Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bcl-2-like protein 2

Gene

BCL2L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.1 Publication

GO - Molecular functioni

  • BH domain binding Source: Ensembl
  • disordered domain specific binding Source: CAFA
  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: CAFA
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

SIGNORiQ92843

Protein family/group databases

TCDBi1.A.21.1.5 the bcl-2 (bcl-2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 2
Short name:
Bcl2-L-2
Alternative name(s):
Apoptosis regulator Bcl-W
Gene namesi
Name:BCL2L2
Synonyms:BCLW, KIAA0271
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000129473.9
HostDB:ENSG00000258643.5
HGNCiHGNC:995 BCL2L2
HGNC:42959 BCL2L2-PABPN1
MIMi601931 gene
neXtProtiNX_Q92843

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi100529063
599
OpenTargetsiENSG00000129473
ENSG00000258643
PharmGKBiPA25307

Chemistry databases

ChEMBLiCHEMBL4677
DrugBankiDB05764 ABT-263
GuidetoPHARMACOLOGYi2846

Polymorphism and mutation databases

BioMutaiBCL2L2
DMDMi296434404

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001430662 – 193Bcl-2-like protein 2Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Isoform 3 (identifier: Q92843-2)
Modified residuei177PhosphoserineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei286Omega-N-methylarginineCombined sources1
Modified residuei290Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ92843
PaxDbiQ92843
PeptideAtlasiQ92843
PRIDEiQ92843
ProteomicsDBi75535
75536 [Q92843-2]

PTM databases

iPTMnetiQ92843
PhosphoSitePlusiQ92843

Expressioni

Tissue specificityi

Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.1 Publication

Gene expression databases

BgeeiENSG00000129473
CleanExiHS_BCL2L2
ExpressionAtlasiQ92843 baseline and differential
GenevisibleiQ92843 HS

Organism-specific databases

HPAiCAB040539
HPA000637

Interactioni

Subunit structurei

Interacts with HIF3A (via C-terminus domain). Interacts with BOP.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • BH domain binding Source: Ensembl
  • disordered domain specific binding Source: CAFA
  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: CAFA
  • protein homodimerization activity Source: GO_Central

Protein-protein interaction databases

BioGridi107071, 25 interactors
ComplexPortaliCPX-309 BIK:BCL-w complex
DIPiDIP-33700N
IntActiQ92843, 53 interactors
MINTiQ92843
STRINGi9606.ENSP00000250405

Chemistry databases

BindingDBiQ92843

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 24Combined sources15
Beta strandi30 – 32Combined sources3
Beta strandi35 – 37Combined sources3
Helixi41 – 60Combined sources20
Helixi65 – 67Combined sources3
Turni68 – 70Combined sources3
Turni72 – 74Combined sources3
Helixi75 – 86Combined sources12
Turni87 – 89Combined sources3
Helixi93 – 112Combined sources20
Helixi117 – 133Combined sources17
Helixi135 – 140Combined sources6
Helixi144 – 151Combined sources8
Helixi156 – 168Combined sources13
Turni171 – 176Combined sources6

3D structure databases

ProteinModelPortaliQ92843
SMRiQ92843
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92843

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 29BH4Add BLAST21
Motifi85 – 104BH1Add BLAST20
Motifi136 – 151BH2Add BLAST16

Domaini

The BH4 motif seems to be involved in the anti-apoptotic function.
The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiKOG4209 Eukaryota
ENOG4111PFV LUCA
GeneTreeiENSGT00390000001517
ENSGT00530000062935
HOGENOMiHOG000056452
InParanoidiQ92843
KOiK02163
OMAiVQDWMVT
OrthoDBiEOG09370XO5
PhylomeDBiQ92843
TreeFamiTF105907
TF315834

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR013280 Apop_reg_BclW
IPR002475 Bcl2-like
IPR020717 Bcl2_BH1_motif_CS
IPR020726 Bcl2_BH2_motif_CS
IPR003093 Bcl2_BH4
IPR020731 Bcl2_BH4_motif_CS
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PANTHERiPTHR11256 PTHR11256, 1 hit
PTHR11256:SF13 PTHR11256:SF13, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
PF02180 BH4, 1 hit
PRINTSiPR01865 APOPREGBCLW
PR01862 BCL2FAMILY
SMARTiView protein in SMART
SM00265 BH4, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS01258 BH2, 1 hit
PS01260 BH4_1, 1 hit
PS50063 BH4_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92843-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG
60 70 80 90 100
DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF
110 120 130 140 150
VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETQLADWIHS SGGWAEFTAL
160 170 180 190
YGDGALEEAR RLREGNWASV RTVLTGAVAL GALVTVGAFF ASK
Length:193
Mass (Da):20,746
Last modified:May 18, 2010 - v2
Checksum:i3542243A532B1762
GO
Isoform 3 (identifier: Q92843-2) [UniParc]FASTAAdd to basket
Also known as: BCL2L2-PABPN1

The sequence of this isoform differs from the canonical sequence as follows:
     145-193: AEFTALYGDG...VTVGAFFASK → ELEAIKARVR...ARATSWYSPY

Note: Based on a readthrough transcript which may produce a BCL2L2-PABPN1 fusion protein. No experimental confirmation available.Combined sources
Show »
Length:333
Mass (Da):37,171
Checksum:iF2C9A67BF3D38122
GO

Sequence cautioni

The sequence BAA19666 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048418133Q → R6 PublicationsCorresponds to variant dbSNP:rs910332Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042064145 – 193AEFTA…FFASK → ELEAIKARVREMEEEAEKLK ELQNEVEKQMNMSPPPGNAG PVIMSIEEKMEADARSIYVG NVDYGATAEELEAHFHGCGS VNRVTILCDKFSGHPKGFAY IEFSDKESVRTSLALDESLF RGRQIKVIPKRTNRPGISTT DRGFPRARYRARTTNYNSSR SRFYSGFNSRPRGRVYRGRA RATSWYSPY in isoform 3. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59747 mRNA Translation: AAB09055.1
D87461 mRNA Translation: BAA19666.2 Different initiation.
BT019549 mRNA Translation: AAV38356.1
AK289519 mRNA Translation: BAF82208.1
AL049829 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66169.1
BC011637 mRNA No translation available.
BC021198 mRNA Translation: AAH21198.1
BC104789 mRNA Translation: AAI04790.1
BC113522 mRNA Translation: AAI13523.1
RefSeqiNP_001186768.1, NM_001199839.1
NP_004041.1, NM_004050.4
UniGeneiHs.410026
Hs.735863

Genome annotation databases

EnsembliENST00000250405; ENSP00000250405; ENSG00000129473 [Q92843-1]
ENST00000553781; ENSP00000451320; ENSG00000258643 [Q92843-2]
ENST00000557008; ENSP00000452479; ENSG00000258643 [Q92843-2]
GeneIDi599
KEGGihsa:599
UCSCiuc001wjg.4 human [Q92843-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiB2CL2_HUMAN
AccessioniPrimary (citable) accession number: Q92843
Secondary accession number(s): A8K0F4, Q2M3U0, Q5U0H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health