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UniProtKB - Q92843 (B2CL2_HUMAN)

Entry version 197 (17 Jun 2020)
Sequence version 2 (18 May 2010)
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Protein

Bcl-2-like protein 2

Gene

BCL2L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92843

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.21.1.5 the bcl-2 (bcl-2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bcl-2-like protein 2
Short name:
Bcl2-L-2
Alternative name(s):
Apoptosis regulator Bcl-W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCL2L2
Synonyms:BCLW, KIAA0271
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000129473.9
HostDB:ENSG00000258643.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:995 BCL2L2
HGNC:42959 BCL2L2-PABPN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601931 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92843

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		100529063
599

Open Targets

More...OpenTargetsi		ENSG00000129473
ENSG00000258643

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25307

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92843 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4677

Drug and drug target database

More...DrugBanki		DB12340 Navitoclax

DrugCentral

More...DrugCentrali		Q92843

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2846

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BCL2L2-PABPN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434404

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001430662 – 193Bcl-2-like protein 2Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Isoform 3 (identifier: Q92843-2)
Modified residuei177PhosphoserineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei286Omega-N-methylarginineCombined sources1
Modified residuei290Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92843

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92843

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92843

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92843

PeptideAtlas

More...PeptideAtlasi		Q92843

PRoteomics IDEntifications database

More...PRIDEi		Q92843

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75535 [Q92843-1]
75536 [Q92843-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92843

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92843

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q92843

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000129473 Expressed in C1 segment of cervical spinal cord and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92843 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92843 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000129473 Low tissue specificity
ENSG00000258643 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HIF3A (via C-terminus domain).

Interacts with BOP.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q92843
With#Exp.IntAct
ANKS6 [Q68DC2]3EBI-707714,EBI-7054139
APOC1 [P02654]3EBI-707714,EBI-1220105
APOC4 [P55056]3EBI-707714,EBI-18302142
ATP5PF [P18859]3EBI-707714,EBI-2606700
BAD [Q92934]7EBI-707714,EBI-700771
BAK1 [Q16611]8EBI-707714,EBI-519866
BAX [Q07812]5EBI-707714,EBI-516580
BBC3 [Q9BXH1]3EBI-707714,EBI-519884
BCL2L11 [O43521]9EBI-707714,EBI-526406
itself3EBI-707714,EBI-707714
BHLHA9 [Q7RTU4]3EBI-707714,EBI-17508719
BID [P55957]5EBI-707714,EBI-519672
BIK [Q13323]22EBI-707714,EBI-700794
BMF [Q96LC9]13EBI-707714,EBI-3919268
BNIP5 [P0C671]3EBI-707714,EBI-12806802
C10orf67 - isoform 2 [Q8IYJ2-2]3EBI-707714,EBI-13381098
CCDC155 [Q8N6L0]8EBI-707714,EBI-749265
CD79A [P11912]3EBI-707714,EBI-7797864
CHODL [Q9H9P2]3EBI-707714,EBI-17447707
CIDEB [Q9UHD4]3EBI-707714,EBI-7062247
CISD2 [Q8N5K1]3EBI-707714,EBI-1045797
CLDN7 [O95471]3EBI-707714,EBI-740744
ERGIC3 [Q9Y282]3EBI-707714,EBI-781551
ERVFRD-1 [P60508]3EBI-707714,EBI-17973325
FATE1 [Q969F0]6EBI-707714,EBI-743099
FGF14 - isoform 2 [Q92915-2]3EBI-707714,EBI-12836320
G0S2 [P27469]3EBI-707714,EBI-3939849
GORAB [Q5T7V8]3EBI-707714,EBI-3917143
GPR151 [Q8TDV0]3EBI-707714,EBI-11955647
GPX8 [Q8TED1]3EBI-707714,EBI-11721746
KCNJ6 [P48051]3EBI-707714,EBI-12017638
LRP10 [Q7Z4F1]3EBI-707714,EBI-2830349
MGST2 [Q99735]3EBI-707714,EBI-11324706
MUC1 - isoform Y-LSP [P15941-11]3EBI-707714,EBI-17263240
PANX1 [Q96RD7]3EBI-707714,EBI-7037612
RHBDD2 - isoform 3 [Q6NTF9-3]3EBI-707714,EBI-17589229
RTL10 [Q7L3V2]5EBI-707714,EBI-10697720
SAR1A [Q9NR31]3EBI-707714,EBI-3920694
SGPL1 [O95470]3EBI-707714,EBI-1046170
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-707714,EBI-17295964
SLC35E3 [Q7Z769]3EBI-707714,EBI-13389236
SLC39A2 [Q9NP94]3EBI-707714,EBI-12898013
SLC39A6 - isoform 2 [Q13433-2]3EBI-707714,EBI-12956703
STOM [P27105]3EBI-707714,EBI-1211440
SUSD3 [Q96L08]3EBI-707714,EBI-18194029
TCF4 [P15884]3EBI-707714,EBI-533224
TEX11 - isoform 3 [Q8IYF3-3]3EBI-707714,EBI-11523345
TMEM139 [Q8IV31]3EBI-707714,EBI-7238458
TMEM179B [Q7Z7N9]3EBI-707714,EBI-11724423
TMX1 [Q9H3N1]3EBI-707714,EBI-1051115
TP53BP2 [Q13625]4EBI-707714,EBI-77642
Bmf [Q91ZE9] from Mus musculus.2EBI-707714,EBI-708032

