Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q92844 (TANK_HUMAN)

Entry version 204 (25 May 2022)
Sequence version 2 (03 Apr 2007)
Previous versions | rss
Add a publicationFeedback
Protein

TRAF family member-associated NF-kappa-B activator

Gene

TANK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989).

Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).

Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989).

May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei272 – 273(Microbial infection) Cleavage; by viral Seneca Valley virus protease 3C1 Publication2
Sitei291 – 292(Microbial infection) Cleavage; by viral Seneca Valley virus protease 3C1 Publication2
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi396ZincPROSITE-ProRule annotation1
Metal bindingi399ZincPROSITE-ProRule annotation1
Metal bindingi416ZincPROSITE-ProRule annotation1
Metal bindingi420ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri393 – 420UBZ1-typePROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • deubiquitinase activator activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase binding Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, Host-virus interaction
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92844

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9013973, TICAM1-dependent activation of IRF3/IRF7
R-HSA-933541, TRAF6 mediated IRF7 activation
R-HSA-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q92844

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92844

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TRAF family member-associated NF-kappa-B activator
Alternative name(s):
TRAF-interacting protein
Short name:
I-TRAF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TANK
Synonyms:ITRAF, TRAF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11562, TANK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603893, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92844

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000136560

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi182Q → A: Abolishes interaction with TRAF2 and TRAF3. 1 Publication1
Mutagenesisi184T → A: Abolishes interaction with TRAF2 and TRAF3. 1 Publication1
Mutagenesisi185D → A: Abolishes interaction with TRAF2; greatly diminishes interaction with TRAF3. 1 Publication1
Mutagenesisi188D → A: Diminishes interaction with TRAF2 and TRAF3. 1 Publication1
Mutagenesisi194F → A: Diminishes interaction with TRAF2 and TRAF3. 1 Publication1
Mutagenesisi197Q → A: No effect on cleavage by Seneca Valley virus protease 3C. 1 Publication1
Mutagenesisi247H → A: No effect on cleavage by Seneca Valley virus protease 3C. 1 Publication1
Mutagenesisi251E → A: No effect on cleavage by Seneca Valley virus protease 3C. 1 Publication1
Mutagenesisi262E → A: No effect on cleavage by Seneca Valley virus protease 3C. 1 Publication1
Mutagenesisi266Q → A: No effect on cleavage by Seneca Valley virus protease 3C. 1 Publication1
Mutagenesisi267E → A: No effect on cleavage by Seneca Valley virus protease 3C. 1 Publication1
Mutagenesisi272E → A: Complete loss of cleavage by Seneca Valley virus protease 3C. 1 Publication1
Mutagenesisi291Q → A: Complete loss of cleavage by Seneca Valley virus protease 3C. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10010

Open Targets

More...OpenTargetsi		ENSG00000136560

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36330

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92844, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523420

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TANK

Domain mapping of disease mutations (DMDM)

More...DMDMi		143811466

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724271 – 425TRAF family member-associated NF-kappa-B activatorAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei213PhosphothreonineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by IKBKE.1 Publication
(Microbial infection) Cleaved by encephalomyocarditis virus (EMCV) protease 3C (PubMed:26363073). This cleavage allows the virus to disrupt the TANK-TBK1-IKKepsilon-IRF3 complex, thereby inhibiting the induction of the IFN-beta signal pathway (PubMed:28487378).2 Publications
(Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I through both RIG-I and Toll-like receptor-dependent pathways.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei197Cleavage by EMCV protease 3C1 Publication1
Sitei291Cleavage by EMCV protease 3C1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92844

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92844

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92844

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92844

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92844

PeptideAtlas

More...PeptideAtlasi		Q92844

PRoteomics IDEntifications database

More...PRIDEi		Q92844

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75537 [Q92844-1]
75538 [Q92844-2]
75539 [Q92844-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q92844, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92844

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92844

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136560, Expressed in calcaneal tendon and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92844, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92844, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136560, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta-mediated NF-kappaB activation by promoting IKBKG or TRAF6 deubiquitination (PubMed:25861989).

Interacts with IKBKG; this interaction increases in response to DNA damage (PubMed:25861989).

Interacts with TRAF6; this interaction increases in response to DNA damage and recruits USP10 to the ubiquitinated TRAF6 (PubMed:25861989).

Interacts with USP10; this interaction increases in response to DNA damage (PubMed:25861989).

Interacts with ZC3H12A; this interaction increases in response to DNA damage (PubMed:25861989).

Interacts with TBK1 (PubMed:10581243, PubMed:21931631, PubMed:29251827).

Interacts with IKBKE (PubMed:17568778).

Interacts also with TRAF1, TRAF2, and TRAF3 by binding to their TRAF-C domains; the interaction with TRAF2 is disrupted by the phosphorylation of TANK by IKBKE (PubMed:10759890, PubMed:12005438).

Interacts more strongly with TRAF1 and TRAF2 than TRAF3 (PubMed:10759890, PubMed:12005438).

Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1 (PubMed:12133833).

Part of a ternary complex consisting of TANK, IKBKB and IKBKG (PubMed:12133833).

8 Publications

(Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555).

1 Publication

(Microbial infection) Interacts with Seneca Valley virus protease 3C; this interaction allows the cleavage of TANK and subsequent suppression of host innate immunity.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115328, 211 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6089, TBK1-IKKepsilon-TANK complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q92844

Database of interacting proteins

More...DIPi		DIP-27516N

Protein interaction database and analysis system

More...IntActi		Q92844, 191 interactors

Molecular INTeraction database

More...MINTi		Q92844

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000376505

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92844, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q92844

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92844

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q92844

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31Necessary for interaction with ZC3H12A1 PublicationAdd BLAST31
Regioni70 – 191Necessary for interaction with TRAF61 PublicationAdd BLAST122
Regioni133 – 172Interaction with TBK1 and IKBKEBy similarityAdd BLAST40
Regioni172 – 191TRAF family member interactionAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili22 – 62Sequence analysisAdd BLAST41

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri393 – 420UBZ1-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRM3, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008712

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_053153_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92844

Identification of Orthologs from Complete Genome Data

More...OMAi		EKPTVPC

Database of Orthologous Groups

More...OrthoDBi		1288111at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92844

TreeFam database of animal gene trees

More...TreeFami		TF336453

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041641, CALCOCO1/2_Zn_UBZ1
IPR039669, TANK
IPR024581, TBD

The PANTHER Classification System

More...PANTHERi		PTHR15249, PTHR15249, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12845, TBD, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51905, ZF_UBZ1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q92844-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL 
        60         70         80         90        100
QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS 
       110        120        130        140        150
GIAREKLPKV RRQEVSSPRK ETSARSLGSP LLHERGNIEK TFWDLKEEFH 
       160        170        180        190        200
KICMLAKAQK DHLSKLNIPD TATETQCSVP IQCTDKTDKQ EALFKPQAKD 
       210        220        230        240        250
DINRGAPSIT SVTPRGLCRD EEDTSFESLS KFNVKFPPMD NDSTFLHSTP 
       260        270        280        290        300
ERPGILSPAT SEAVCQEKFN MEFRDNPGNF VKTEETLFEI QGIDPIASAI 
       310        320        330        340        350
QNLKTTDKTK PSNLVNTCIR TTLDRAACLP PGDHNALYVN SFPLLDPSDA 
       360        370        380        390        400
PFPSLDSPGK AIRGPQQPIW KPFPNQDSDS VVLSGTDSEL HIPRVCEFCQ 
       410        420 
AVFPPSITSR GDFLRHLNSH FNGET
Length:425
Mass (Da):47,816
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i718D30CF03EB27FF
GO
Isoform Short (identifier: Q92844-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-117: RRQEVSS → DIASAES
     118-425: Missing.

Show »
Length:117
Mass (Da):13,426
Checksum:i22A8BEC63333011C
GO
Isoform 3 (identifier: Q92844-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-119: RRQEVSSPR → DIASAESSI
     120-425: Missing.

Show »
Length:119
Mass (Da):13,626
Checksum:i61E5B2A8BEC63333
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EV32E7EV32_HUMAN
TRAF family member-associated NF-ka...
TANK
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVA2E7EVA2_HUMAN
TRAF family member-associated NF-ka...
TANK
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EW82E7EW82_HUMAN
TRAF family member-associated NF-ka...
TANK
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMT6E7EMT6_HUMAN
TRAF family member-associated NF-ka...
TANK
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENY2E7ENY2_HUMAN
TRAF family member-associated NF-ka...
TANK
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQA9E7EQA9_HUMAN
TRAF family member-associated NF-ka...
TANK
408Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWR8E7EWR8_HUMAN
TRAF family member-associated NF-ka...
TANK
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EM55E7EM55_HUMAN
TRAF family member-associated NF-ka...
TANK
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERM9E7ERM9_HUMAN
TRAF family member-associated NF-ka...
TANK
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3L4H7C3L4_HUMAN
TRAF family member-associated NF-ka...
TANK
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83E → D in AAC50681 (PubMed:8710854).Curated1
Sequence conflicti88N → T in AAC50681 (PubMed:8710854).Curated1
Sequence conflicti92D → A in AAC50681 (PubMed:8710854).Curated1
Sequence conflicti142F → S in AAC50681 (PubMed:8710854).Curated1
Sequence conflicti195K → T in AAC50681 (PubMed:8710854).Curated1
Sequence conflicti226F → L in AAC50681 (PubMed:8710854).Curated1
Sequence conflicti303L → P in AAC50770 (PubMed:8855313).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051409292G → R. Corresponds to variant dbSNP:rs10183668Ensembl.1
Natural variantiVAR_051410358P → L. Corresponds to variant dbSNP:rs2229759EnsemblClinVar.1
Natural variantiVAR_051411394R → Q. Corresponds to variant dbSNP:rs3769969Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043702111 – 119RRQEVSSPR → DIASAESSI in isoform 3. 1 Publication9
Alternative sequenceiVSP_004442111 – 117RRQEVSS → DIASAES in isoform Short. 1 Publication7
Alternative sequenceiVSP_004443118 – 425Missing in isoform Short. 1 PublicationAdd BLAST308
Alternative sequenceiVSP_043703120 – 425Missing in isoform 3. 1 PublicationAdd BLAST306

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U59863 mRNA Translation: AAC50681.1
U63830 mRNA Translation: AAC50770.1
BT009855 mRNA Translation: AAP88857.1
AC009299 Genomic DNA No translation available.
AC009313 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11374.1
CH471058 Genomic DNA Translation: EAX11375.1
CH471058 Genomic DNA Translation: EAX11377.1
BC003388 mRNA Translation: AAH03388.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2215.1 [Q92844-1]
CCDS46436.1 [Q92844-3]

NCBI Reference Sequences

More...RefSeqi		NP_001186064.1, NM_001199135.1 [Q92844-1]
NP_004171.2, NM_004180.2 [Q92844-1]
NP_597841.1, NM_133484.1 [Q92844-3]
XP_016858585.1, XM_017003096.1 [Q92844-1]
XP_016858586.1, XM_017003097.1 [Q92844-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000259075.6; ENSP00000259075.2; ENSG00000136560.14
ENST00000392749.7; ENSP00000376505.2; ENSG00000136560.14
ENST00000403609.1; ENSP00000385983.1; ENSG00000136560.14 [Q92844-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10010

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10010

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000392749.7; ENSP00000376505.2; NM_001199135.3; NP_001186064.1

