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UniProtKB - Q92854 (SEM4D_HUMAN)

Entry version 213 (23 Feb 2022)
Sequence version 1 (01 Feb 1997)
Previous versions | rss
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Protein

Semaphorin-4D

Gene

SEMA4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282).

Regulates GABAergic synapse development (By similarity).

Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity).

Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569).

Promotes the migration of cerebellar granule cells (PubMed:16055703).

Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214).

Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).

By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92854

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-416550, Sema4D mediated inhibition of cell attachment and migration
R-HSA-416572, Sema4D induced cell migration and growth-cone collapse
R-HSA-416700, Other semaphorin interactions

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q92854

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92854

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Semaphorin-4D
Alternative name(s):
A8
BB18
GR3
CD_antigen: CD100
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEMA4D
Synonyms:C9orf164, CD100, SEMAJ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10732, SEMA4D

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601866, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92854

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000187764

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 734ExtracellularSequence analysisAdd BLAST713
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei735 – 755HelicalSequence analysisAdd BLAST21
Topological domaini756 – 862CytoplasmicSequence analysisAdd BLAST107

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi100 – 101KG → DT: Abolishes PLXNB1 binding. 1 Publication2
Mutagenesisi181 – 182FL → ER: Abolishes PLXNB1 binding. 1 Publication2
Mutagenesisi244F → N: Abolishes homodimerization, abolishes collapse of growth cones and reduces PLXNB1 binding; when associated with S-246. 1 Publication1
Mutagenesisi246F → S: Abolishes homodimerization, abolishes collapse of growth cones and reduces PLXNB1 binding; when associated with N-244. 1 Publication1
Mutagenesisi395K → E: Strongly reduces PLXNB1 binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10507

Open Targets

More...OpenTargetsi		ENSG00000187764

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		171, Primary sclerosing cholangitis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35654

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92854, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4630887

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2883

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SEMA4D

Domain mapping of disease mutations (DMDM)

More...DMDMi		8134701

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003232722 – 862Semaphorin-4DAdd BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi49N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi77N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi97 ↔ 108
Disulfide bondi126 ↔ 135
Glycosylationi139N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi191N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi257 ↔ 370
Disulfide bondi281 ↔ 326
Glycosylationi329N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi379N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi419N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi503 ↔ 520
Disulfide bondi509 ↔ 553
Disulfide bondi512 ↔ 529
Disulfide bondi576 ↔ 624
Glycosylationi613N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi632N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei833PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92854

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92854

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92854

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92854

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92854

PeptideAtlas

More...PeptideAtlasi		Q92854

PRoteomics IDEntifications database

More...PRIDEi		Q92854

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75549 [Q92854-1]
75550 [Q92854-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1734, 13 N-Linked glycans (4 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q92854, 12 sites, 13 N-linked glycans (4 sites), 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92854

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92854

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q92854

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000187764, Expressed in C1 segment of cervical spinal cord and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92854, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92854, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000187764, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:20877282).

Interacts with PLXNB2 (By similarity).

Interacts with PLXNB1 (PubMed:10520995).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115766, 28 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q92854

Database of interacting proteins

More...DIPi		DIP-59221N

Protein interaction database and analysis system

More...IntActi		Q92854, 10 interactors

Molecular INTeraction database

More...MINTi		Q92854

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000416523

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92854, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1862
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92854

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q92854

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 500SemaPROSITE-ProRule annotationAdd BLAST479
Domaini502 – 551PSIAdd BLAST50
Domaini554 – 636Ig-like C2-typeAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni794 – 837DisorderedSequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi823 – 837Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3611, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159594

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009051_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92854

Identification of Orthologs from Complete Genome Data

More...OMAi		FRQHFFK

Database of Orthologous Groups

More...OrthoDBi		64683at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92854