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107071, 35 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-309 BIK:BCL-w complex

Database of interacting proteins

More...DIPi		DIP-33700N

Protein interaction database and analysis system

More...IntActi		Q92843, 62 interactors

Molecular INTeraction database

More...MINTi		Q92843

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000250405

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q92843

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92843 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92843

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q92843

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi9 – 29BH4Add BLAST21
Motifi85 – 104BH1Add BLAST20
Motifi136 – 151BH2Add BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The BH4 motif seems to be involved in the anti-apoptotic function.
The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4209 Eukaryota
ENOG4111PFV LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154606
ENSGT00970000193374

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_834081_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92843

KEGG Orthology (KO)

More...KOi		K02163

Identification of Orthologs from Complete Genome Data

More...OMAi		DVARWMT

Database of Orthologous Groups

More...OrthoDBi		1412946at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92843

TreeFam database of animal gene trees

More...TreeFami		TF105907
TF315834

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.437.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013280 Apop_reg_BclW
IPR002475 Bcl2-like
IPR020717 Bcl2_BH1_motif_CS
IPR020726 Bcl2_BH2_motif_CS
IPR003093 Bcl2_BH4
IPR020731 Bcl2_BH4_motif_CS
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam

The PANTHER Classification System

More...PANTHERi		PTHR11256 PTHR11256, 1 hit
PTHR11256:SF51 PTHR11256:SF51, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00452 Bcl-2, 1 hit
PF02180 BH4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01865 APOPREGBCLW
PR01862 BCL2FAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00265 BH4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56854 SSF56854, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS01258 BH2, 1 hit
PS01260 BH4_1, 1 hit
PS50063 BH4_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92843-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG 
        60         70         80         90        100
DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF 
       110        120        130        140        150
VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETQLADWIHS SGGWAEFTAL 
       160        170        180        190 
YGDGALEEAR RLREGNWASV RTVLTGAVAL GALVTVGAFF ASK
Length:193
Mass (Da):20,746
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3542243A532B1762
GO
Isoform 3 (identifier: Q92843-2) [UniParc]FASTAAdd to basket
Also known as: BCL2L2-PABPN1

The sequence of this isoform differs from the canonical sequence as follows:
     145-193: AEFTALYGDG...VTVGAFFASK → ELEAIKARVR...ARATSWYSPY

Note: Based on a readthrough transcript which may produce a BCL2L2-PABPN1 fusion protein.Curated
Show »
Length:333
Mass (Da):37,171
Checksum:iF2C9A67BF3D38122
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJC7H0YJC7_HUMAN
Bcl-2-like protein 2
BCL2L2
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5A9G3V5A9_HUMAN
Bcl-2-like protein 2
BCL2L2
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3B7G3V3B7_HUMAN
Bcl-2-like protein 2
BCL2L2
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3G8G3V3G8_HUMAN
Bcl-2-like protein 2
BCL2L2
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4B7G3V4B7_HUMAN
Bcl-2-like protein 2
BCL2L2
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA19666 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048418133Q → R6 PublicationsCorresponds to variant dbSNP:rs910332Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042064145 – 193AEFTA…FFASK → ELEAIKARVREMEEEAEKLK ELQNEVEKQMNMSPPPGNAG PVIMSIEEKMEADARSIYVG NVDYGATAEELEAHFHGCGS VNRVTILCDKFSGHPKGFAY IEFSDKESVRTSLALDESLF RGRQIKVIPKRTNRPGISTT DRGFPRARYRARTTNYNSSR SRFYSGFNSRPRGRVYRGRA RATSWYSPY in isoform 3. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U59747 mRNA Translation: AAB09055.1
D87461 mRNA Translation: BAA19666.2 Different initiation.
BT019549 mRNA Translation: AAV38356.1
AK289519 mRNA Translation: BAF82208.1
AL049829 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66169.1
BC011637 mRNA No translation available.
BC021198 mRNA Translation: AAH21198.1
BC104789 mRNA Translation: AAI04790.1
BC113522 mRNA Translation: AAI13523.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9591.1 [Q92843-1]

NCBI Reference Sequences

More...RefSeqi		NP_001186768.1, NM_001199839.1
NP_004041.1, NM_004050.4 [Q92843-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000250405; ENSP00000250405; ENSG00000129473 [Q92843-1]
ENST00000553781; ENSP00000451320; ENSG00000258643 [Q92843-2]
ENST00000557008; ENSP00000452479; ENSG00000258643 [Q92843-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		599

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:599

UCSC genome browser

More...UCSCi		uc001wjg.4 human [Q92843-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59747 mRNA Translation: AAB09055.1
D87461 mRNA Translation: BAA19666.2 Different initiation.
BT019549 mRNA Translation: AAV38356.1
AK289519 mRNA Translation: BAF82208.1
AL049829 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66169.1
BC011637 mRNA No translation available.
BC021198 mRNA Translation: AAH21198.1
BC104789 mRNA Translation: AAI04790.1
BC113522 mRNA Translation: AAI13523.1
CCDSiCCDS9591.1 [Q92843-1]
RefSeqiNP_001186768.1, NM_001199839.1
NP_004041.1, NM_004050.4 [Q92843-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MK3NMR-A2-171[»]
1O0LNMR-A1-183[»]
1ZY3NMR-A2-171[»]
2Y6WX-ray2.00A/B1-164[»]
4CIMX-ray1.50A/B1-163[»]
P/Q38-58[»]
SMRiQ92843
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107071, 35 interactors
ComplexPortaliCPX-309 BIK:BCL-w complex
DIPiDIP-33700N
IntActiQ92843, 62 interactors
MINTiQ92843
STRINGi9606.ENSP00000250405

Chemistry databases

BindingDBiQ92843
ChEMBLiCHEMBL4677
DrugBankiDB12340 Navitoclax
DrugCentraliQ92843
GuidetoPHARMACOLOGYi2846

Protein family/group databases

TCDBi1.A.21.1.5 the bcl-2 (bcl-2) family

PTM databases

iPTMnetiQ92843
PhosphoSitePlusiQ92843
SwissPalmiQ92843

Polymorphism and mutation databases

BioMutaiBCL2L2-PABPN1
DMDMi296434404

Proteomic databases

jPOSTiQ92843
MassIVEiQ92843
MaxQBiQ92843
PaxDbiQ92843
PeptideAtlasiQ92843
PRIDEiQ92843
ProteomicsDBi75535 [Q92843-1]
75536 [Q92843-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3670 406 antibodies

The DNASU plasmid repository

More...DNASUi		599

Genome annotation databases

EnsembliENST00000250405; ENSP00000250405; ENSG00000129473 [Q92843-1]
ENST00000553781; ENSP00000451320; ENSG00000258643 [Q92843-2]
ENST00000557008; ENSP00000452479; ENSG00000258643 [Q92843-2]
GeneIDi599
KEGGihsa:599
UCSCiuc001wjg.4 human [Q92843-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		599
DisGeNETi100529063
599
EuPathDBiHostDB:ENSG00000129473.9
HostDB:ENSG00000258643.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		BCL2L2
BCL2L2-PABPN1
HGNCiHGNC:995 BCL2L2
HGNC:42959 BCL2L2-PABPN1
HPAiENSG00000129473 Low tissue specificity
ENSG00000258643 Low tissue specificity
MIMi601931 gene
neXtProtiNX_Q92843
OpenTargetsiENSG00000129473
ENSG00000258643
PharmGKBiPA25307

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4209 Eukaryota
ENOG4111PFV LUCA
GeneTreeiENSGT00940000154606
ENSGT00970000193374
HOGENOMiCLU_834081_0_0_1
InParanoidiQ92843
KOiK02163
OMAiDVARWMT
OrthoDBi1412946at2759
PhylomeDBiQ92843
TreeFamiTF105907
TF315834

Enzyme and pathway databases

SIGNORiQ92843

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		599 17 hits in 785 CRISPR screens
EvolutionaryTraceiQ92843

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BCL2L2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		599
PharosiQ92843 Tchem
RNActiQ92843 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000129473 Expressed in C1 segment of cervical spinal cord and 222 other tissues
ExpressionAtlasiQ92843 baseline and differential
GenevisibleiQ92843 HS

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR013280 Apop_reg_BclW
IPR002475 Bcl2-like
IPR020717 Bcl2_BH1_motif_CS
IPR020726 Bcl2_BH2_motif_CS
IPR003093 Bcl2_BH4
IPR020731 Bcl2_BH4_motif_CS
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PANTHERiPTHR11256 PTHR11256, 1 hit
PTHR11256:SF51 PTHR11256:SF51, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
PF02180 BH4, 1 hit
PRINTSiPR01865 APOPREGBCLW
PR01862 BCL2FAMILY
SMARTiView protein in SMART
SM00265 BH4, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS01258 BH2, 1 hit
PS01260 BH4_1, 1 hit
PS50063 BH4_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2CL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92843
Secondary accession number(s): A8K0F4, Q2M3U0, Q5U0H4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: June 17, 2020
This is version 197 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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