BCL2L2

Functionⁱ

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.1 Publication

GO - Molecular functionⁱ

BH domain binding Source: Ensembl
disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 16645638
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 22000515
protein heterodimerization activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 16645638
protein homodimerization activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
negative regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17289999
negative regulation of intrinsic apoptotic signaling pathway Source: GO_Central
Sertoli cell proliferation Source: Ensembl
spermatogenesis
Source: ProtInc
Traceable author statementⁱ
- 8761287

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Enzyme and pathway databases

SIGNORⁱ	Q92843

SIGNORⁱ

Q92843

Protein family/group databases

TCDBⁱ	1.A.21.1.5 the bcl-2 (bcl-2) family

TCDBⁱ

1.A.21.1.5 the bcl-2 (bcl-2) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Bcl-2-like protein 2 Short name: Bcl2-L-2 Alternative name(s): Apoptosis regulator Bcl-W
Gene namesⁱ	Name:BCL2L2 Synonyms:BCLW, KIAA0271
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000129473.9 HostDB:ENSG00000258643.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:995 BCL2L2 HGNC:42959 BCL2L2-PABPN1
MIMⁱ	601931 gene
neXtProtⁱ	NX_Q92843

Keywords - Cellular componentⁱ

Membrane, Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	100529063 599
Open Targets More...OpenTargetsⁱ	ENSG00000129473 ENSG00000258643
PharmGKBⁱ	PA25307

Chemistry databases

ChEMBLⁱ	CHEMBL4677
Drug and drug target database More...DrugBankⁱ	DB05764 ABT-263
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2846

Polymorphism and mutation databases

BioMutaⁱ	BCL2L2
DMDMⁱ	296434404

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000143066	2 – 193	Bcl-2-like protein 2Add BLAST		192

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Isoform 3 (identifier: Q92843-2)
Modified residueⁱ	177	PhosphoserineCombined sources	1
Modified residueⁱ	262	PhosphoserineCombined sources	1
Modified residueⁱ	286	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	290	Omega-N-methylarginineCombined sources	1

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92843
PaxDbⁱ	Q92843
PeptideAtlas More...PeptideAtlasⁱ	Q92843
PRIDEⁱ	Q92843
ProteomicsDBⁱ	75535 75536 [Q92843-2]

PTM databases

iPTMnetⁱ	Q92843
PhosphoSitePlusⁱ	Q92843

Expressionⁱ

Tissue specificityⁱ

Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000129473 Expressed in 223 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_BCL2L2
ExpressionAtlasⁱ	Q92843 baseline and differential
Genevisibleⁱ	Q92843 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB040539 HPA000637

HPAⁱ

CAB040539
HPA000637

Interactionⁱ

Subunit structureⁱ

Interacts with HIF3A (via C-terminus domain). Interacts with BOP.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-707714,EBI-707714
BAD	Q92934	4	EBI-707714,EBI-700771
BAK1	Q16611	7	EBI-707714,EBI-519866
BAX	Q07812	5	EBI-707714,EBI-516580
BBC3	Q9BXH1	2	EBI-707714,EBI-519884
BCL2L11	O43521	6	EBI-707714,EBI-526406
BID	P55957	5	EBI-707714,EBI-519672
BIK	Q13323	17	EBI-707714,EBI-700794
BMF	Q96LC9	9	EBI-707714,EBI-3919268
Bmf	Q91ZE9	2	EBI-707714,EBI-708032	From Mus musculus.
CCDC155	Q8N6L0	7	EBI-707714,EBI-749265
FATE1	Q969F0	5	EBI-707714,EBI-743099
RTL10	Q7L3V2	5	EBI-707714,EBI-10697720
TCF4	P15884	3	EBI-707714,EBI-533224
TEX11	Q8IYF3-3	3	EBI-707714,EBI-11523345
TP53BP2	Q13625	4	EBI-707714,EBI-77642

GO - Molecular functionⁱ

BH domain binding Source: Ensembl
disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 16645638
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 22000515
protein heterodimerization activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 16645638
protein homodimerization activity Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107071, 25 interactors
ComplexPortalⁱ	CPX-309 BIK:BCL-w complex
Database of interacting proteins More...DIPⁱ	DIP-33700N
IntActⁱ	Q92843, 52 interactors
Molecular INTeraction database More...MINTⁱ	Q92843
STRINGⁱ	9606.ENSP00000250405

Chemistry databases

BindingDBⁱ

Q92843

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	10 – 24	Combined sources	15
Beta strandⁱ	30 – 32	Combined sources	3
Beta strandⁱ	35 – 37	Combined sources	3
Helixⁱ	41 – 60	Combined sources	20
Helixⁱ	65 – 67	Combined sources	3
Turnⁱ	68 – 70	Combined sources	3
Turnⁱ	72 – 74	Combined sources	3
Helixⁱ	75 – 86	Combined sources	12
Turnⁱ	87 – 89	Combined sources	3
Helixⁱ	93 – 112	Combined sources	20
Helixⁱ	117 – 133	Combined sources	17
Helixⁱ	135 – 140	Combined sources	6
Helixⁱ	144 – 151	Combined sources	8
Helixⁱ	156 – 168	Combined sources	13
Turnⁱ	171 – 176	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q92843
SMRⁱ	Q92843
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q92843

EvolutionaryTraceⁱ

Q92843

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	9 – 29	BH4Add BLAST	21
Motifⁱ	85 – 104	BH1Add BLAST	20
Motifⁱ	136 – 151	BH2Add BLAST	16

Domainⁱ

The BH4 motif seems to be involved in the anti-apoptotic function.

The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.

Sequence similaritiesⁱ

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4209 Eukaryota ENOG4111PFV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001517 ENSGT00530000062935
HOGENOMⁱ	HOG000056452
InParanoidⁱ	Q92843
KEGG Orthology (KO) More...KOⁱ	K02163
OMAⁱ	VQDWMVT
Database of Orthologous Groups More...OrthoDBⁱ	EOG09370XO5
PhylomeDBⁱ	Q92843
TreeFamⁱ	TF105907 TF315834

Family and domain databases

Gene3Dⁱ	1.10.437.10, 1 hit
InterProⁱ	View protein in InterPro IPR013280 Apop_reg_BclW IPR002475 Bcl2-like IPR020717 Bcl2_BH1_motif_CS IPR020726 Bcl2_BH2_motif_CS IPR003093 Bcl2_BH4 IPR020731 Bcl2_BH4_motif_CS IPR036834 Blc2-like_sf IPR026298 Blc2_fam
PANTHERⁱ	PTHR11256 PTHR11256, 1 hit PTHR11256:SF13 PTHR11256:SF13, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00452 Bcl-2, 1 hit PF02180 BH4, 1 hit
PRINTSⁱ	PR01865 APOPREGBCLW PR01862 BCL2FAMILY
SMARTⁱ	View protein in SMART SM00265 BH4, 1 hit
SUPFAMⁱ	SSF56854 SSF56854, 1 hit
PROSITEⁱ	View protein in PROSITE PS50062 BCL2_FAMILY, 1 hit PS01080 BH1, 1 hit PS01258 BH2, 1 hit PS01260 BH4_1, 1 hit PS50063 BH4_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q92843-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG 
        60         70         80         90        100
DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF 
       110        120        130        140        150
VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETQLADWIHS SGGWAEFTAL 
       160        170        180        190 
YGDGALEEAR RLREGNWASV RTVLTGAVAL GALVTVGAFF ASK

Length:193

Mass (Da):20,746

Last modified:May 18, 2010 - v2

Checksum:ⁱ3542243A532B1762

GO

Isoform 3 (identifier: Q92843-2) [UniParc]FASTA Add to basket

Also known as: BCL2L2-PABPN1

The sequence of this isoform differs from the canonical sequence as follows:
145-193: AEFTALYGDG...VTVGAFFASK → ELEAIKARVR...ARATSWYSPY

« Hide

        10         20         30         40         50
MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG 
        60         70         80         90        100
DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF 
       110        120        130        140        150
VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETQLADWIHS SGGWELEAIK 
       160        170        180        190        200
ARVREMEEEA EKLKELQNEV EKQMNMSPPP GNAGPVIMSI EEKMEADARS 
       210        220        230        240        250
IYVGNVDYGA TAEELEAHFH GCGSVNRVTI LCDKFSGHPK GFAYIEFSDK 
       260        270        280        290        300
ESVRTSLALD ESLFRGRQIK VIPKRTNRPG ISTTDRGFPR ARYRARTTNY 
       310        320        330 
NSSRSRFYSG FNSRPRGRVY RGRARATSWY SPY

Note: Based on a readthrough transcript which may produce a BCL2L2-PABPN1 fusion protein. No experimental confirmation available.Combined sources

Show »

Length:333

Mass (Da):37,171

Checksum:ⁱF2C9A67BF3D38122

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YJC7	H0YJC7_HUMAN	Bcl-2-like protein 2 Bcl-2-like protein 2	BCL2L2	167	Annotation score:
G3V3B7	G3V3B7_HUMAN	Bcl-2-like protein 2 Bcl-2-like protein 2	BCL2L2	51	Annotation score:
G3V5A9	G3V5A9_HUMAN	Bcl-2-like protein 2 Bcl-2-like protein 2	BCL2L2	144	Annotation score:
G3V4B7	G3V4B7_HUMAN	Bcl-2-like protein 2 Bcl-2-like protein 2	BCL2L2	149	Annotation score:
G3V3G8	G3V3G8_HUMAN	Bcl-2-like protein 2 Bcl-2-like protein 2	BCL2L2	71	Annotation score:

Sequence cautionⁱ

The sequence BAA19666 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048418	133	Q → R6 PublicationsCorresponds to variant dbSNP:rs910332Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042064	145 – 193	AEFTA…FFASK → ELEAIKARVREMEEEAEKLK ELQNEVEKQMNMSPPPGNAG PVIMSIEEKMEADARSIYVG NVDYGATAEELEAHFHGCGS VNRVTILCDKFSGHPKGFAY IEFSDKESVRTSLALDESLF RGRQIKVIPKRTNRPGISTT DRGFPRARYRARTTNYNSSR SRFYSGFNSRPRGRVYRGRA RATSWYSPY in isoform 3. 1 PublicationAdd BLAST		49

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U59747 mRNA Translation: AAB09055.1 D87461 mRNA Translation: BAA19666.2 Different initiation. BT019549 mRNA Translation: AAV38356.1 AK289519 mRNA Translation: BAF82208.1 AL049829 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66169.1 BC011637 mRNA No translation available. BC021198 mRNA Translation: AAH21198.1 BC104789 mRNA Translation: AAI04790.1 BC113522 mRNA Translation: AAI13523.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001186768.1, NM_001199839.1 NP_004041.1, NM_004050.4
UniGeneⁱ	Hs.410026 Hs.735863

Genome annotation databases

Ensemblⁱ	ENST00000250405; ENSP00000250405; ENSG00000129473 [Q92843-1] ENST00000553781; ENSP00000451320; ENSG00000258643 [Q92843-2] ENST00000557008; ENSP00000452479; ENSG00000258643 [Q92843-2]
GeneIDⁱ	599
KEGGⁱ	hsa:599
UCSC genome browser More...UCSCⁱ	uc001wjg.4 human [Q92843-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92843	Bcl-2-like protein 2 (Fragment)		HUMAN		149	UniRef100_Q92843
Q92843-2	Bcl-2-like protein 2 (Fragment)		HUMAN		144	UniRef100_Q92843-2

Protein	Similar proteins		Species	Score	Length	Source
Q92843	Bcl-2-like protein 2		MOUSE		193	UniRef90_Q92843
Bcl-2-like protein 2 (Fragment)		HUMAN		149
Putative apoptosis regulator (Fragment)		DESRO		238
BCL2L2-PABPN1 readthrough		SAIBB		204
Uncharacterized protein		Cebus capucinus imitator		204
+28
Q92843-2	Bcl-2-like protein 2 (Fragment)		HUMAN		144	UniRef90_Q92843-2
BCL2L2-PABPN1 readthrough		SHEEP		363
BCL2 like 2		PANTR		333
Uncharacterized protein		MACMU		333
Uncharacterized protein		COLAP		333
+34

Protein	Similar proteins		Species	Score	Length	Source
Q92843	Bcl-2-like protein 2		MOUSE		193	UniRef50_Q92843
Bcl-2-like protein 2	)	BOVIN		193
Bcl-2-like protein 2		CANLF		193
Apoptosis regulator R1 (Fragment)		XENLA		228
Bcl-2-like protein 2 (Fragment)		HUMAN		149
+100
Q92843-2	Polyadenylate-binding protein 2	)	HUMAN		306	UniRef50_Q86U42
Polyadenylate-binding protein 2		BOVIN		306
Polyadenylate-binding protein 2		MOUSE		302
Polyadenylate-binding protein 2		CALJA		306
Polyadenylate-binding protein 2		MACMU		306
+142

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U59747 mRNA Translation: AAB09055.1 D87461 mRNA Translation: BAA19666.2 Different initiation. BT019549 mRNA Translation: AAV38356.1 AK289519 mRNA Translation: BAF82208.1 AL049829 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66169.1 BC011637 mRNA No translation available. BC021198 mRNA Translation: AAH21198.1 BC104789 mRNA Translation: AAI04790.1 BC113522 mRNA Translation: AAI13523.1
RefSeqⁱ	NP_001186768.1, NM_001199839.1 NP_004041.1, NM_004050.4
UniGeneⁱ	Hs.410026 Hs.735863

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1MK3	NMR	-	A	2-171	[»]
	1O0L	NMR	-	A	1-183	[»]
	1ZY3	NMR	-	A	2-171	[»]
	2Y6W	X-ray	2.00	A/B	1-164	[»]
	4CIM	X-ray	1.50	A/B	1-163	[»]
				P/Q	38-58	[»]
ProteinModelPortalⁱ	Q92843
SMRⁱ	Q92843
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107071, 25 interactors
ComplexPortalⁱ	CPX-309 BIK:BCL-w complex
DIPⁱ	DIP-33700N
IntActⁱ	Q92843, 52 interactors
MINTⁱ	Q92843
STRINGⁱ	9606.ENSP00000250405

Chemistry databases

BindingDBⁱ	Q92843
ChEMBLⁱ	CHEMBL4677
DrugBankⁱ	DB05764 ABT-263
GuidetoPHARMACOLOGYⁱ	2846

Protein family/group databases

TCDBⁱ	1.A.21.1.5 the bcl-2 (bcl-2) family

TCDBⁱ

1.A.21.1.5 the bcl-2 (bcl-2) family

PTM databases

iPTMnetⁱ	Q92843
PhosphoSitePlusⁱ	Q92843

Polymorphism and mutation databases

BioMutaⁱ	BCL2L2
DMDMⁱ	296434404

Proteomic databases

MaxQBⁱ	Q92843
PaxDbⁱ	Q92843
PeptideAtlasⁱ	Q92843
PRIDEⁱ	Q92843
ProteomicsDBⁱ	75535 75536 [Q92843-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	599
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000250405; ENSP00000250405; ENSG00000129473 [Q92843-1] ENST00000553781; ENSP00000451320; ENSG00000258643 [Q92843-2] ENST00000557008; ENSP00000452479; ENSG00000258643 [Q92843-2]
GeneIDⁱ	599
KEGGⁱ	hsa:599
UCSCⁱ	uc001wjg.4 human [Q92843-1]

Organism-specific databases

CTDⁱ	599
DisGeNETⁱ	100529063 599
EuPathDBⁱ	HostDB:ENSG00000129473.9 HostDB:ENSG00000258643.5
GeneCardsⁱ	BCL2L2 BCL2L2-PABPN1
HGNCⁱ	HGNC:995 BCL2L2 HGNC:42959 BCL2L2-PABPN1
HPAⁱ	CAB040539 HPA000637
MIMⁱ	601931 gene
neXtProtⁱ	NX_Q92843
OpenTargetsⁱ	ENSG00000129473 ENSG00000258643
PharmGKBⁱ	PA25307
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4209 Eukaryota ENOG4111PFV LUCA
GeneTreeⁱ	ENSGT00390000001517 ENSGT00530000062935
HOGENOMⁱ	HOG000056452
InParanoidⁱ	Q92843
KOⁱ	K02163
OMAⁱ	VQDWMVT
OrthoDBⁱ	EOG09370XO5
PhylomeDBⁱ	Q92843
TreeFamⁱ	TF105907 TF315834

Enzyme and pathway databases

SIGNORⁱ	Q92843

SIGNORⁱ

Q92843

Miscellaneous databases

ChiTaRSⁱ	BCL2L2 human
EvolutionaryTraceⁱ	Q92843
GeneWikiⁱ	BCL2L2
GenomeRNAiⁱ	599
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000129473 Expressed in 223 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_BCL2L2
ExpressionAtlasⁱ	Q92843 baseline and differential
Genevisibleⁱ	Q92843 HS

Family and domain databases

Gene3Dⁱ	1.10.437.10, 1 hit
InterProⁱ	View protein in InterPro IPR013280 Apop_reg_BclW IPR002475 Bcl2-like IPR020717 Bcl2_BH1_motif_CS IPR020726 Bcl2_BH2_motif_CS IPR003093 Bcl2_BH4 IPR020731 Bcl2_BH4_motif_CS IPR036834 Blc2-like_sf IPR026298 Blc2_fam
PANTHERⁱ	PTHR11256 PTHR11256, 1 hit PTHR11256:SF13 PTHR11256:SF13, 1 hit
Pfamⁱ	View protein in Pfam PF00452 Bcl-2, 1 hit PF02180 BH4, 1 hit
PRINTSⁱ	PR01865 APOPREGBCLW PR01862 BCL2FAMILY
SMARTⁱ	View protein in SMART SM00265 BH4, 1 hit
SUPFAMⁱ	SSF56854 SSF56854, 1 hit
PROSITEⁱ	View protein in PROSITE PS50062 BCL2_FAMILY, 1 hit PS01080 BH1, 1 hit PS01258 BH2, 1 hit PS01260 BH4_1, 1 hit PS50063 BH4_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B2CL2_HUMAN
Accessionⁱ	Q92843Primary (citable) accession number: Q92843 Secondary accession number(s): A8K0F4, Q2M3U0, Q5U0H4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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Supporting data

UniProtKB - Q92843 (B2CL2_HUMAN)

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Bcl-2-like protein 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