TreeFam database of animal gene trees

More...TreeFami		TF316102

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013151, Immunoglobulin
IPR002165, Plexin_repeat
IPR016201, PSI
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR027231, Semaphorin
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11036, PTHR11036, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00047, ig, 1 hit
PF01437, PSI, 1 hit
PF01403, Sema, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00423, PSI, 1 hit
SM00630, Sema, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101912, SSF101912, 1 hit
SSF48726, SSF48726, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS51004, SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92854-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRMCTPIRGL LMALAVMFGT AMAFAPIPRI TWEHREVHLV QFHEPDIYNY 
        60         70         80         90        100
SALLLSEDKD TLYIGAREAV FAVNALNISE KQHEVYWKVS EDKKAKCAEK 
       110        120        130        140        150
GKSKQTECLN YIRVLQPLSA TSLYVCGTNA FQPACDHLNL TSFKFLGKNE 
       160        170        180        190        200
DGKGRCPFDP AHSYTSVMVD GELYSGTSYN FLGSEPIISR NSSHSPLRTE 
       210        220        230        240        250
YAIPWLNEPS FVFADVIRKS PDSPDGEDDR VYFFFTEVSV EYEFVFRVLI 
       260        270        280        290        300
PRIARVCKGD QGGLRTLQKK WTSFLKARLI CSRPDSGLVF NVLRDVFVLR 
       310        320        330        340        350
SPGLKVPVFY ALFTPQLNNV GLSAVCAYNL STAEEVFSHG KYMQSTTVEQ 
       360        370        380        390        400
SHTKWVRYNG PVPKPRPGAC IDSEARAANY TSSLNLPDKT LQFVKDHPLM 
       410        420        430        440        450
DDSVTPIDNR PRLIKKDVNY TQIVVDRTQA LDGTVYDVMF VSTDRGALHK 
       460        470        480        490        500
AISLEHAVHI IEETQLFQDF EPVQTLLLSS KKGNRFVYAG SNSGVVQAPL 
       510        520        530        540        550
AFCGKHGTCE DCVLARDPYC AWSPPTATCV ALHQTESPSR GLIQEMSGDA 
       560        570        580        590        600
SVCPDKSKGS YRQHFFKHGG TAELKCSQKS NLARVFWKFQ NGVLKAESPK 
       610        620        630        640        650
YGLMGRKNLL IFNLSEGDSG VYQCLSEERV KNKTVFQVVA KHVLEVKVVP 
       660        670        680        690        700
KPVVAPTLSV VQTEGSRIAT KVLVASTQGS SPPTPAVQAT SSGAITLPPK 
       710        720        730        740        750
PAPTGTSCEP KIVINTVPQL HSEKTMYLKS SDNRLLMSLF LFFFVLFLCL 
       760        770        780        790        800
FFYNCYKGYL PRQCLKFRSA LLIGKKKPKS DFCDREQSLK ETLVEPGSFS 
       810        820        830        840        850
QQNGEHPKPA LDTGYETEQD TITSKVPTDR EDSQRIDDLS ARDKPFDVKC 
       860 
ELKFADSDAD GD
Length:862
Mass (Da):96,150
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B18EFEA98789371
GO
Isoform 2 (identifier: Q92854-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     555-738: DKSKGSYRQH...KSSDNRLLMS → ASSPKPLPPP...AWESCSKDTL
     739-862: Missing.

Show »
Length:738
Mass (Da):82,164
Checksum:i93ED5D62D6A17ED1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JFP1C9JFP1_HUMAN
Semaphorin-4D
SEMA4D
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYS7C9JYS7_HUMAN
Semaphorin-4D
SEMA4D
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFD9E9PFD9_HUMAN
Semaphorin-4D
SEMA4D
548Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H044F5H044_HUMAN
Semaphorin-4D
SEMA4D
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JD54C9JD54_HUMAN
Semaphorin-4D
SEMA4D
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG45A0A0C4DG45_HUMAN
Semaphorin-4D
SEMA4D
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI37516 differs from that shown. Cloning artifact.Curated
The sequence AAI37519 differs from that shown. Cloning artifact.Curated
The sequence BAC04938 differs from that shown. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti592G → D in AAH54500 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03029372A → T. Corresponds to variant dbSNP:rs13284404Ensembl.1
Natural variantiVAR_057175327A → T. Corresponds to variant dbSNP:rs11526468Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039483555 – 738DKSKG…RLLMS → ASSPKPLPPPGSSSLSCLGH VGDRRLSSPWTPWPASGAGP DSSSRVSLLPPFLSDQAQHV HALGNFYLFCQATGPADIRF VWEKNGRALETCVPVQTHAL PDGRAHALSWLQDAIRESAE YRCSVLSSAGNKTSKVQVAV MRPEVTHQERWTRELSAWRA VAGEHDRMMQSWRKAWESCS KDTL in isoform 2. CuratedAdd BLAST184
Alternative sequenceiVSP_039484739 – 862Missing in isoform 2. CuratedAdd BLAST124

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U60800 mRNA Translation: AAC50810.1
AL590233 Genomic DNA No translation available.
AL929575 Genomic DNA No translation available.
BC054500 mRNA Translation: AAH54500.1
BC137515 mRNA Translation: AAI37516.1 Sequence problems.
BC137518 mRNA Translation: AAI37519.1 Sequence problems.
AK097056 mRNA Translation: BAC04938.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47991.1 [Q92854-2]
CCDS6685.1 [Q92854-1]

NCBI Reference Sequences

More...RefSeqi		NP_001135759.1, NM_001142287.1 [Q92854-2]
NP_006369.3, NM_006378.3 [Q92854-1]
XP_005251711.1, XM_005251654.3
XP_011516425.1, XM_011518123.2 [Q92854-1]
XP_011516426.1, XM_011518124.2 [Q92854-1]
XP_011516427.1, XM_011518125.1 [Q92854-1]
XP_011516429.1, XM_011518127.2 [Q92854-1]
XP_011516430.1, XM_011518128.2 [Q92854-1]
XP_011516431.1, XM_011518129.1 [Q92854-1]
XP_011516432.1, XM_011518130.2 [Q92854-1]
XP_011516433.1, XM_011518131.2 [Q92854-1]
XP_011516435.1, XM_011518133.2 [Q92854-1]
XP_011516436.1, XM_011518134.2 [Q92854-1]
XP_016869682.1, XM_017014193.1 [Q92854-1]
XP_016869683.1, XM_017014194.1 [Q92854-1]
XP_016869684.1, XM_017014195.1 [Q92854-1]
XP_016869685.1, XM_017014196.1
XP_016869686.1, XM_017014197.1
XP_016869687.1, XM_017014198.1 [Q92854-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339861; ENSP00000344923; ENSG00000187764 [Q92854-2]
ENST00000356444; ENSP00000348822; ENSG00000187764
ENST00000420987; ENSP00000391733; ENSG00000187764 [Q92854-2]
ENST00000422704; ENSP00000388768; ENSG00000187764
ENST00000438547; ENSP00000405102; ENSG00000187764
ENST00000450295; ENSP00000416523; ENSG00000187764
ENST00000455551; ENSP00000411981; ENSG00000187764 [Q92854-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10507

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10507

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000422704.7; ENSP00000388768.2; NM_001371194.2; NP_001358123.1

UCSC genome browser

More...UCSCi		uc004aqo.2, human [Q92854-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60800 mRNA Translation: AAC50810.1
AL590233 Genomic DNA No translation available.
AL929575 Genomic DNA No translation available.
BC054500 mRNA Translation: AAH54500.1
BC137515 mRNA Translation: AAI37516.1 Sequence problems.
BC137518 mRNA Translation: AAI37519.1 Sequence problems.
AK097056 mRNA Translation: BAC04938.1 Sequence problems.
CCDSiCCDS47991.1 [Q92854-2]
CCDS6685.1 [Q92854-1]
RefSeqiNP_001135759.1, NM_001142287.1 [Q92854-2]
NP_006369.3, NM_006378.3 [Q92854-1]
XP_005251711.1, XM_005251654.3
XP_011516425.1, XM_011518123.2 [Q92854-1]
XP_011516426.1, XM_011518124.2 [Q92854-1]
XP_011516427.1, XM_011518125.1 [Q92854-1]
XP_011516429.1, XM_011518127.2 [Q92854-1]
XP_011516430.1, XM_011518128.2 [Q92854-1]
XP_011516431.1, XM_011518129.1 [Q92854-1]
XP_011516432.1, XM_011518130.2 [Q92854-1]
XP_011516433.1, XM_011518131.2 [Q92854-1]
XP_011516435.1, XM_011518133.2 [Q92854-1]
XP_011516436.1, XM_011518134.2 [Q92854-1]
XP_016869682.1, XM_017014193.1 [Q92854-1]
XP_016869683.1, XM_017014194.1 [Q92854-1]
XP_016869684.1, XM_017014195.1 [Q92854-1]
XP_016869685.1, XM_017014196.1
XP_016869686.1, XM_017014197.1
XP_016869687.1, XM_017014198.1 [Q92854-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OLZX-ray2.00A/B22-677[»]
3OL2X-ray2.99A22-677[»]
SMRiQ92854
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115766, 28 interactors
CORUMiQ92854
DIPiDIP-59221N
IntActiQ92854, 10 interactors
MINTiQ92854
STRINGi9606.ENSP00000416523

