UniProtKB - Q92843 (B2CL2_HUMAN)
Bcl-2-like protein 2
BCL2L2
Functioni
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
1 PublicationGO - Molecular functioni
- BH domain binding Source: Ensembl
- disordered domain specific binding Source: CAFA
- identical protein binding Source: IntAct
- protein-containing complex binding Source: Ensembl
- protein heterodimerization activity Source: GO_Central
- protein homodimerization activity Source: GO_Central
GO - Biological processi
- brain development Source: Ensembl
- cellular response to amyloid-beta Source: Ensembl
- cellular response to estradiol stimulus Source: Ensembl
- cellular response to glycine Source: Ensembl
- extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
- intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of intrinsic apoptotic signaling pathway Source: GO_Central
- negative regulation of mitochondrial membrane permeability Source: Ensembl
- negative regulation of release of cytochrome c from mitochondria Source: Ensembl
- regulation of apoptotic process Source: ComplexPortal
- response to ischemia Source: Ensembl
- Sertoli cell proliferation Source: Ensembl
- spermatogenesis Source: ProtInc
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q92843 |
SignaLinki | Q92843 |
SIGNORi | Q92843 |
Protein family/group databases
TCDBi | 1.A.21.1.5, the bcl-2 (bcl-2) family |
Names & Taxonomyi
Protein namesi | Recommended name: Bcl-2-like protein 2Short name: Bcl2-L-2 Alternative name(s): Apoptosis regulator Bcl-W |
Gene namesi | Name:BCL2L2 Synonyms:BCLW, KIAA0271 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:995, BCL2L2 HGNC:42959, BCL2L2-PABPN1 |
MIMi | 601931, gene |
neXtProti | NX_Q92843 |
VEuPathDBi | HostDB:ENSG00000129473 HostDB:ENSG00000258643 |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane 2 Publications; Peripheral membrane protein 2 Publications
Note: Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
Cytosol
- cytosol Source: Ensembl
Mitochondrion
- mitochondrial outer membrane Source: GO_Central
Other locations
- Bcl-2 family protein complex Source: CAFA
Keywords - Cellular componenti
Membrane, MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 599 |
MalaCardsi | BCL2L2-PABPN1 |
OpenTargetsi | ENSG00000129473 ENSG00000258643 |
PharmGKBi | PA25307 |
Miscellaneous databases
Pharosi | Q92843, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4677 |
DrugBanki | DB12340, Navitoclax |
DrugCentrali | Q92843 |
GuidetoPHARMACOLOGYi | 2846 |
Genetic variation databases
BioMutai | BCL2L2-PABPN1 |
DMDMi | 296434404 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000143066 | 2 – 193 | Bcl-2-like protein 2Add BLAST | 192 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | ||
Isoform 3 (identifier: Q92843-2) | |||||
Modified residuei | 177 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 262 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 286 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 290 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | Q92843 |
jPOSTi | Q92843 |
MassIVEi | Q92843 |
MaxQBi | Q92843 |
PaxDbi | Q92843 |
PeptideAtlasi | Q92843 |
PRIDEi | Q92843 |
ProteomicsDBi | 75535 [Q92843-1] 75536 [Q92843-2] |
PTM databases
iPTMneti | Q92843 |
PhosphoSitePlusi | Q92843 |
SwissPalmi | Q92843 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000129473, Expressed in C1 segment of cervical spinal cord and 238 other tissues |
ExpressionAtlasi | Q92843, baseline and differential |
Genevisiblei | Q92843, HS |
Organism-specific databases
HPAi | ENSG00000129473, Low tissue specificity ENSG00000258643, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with HIF3A (via C-terminus domain).
Interacts with BOP.
