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Protein

TRAF family member-associated NF-kappa-B activator

Gene

TANK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri394 – 420C2H2-typeAdd BLAST27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • deubiquitinase activator activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, Host-virus interaction
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q92844

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TRAF family member-associated NF-kappa-B activator
Alternative name(s):
TRAF-interacting protein
Short name:
I-TRAF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TANK
Synonyms:ITRAF, TRAF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000136560.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11562 TANK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603893 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92844

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi182Q → A: Abolishes interaction with TRAF2 and TRAF3. 1 Publication1
Mutagenesisi184T → A: Abolishes interaction with TRAF2 and TRAF3. 1 Publication1
Mutagenesisi185D → A: Abolishes interaction with TRAF2; greatly diminishes interaction with TRAF3. 1 Publication1
Mutagenesisi188D → A: Diminishes interaction with TRAF2 and TRAF3. 1 Publication1
Mutagenesisi194F → A: Diminishes interaction with TRAF2 and TRAF3. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10010

Open Targets

More...
OpenTargetsi
ENSG00000136560

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36330

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TANK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811466

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724271 – 425TRAF family member-associated NF-kappa-B activatorAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei213PhosphothreonineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by IKBKE.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92844

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92844

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92844

PeptideAtlas

More...
PeptideAtlasi
Q92844

PRoteomics IDEntifications database

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PRIDEi
Q92844

ProteomicsDB human proteome resource

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ProteomicsDBi
75537
75538 [Q92844-2]
75539 [Q92844-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92844

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92844

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136560 Expressed in 232 organ(s), highest expression level in bone marrow

CleanEx database of gene expression profiles

More...
CleanExi
HS_TANK
HS_TRAF2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q92844 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92844 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010345
HPA037675
HPA037676

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta-mediated NF-kappaB activation by promoting IKBKG or TRAF6 deubiquitination (PubMed:25861989). Interacts with IKBKG; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TRAF6; this interaction increases in response to DNA damage and recruits USP10 to the ubiquitinated TRAF6 (PubMed:25861989). Interacts with USP10; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with ZC3H12A; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TBK1 (PubMed:10581243, PubMed:21931631). Interacts with IKBKE (PubMed:17568778). Interacts also with TRAF1, TRAF2, and TRAF3 by binding to their TRAF-C domains; the interaction with TRAF2 is disrupted by the phosphorylation of TANK by IKBKE (PubMed:10759890, PubMed:12005438). Interacts more strongly with TRAF1 and TRAF2 than TRAF3 (PubMed:10759890, PubMed:12005438). Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1 (PubMed:12133833). Part of a ternary complex consisting of TANK, IKBKB and IKBKG (PubMed:12133833).7 Publications
(Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115328, 49 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q92844

Database of interacting proteins

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DIPi
DIP-27516N

Protein interaction database and analysis system

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IntActi
Q92844, 186 interactors

Molecular INTeraction database

More...
MINTi
Q92844

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259075

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q92844

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92844

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q92844

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31Necessary for interaction with ZC3H12A1 PublicationAdd BLAST31
Regioni70 – 191Necessary for interaction with TRAF61 PublicationAdd BLAST122
Regioni133 – 172Interaction with TBK1 and IKBKEBy similarityAdd BLAST40
Regioni172 – 191TRAF family member interactionAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili22 – 62Sequence analysisAdd BLAST41

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri394 – 420C2H2-typeAdd BLAST27

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGRF Eukaryota
ENOG410Y7D3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008712

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231816

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG019299

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92844

KEGG Orthology (KO)

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KOi
K12650

Identification of Orthologs from Complete Genome Data

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OMAi
NVKFPPT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0A8P

