

Polymorphism and mutation databases

BioMutaiATOH1
DMDMi3913115

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271391 – 354Protein atonal homolog 1Add BLAST354

Proteomic databases

PaxDbiQ92858
PeptideAtlasiQ92858
PRIDEiQ92858
ProteomicsDBi75551

PTM databases

iPTMnetiQ92858
PhosphoSitePlusiQ92858

Expressioni

Gene expression databases

BgeeiENSG00000172238 Expressed in 13 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_ATOH1
GenevisibleiQ92858 HS

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106964, 75 interactors
STRINGi9606.ENSP00000302216

Structurei

3D structure databases

ProteinModelPortaliQ92858
SMRiQ92858
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 211bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 38Poly-Pro10
Compositional biasi224 – 228Poly-Pro5

Phylogenomic databases

eggNOGiKOG4395 Eukaryota
ENOG411269K LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000261611
HOVERGENiHBG050609
InParanoidiQ92858
KOiK09083
OMAiKQVNGVQ
OrthoDBiEOG091G0R1N
PhylomeDBiQ92858
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR032661 ATOH1
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR19290:SF82 PTHR19290:SF82, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q92858-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP
60 70 80 90 100
PELSLLDSTD PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD
110 120 130 140 150
GRGELVRRSS GGASSSKSPG PVKVREQLCK LKGGVVVDEL GCSRQRAPSS
160 170 180 190 200
KQVNGVQKQR RLAANARERR RMHGLNHAFD QLRNVIPSFN NDKKLSKYET
210 220 230 240 250
LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT AASYEGGAGN
260 270 280 290 300
ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS
310 320 330 340 350
ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS

DEAS
Length:354
Mass (Da):38,160
Last modified:February 1, 1997 - v1
Checksum:iAB12F1E917A00A8D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049539237H → Q. Corresponds to variant dbSNP:rs35182771Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61148 Genomic DNA Translation: AAB41305.1
BC069145 mRNA Translation: AAH69145.1
BC069594 mRNA Translation: AAH69594.1
BC069604 mRNA Translation: AAH69604.1
BC113623 mRNA Translation: AAI13624.1
BC113625 mRNA Translation: AAI13626.1
CCDSiCCDS3638.1
RefSeqiNP_005163.1, NM_005172.1
UniGeneiHs.532680

Genome annotation databases

EnsembliENST00000306011; ENSP00000302216; ENSG00000172238
GeneIDi474
KEGGihsa:474
UCSCiuc003hta.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61148 Genomic DNA Translation: AAB41305.1
BC069145 mRNA Translation: AAH69145.1
BC069594 mRNA Translation: AAH69594.1
BC069604 mRNA Translation: AAH69604.1
BC113623 mRNA Translation: AAI13624.1
BC113625 mRNA Translation: AAI13626.1
CCDSiCCDS3638.1
RefSeqiNP_005163.1, NM_005172.1
UniGeneiHs.532680

3D structure databases

ProteinModelPortaliQ92858
SMRiQ92858
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106964, 75 interactors
STRINGi9606.ENSP00000302216

PTM databases

iPTMnetiQ92858
PhosphoSitePlusiQ92858

Polymorphism and mutation databases

BioMutaiATOH1
DMDMi3913115

Proteomic databases

PaxDbiQ92858
PeptideAtlasiQ92858
PRIDEiQ92858
ProteomicsDBi75551

Protocols and materials databases

DNASUi474
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306011; ENSP00000302216; ENSG00000172238
GeneIDi474
KEGGihsa:474
UCSCiuc003hta.2 human

Organism-specific databases

CTDi474
DisGeNETi474
EuPathDBiHostDB:ENSG00000172238.4
GeneCardsiATOH1
HGNCiHGNC:797 ATOH1
MIMi601461 gene
neXtProtiNX_Q92858
OpenTargetsiENSG00000172238
PharmGKBiPA25095
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4395 Eukaryota
ENOG411269K LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000261611
HOVERGENiHBG050609
InParanoidiQ92858
KOiK09083
OMAiKQVNGVQ
OrthoDBiEOG091G0R1N
PhylomeDBiQ92858
TreeFamiTF315153

Enzyme and pathway databases

SIGNORiQ92858

Miscellaneous databases

GeneWikiiATOH1
GenomeRNAii474
PROiPR:Q92858
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172238 Expressed in 13 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_ATOH1
GenevisibleiQ92858 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR032661 ATOH1
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR19290:SF82 PTHR19290:SF82, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATOH1_HUMAN
AccessioniPrimary (citable) accession number: Q92858
Secondary accession number(s): Q14CT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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