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Entry version 166 (08 May 2019)
Sequence version 2 (15 Mar 2005)
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Protein

Protein Jumonji

Gene

JARID2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, Repressor
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-212300 PRC2 methylates histones and DNA

SIGNOR Signaling Network Open Resource

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SIGNORi
Q92833

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Jumonji
Alternative name(s):
Jumonji/ARID domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JARID2
Synonyms:JMJ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6196 JARID2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601594 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q92833

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
3720

Open Targets

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OpenTargetsi
ENSG00000008083

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29995

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
JARID2

Domain mapping of disease mutations (DMDM)

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DMDMi
61252601

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002005911 – 1246Protein JumonjiAdd BLAST1246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78PhosphoserineCombined sources1
Modified residuei378N6-acetyllysineCombined sources1
Modified residuei455PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q92833

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q92833

MaxQB - The MaxQuant DataBase

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MaxQBi
Q92833

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q92833

PeptideAtlas

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PeptideAtlasi
Q92833

PRoteomics IDEntifications database

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PRIDEi
Q92833

ProteomicsDB human proteome resource

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ProteomicsDBi
75511
75512 [Q92833-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q92833

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q92833

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000008083 Expressed in 238 organ(s), highest expression level in secondary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92833 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB069890
HPA063889

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with a histone methyltransferase complex containing GLP1/EHMT1 and G9a/EHMT2. Interacts with SUZ12; the interaction is direct. Interacts with GATA4 (via the N-terminal region). Interacts with NKX2-5 (via the C-terminal region). Interacts with RB1. Interacts with ZNF496 (By similarity). Associates with the PRC2 complex, which includes EED, EZH1, EZH2, SUZ12, RBBP4 and AEBP2; JARID2 is probably not a core component of the PRC2 complex and associates to PRC2 via its interaction with SUZ12. Interacts with ESRRB (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109923, 27 interactors

Database of interacting proteins

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DIPi
DIP-45494N

Protein interaction database and analysis system

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IntActi
Q92833, 24 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000341280

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HYNX-ray2.95E/J/P/U110-121[»]
5LS6X-ray3.47Q/R/S/T110-120[»]
6C23electron microscopy3.90B/E106-450[»]
6C24electron microscopy3.50B/E106-450[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92833

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini557 – 598JmjNPROSITE-ProRule annotationAdd BLAST42
Domaini621 – 713ARIDPROSITE-ProRule annotationAdd BLAST93
Domaini884 – 1048JmjCPROSITE-ProRule annotationAdd BLAST165

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi104 – 110Nuclear localization signalBy similarity7
Motifi874 – 878GSGFP motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1234 – 1246Poly-SerAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ARID domain is required to target the PRC2 complex to its target genes.By similarity
The GSGFP motif is required for the interaction with SUZ12.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ISPM Eukaryota
ENOG410YJEB LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159220

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000013203

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92833

KEGG Orthology (KO)

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KOi
K11478

Identification of Orthologs from Complete Genome Data

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OMAi
MCFNKEP

Database of Orthologous Groups

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OrthoDBi
664180at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q92833

TreeFam database of animal gene trees

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TreeFami
TF323264

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR003347 JmjC_dom
IPR003349 JmjN
IPR004198 Znf_C5HC2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01388 ARID, 1 hit
PF02373 JmjC, 1 hit
PF02375 JmjN, 1 hit
PF02928 zf-C5HC2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00501 BRIGHT, 1 hit
SM00558 JmjC, 1 hit
SM00545 JmjN, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46774 SSF46774, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51011 ARID, 1 hit
PS51184 JMJC, 1 hit
PS51183 JMJN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q92833-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKERPKRNI IQKKYDDSDG IPWSEERVVR KVLYLSLKEF KNSQKRQHAE
60 70 80 90 100
GIAGSLKTVN GLLGNDQSKG LGPASEQSEN EKDDASQVSS TSNDVSSSDF
110 120 130 140 150
EEGPSRKRPR LQAQRKFAQS QPNSPSTTPV KIVEPLLPPP ATQISDLSKR
160 170 180 190 200
KPKTEDFLTF LCLRGSPALP NSMVYFGSSQ DEEEVEEEDD ETEDVKTATN
210 220 230 240 250
NASSSCQSTP RKGKTHKHVH NGHVFNGSSR STREKEPVQK HKSKEATPAK
260 270 280 290 300
EKHSDHRADS RREQASANHP AAAPSTGSSA KGLAATHHHP PLHRSAQDLR
310 320 330 340 350
KQVSKVNGVT RMSSLGAGVT SAKKMREVRP SPSKTVKYTA TVTKGAVTYT
360 370 380 390 400
KAKRELVKDT KPNHHKPSSA VNHTISGKTE SSNAKTRKQV LSLGGASKST
410 420 430 440 450
GPAVNGLKVS GRLNPKSCTK EVGGRQLREG LQLREGLRNS KRRLEEAHQA
460 470 480 490 500
EKPQSPPKKM KGAAGPAEGP GKKAPAERGL LNGHVKKEVP ERSLERNRPK
510 520 530 540 550
RATAGKSTPG RQAHGKADSA SCENRSTSQP ESVHKPQDSG KAEKGGGKAG
560 570 580 590 600
WAAMDEIPVL RPSAKEFHDP LIYIESVRAQ VEKFGMCRVI PPPDWRPECK
610 620 630 640 650
LNDEMRFVTQ IQHIHKLGRR WGPNVQRLAC IKKHLKSQGI TMDELPLIGG
660 670 680 690 700
CELDLACFFR LINEMGGMQQ VTDLKKWNKL ADMLRIPRTA QDRLAKLQEA
710 720 730 740 750
YCQYLLSYDS LSPEEHRRLE KEVLMEKEIL EKRKGPLEGH TENDHHKFHP
760 770 780 790 800
LPRFEPKNGL IHGVAPRNGF RSKLKEVGQA QLKTGRRRLF AQEKEVVKEE
810 820 830 840 850
EEDKGVLNDF HKCIYKGRSV SLTTFYRTAR NIMSMCFSKE PAPAEIEQEY
860 870 880 890 900
WRLVEEKDCH VAVHCGKVDT NTHGSGFPVG KSEPFSRHGW NLTVLPNNTG
910 920 930 940 950
SILRHLGAVP GVTIPWLNIG MVFSTSCWSR DQNHLPYIDY LHTGADCIWY
960 970 980 990 1000
CIPAEEENKL EDVVHTLLQA NGTPGLQMLE SNVMISPEVL CKEGIKVHRT
1010 1020 1030 1040 1050
VQQSGQFVVC FPGSFVSKVC CGYSVSETVH FATTQWTSMG FETAKEMKRR
1060 1070 1080 1090 1100
HIAKPFSMEK LLYQIAQAEA KKENGPTLST ISALLDELRD TELRQRRQLF
1110 1120 1130 1140 1150
EAGLHSSARY GSHDGSSTVA DGKKKPRKWL QLETSERRCQ ICQHLCYLSM
1160 1170 1180 1190 1200
VVQENENVVF CLECALRHVE KQKSCRGLKL MYRYDEEQII SLVNQICGKV
1210 1220 1230 1240
SGKNGSIENC LSKPTPKRGP RKRATVDVPP SRLSASSSSK SASSSS
Length:1,246
Mass (Da):138,734
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4929984259110DB
GO
Isoform 2 (identifier: Q92833-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MSKERPKRNI...GIAGSLKTVN → MAAPRVCQVQFLVAYLEEPGIE
     949-1246: WYCIPAEEEN...SSSKSASSSS → CLSVEPVFPH...AWRGVLGPRL

Note: No experimental confirmation available.
Show »
Length:960
Mass (Da):106,139
Checksum:i985C77D3B34F699B
GO
Isoform 3 (identifier: Q92833-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.

Note: No experimental confirmation available.
Show »
Length:1,074
Mass (Da):119,689
Checksum:iA913DFCF25573C4A
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50822 differs from that shown. Reason: Frameshift at position 1233.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti250K → E in BAH13011 (PubMed:14702039).Curated1
Sequence conflicti599C → S in BAH13011 (PubMed:14702039).Curated1
Sequence conflicti673D → E in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti681A → S in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti688R → K in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti692D → E in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti705L → I in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti754F → L in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti1212S → H in AAC50822 (PubMed:8894700).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0450411 – 172Missing in isoform 3. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_0387561 – 60MSKER…LKTVN → MAAPRVCQVQFLVAYLEEPG IE in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_038757949 – 1246WYCIP…ASSSS → CLSVEPVFPHLSVAVGSIVD LGISFLPCGDTRVMYPVESV AWRGVLGPRL in isoform 2. 1 PublicationAdd BLAST298

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U57592 mRNA Translation: AAC50822.1 Frameshift.
AK292861 mRNA Translation: BAF85550.1
AK299349 mRNA Translation: BAH13011.1
AK303610 mRNA Translation: BAH13996.1
AL021938 Genomic DNA No translation available.
AL136162 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55357.1
BC046184 mRNA Translation: AAH46184.1
BC046246 mRNA Translation: AAH46246.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4533.1 [Q92833-1]
CCDS58996.1 [Q92833-3]

NCBI Reference Sequences

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RefSeqi
NP_001253969.1, NM_001267040.1 [Q92833-3]
NP_004964.2, NM_004973.3 [Q92833-1]
XP_005249146.1, XM_005249089.3
XP_016866323.1, XM_017010834.1 [Q92833-3]
XP_016866324.1, XM_017010835.1 [Q92833-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000341776; ENSP00000341280; ENSG00000008083 [Q92833-1]
ENST00000397311; ENSP00000380478; ENSG00000008083 [Q92833-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3720

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3720

UCSC genome browser

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UCSCi
uc003nbj.5 human [Q92833-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57592 mRNA Translation: AAC50822.1 Frameshift.
AK292861 mRNA Translation: BAF85550.1
AK299349 mRNA Translation: BAH13011.1
AK303610 mRNA Translation: BAH13996.1
AL021938 Genomic DNA No translation available.
AL136162 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55357.1
BC046184 mRNA Translation: AAH46184.1
BC046246 mRNA Translation: AAH46246.1
CCDSiCCDS4533.1 [Q92833-1]
CCDS58996.1 [Q92833-3]
RefSeqiNP_001253969.1, NM_001267040.1 [Q92833-3]
NP_004964.2, NM_004973.3 [Q92833-1]
XP_005249146.1, XM_005249089.3
XP_016866323.1, XM_017010834.1 [Q92833-3]
XP_016866324.1, XM_017010835.1 [Q92833-3]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HYNX-ray2.95E/J/P/U110-121[»]
5LS6X-ray3.47Q/R/S/T110-120[»]
6C23electron microscopy3.90B/E106-450[»]
6C24electron microscopy3.50B/E106-450[»]
SMRiQ92833
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109923, 27 interactors
DIPiDIP-45494N
IntActiQ92833, 24 interactors
STRINGi9606.ENSP00000341280

PTM databases

iPTMnetiQ92833
PhosphoSitePlusiQ92833

Polymorphism and mutation databases

BioMutaiJARID2
DMDMi61252601

Proteomic databases

EPDiQ92833
jPOSTiQ92833
MaxQBiQ92833
PaxDbiQ92833
PeptideAtlasiQ92833
PRIDEiQ92833
ProteomicsDBi75511
75512 [Q92833-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341776; ENSP00000341280; ENSG00000008083 [Q92833-1]
ENST00000397311; ENSP00000380478; ENSG00000008083 [Q92833-3]
GeneIDi3720
KEGGihsa:3720
UCSCiuc003nbj.5 human [Q92833-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3720
DisGeNETi3720

GeneCards: human genes, protein and diseases

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GeneCardsi
JARID2
HGNCiHGNC:6196 JARID2
HPAiCAB069890
HPA063889
MIMi601594 gene
neXtProtiNX_Q92833
OpenTargetsiENSG00000008083
PharmGKBiPA29995

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISPM Eukaryota
ENOG410YJEB LUCA
GeneTreeiENSGT00940000159220
HOGENOMiHOG000013203
InParanoidiQ92833
KOiK11478
OMAiMCFNKEP
OrthoDBi664180at2759
PhylomeDBiQ92833
TreeFamiTF323264

Enzyme and pathway databases

ReactomeiR-HSA-212300 PRC2 methylates histones and DNA
SIGNORiQ92833

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
JARID2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
JARID2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3720

Protein Ontology

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PROi
PR:Q92833

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000008083 Expressed in 238 organ(s), highest expression level in secondary oocyte
GenevisibleiQ92833 HS

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR003347 JmjC_dom
IPR003349 JmjN
IPR004198 Znf_C5HC2
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF02373 JmjC, 1 hit
PF02375 JmjN, 1 hit
PF02928 zf-C5HC2, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SM00558 JmjC, 1 hit
SM00545 JmjN, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
PS51184 JMJC, 1 hit
PS51183 JMJN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJARD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92833
Secondary accession number(s): A8K9Z6
, B7Z5S5, B7Z8L0, Q5U5L5, Q86X63
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 15, 2005
Last modified: May 8, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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