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UniProtKB - Q92833 (JARD2_HUMAN)

Entry version 184 (25 May 2022)
Sequence version 2 (15 Mar 2005)
Previous versions | rss
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Protein

Protein Jumonji

Gene

JARID2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857).

Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557).

Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857).

In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity).

Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity).

Participates in the negative regulation of cell proliferation signaling (By similarity).

Does not have histone demethylase activity (By similarity).

By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, Repressor
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92833

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212300, PRC2 methylates histones and DNA

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q92833

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92833

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Jumonji
Alternative name(s):
Jumonji/ARID domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JARID2
Synonyms:JMJ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6196, JARID2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601594, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92833

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000008083

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi149 – 150KR → DE or AA: Abolishes nucleosome binding activity of a minimal SUZ12-RBBP4-AEBP2-JARID2 PRC2 complex. 1 Publication2
Mutagenesisi151 – 153KPK → EPE or APA: Abolishes nucleosome binding activity of a minimal SUZ12-RBBP4-AEBP2-JARID2 PRC2 complex. 1 Publication3

Organism-specific databases

DisGeNET

More...DisGeNETi		3720

Open Targets

More...OpenTargetsi		ENSG00000008083

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		528084, Non-specific syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29995

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92833, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		JARID2

Domain mapping of disease mutations (DMDM)

More...DMDMi		61252601

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002005911 – 1246Protein JumonjiAdd BLAST1246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78PhosphoserineCombined sources1
Modified residuei378N6-acetyllysineCombined sources1
Modified residuei455PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92833

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92833

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92833

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92833

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92833

PeptideAtlas

More...PeptideAtlasi		Q92833

PRoteomics IDEntifications database

More...PRIDEi		Q92833

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		6958
75511 [Q92833-1]
75512 [Q92833-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92833

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92833

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000008083, Expressed in secondary oocyte and 250 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92833, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000008083, Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:29499137, PubMed:31959557).

Found in a monomeric PRC2.2 (class 2) complex consisting of at least SUZ12, RBBP4, AEBP2 and JARID2 (PubMed:29499137). Faciliates nucleosome binding of the PRC2 complex (PubMed:29499137).

Interacts with SUZ12 (via C2H2-type zinc finger domain); the interaction is direct; competes with EPOP for SUZ12 binding (PubMed:29499137).

Interacts with histone methyltransferases EHMT1/GLP1 and EHMT2/G9a (By similarity).

Interacts with GATA4 (via the N-terminal region) (By similarity).

Interacts with NKX2-5 (via the C-terminal region) (By similarity).

Interacts with RB1 (By similarity).

Interacts with ZNF496 (By similarity).

Interacts with ESRRB (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109923, 37 interactors

Database of interacting proteins

More...DIPi		DIP-45494N

Protein interaction database and analysis system

More...IntActi		Q92833, 26 interactors

Molecular INTeraction database

More...MINTi		Q92833

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000341280

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92833, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q92833

Biological Magnetic Resonance Data Bank

More...BMRBi		Q92833

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92833

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini557 – 598JmjNPROSITE-ProRule annotationAdd BLAST42
Domaini621 – 713ARIDPROSITE-ProRule annotationAdd BLAST93
Domaini884 – 1048JmjCPROSITE-ProRule annotationAdd BLAST165

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni59 – 150DisorderedSequence analysisAdd BLAST92
Regioni141 – 170Sufficient for interaction with the PRC2 complex1 PublicationAdd BLAST30
Regioni169 – 299DisorderedSequence analysisAdd BLAST131
Regioni357 – 548DisorderedSequence analysisAdd BLAST192
Regioni1208 – 1246DisorderedSequence analysisAdd BLAST39

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi104 – 110Nuclear localization signalBy similarity7
Motifi874 – 878GSGFP motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi60 – 75Polar residuesSequence analysisAdd BLAST16
Compositional biasi84 – 99Polar residuesSequence analysisAdd BLAST16
Compositional biasi114 – 130Polar residuesSequence analysisAdd BLAST17
Compositional biasi180 – 194Acidic residuesSequence analysisAdd BLAST15
Compositional biasi229 – 264Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi367 – 399Polar residuesSequence analysisAdd BLAST33
Compositional biasi427 – 455Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi479 – 502Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi519 – 535Polar residuesSequence analysisAdd BLAST17
Compositional biasi1230 – 1246Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ARID domain is required to target the PRC2 complex to its target genes.By similarity
The GSGFP motif is required for the interaction with SUZ12.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1246, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159220

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007086_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92833

Identification of Orthologs from Complete Genome Data

More...OMAi		VFNGSNR

Database of Orthologous Groups

More...OrthoDBi		664180at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92833

TreeFam database of animal gene trees

More...TreeFami		TF323264

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR003347, JmjC_dom
IPR003349, JmjN
IPR004198, Znf_C5HC2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01388, ARID, 1 hit
PF02373, JmjC, 1 hit
PF02375, JmjN, 1 hit
PF02928, zf-C5HC2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00501, BRIGHT, 1 hit
SM00558, JmjC, 1 hit
SM00545, JmjN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46774, SSF46774, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51011, ARID, 1 hit
PS51184, JMJC, 1 hit
PS51183, JMJN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q92833-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKERPKRNI IQKKYDDSDG IPWSEERVVR KVLYLSLKEF KNSQKRQHAE 
        60         70         80         90        100
GIAGSLKTVN GLLGNDQSKG LGPASEQSEN EKDDASQVSS TSNDVSSSDF 
       110        120        130        140        150
EEGPSRKRPR LQAQRKFAQS QPNSPSTTPV KIVEPLLPPP ATQISDLSKR 
       160        170        180        190        200
KPKTEDFLTF LCLRGSPALP NSMVYFGSSQ DEEEVEEEDD ETEDVKTATN 
       210        220        230        240        250
NASSSCQSTP RKGKTHKHVH NGHVFNGSSR STREKEPVQK HKSKEATPAK 
       260        270        280        290        300
EKHSDHRADS RREQASANHP AAAPSTGSSA KGLAATHHHP PLHRSAQDLR 
       310        320        330        340        350
KQVSKVNGVT RMSSLGAGVT SAKKMREVRP SPSKTVKYTA TVTKGAVTYT 
       360        370        380        390        400
KAKRELVKDT KPNHHKPSSA VNHTISGKTE SSNAKTRKQV LSLGGASKST 
       410        420        430        440        450
GPAVNGLKVS GRLNPKSCTK EVGGRQLREG LQLREGLRNS KRRLEEAHQA 
       460        470        480        490        500
EKPQSPPKKM KGAAGPAEGP GKKAPAERGL LNGHVKKEVP ERSLERNRPK 
       510        520        530        540        550
RATAGKSTPG RQAHGKADSA SCENRSTSQP ESVHKPQDSG KAEKGGGKAG 
       560        570        580        590        600
WAAMDEIPVL RPSAKEFHDP LIYIESVRAQ VEKFGMCRVI PPPDWRPECK 
       610        620        630        640        650
LNDEMRFVTQ IQHIHKLGRR WGPNVQRLAC IKKHLKSQGI TMDELPLIGG 
       660        670        680        690        700
CELDLACFFR LINEMGGMQQ VTDLKKWNKL ADMLRIPRTA QDRLAKLQEA 
       710        720        730        740        750
YCQYLLSYDS LSPEEHRRLE KEVLMEKEIL EKRKGPLEGH TENDHHKFHP 
       760        770        780        790        800
LPRFEPKNGL IHGVAPRNGF RSKLKEVGQA QLKTGRRRLF AQEKEVVKEE 
       810        820        830        840        850
EEDKGVLNDF HKCIYKGRSV SLTTFYRTAR NIMSMCFSKE PAPAEIEQEY 
       860        870        880        890        900
WRLVEEKDCH VAVHCGKVDT NTHGSGFPVG KSEPFSRHGW NLTVLPNNTG 
       910        920        930        940        950
SILRHLGAVP GVTIPWLNIG MVFSTSCWSR DQNHLPYIDY LHTGADCIWY 
       960        970        980        990       1000
CIPAEEENKL EDVVHTLLQA NGTPGLQMLE SNVMISPEVL CKEGIKVHRT 
      1010       1020       1030       1040       1050
VQQSGQFVVC FPGSFVSKVC CGYSVSETVH FATTQWTSMG FETAKEMKRR 
      1060       1070       1080       1090       1100
HIAKPFSMEK LLYQIAQAEA KKENGPTLST ISALLDELRD TELRQRRQLF 
      1110       1120       1130       1140       1150
EAGLHSSARY GSHDGSSTVA DGKKKPRKWL QLETSERRCQ ICQHLCYLSM 
      1160       1170       1180       1190       1200
VVQENENVVF CLECALRHVE KQKSCRGLKL MYRYDEEQII SLVNQICGKV 
      1210       1220       1230       1240 
SGKNGSIENC LSKPTPKRGP RKRATVDVPP SRLSASSSSK SASSSS
Length:1,246
Mass (Da):138,734
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4929984259110DB
GO
Isoform 2 (identifier: Q92833-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MSKERPKRNI...GIAGSLKTVN → MAAPRVCQVQFLVAYLEEPGIE
     949-1246: WYCIPAEEEN...SSSKSASSSS → CLSVEPVFPH...AWRGVLGPRL

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Length:960
Mass (Da):106,139
Checksum:i985C77D3B34F699B
GO
Isoform 3 (identifier: Q92833-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.