By similarityBinary interactionsi
Q92843
GO - Molecular functioni
- BH domain binding Source: Ensembl
- disordered domain specific binding Source: CAFA
- identical protein binding Source: IntAct
- protein heterodimerization activity Source: GO_Central
- protein homodimerization activity Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 107071, 78 interactors |
ComplexPortali | CPX-309, BIK:BCL-w complex |
DIPi | DIP-33700N |
IntActi | Q92843, 62 interactors |
MINTi | Q92843 |
STRINGi | 9606.ENSP00000250405 |
Chemistry databases
BindingDBi | Q92843 |
Miscellaneous databases
RNActi | Q92843, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q92843 |
SMRi | Q92843 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92843 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 9 – 29 | BH4Add BLAST | 21 | |
Motifi | 85 – 104 | BH1Add BLAST | 20 | |
Motifi | 136 – 151 | BH2Add BLAST | 16 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4728, Eukaryota |
GeneTreei | ENSGT00940000154606 ENSGT01020000230347 |
HOGENOMi | CLU_834081_0_0_1 |
InParanoidi | Q92843 |
OMAi | DVARWMT |
OrthoDBi | 1412946at2759 |
PhylomeDBi | Q92843 |
TreeFami | TF105907 TF315834 |
Family and domain databases
CDDi | cd06845, Bcl-2_like, 1 hit |
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR013280, Apop_reg_BclW IPR036834, Bcl-2-like_sf IPR046371, Bcl-2_BH1-3 IPR026298, Bcl-2_fam IPR002475, Bcl2-like IPR020717, Bcl2_BH1_motif_CS IPR020726, Bcl2_BH2_motif_CS IPR003093, Bcl2_BH4 IPR020731, Bcl2_BH4_motif_CS |
PANTHERi | PTHR11256, PTHR11256, 1 hit PTHR11256:SF51, PTHR11256:SF51, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit PF02180, BH4, 1 hit |
PRINTSi | PR01865, APOPREGBCLW PR01862, BCL2FAMILY |
SMARTi | View protein in SMART SM00337, BCL, 1 hit SM00265, BH4, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit PS01080, BH1, 1 hit PS01258, BH2, 1 hit PS01260, BH4_1, 1 hit PS50063, BH4_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG
60 70 80 90 100
DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF
110 120 130 140 150
VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETQLADWIHS SGGWAEFTAL
160 170 180 190
YGDGALEEAR RLREGNWASV RTVLTGAVAL GALVTVGAFF ASK
The sequence of this isoform differs from the canonical sequence as follows:
145-193: AEFTALYGDG...VTVGAFFASK → ELEAIKARVR...ARATSWYSPY
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A7I2V383 | A0A7I2V383_HUMAN | BCL2L2-PABPN1 readthrough | BCL2L2-PABPN1 | 365 | Annotation score: | ||
G3V5A9 | G3V5A9_HUMAN | Bcl-2-like protein 2 | BCL2L2 | 185 | Annotation score: | ||
G3V4B7 | G3V4B7_HUMAN | Bcl-2-like protein 2 | BCL2L2 | 168 | Annotation score: | ||
H0YJC7 | H0YJC7_HUMAN | Bcl-2-like protein 2 | BCL2L2 | 167 | Annotation score: | ||
G3V3B7 | G3V3B7_HUMAN | Bcl-2-like protein 2 | BCL2L2 | 51 | Annotation score: | ||
G3V3G8 | G3V3G8_HUMAN | Bcl-2-like protein 2 | BCL2L2 | 71 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048418 | 133 | Q → R6 PublicationsCorresponds to variant dbSNP:rs910332Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042064 | 145 – 193 | AEFTA…FFASK → ELEAIKARVREMEEEAEKLK ELQNEVEKQMNMSPPPGNAG PVIMSIEEKMEADARSIYVG NVDYGATAEELEAHFHGCGS VNRVTILCDKFSGHPKGFAY IEFSDKESVRTSLALDESLF RGRQIKVIPKRTNRPGISTT DRGFPRARYRARTTNYNSSR SRFYSGFNSRPRGRVYRGRA RATSWYSPY in isoform 3. 1 PublicationAdd BLAST | 49 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U59747 mRNA Translation: AAB09055.1 D87461 mRNA Translation: BAA19666.2 Different initiation. BT019549 mRNA Translation: AAV38356.1 AK289519 mRNA Translation: BAF82208.1 AL049829 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66169.1 BC011637 mRNA No translation available. BC021198 mRNA Translation: AAH21198.1 BC104789 mRNA Translation: AAI04790.1 BC113522 mRNA Translation: AAI13523.1 |
CCDSi | CCDS9591.1 [Q92843-1] |
RefSeqi | NP_001186768.1, NM_001199839.1 [Q92843-1] NP_004041.1, NM_004050.4 [Q92843-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U59747 mRNA Translation: AAB09055.1 D87461 mRNA Translation: BAA19666.2 Different initiation. BT019549 mRNA Translation: AAV38356.1 AK289519 mRNA Translation: BAF82208.1 AL049829 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66169.1 BC011637 mRNA No translation available. BC021198 mRNA Translation: AAH21198.1 BC104789 mRNA Translation: AAI04790.1 BC113522 mRNA Translation: AAI13523.1 |
CCDSi | CCDS9591.1 [Q92843-1] |
RefSeqi | NP_001186768.1, NM_001199839.1 [Q92843-1] NP_004041.1, NM_004050.4 [Q92843-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MK3 | NMR | - | A | 2-171 | [»] | |
1O0L | NMR | - | A | 1-183 | [»] | |
1ZY3 | NMR | - | A | 2-171 | [»] | |
2Y6W | X-ray | 2.00 | A/B | 1-164 | [»] | |
4CIM | X-ray | 1.50 | A/B | 1-163 | [»] | |
P/Q | 38-58 | [»] | ||||
AlphaFoldDBi | Q92843 | |||||
SMRi | Q92843 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107071, 78 interactors |
ComplexPortali | CPX-309, BIK:BCL-w complex |
DIPi | DIP-33700N |
IntActi | Q92843, 62 interactors |
MINTi | Q92843 |
STRINGi | 9606.ENSP00000250405 |
Chemistry databases
BindingDBi | Q92843 |
ChEMBLi | CHEMBL4677 |
DrugBanki | DB12340, Navitoclax |
DrugCentrali | Q92843 |
GuidetoPHARMACOLOGYi | 2846 |
Protein family/group databases
TCDBi | 1.A.21.1.5, the bcl-2 (bcl-2) family |
PTM databases
iPTMneti | Q92843 |
PhosphoSitePlusi | Q92843 |
SwissPalmi | Q92843 |
Genetic variation databases
BioMutai | BCL2L2-PABPN1 |
DMDMi | 296434404 |
Proteomic databases
EPDi | Q92843 |
jPOSTi | Q92843 |
MassIVEi | Q92843 |
MaxQBi | Q92843 |
PaxDbi | Q92843 |
PeptideAtlasi | Q92843 |
PRIDEi | Q92843 |
ProteomicsDBi | 75535 [Q92843-1] 75536 [Q92843-2] |
Protocols and materials databases
Antibodypediai | 3670, 434 antibodies from 38 providers |
CPTCi | Q92843, 3 antibodies |
DNASUi | 599 |
Genome annotation databases
Organism-specific databases
CTDi | 599 |
DisGeNETi | 599 |
GeneCardsi | BCL2L2 BCL2L2-PABPN1 |
HGNCi | HGNC:995, BCL2L2 HGNC:42959, BCL2L2-PABPN1 |
HPAi | ENSG00000129473, Low tissue specificity ENSG00000258643, Low tissue specificity |
MalaCardsi | BCL2L2-PABPN1 |
MIMi | 601931, gene |
neXtProti | NX_Q92843 |
OpenTargetsi | ENSG00000129473 ENSG00000258643 |
PharmGKBi | PA25307 |
VEuPathDBi | HostDB:ENSG00000129473 HostDB:ENSG00000258643 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4728, Eukaryota |
GeneTreei | ENSGT00940000154606 ENSGT01020000230347 |
HOGENOMi | CLU_834081_0_0_1 |
InParanoidi | Q92843 |
OMAi | DVARWMT |
OrthoDBi | 1412946at2759 |
PhylomeDBi | Q92843 |
TreeFami | TF105907 TF315834 |
Enzyme and pathway databases
PathwayCommonsi | Q92843 |
SignaLinki | Q92843 |
SIGNORi | Q92843 |
Miscellaneous databases
BioGRID-ORCSi | 599, 27 hits in 1053 CRISPR screens |
EvolutionaryTracei | Q92843 |
GeneWikii | BCL2L2 |
GenomeRNAii | 599 |
Pharosi | Q92843, Tchem |
RNActi | Q92843, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000129473, Expressed in C1 segment of cervical spinal cord and 238 other tissues |
ExpressionAtlasi | Q92843, baseline and differential |
Genevisiblei | Q92843, HS |
Family and domain databases
CDDi | cd06845, Bcl-2_like, 1 hit |
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR013280, Apop_reg_BclW IPR036834, Bcl-2-like_sf IPR046371, Bcl-2_BH1-3 IPR026298, Bcl-2_fam IPR002475, Bcl2-like IPR020717, Bcl2_BH1_motif_CS IPR020726, Bcl2_BH2_motif_CS IPR003093, Bcl2_BH4 IPR020731, Bcl2_BH4_motif_CS |
PANTHERi | PTHR11256, PTHR11256, 1 hit PTHR11256:SF51, PTHR11256:SF51, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit PF02180, BH4, 1 hit |
PRINTSi | PR01865, APOPREGBCLW PR01862, BCL2FAMILY |
SMARTi | View protein in SMART SM00337, BCL, 1 hit SM00265, BH4, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit PS01080, BH1, 1 hit PS01258, BH2, 1 hit PS01260, BH4_1, 1 hit PS50063, BH4_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B2CL2_HUMAN | |
Accessioni | Q92843Primary (citable) accession number: Q92843 Secondary accession number(s): A8K0F4, Q2M3U0, Q5U0H4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 206 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families