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Protein

Semaphorin-4D

Gene

SEMA4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.4 Publications

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • identical protein binding Source: IntAct
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: UniProtKB
  • signaling receptor activity Source: HGNC
  • signaling receptor binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-416550 Sema4D mediated inhibition of cell attachment and migration
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-416700 Other semaphorin interactions
SIGNORiQ92854

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4D
Alternative name(s):
A8
BB18
GR3
CD_antigen: CD100
Gene namesi
Name:SEMA4D
Synonyms:C9orf164, CD100, SEMAJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000187764.11
HGNCiHGNC:10732 SEMA4D
MIMi601866 gene
neXtProtiNX_Q92854

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 734ExtracellularSequence analysisAdd BLAST713
Transmembranei735 – 755HelicalSequence analysisAdd BLAST21
Topological domaini756 – 862CytoplasmicSequence analysisAdd BLAST107

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi100 – 101KG → DT: Abolishes PLXNB1 binding. 1 Publication2
Mutagenesisi181 – 182FL → ER: Abolishes PLXNB1 binding. 1 Publication2
Mutagenesisi244F → N: Abolishes homodimerization, abolishes collapse of growth cones and reduces PLXNB1 binding; when associated with S-246. 1 Publication1
Mutagenesisi246F → S: Abolishes homodimerization, abolishes collapse of growth cones and reduces PLXNB1 binding; when associated with N-244. 1 Publication1
Mutagenesisi395K → E: Strongly reduces PLXNB1 binding. 1 Publication1

Organism-specific databases

DisGeNETi10507
OpenTargetsiENSG00000187764
PharmGKBiPA35654

Chemistry databases

GuidetoPHARMACOLOGYi2883

Polymorphism and mutation databases

BioMutaiSEMA4D
DMDMi8134701

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003232722 – 862Semaphorin-4DAdd BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi77N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi97 ↔ 108
Disulfide bondi126 ↔ 135
Glycosylationi139N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi191N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi257 ↔ 370
Disulfide bondi281 ↔ 326
Glycosylationi329N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi379N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi419N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi503 ↔ 520
Disulfide bondi509 ↔ 553
Disulfide bondi512 ↔ 529
Disulfide bondi576 ↔ 624
Glycosylationi613N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi632N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei833PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ92854
MaxQBiQ92854
PaxDbiQ92854
PeptideAtlasiQ92854
PRIDEiQ92854
ProteomicsDBi75549
75550 [Q92854-2]

PTM databases

GlyConnecti1734
iPTMnetiQ92854
PhosphoSitePlusiQ92854
SwissPalmiQ92854

Expressioni

Tissue specificityi

Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.1 Publication

Gene expression databases

BgeeiENSG00000187764 Expressed in 211 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_SEMA4D
ExpressionAtlasiQ92854 baseline and differential
GenevisibleiQ92854 HS

Organism-specific databases

HPAiHPA015662
HPA023277

Interactioni

Subunit structurei

Homodimer. Interacts with PLXNB2 (By similarity). Binds PLXNB1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PLXNB1O43157-13EBI-15880903,EBI-15880891

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115766, 13 interactors
CORUMiQ92854
DIPiDIP-59221N
IntActiQ92854, 4 interactors
MINTiQ92854
STRINGi9606.ENSP00000348822

Structurei

Secondary structure

1862
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92854
SMRiQ92854
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92854

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 500SemaPROSITE-ProRule annotationAdd BLAST479
Domaini502 – 551PSIAdd BLAST50
Domaini554 – 636Ig-like C2-typeAdd BLAST83

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000111669
HOVERGENiHBG061627
InParanoidiQ92854
KOiK06521
OMAiFRQHFFK
OrthoDBiEOG091G01W0
PhylomeDBiQ92854
TreeFamiTF316102

