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Entry version 163 (18 Sep 2019)
Sequence version 2 (14 Oct 2008)
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Protein

Hyaluronan synthase 1

Gene

HAS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: hyaluronan biosynthesis

This protein is involved in the pathway hyaluronan biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway hyaluronan biosynthesis and in Glycan biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.212 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2142850 Hyaluronan biosynthesis and export

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00341

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT2 Glycosyltransferase Family 2

Transport Classification Database

More...
TCDBi
4.D.1.1.10 the putative vectorial glycosyl polymerization (vgp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hyaluronan synthase 1 (EC:2.4.1.212)
Alternative name(s):
Hyaluronate synthase 1
Hyaluronic acid synthase 1
Short name:
HA synthase 1
Short name:
HuHAS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HAS1
Synonyms:HAS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4818 HAS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601463 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92839

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 52ExtracellularSequence analysis6
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 399CytoplasmicSequence analysisAdd BLAST326
Transmembranei400 – 420Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini421 – 430ExtracellularSequence analysis10
Transmembranei431 – 451Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini452 – 457CytoplasmicSequence analysis6
Transmembranei458 – 478Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini479 – 497ExtracellularSequence analysisAdd BLAST19
Transmembranei498 – 518Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini519 – 540CytoplasmicSequence analysisAdd BLAST22
Transmembranei541 – 561Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini562 – 578ExtracellularSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3036

Open Targets

More...
OpenTargetsi
ENSG00000105509

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29194

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HAS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572627

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001971691 – 578Hyaluronan synthase 1Add BLAST578

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92839

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92839

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92839

PeptideAtlas

More...
PeptideAtlasi
Q92839

PRoteomics IDEntifications database

More...
PRIDEi
Q92839

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75530

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92839

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92839

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105509 Expressed in 96 organ(s), highest expression level in layer of synovial tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92839 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92839 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA067602

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109286, 7 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q92839

Protein interaction database and analysis system

More...
IntActi
Q92839, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000222115

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NodC/HAS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2571 Eukaryota
COG1215 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010337

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112847

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92839

KEGG Orthology (KO)

More...
KOi
K00752

Database of Orthologous Groups

More...
OrthoDBi
332363at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92839

TreeFam database of animal gene trees

More...
TreeFami
TF332506

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028385 HAS1
IPR029044 Nucleotide-diphossugar_trans

The PANTHER Classification System

More...
PANTHERi
PTHR22913:SF4 PTHR22913:SF4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448 SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q92839-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRQQDAPKPT PAACRCSGLA RRVLTIAFAL LILGLMTWAY AAGVPLASDR
60 70 80 90 100
YGLLAFGLYG AFLSAHLVAQ SLFAYLEHRR VAAAARGPLD AATARSVALT
110 120 130 140 150
ISAYQEDPAY LRQCLASARA LLYPRARLRV LMVVDGNRAE DLYMVDMFRE
160 170 180 190 200
VFADEDPATY VWDGNYHQPW EPAAAGAVGA GAYREVEAED PGRLAVEALV
210 220 230 240 250
RTRRCVCVAQ RWGGKREVMY TAFKALGDSV DYVQVCDSDT RLDPMALLEL
260 270 280 290 300
VRVLDEDPRV GAVGGDVRIL NPLDSWVSFL SSLRYWVAFN VERACQSYFH
310 320 330 340 350
CVSCISGPLG LYRNNLLQQF LEAWYNQKFL GTHCTFGDDR HLTNRMLSMG
360 370 380 390 400
YATKYTSRSR CYSETPSSFL RWLSQQTRWS KSYFREWLYN ALWWHRHHAW
410 420 430 440 450
MTYEAVVSGL FPFFVAATVL RLFYAGRPWA LLWVLLCVQG VALAKAAFAA
460 470 480 490 500
WLRGCLRMVL LSLYAPLYMC GLLPAKFLAL VTMNQSGWGT SGRRKLAANY
510 520 530 540 550
VPLLPLALWA LLLLGGLVRS VAHEARADWS GPSRAAEAYH LAAGAGAYVG
560 570
YWVAMLTLYW VGVRRLCRRR TGGYRVQV
Length:578
Mass (Da):64,832
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FE3A44B0D5380FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1S7G3V1S7_HUMAN
Hyaluronan synthase 1
HAS1 hCG_91965
577Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2V0M0R2V0_HUMAN
Hyaluronan synthase 1
HAS1
585Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXH4M0QXH4_HUMAN
Hyaluronan synthase 1
HAS1
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1L3M0R1L3_HUMAN
Hyaluronan synthase 1
HAS1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA12351 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 2MR → RS in BAA12351 (PubMed:8651928).Curated2
Sequence conflicti34G → A in BAA12351 (PubMed:8651928).Curated1
Sequence conflicti128L → V in BAA12351 (PubMed:8651928).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04702514C → R2 PublicationsCorresponds to variant dbSNP:rs7248778Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D84424 mRNA Translation: BAA12351.1 Different initiation.
U59269 mRNA Translation: AAC50706.1
AC018755 Genomic DNA Translation: AAF87845.1
CH471135 Genomic DNA Translation: EAW72038.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12838.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC4812

NCBI Reference Sequences

More...
RefSeqi
NP_001514.2, NM_001523.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000222115; ENSP00000222115; ENSG00000105509

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3036

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3036

UCSC genome browser

More...
UCSCi
uc002pxo.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84424 mRNA Translation: BAA12351.1 Different initiation.
U59269 mRNA Translation: AAC50706.1
AC018755 Genomic DNA Translation: AAF87845.1
CH471135 Genomic DNA Translation: EAW72038.1
CCDSiCCDS12838.1
PIRiJC4812
RefSeqiNP_001514.2, NM_001523.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi109286, 7 interactors
CORUMiQ92839
IntActiQ92839, 2 interactors
STRINGi9606.ENSP00000222115

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2
TCDBi4.D.1.1.10 the putative vectorial glycosyl polymerization (vgp) family

PTM databases

iPTMnetiQ92839
PhosphoSitePlusiQ92839

Polymorphism and mutation databases

BioMutaiHAS1
DMDMi209572627

Proteomic databases

jPOSTiQ92839
MassIVEiQ92839
PaxDbiQ92839
PeptideAtlasiQ92839
PRIDEiQ92839
ProteomicsDBi75530

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3036
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222115; ENSP00000222115; ENSG00000105509
GeneIDi3036
KEGGihsa:3036
UCSCiuc002pxo.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3036
DisGeNETi3036

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HAS1
HGNCiHGNC:4818 HAS1
HPAiHPA067602
MIMi601463 gene
neXtProtiNX_Q92839
OpenTargetsiENSG00000105509
PharmGKBiPA29194

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2571 Eukaryota
COG1215 LUCA
GeneTreeiENSGT00390000010337
HOGENOMiHOG000112847
InParanoidiQ92839
KOiK00752
OrthoDBi332363at2759
PhylomeDBiQ92839
TreeFamiTF332506

Enzyme and pathway databases

UniPathwayiUPA00341
BRENDAi2.4.1.212 2681
ReactomeiR-HSA-2142850 Hyaluronan biosynthesis and export

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HAS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3036

Pharos

More...
Pharosi
Q92839

Protein Ontology

More...
PROi
PR:Q92839

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105509 Expressed in 96 organ(s), highest expression level in layer of synovial tissue
ExpressionAtlasiQ92839 baseline and differential
GenevisibleiQ92839 HS

Family and domain databases

InterProiView protein in InterPro
IPR028385 HAS1
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR22913:SF4 PTHR22913:SF4, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHYAS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92839
Secondary accession number(s): Q14470, Q9NS49
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 14, 2008
Last modified: September 18, 2019
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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