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92844

TreeFam database of animal gene trees

More...
TreeFami
TF336453

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039669 TANK
IPR024581 TBD

The PANTHER Classification System

More...
PANTHERi
PTHR15249 PTHR15249, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12845 TBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q92844-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL
60 70 80 90 100
QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS
110 120 130 140 150
GIAREKLPKV RRQEVSSPRK ETSARSLGSP LLHERGNIEK TFWDLKEEFH
160 170 180 190 200
KICMLAKAQK DHLSKLNIPD TATETQCSVP IQCTDKTDKQ EALFKPQAKD
210 220 230 240 250
DINRGAPSIT SVTPRGLCRD EEDTSFESLS KFNVKFPPMD NDSTFLHSTP
260 270 280 290 300
ERPGILSPAT SEAVCQEKFN MEFRDNPGNF VKTEETLFEI QGIDPIASAI
310 320 330 340 350
QNLKTTDKTK PSNLVNTCIR TTLDRAACLP PGDHNALYVN SFPLLDPSDA
360 370 380 390 400
PFPSLDSPGK AIRGPQQPIW KPFPNQDSDS VVLSGTDSEL HIPRVCEFCQ
410 420
AVFPPSITSR GDFLRHLNSH FNGET
Length:425
Mass (Da):47,816
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i718D30CF03EB27FF
GO
Isoform Short (identifier: Q92844-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-117: RRQEVSS → DIASAES
     118-425: Missing.

Note: No experimental confirmation available.
Show »
Length:117
Mass (Da):13,426
Checksum:i22A8BEC63333011C
GO
Isoform 3 (identifier: Q92844-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-119: RRQEVSSPR → DIASAESSI
     120-425: Missing.

Note: No experimental confirmation available.
Show »
Length:119
Mass (Da):13,626
Checksum:i61E5B2A8BEC63333
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVA2E7EVA2_HUMAN
TRAF family member-associated NF-ka...
TANK
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQA9E7EQA9_HUMAN
TRAF family member-associated NF-ka...
TANK
408Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EW82E7EW82_HUMAN
TRAF family member-associated NF-ka...
TANK
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENY2E7ENY2_HUMAN
TRAF family member-associated NF-ka...
TANK
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWR8E7EWR8_HUMAN
TRAF family member-associated NF-ka...
TANK
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EV32E7EV32_HUMAN
TRAF family member-associated NF-ka...
TANK
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMT6E7EMT6_HUMAN
TRAF family member-associated NF-ka...
TANK
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERM9E7ERM9_HUMAN
TRAF family member-associated NF-ka...
TANK
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EM55E7EM55_HUMAN
TRAF family member-associated NF-ka...
TANK
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3L4H7C3L4_HUMAN
TRAF family member-associated NF-ka...
TANK
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83E → D in AAC50681 (PubMed:8710854).Curated1
Sequence conflicti88N → T in AAC50681 (PubMed:8710854).Curated1
Sequence conflicti92D → A in AAC50681 (PubMed:8710854).Curated1
Sequence conflicti142F → S in AAC50681 (PubMed:8710854).Curated1
Sequence conflicti195K → T in AAC50681 (PubMed:8710854).Curated1
Sequence conflicti226F → L in AAC50681 (PubMed:8710854).Curated1
Sequence conflicti303L → P in AAC50770 (PubMed:8855313).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051409292G → R. Corresponds to variant dbSNP:rs10183668Ensembl.1
Natural variantiVAR_051410358P → L. Corresponds to variant dbSNP:rs2229759Ensembl.1
Natural variantiVAR_051411394R → Q. Corresponds to variant dbSNP:rs3769969Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043702111 – 119RRQEVSSPR → DIASAESSI in isoform 3. 1 Publication9
Alternative sequenceiVSP_004442111 – 117RRQEVSS → DIASAES in isoform Short. 1 Publication7
Alternative sequenceiVSP_004443118 – 425Missing in isoform Short. 1 PublicationAdd BLAST308
Alternative sequenceiVSP_043703120 – 425Missing in isoform 3. 1 PublicationAdd BLAST306

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U59863 mRNA Translation: AAC50681.1
U63830 mRNA Translation: AAC50770.1
BT009855 mRNA Translation: AAP88857.1
AC009299 Genomic DNA No translation available.
AC009313 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11374.1
CH471058 Genomic DNA Translation: EAX11375.1
CH471058 Genomic DNA Translation: EAX11377.1
BC003388 mRNA Translation: AAH03388.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2215.1 [Q92844-1]
CCDS46436.1 [Q92844-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001186064.1, NM_001199135.1 [Q92844-1]
NP_004171.2, NM_004180.2 [Q92844-1]
NP_597841.1, NM_133484.1 [Q92844-3]
XP_016858585.1, XM_017003096.1 [Q92844-1]
XP_016858586.1, XM_017003097.1 [Q92844-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.132257