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92854-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRMCTPIRGL LMALAVMFGT AMAFAPIPRI TWEHREVHLV QFHEPDIYNY
60 70 80 90 100
SALLLSEDKD TLYIGAREAV FAVNALNISE KQHEVYWKVS EDKKAKCAEK
110 120 130 140 150
GKSKQTECLN YIRVLQPLSA TSLYVCGTNA FQPACDHLNL TSFKFLGKNE
160 170 180 190 200
DGKGRCPFDP AHSYTSVMVD GELYSGTSYN FLGSEPIISR NSSHSPLRTE
210 220 230 240 250
YAIPWLNEPS FVFADVIRKS PDSPDGEDDR VYFFFTEVSV EYEFVFRVLI
260 270 280 290 300
PRIARVCKGD QGGLRTLQKK WTSFLKARLI CSRPDSGLVF NVLRDVFVLR
310 320 330 340 350
SPGLKVPVFY ALFTPQLNNV GLSAVCAYNL STAEEVFSHG KYMQSTTVEQ
360 370 380 390 400
SHTKWVRYNG PVPKPRPGAC IDSEARAANY TSSLNLPDKT LQFVKDHPLM
410 420 430 440 450
DDSVTPIDNR PRLIKKDVNY TQIVVDRTQA LDGTVYDVMF VSTDRGALHK
460 470 480 490 500
AISLEHAVHI IEETQLFQDF EPVQTLLLSS KKGNRFVYAG SNSGVVQAPL
510 520 530 540 550
AFCGKHGTCE DCVLARDPYC AWSPPTATCV ALHQTESPSR GLIQEMSGDA
560 570 580 590 600
SVCPDKSKGS YRQHFFKHGG TAELKCSQKS NLARVFWKFQ NGVLKAESPK
610 620 630 640 650
YGLMGRKNLL IFNLSEGDSG VYQCLSEERV KNKTVFQVVA KHVLEVKVVP
660 670 680 690 700
KPVVAPTLSV VQTEGSRIAT KVLVASTQGS SPPTPAVQAT SSGAITLPPK
710 720 730 740 750
PAPTGTSCEP KIVINTVPQL HSEKTMYLKS SDNRLLMSLF LFFFVLFLCL
760 770 780 790 800
FFYNCYKGYL PRQCLKFRSA LLIGKKKPKS DFCDREQSLK ETLVEPGSFS
810 820 830 840 850
QQNGEHPKPA LDTGYETEQD TITSKVPTDR EDSQRIDDLS ARDKPFDVKC
860
ELKFADSDAD GD
Length:862
Mass (Da):96,150
Last modified:February 1, 1997 - v1
Checksum:i7B18EFEA98789371
GO
Isoform 2 (identifier: Q92854-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     555-738: DKSKGSYRQH...KSSDNRLLMS → ASSPKPLPPP...AWESCSKDTL
     739-862: Missing.

Show »
Length:738
Mass (Da):82,164
Checksum:i93ED5D62D6A17ED1
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFD9E9PFD9_HUMAN
Semaphorin-4D
SEMA4D
548Annotation score:
C9JFP1C9JFP1_HUMAN
Semaphorin-4D
SEMA4D
146Annotation score:
C9JYS7C9JYS7_HUMAN
Semaphorin-4D
SEMA4D
75Annotation score:
F5H044F5H044_HUMAN
Semaphorin-4D
SEMA4D
66Annotation score:
C9JD54C9JD54_HUMAN
Semaphorin-4D
SEMA4D
59Annotation score:
A0A0C4DG45A0A0C4DG45_HUMAN
Semaphorin-4D
SEMA4D
123Annotation score:

Sequence cautioni

The sequence AAI37516 differs from that shown. Cloning artifact.Curated
The sequence AAI37519 differs from that shown. Cloning artifact.Curated
The sequence BAC04938 differs from that shown. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti592G → D in AAH54500 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03029372A → T. Corresponds to variant dbSNP:rs13284404Ensembl.1
Natural variantiVAR_057175327A → T. Corresponds to variant dbSNP:rs11526468Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039483555 – 738DKSKG…RLLMS → ASSPKPLPPPGSSSLSCLGH VGDRRLSSPWTPWPASGAGP DSSSRVSLLPPFLSDQAQHV HALGNFYLFCQATGPADIRF VWEKNGRALETCVPVQTHAL PDGRAHALSWLQDAIRESAE YRCSVLSSAGNKTSKVQVAV MRPEVTHQERWTRELSAWRA VAGEHDRMMQSWRKAWESCS KDTL in isoform 2. CuratedAdd BLAST184
Alternative sequenceiVSP_039484739 – 862Missing in isoform 2. CuratedAdd BLAST124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60800 mRNA Translation: AAC50810.1
AL590233 Genomic DNA No translation available.
AL929575 Genomic DNA No translation available.
BC054500 mRNA Translation: AAH54500.1
BC137515 mRNA Translation: AAI37516.1 Sequence problems.
BC137518 mRNA Translation: AAI37519.1 Sequence problems.
AK097056 mRNA Translation: BAC04938.1 Sequence problems.
CCDSiCCDS47991.1 [Q92854-2]
CCDS6685.1 [Q92854-1]
RefSeqiNP_001135759.1, NM_001142287.1 [Q92854-2]
NP_006369.3, NM_006378.3 [Q92854-1]
XP_005251711.1, XM_005251654.3 [Q92854-1]
XP_011516425.1, XM_011518123.2 [Q92854-1]
XP_011516426.1, XM_011518124.2 [Q92854-1]
XP_011516427.1, XM_011518125.1 [Q92854-1]
XP_011516429.1, XM_011518127.2 [Q92854-1]
XP_011516430.1, XM_011518128.2 [Q92854-1]
XP_011516431.1, XM_011518129.1 [Q92854-1]
XP_011516432.1, XM_011518130.2 [Q92854-1]
XP_011516433.1, XM_011518131.2 [Q92854-1]
XP_011516435.1, XM_011518133.2 [Q92854-1]
XP_011516436.1, XM_011518134.2 [Q92854-1]
XP_016869682.1, XM_017014193.1 [Q92854-1]
XP_016869683.1, XM_017014194.1 [Q92854-1]
XP_016869684.1, XM_017014195.1 [Q92854-1]
XP_016869685.1, XM_017014196.1 [Q92854-1]
XP_016869686.1, XM_017014197.1 [Q92854-1]
XP_016869687.1, XM_017014198.1 [Q92854-1]
UniGeneiHs.494406

Genome annotation databases

EnsembliENST00000339861; ENSP00000344923; ENSG00000187764 [Q92854-2]
ENST00000356444; ENSP00000348822; ENSG00000187764 [Q92854-1]
ENST00000420987; ENSP00000391733; ENSG00000187764 [Q92854-2]
ENST00000422704; ENSP00000388768; ENSG00000187764 [Q92854-1]
ENST00000438547; ENSP00000405102; ENSG00000187764 [Q92854-1]
ENST00000450295; ENSP00000416523; ENSG00000187764 [Q92854-1]
ENST00000455551; ENSP00000411981; ENSG00000187764 [Q92854-2]
GeneIDi10507
KEGGihsa:10507
UCSCiuc004aqo.2 human [Q92854-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60800 mRNA Translation: AAC50810.1
AL590233 Genomic DNA No translation available.
AL929575 Genomic DNA No translation available.
BC054500 mRNA Translation: AAH54500.1
BC137515 mRNA Translation: AAI37516.1 Sequence problems.
BC137518 mRNA Translation: AAI37519.1 Sequence problems.
AK097056 mRNA Translation: BAC04938.1 Sequence problems.
CCDSiCCDS47991.1 [Q92854-2]
CCDS6685.1 [Q92854-1]
RefSeqiNP_001135759.1, NM_001142287.1 [Q92854-2]
NP_006369.3, NM_006378.3 [Q92854-1]
XP_005251711.1, XM_005251654.3 [Q92854-1]
XP_011516425.1, XM_011518123.2 [Q92854-1]
XP_011516426.1, XM_011518124.2 [Q92854-1]
XP_011516427.1, XM_011518125.1 [Q92854-1]
XP_011516429.1, XM_011518127.2 [Q92854-1]
XP_011516430.1, XM_011518128.2 [Q92854-1]
XP_011516431.1, XM_011518129.1 [Q92854-1]
XP_011516432.1, XM_011518130.2 [Q92854-1]
XP_011516433.1, XM_011518131.2 [Q92854-1]
XP_011516435.1, XM_011518133.2 [Q92854-1]
XP_011516436.1, XM_011518134.2 [Q92854-1]
XP_016869682.1, XM_017014193.1 [Q92854-1]
XP_016869683.1, XM_017014194.1 [Q92854-1]
XP_016869684.1, XM_017014195.1 [Q92854-1]
XP_016869685.1, XM_017014196.1 [Q92854-1]
XP_016869686.1, XM_017014197.1 [Q92854-1]
XP_016869687.1, XM_017014198.1 [Q92854-1]
UniGeneiHs.494406

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OLZX-ray2.00A/B22-677[»]
3OL2X-ray2.99A22-677[»]
ProteinModelPortaliQ92854
SMRiQ92854
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115766, 13 interactors
CORUMiQ92854
DIPiDIP-59221N
IntActiQ92854, 4 interactors
MINTiQ92854
STRINGi9606.ENSP00000348822

Chemistry databases

GuidetoPHARMACOLOGYi2883

PTM databases

GlyConnecti1734
iPTMnetiQ92854
PhosphoSitePlusiQ92854
SwissPalmiQ92854

Polymorphism and mutation databases

BioMutaiSEMA4D
DMDMi8134701

Proteomic databases

EPDiQ92854
MaxQBiQ92854
PaxDbiQ92854
PeptideAtlasiQ92854
PRIDEiQ92854
ProteomicsDBi75549
75550 [Q92854-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339861; ENSP00000344923; ENSG00000187764 [Q92854-2]
ENST00000356444; ENSP00000348822; ENSG00000187764 [Q92854-1]
ENST00000420987; ENSP00000391733; ENSG00000187764 [Q92854-2]
ENST00000422704; ENSP00000388768; ENSG00000187764 [Q92854-1]
ENST00000438547; ENSP00000405102; ENSG00000187764 [Q92854-1]
ENST00000450295; ENSP00000416523; ENSG00000187764 [Q92854-1]
ENST00000455551; ENSP00000411981; ENSG00000187764 [Q92854-2]
GeneIDi10507
KEGGihsa:10507
UCSCiuc004aqo.2 human [Q92854-1]

Organism-specific databases

CTDi10507
DisGeNETi10507
EuPathDBiHostDB:ENSG00000187764.11
GeneCardsiSEMA4D
HGNCiHGNC:10732 SEMA4D
HPAiHPA015662
HPA023277
MIMi601866 gene
neXtProtiNX_Q92854
OpenTargetsiENSG00000187764
PharmGKBiPA35654
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000111669
HOVERGENiHBG061627
InParanoidiQ92854
KOiK06521
OMAiFRQHFFK
OrthoDBiEOG091G01W0
PhylomeDBiQ92854
TreeFamiTF316102

Enzyme and pathway databases

ReactomeiR-HSA-416550 Sema4D mediated inhibition of cell attachment and migration
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-416700 Other semaphorin interactions
SIGNORiQ92854

Miscellaneous databases

ChiTaRSiSEMA4D human
EvolutionaryTraceiQ92854
GeneWikiiSEMA4D
GenomeRNAii10507
PROiPR:Q92854
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187764 Expressed in 211 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_SEMA4D
ExpressionAtlasiQ92854 baseline and differential
GenevisibleiQ92854 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEM4D_HUMAN
AccessioniPrimary (citable) accession number: Q92854
Secondary accession number(s): B2RPM6, Q7Z5S4, Q8N8B0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 193 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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