Chemistry databases

ChEMBLiCHEMBL4630887
GuidetoPHARMACOLOGYi2883

PTM databases

GlyConnecti1734, 13 N-Linked glycans (4 sites)
GlyGeniQ92854, 12 sites, 13 N-linked glycans (4 sites), 1 O-linked glycan (2 sites)
iPTMnetiQ92854
PhosphoSitePlusiQ92854
SwissPalmiQ92854

Genetic variation databases

BioMutaiSEMA4D
DMDMi8134701

Proteomic databases

EPDiQ92854
jPOSTiQ92854
MassIVEiQ92854
MaxQBiQ92854
PaxDbiQ92854
PeptideAtlasiQ92854
PRIDEiQ92854
ProteomicsDBi75549 [Q92854-1]
75550 [Q92854-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q92854, 20 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3064, 935 antibodies from 39 providers

The DNASU plasmid repository

More...DNASUi		10507

Genome annotation databases

EnsembliENST00000339861; ENSP00000344923; ENSG00000187764 [Q92854-2]
ENST00000356444; ENSP00000348822; ENSG00000187764
ENST00000420987; ENSP00000391733; ENSG00000187764 [Q92854-2]
ENST00000422704; ENSP00000388768; ENSG00000187764
ENST00000438547; ENSP00000405102; ENSG00000187764
ENST00000450295; ENSP00000416523; ENSG00000187764
ENST00000455551; ENSP00000411981; ENSG00000187764 [Q92854-2]
GeneIDi10507
KEGGihsa:10507
MANE-SelectiENST00000422704.7; ENSP00000388768.2; NM_001371194.2; NP_001358123.1
UCSCiuc004aqo.2, human [Q92854-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10507
DisGeNETi10507

GeneCards: human genes, protein and diseases

More...GeneCardsi		SEMA4D
HGNCiHGNC:10732, SEMA4D
HPAiENSG00000187764, Tissue enhanced (brain)
MIMi601866, gene
neXtProtiNX_Q92854
OpenTargetsiENSG00000187764
Orphaneti171, Primary sclerosing cholangitis
PharmGKBiPA35654
VEuPathDBiHostDB:ENSG00000187764

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3611, Eukaryota
GeneTreeiENSGT00940000159594
HOGENOMiCLU_009051_4_0_1
InParanoidiQ92854
OMAiFRQHFFK
OrthoDBi64683at2759
PhylomeDBiQ92854
TreeFamiTF316102

Enzyme and pathway databases

PathwayCommonsiQ92854
ReactomeiR-HSA-416550, Sema4D mediated inhibition of cell attachment and migration
R-HSA-416572, Sema4D induced cell migration and growth-cone collapse
R-HSA-416700, Other semaphorin interactions
SignaLinkiQ92854
SIGNORiQ92854

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10507, 5 hits in 1038 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SEMA4D, human
EvolutionaryTraceiQ92854

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SEMA4D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10507
PharosiQ92854, Tbio

Protein Ontology

More...PROi		PR:Q92854
RNActiQ92854, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000187764, Expressed in C1 segment of cervical spinal cord and 224 other tissues
ExpressionAtlasiQ92854, baseline and differential
GenevisibleiQ92854, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013151, Immunoglobulin
IPR002165, Plexin_repeat
IPR016201, PSI
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR027231, Semaphorin
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036, PTHR11036, 1 hit
PfamiView protein in Pfam
PF00047, ig, 1 hit
PF01437, PSI, 1 hit
PF01403, Sema, 1 hit
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00423, PSI, 1 hit
SM00630, Sema, 1 hit
SUPFAMiSSF101912, SSF101912, 1 hit
SSF48726, SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS51004, SEMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEM4D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92854
Secondary accession number(s): B2RPM6, Q7Z5S4, Q8N8B0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: February 23, 2022
This is version 213 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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