FRAT1

Functionⁱ

Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.1 Publication

GO - Biological processⁱ

beta-catenin destruction complex disassembly Source: Reactome
canonical Wnt signaling pathway
Source: WormBase
Inferred from genetic interactionⁱ
- 12556519
positive regulation of canonical Wnt signaling pathway
Source: WormBase
Inferred from genetic interactionⁱ
- 12556519

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Wnt signaling pathway

Biological process

Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-196299 Beta-catenin phosphorylation cascade R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
SignaLinkⁱ	Q92837
SIGNORⁱ	Q92837

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Proto-oncogene FRAT1 Alternative name(s): Frequently rearranged in advanced T-cell lymphomas 1 Short name: FRAT-1
Gene namesⁱ	Name:FRAT1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165879.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3944 FRAT1
MIMⁱ	602503 gene
neXtProtⁱ	NX_Q92837

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10023
Open Targets More...OpenTargetsⁱ	ENSG00000165879
PharmGKBⁱ	PA28361

Polymorphism and mutation databases

BioMutaⁱ	FRAT1
DMDMⁱ	51338813

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000087332	1 – 279	Proto-oncogene FRAT1Add BLAST		279

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	88	PhosphoserineCombined sources	1
Modified residueⁱ	249	PhosphoserineBy similarity	1
Modified residueⁱ	252	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q92837
PeptideAtlas More...PeptideAtlasⁱ	Q92837
PRIDEⁱ	Q92837
ProteomicsDBⁱ	75521

PTM databases

iPTMnetⁱ	Q92837
PhosphoSitePlusⁱ	Q92837

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000165879
CleanExⁱ	HS_FRAT1
Genevisibleⁱ	Q92837 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB046472 HPA055258

HPAⁱ

CAB046472
HPA055258

Interactionⁱ

Subunit structureⁱ

Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GSK3A	P49840	3	EBI-3934879,EBI-1044067
GSK3B	P49841	5	EBI-3934879,EBI-373586

Show more details

Protein-protein interaction databases

BioGridⁱ	115340, 17 interactors
ComplexPortalⁱ	CPX-459 Nuclear export complex FRAT1-GSK3B
IntActⁱ	Q92837, 19 interactors
STRINGⁱ	9606.ENSP00000360060

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	201 – 209	Combined sources		9
Helixⁱ	212 – 219	Combined sources		8

3D structure databases

ProteinModelPortalⁱ	Q92837
SMRⁱ	Q92837
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q92837

EvolutionaryTraceⁱ

Q92837

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	198 – 220	Involved in GSK-3 bindingAdd BLAST		23

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	6 – 22	Glu-rich (highly acidic)Add BLAST	17
Compositional biasⁱ	6 – 10	Poly-Glu	5
Compositional biasⁱ	13 – 22	Poly-Glu	10

Sequence similaritiesⁱ

Belongs to the GSK-3-binding protein family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IX6F Eukaryota ENOG41119TC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007081
HOGENOMⁱ	HOG000112642
HOVERGENⁱ	HBG051660
InParanoidⁱ	Q92837
KEGG Orthology (KO) More...KOⁱ	K03069
OMAⁱ	WYLAANT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PDL
PhylomeDBⁱ	Q92837
TreeFamⁱ	TF330804

Family and domain databases

InterProⁱ	View protein in InterPro IPR008014 GSK3-bd
PANTHERⁱ	PTHR35154 PTHR35154, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05350 GSK-3_bind, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q92837-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPCRREEEEE AGEEAEGEEE EEDSFLLLQQ SVALGSSGEV DRLVAQIGET 
        60         70         80         90        100
LQLDAAQHSP ASPCGPPGAP LRAPGPLAAA VPADKARSPA VPLLLPPALA 
       110        120        130        140        150
ETVGPAPPGV LRCALGDRGR VRGRAAPYCV AELATGPSAL SPLPPQADLD 
       160        170        180        190        200
GPPGAGKQGI PQPLSGPCRR GWLRGAAASR RLQQRRGSQP ETRTGDDDPH 
       210        220        230        240        250
RLLQQLVLSG NLIKEAVRRL HSRRLQLRAK LPQRPLLGPL SAPVHEPPSP 
       260        270 
RSPRAACSDP GASGRAQLRT GDGVLVPGS

Length:279

Mass (Da):29,093

Last modified:August 16, 2004 - v3

Checksum:ⁱ629AFD6CEA1DC0BD

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	58	H → D in AAB97096 (PubMed:9034327).Curated		1
Sequence conflictⁱ	179	S → P in AAH34476 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U58975 mRNA Translation: AAB97096.2 AB074890 mRNA Translation: BAB86352.1 AL355490 Genomic DNA No translation available. BC034476 mRNA Translation: AAH34476.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7455.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005470.2, NM_005479.3
UniGeneⁱ	Hs.126057

