UniProtKB - Q92837 (FRAT1_HUMAN)
Protein
Proto-oncogene FRAT1
Gene
FRAT1
Organism
Homo sapiens (Human)
Status
Functioni
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.1 Publication
GO - Biological processi
- beta-catenin destruction complex disassembly Source: Reactome
- canonical Wnt signaling pathway Source: WormBase
- positive regulation of canonical Wnt signaling pathway Source: WormBase
Keywordsi
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q92837 |
Reactomei | R-HSA-196299, Beta-catenin phosphorylation cascade R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane |
SignaLinki | Q92837 |
SIGNORi | Q92837 |
Names & Taxonomyi
Protein namesi | Recommended name: Proto-oncogene FRAT1Alternative name(s): Frequently rearranged in advanced T-cell lymphomas 1 Short name: FRAT-1 |
Gene namesi | Name:FRAT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165879.8 |
HGNCi | HGNC:3944, FRAT1 |
MIMi | 602503, gene |
neXtProti | NX_Q92837 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: HPA
Other locations
- cytoplasm Source: WormBase
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 10023 |
OpenTargetsi | ENSG00000165879 |
PharmGKBi | PA28361 |
Miscellaneous databases
Pharosi | Q92837, Tbio |
Polymorphism and mutation databases
BioMutai | FRAT1 |
DMDMi | 51338813 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087332 | 1 – 279 | Proto-oncogene FRAT1Add BLAST | 279 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 88 | PhosphoserineCombined sources | 1 | |
Modified residuei | 249 | PhosphoserineBy similarity | 1 | |
Modified residuei | 252 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q92837 |
PaxDbi | Q92837 |
PeptideAtlasi | Q92837 |
PRIDEi | Q92837 |
ProteomicsDBi | 75521 |
PTM databases
iPTMneti | Q92837 |
PhosphoSitePlusi | Q92837 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165879, Expressed in blood and 201 other tissues |
Genevisiblei | Q92837, HS |
Organism-specific databases
HPAi | ENSG00000165879, Low tissue specificity |
Interactioni
Subunit structurei
Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation.
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 115340, 17 interactors |
ComplexPortali | CPX-459, Nuclear export complex FRAT1-GSK3B |
IntActi | Q92837, 19 interactors |
STRINGi | 9606.ENSP00000360060 |
Miscellaneous databases
RNActi | Q92837, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q92837 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92837 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 198 – 220 | Involved in GSK-3 bindingAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 6 – 22 | Glu-rich (highly acidic)Add BLAST | 17 | |
Compositional biasi | 6 – 10 | Poly-Glu | 5 | |
Compositional biasi | 13 – 22 | Poly-Glu | 10 |
Sequence similaritiesi
Belongs to the GSK-3-binding protein family.Curated
Phylogenomic databases
eggNOGi | ENOG502T09T, Eukaryota |
GeneTreei | ENSGT00390000007081 |
HOGENOMi | CLU_101225_1_0_1 |
InParanoidi | Q92837 |
OMAi | PCRQHPE |
OrthoDBi | 1477860at2759 |
PhylomeDBi | Q92837 |
TreeFami | TF330804 |
Family and domain databases
IDEALi | IID00093 |
InterProi | View protein in InterPro IPR008014, GSK3-bd |
PANTHERi | PTHR35154, PTHR35154, 1 hit |
Pfami | View protein in Pfam PF05350, GSK-3_bind, 1 hit |
i Sequence
Sequence statusi: Complete.