UCSC genome browser

More...UCSCi		uc002ubr.3, human [Q92844-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59863 mRNA Translation: AAC50681.1
U63830 mRNA Translation: AAC50770.1
BT009855 mRNA Translation: AAP88857.1
AC009299 Genomic DNA No translation available.
AC009313 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11374.1
CH471058 Genomic DNA Translation: EAX11375.1
CH471058 Genomic DNA Translation: EAX11377.1
BC003388 mRNA Translation: AAH03388.1
CCDSiCCDS2215.1 [Q92844-1]
CCDS46436.1 [Q92844-3]
RefSeqiNP_001186064.1, NM_001199135.1 [Q92844-1]
NP_004171.2, NM_004180.2 [Q92844-1]
NP_597841.1, NM_133484.1 [Q92844-3]
XP_016858585.1, XM_017003096.1 [Q92844-1]
XP_016858586.1, XM_017003097.1 [Q92844-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KZZX-ray3.50B177-187[»]
1L0AX-ray2.90B178-195[»]
5H10X-ray3.21D/E/F178-185[»]
AlphaFoldDBiQ92844
SMRiQ92844
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115328, 211 interactors
ComplexPortaliCPX-6089, TBK1-IKKepsilon-TANK complex
CORUMiQ92844
DIPiDIP-27516N
IntActiQ92844, 191 interactors
MINTiQ92844
STRINGi9606.ENSP00000376505

Chemistry databases

ChEMBLiCHEMBL4523420

PTM databases

GlyGeniQ92844, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ92844
PhosphoSitePlusiQ92844

Genetic variation databases

BioMutaiTANK
DMDMi143811466

Proteomic databases

EPDiQ92844
jPOSTiQ92844
MassIVEiQ92844
MaxQBiQ92844
PaxDbiQ92844
PeptideAtlasiQ92844
PRIDEiQ92844
ProteomicsDBi75537 [Q92844-1]
75538 [Q92844-2]
75539 [Q92844-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4155, 474 antibodies from 38 providers

The DNASU plasmid repository

More...DNASUi		10010

Genome annotation databases

EnsembliENST00000259075.6; ENSP00000259075.2; ENSG00000136560.14
ENST00000392749.7; ENSP00000376505.2; ENSG00000136560.14
ENST00000403609.1; ENSP00000385983.1; ENSG00000136560.14 [Q92844-3]
GeneIDi10010
KEGGihsa:10010
MANE-SelectiENST00000392749.7; ENSP00000376505.2; NM_001199135.3; NP_001186064.1
UCSCiuc002ubr.3, human [Q92844-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10010
DisGeNETi10010

GeneCards: human genes, protein and diseases

More...GeneCardsi		TANK
HGNCiHGNC:11562, TANK
HPAiENSG00000136560, Low tissue specificity
MIMi603893, gene
neXtProtiNX_Q92844
OpenTargetsiENSG00000136560
PharmGKBiPA36330
VEuPathDBiHostDB:ENSG00000136560

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRM3, Eukaryota
GeneTreeiENSGT00390000008712
HOGENOMiCLU_053153_0_0_1
InParanoidiQ92844
OMAiEKPTVPC
OrthoDBi1288111at2759
PhylomeDBiQ92844
TreeFamiTF336453

Enzyme and pathway databases

PathwayCommonsiQ92844
ReactomeiR-HSA-9013973, TICAM1-dependent activation of IRF3/IRF7
R-HSA-933541, TRAF6 mediated IRF7 activation
R-HSA-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
SignaLinkiQ92844
SIGNORiQ92844

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10010, 21 hits in 1080 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TANK, human
EvolutionaryTraceiQ92844

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TANK_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10010
PharosiQ92844, Tbio

Protein Ontology

More...PROi		PR:Q92844
RNActiQ92844, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136560, Expressed in calcaneal tendon and 244 other tissues
ExpressionAtlasiQ92844, baseline and differential
GenevisibleiQ92844, HS

Family and domain databases

InterProiView protein in InterPro
IPR041641, CALCOCO1/2_Zn_UBZ1
IPR039669, TANK
IPR024581, TBD
PANTHERiPTHR15249, PTHR15249, 1 hit
PfamiView protein in Pfam
PF12845, TBD, 1 hit
PROSITEiView protein in PROSITE
PS51905, ZF_UBZ1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTANK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92844
Secondary accession number(s): D3DPB5, Q7Z4J6, Q92885
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: April 3, 2007
Last modified: May 25, 2022
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again