Genome annotation databases

Ensemblⁱ	ENST00000371021; ENSP00000360060; ENSG00000165879
GeneIDⁱ	10023
KEGGⁱ	hsa:10023
UCSC genome browser More...UCSCⁱ	uc001knc.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q92837	FRAT1, WNT signaling pathway regulator		CALJA		279
FRAT1 isoform 1		PANTR		279
FRAT1, WNT signaling pathway regulator		MACMU		279
FRAT1 isoform 1		PONAB		279
FRAT1, WNT signaling pathway regulator		MACFA		279
+13

Protein	Similar proteins		Species	Score	Length
Q92837	FRAT1, WNT signaling pathway regulator		PAPAN		279
FRAT1, WNT signaling pathway regulator		CALJA		279
FRAT1, WNT signaling pathway regulator		CHLSB		279
FRAT1, WNT signaling pathway regulator		MACMU		279
FRAT1 isoform 1		PANTR		279
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U58975 mRNA Translation: AAB97096.2 AB074890 mRNA Translation: BAB86352.1 AL355490 Genomic DNA No translation available. BC034476 mRNA Translation: AAH34476.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7455.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005470.2, NM_005479.3
UniGeneⁱ	Hs.126057

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1GNG	X-ray	2.60	X/Y	188-226	[»]
	3ZRK	X-ray	2.37	X/Y	197-226	[»]
	3ZRL	X-ray	2.48	X/Y	197-226	[»]
	3ZRM	X-ray	2.49	X/Y	197-226	[»]
	4AFJ	X-ray	1.98	X/Y	197-226	[»]
	5OY4	X-ray	3.20	X/Y	1-279	[»]
ProteinModelPortalⁱ	Q92837
SMRⁱ	Q92837
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115340, 17 interactors
ComplexPortalⁱ	CPX-459 Nuclear export complex FRAT1-GSK3B
IntActⁱ	Q92837, 19 interactors
STRINGⁱ	9606.ENSP00000360060

PTM databases

iPTMnetⁱ	Q92837
PhosphoSitePlusⁱ	Q92837

Polymorphism and mutation databases

BioMutaⁱ	FRAT1
DMDMⁱ	51338813

Proteomic databases

PaxDbⁱ	Q92837
PeptideAtlas More...PeptideAtlasⁱ	Q92837
PRIDEⁱ	Q92837
ProteomicsDBⁱ	75521

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10023
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371021; ENSP00000360060; ENSG00000165879
GeneIDⁱ	10023
KEGGⁱ	hsa:10023
UCSC genome browser More...UCSCⁱ	uc001knc.2 human

Organism-specific databases

CTDⁱ	10023
DisGeNET More...DisGeNETⁱ	10023
EuPathDBⁱ	HostDB:ENSG00000165879.8
GeneCardsⁱ	FRAT1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3944 FRAT1
Human Protein Atlas More...HPAⁱ	CAB046472 HPA055258
MIMⁱ	602503 gene
neXtProtⁱ	NX_Q92837
Open Targets More...OpenTargetsⁱ	ENSG00000165879
PharmGKBⁱ	PA28361
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IX6F Eukaryota ENOG41119TC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007081
HOGENOMⁱ	HOG000112642
HOVERGENⁱ	HBG051660
InParanoidⁱ	Q92837
KEGG Orthology (KO) More...KOⁱ	K03069
OMAⁱ	WYLAANT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PDL
PhylomeDBⁱ	Q92837
TreeFamⁱ	TF330804

Enzyme and pathway databases

Reactomeⁱ	R-HSA-196299 Beta-catenin phosphorylation cascade R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
SignaLinkⁱ	Q92837
SIGNORⁱ	Q92837

Miscellaneous databases

ChiTaRSⁱ	FRAT1 human
EvolutionaryTraceⁱ	Q92837
GeneWikiⁱ	FRAT1
GenomeRNAiⁱ	10023
Protein Ontology More...PROⁱ	PR:Q92837
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165879
CleanExⁱ	HS_FRAT1
Genevisibleⁱ	Q92837 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008014 GSK3-bd
PANTHERⁱ	PTHR35154 PTHR35154, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05350 GSK-3_bind, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FRAT1_HUMAN
Accessionⁱ	Q92837Primary (citable) accession number: Q92837 Secondary accession number(s): Q5JTI1, Q8NE74, Q8TDW9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	August 16, 2004
	Last modified:	July 18, 2018
	This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q92837 (FRAT1_HUMAN)

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Proto-oncogene FRAT1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