Q92837-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPCRREEEEE AGEEAEGEEE EEDSFLLLQQ SVALGSSGEV DRLVAQIGET
60 70 80 90 100
LQLDAAQHSP ASPCGPPGAP LRAPGPLAAA VPADKARSPA VPLLLPPALA
110 120 130 140 150
ETVGPAPPGV LRCALGDRGR VRGRAAPYCV AELATGPSAL SPLPPQADLD
160 170 180 190 200
GPPGAGKQGI PQPLSGPCRR GWLRGAAASR RLQQRRGSQP ETRTGDDDPH
210 220 230 240 250
RLLQQLVLSG NLIKEAVRRL HSRRLQLRAK LPQRPLLGPL SAPVHEPPSP
260 270
RSPRAACSDP GASGRAQLRT GDGVLVPGS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 58 | H → D in AAB97096 (PubMed:9034327).Curated | 1 | |
Sequence conflicti | 179 | S → P in AAH34476 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U58975 mRNA Translation: AAB97096.2 AB074890 mRNA Translation: BAB86352.1 AL355490 Genomic DNA No translation available. BC034476 mRNA Translation: AAH34476.1 |
CCDSi | CCDS7455.1 |
RefSeqi | NP_005470.2, NM_005479.3 |
Genome annotation databases
Ensembli | ENST00000371021; ENSP00000360060; ENSG00000165879 |
GeneIDi | 10023 |
KEGGi | hsa:10023 |
UCSCi | uc001knc.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U58975 mRNA Translation: AAB97096.2 AB074890 mRNA Translation: BAB86352.1 AL355490 Genomic DNA No translation available. BC034476 mRNA Translation: AAH34476.1 |
CCDSi | CCDS7455.1 |
RefSeqi | NP_005470.2, NM_005479.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GNG | X-ray | 2.60 | X/Y | 188-226 | [»] | |
3ZRK | X-ray | 2.37 | X/Y | 197-226 | [»] | |
3ZRL | X-ray | 2.48 | X/Y | 197-226 | [»] | |
3ZRM | X-ray | 2.49 | X/Y | 197-226 | [»] | |
4AFJ | X-ray | 1.98 | X/Y | 197-226 | [»] | |
5OY4 | X-ray | 3.20 | X/Y | 1-279 | [»] | |
SMRi | Q92837 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115340, 17 interactors |
ComplexPortali | CPX-459, Nuclear export complex FRAT1-GSK3B |
IntActi | Q92837, 19 interactors |
STRINGi | 9606.ENSP00000360060 |
PTM databases
iPTMneti | Q92837 |
PhosphoSitePlusi | Q92837 |
Polymorphism and mutation databases
BioMutai | FRAT1 |
DMDMi | 51338813 |
Proteomic databases
MassIVEi | Q92837 |
PaxDbi | Q92837 |
PeptideAtlasi | Q92837 |
PRIDEi | Q92837 |
ProteomicsDBi | 75521 |
Protocols and materials databases
Antibodypediai | 30839, 112 antibodies |
DNASUi | 10023 |
Genome annotation databases
Ensembli | ENST00000371021; ENSP00000360060; ENSG00000165879 |
GeneIDi | 10023 |
KEGGi | hsa:10023 |
UCSCi | uc001knc.2, human |
Organism-specific databases
CTDi | 10023 |
DisGeNETi | 10023 |
EuPathDBi | HostDB:ENSG00000165879.8 |
GeneCardsi | FRAT1 |
HGNCi | HGNC:3944, FRAT1 |
HPAi | ENSG00000165879, Low tissue specificity |
MIMi | 602503, gene |
neXtProti | NX_Q92837 |
OpenTargetsi | ENSG00000165879 |
PharmGKBi | PA28361 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502T09T, Eukaryota |
GeneTreei | ENSGT00390000007081 |
HOGENOMi | CLU_101225_1_0_1 |
InParanoidi | Q92837 |
OMAi | PCRQHPE |
OrthoDBi | 1477860at2759 |
PhylomeDBi | Q92837 |
TreeFami | TF330804 |
Enzyme and pathway databases
PathwayCommonsi | Q92837 |
Reactomei | R-HSA-196299, Beta-catenin phosphorylation cascade R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane |
SignaLinki | Q92837 |
SIGNORi | Q92837 |
Miscellaneous databases
BioGRID-ORCSi | 10023, 9 hits in 843 CRISPR screens |
ChiTaRSi | FRAT1, human |
EvolutionaryTracei | Q92837 |
GeneWikii | FRAT1 |
GenomeRNAii | 10023 |
Pharosi | Q92837, Tbio |
PROi | PR:Q92837 |
RNActi | Q92837, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165879, Expressed in blood and 201 other tissues |
Genevisiblei | Q92837, HS |
Family and domain databases
IDEALi | IID00093 |
InterProi | View protein in InterPro IPR008014, GSK3-bd |
PANTHERi | PTHR35154, PTHR35154, 1 hit |
Pfami | View protein in Pfam PF05350, GSK-3_bind, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FRAT1_HUMAN | |
Accessioni | Q92837Primary (citable) accession number: Q92837 Secondary accession number(s): Q5JTI1, Q8NE74, Q8TDW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | August 16, 2004 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM