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Protein

Proto-oncogene FRAT1

Gene

FRAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.1 Publication

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
SignaLinkiQ92837
SIGNORiQ92837

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene FRAT1
Alternative name(s):
Frequently rearranged in advanced T-cell lymphomas 1
Short name:
FRAT-1
Gene namesi
Name:FRAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165879.8
HGNCiHGNC:3944 FRAT1
MIMi602503 gene
neXtProtiNX_Q92837

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi10023
OpenTargetsiENSG00000165879
PharmGKBiPA28361

Polymorphism and mutation databases

BioMutaiFRAT1
DMDMi51338813

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873321 – 279Proto-oncogene FRAT1Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88PhosphoserineCombined sources1
Modified residuei249PhosphoserineBy similarity1
Modified residuei252PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ92837
PeptideAtlasiQ92837
PRIDEiQ92837
ProteomicsDBi75521

PTM databases

iPTMnetiQ92837
PhosphoSitePlusiQ92837

Expressioni

Gene expression databases

BgeeiENSG00000165879 Expressed in 187 organ(s), highest expression level in blood
CleanExiHS_FRAT1
GenevisibleiQ92837 HS

Organism-specific databases

HPAiCAB046472
HPA055258

Interactioni

Subunit structurei

Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi115340, 17 interactors
ComplexPortaliCPX-459 Nuclear export complex FRAT1-GSK3B
IntActiQ92837, 19 interactors
STRINGi9606.ENSP00000360060

Structurei

Secondary structure

1279
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92837
SMRiQ92837
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92837

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 220Involved in GSK-3 bindingAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 22Glu-rich (highly acidic)Add BLAST17
Compositional biasi6 – 10Poly-Glu5
Compositional biasi13 – 22Poly-Glu10

Sequence similaritiesi

Belongs to the GSK-3-binding protein family.Curated

Phylogenomic databases

eggNOGiENOG410IX6F Eukaryota
ENOG41119TC LUCA
GeneTreeiENSGT00390000007081
HOGENOMiHOG000112642
HOVERGENiHBG051660
InParanoidiQ92837
KOiK03069
OMAiWYLAANT
OrthoDBiEOG091G0PDL
PhylomeDBiQ92837
TreeFamiTF330804

Family and domain databases

InterProiView protein in InterPro
IPR008014 GSK3-bd
PANTHERiPTHR35154 PTHR35154, 1 hit
PfamiView protein in Pfam
PF05350 GSK-3_bind, 1 hit

Sequencei

Sequence statusi: Complete.

Q92837-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPCRREEEEE AGEEAEGEEE EEDSFLLLQQ SVALGSSGEV DRLVAQIGET
60 70 80 90 100
LQLDAAQHSP ASPCGPPGAP LRAPGPLAAA VPADKARSPA VPLLLPPALA
110 120 130 140 150
ETVGPAPPGV LRCALGDRGR VRGRAAPYCV AELATGPSAL SPLPPQADLD
160 170 180 190 200
GPPGAGKQGI PQPLSGPCRR GWLRGAAASR RLQQRRGSQP ETRTGDDDPH
210 220 230 240 250
RLLQQLVLSG NLIKEAVRRL HSRRLQLRAK LPQRPLLGPL SAPVHEPPSP
260 270
RSPRAACSDP GASGRAQLRT GDGVLVPGS
Length:279
Mass (Da):29,093
Last modified:August 16, 2004 - v3
Checksum:i629AFD6CEA1DC0BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58H → D in AAB97096 (PubMed:9034327).Curated1
Sequence conflicti179S → P in AAH34476 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58975 mRNA Translation: AAB97096.2
AB074890 mRNA Translation: BAB86352.1
AL355490 Genomic DNA No translation available.
BC034476 mRNA Translation: AAH34476.1
CCDSiCCDS7455.1
RefSeqiNP_005470.2, NM_005479.3
UniGeneiHs.126057

Genome annotation databases

EnsembliENST00000371021; ENSP00000360060; ENSG00000165879
GeneIDi10023
KEGGihsa:10023
UCSCiuc001knc.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58975 mRNA Translation: AAB97096.2
AB074890 mRNA Translation: BAB86352.1
AL355490 Genomic DNA No translation available.
BC034476 mRNA Translation: AAH34476.1
CCDSiCCDS7455.1
RefSeqiNP_005470.2, NM_005479.3
UniGeneiHs.126057

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GNGX-ray2.60X/Y188-226[»]
3ZRKX-ray2.37X/Y197-226[»]
3ZRLX-ray2.48X/Y197-226[»]
3ZRMX-ray2.49X/Y197-226[»]
4AFJX-ray1.98X/Y197-226[»]
5OY4X-ray3.20X/Y1-279[»]
ProteinModelPortaliQ92837
SMRiQ92837
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115340, 17 interactors
ComplexPortaliCPX-459 Nuclear export complex FRAT1-GSK3B
IntActiQ92837, 19 interactors
STRINGi9606.ENSP00000360060

PTM databases

iPTMnetiQ92837
PhosphoSitePlusiQ92837

Polymorphism and mutation databases

BioMutaiFRAT1
DMDMi51338813

Proteomic databases

PaxDbiQ92837
PeptideAtlasiQ92837
PRIDEiQ92837
ProteomicsDBi75521

Protocols and materials databases

DNASUi10023
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371021; ENSP00000360060; ENSG00000165879
GeneIDi10023
KEGGihsa:10023
UCSCiuc001knc.2 human

Organism-specific databases

CTDi10023
DisGeNETi10023
EuPathDBiHostDB:ENSG00000165879.8
GeneCardsiFRAT1
HGNCiHGNC:3944 FRAT1
HPAiCAB046472
HPA055258
MIMi602503 gene
neXtProtiNX_Q92837
OpenTargetsiENSG00000165879
PharmGKBiPA28361
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX6F Eukaryota
ENOG41119TC LUCA
GeneTreeiENSGT00390000007081
HOGENOMiHOG000112642
HOVERGENiHBG051660
InParanoidiQ92837
KOiK03069
OMAiWYLAANT
OrthoDBiEOG091G0PDL
PhylomeDBiQ92837
TreeFamiTF330804

Enzyme and pathway databases

ReactomeiR-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
SignaLinkiQ92837
SIGNORiQ92837

Miscellaneous databases

ChiTaRSiFRAT1 human
EvolutionaryTraceiQ92837
GeneWikiiFRAT1
GenomeRNAii10023
PROiPR:Q92837
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165879 Expressed in 187 organ(s), highest expression level in blood
CleanExiHS_FRAT1
GenevisibleiQ92837 HS

Family and domain databases

InterProiView protein in InterPro
IPR008014 GSK3-bd
PANTHERiPTHR35154 PTHR35154, 1 hit
PfamiView protein in Pfam
PF05350 GSK-3_bind, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRAT1_HUMAN
AccessioniPrimary (citable) accession number: Q92837
Secondary accession number(s): Q5JTI1, Q8NE74, Q8TDW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 16, 2004
Last modified: September 12, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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