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259075; ENSP00000259075; ENSG00000136560 [Q92844-1]
ENST00000392749; ENSP00000376505; ENSG00000136560 [Q92844-1]
ENST00000403609; ENSP00000385983; ENSG00000136560 [Q92844-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10010

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10010

UCSC genome browser

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UCSCi
uc002ubr.3 human [Q92844-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59863 mRNA Translation: AAC50681.1
U63830 mRNA Translation: AAC50770.1
BT009855 mRNA Translation: AAP88857.1
AC009299 Genomic DNA No translation available.
AC009313 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11374.1
CH471058 Genomic DNA Translation: EAX11375.1
CH471058 Genomic DNA Translation: EAX11377.1
BC003388 mRNA Translation: AAH03388.1
CCDSiCCDS2215.1 [Q92844-1]
CCDS46436.1 [Q92844-3]
RefSeqiNP_001186064.1, NM_001199135.1 [Q92844-1]
NP_004171.2, NM_004180.2 [Q92844-1]
NP_597841.1, NM_133484.1 [Q92844-3]
XP_016858585.1, XM_017003096.1 [Q92844-1]
XP_016858586.1, XM_017003097.1 [Q92844-1]
UniGeneiHs.132257

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KZZX-ray3.50B177-187[»]
1L0AX-ray2.90B178-195[»]
5H10X-ray3.21D/E/F178-185[»]
ProteinModelPortaliQ92844
SMRiQ92844
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115328, 49 interactors
CORUMiQ92844
DIPiDIP-27516N
IntActiQ92844, 186 interactors
MINTiQ92844
STRINGi9606.ENSP00000259075

PTM databases

iPTMnetiQ92844
PhosphoSitePlusiQ92844

Polymorphism and mutation databases

BioMutaiTANK
DMDMi143811466

Proteomic databases

EPDiQ92844
MaxQBiQ92844
PaxDbiQ92844
PeptideAtlasiQ92844
PRIDEiQ92844
ProteomicsDBi75537
75538 [Q92844-2]
75539 [Q92844-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10010
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259075; ENSP00000259075; ENSG00000136560 [Q92844-1]
ENST00000392749; ENSP00000376505; ENSG00000136560 [Q92844-1]
ENST00000403609; ENSP00000385983; ENSG00000136560 [Q92844-3]
GeneIDi10010
KEGGihsa:10010
UCSCiuc002ubr.3 human [Q92844-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10010
DisGeNETi10010
EuPathDBiHostDB:ENSG00000136560.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TANK
HGNCiHGNC:11562 TANK
HPAiCAB010345
HPA037675
HPA037676
MIMi603893 gene
neXtProtiNX_Q92844
OpenTargetsiENSG00000136560
PharmGKBiPA36330

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGRF Eukaryota
ENOG410Y7D3 LUCA
GeneTreeiENSGT00390000008712
HOGENOMiHOG000231816
HOVERGENiHBG019299
InParanoidiQ92844
KOiK12650
OMAiNVKFPPT
OrthoDBiEOG091G0A8P
PhylomeDBiQ92844
TreeFamiTF336453

Enzyme and pathway databases

ReactomeiR-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
SignaLinkiQ92844

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TANK human
EvolutionaryTraceiQ92844

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TANK_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10010

Protein Ontology

More...
PROi
PR:Q92844

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136560 Expressed in 232 organ(s), highest expression level in bone marrow
CleanExiHS_TANK
HS_TRAF2
ExpressionAtlasiQ92844 baseline and differential
GenevisibleiQ92844 HS

Family and domain databases

InterProiView protein in InterPro
IPR039669 TANK
IPR024581 TBD
PANTHERiPTHR15249 PTHR15249, 1 hit
PfamiView protein in Pfam
PF12845 TBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTANK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92844
Secondary accession number(s): D3DPB5, Q7Z4J6, Q92885
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: April 3, 2007
Last modified: December 5, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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