Show »
Length:1,074
Mass (Da):119,689
Checksum:iA913DFCF25573C4A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50822 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti250K → E in BAH13011 (PubMed:14702039).Curated1
Sequence conflicti599C → S in BAH13011 (PubMed:14702039).Curated1
Sequence conflicti673D → E in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti681A → S in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti688R → K in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti692D → E in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti705L → I in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti754F → L in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti1212S → H in AAC50822 (PubMed:8894700).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0450411 – 172Missing in isoform 3. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_0387561 – 60MSKER…LKTVN → MAAPRVCQVQFLVAYLEEPG IE in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_038757949 – 1246WYCIP…ASSSS → CLSVEPVFPHLSVAVGSIVD LGISFLPCGDTRVMYPVESV AWRGVLGPRL in isoform 2. 1 PublicationAdd BLAST298

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U57592 mRNA Translation: AAC50822.1 Frameshift.
AK292861 mRNA Translation: BAF85550.1
AK299349 mRNA Translation: BAH13011.1
AK303610 mRNA Translation: BAH13996.1
AL021938 Genomic DNA No translation available.
AL136162 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55357.1
BC046184 mRNA Translation: AAH46184.1
BC046246 mRNA Translation: AAH46246.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4533.1 [Q92833-1]
CCDS58996.1 [Q92833-3]

NCBI Reference Sequences

More...RefSeqi		NP_001253969.1, NM_001267040.1 [Q92833-3]
NP_004964.2, NM_004973.3 [Q92833-1]
XP_005249146.1, XM_005249089.3
XP_016866323.1, XM_017010834.1 [Q92833-3]
XP_016866324.1, XM_017010835.1 [Q92833-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341776.7; ENSP00000341280.2; ENSG00000008083.14
ENST00000397311.4; ENSP00000380478.3; ENSG00000008083.14 [Q92833-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3720

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000341776.7; ENSP00000341280.2; NM_004973.4; NP_004964.2

UCSC genome browser

More...UCSCi		uc003nbj.5, human [Q92833-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57592 mRNA Translation: AAC50822.1 Frameshift.
AK292861 mRNA Translation: BAF85550.1
AK299349 mRNA Translation: BAH13011.1
AK303610 mRNA Translation: BAH13996.1
AL021938 Genomic DNA No translation available.
AL136162 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55357.1
BC046184 mRNA Translation: AAH46184.1
BC046246 mRNA Translation: AAH46246.1
CCDSiCCDS4533.1 [Q92833-1]
CCDS58996.1 [Q92833-3]
RefSeqiNP_001253969.1, NM_001267040.1 [Q92833-3]
NP_004964.2, NM_004973.3 [Q92833-1]
XP_005249146.1, XM_005249089.3
XP_016866323.1, XM_017010834.1 [Q92833-3]
XP_016866324.1, XM_017010835.1 [Q92833-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HYNX-ray2.95E/J/P/U110-121[»]
5LS6X-ray3.47Q/R/S/T110-120[»]
5WAIX-ray2.90D/H147-165[»]
6C23electron microscopy3.90B/E106-450[»]
6C24electron microscopy3.50B/E106-450[»]
6NQ3X-ray2.89D/H147-165[»]
6WKRelectron microscopy3.50B/E1-450[»]
7KSOelectron microscopy3.90F1-1246[»]
AlphaFoldDBiQ92833
BMRBiQ92833
SMRiQ92833
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109923, 37 interactors
DIPiDIP-45494N
IntActiQ92833, 26 interactors
MINTiQ92833
STRINGi9606.ENSP00000341280

PTM databases

iPTMnetiQ92833
PhosphoSitePlusiQ92833

Genetic variation databases

BioMutaiJARID2
DMDMi61252601

Proteomic databases

EPDiQ92833
jPOSTiQ92833
MassIVEiQ92833
MaxQBiQ92833
PaxDbiQ92833
PeptideAtlasiQ92833
PRIDEiQ92833
ProteomicsDBi6958
75511 [Q92833-1]
75512 [Q92833-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25028, 238 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		3720

Genome annotation databases

EnsembliENST00000341776.7; ENSP00000341280.2; ENSG00000008083.14
ENST00000397311.4; ENSP00000380478.3; ENSG00000008083.14 [Q92833-3]
GeneIDi3720
KEGGihsa:3720
MANE-SelectiENST00000341776.7; ENSP00000341280.2; NM_004973.4; NP_004964.2
UCSCiuc003nbj.5, human [Q92833-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3720
DisGeNETi3720

GeneCards: human genes, protein and diseases

More...GeneCardsi		JARID2
HGNCiHGNC:6196, JARID2
HPAiENSG00000008083, Tissue enhanced (bone)
MIMi601594, gene
neXtProtiNX_Q92833
OpenTargetsiENSG00000008083
Orphaneti528084, Non-specific syndromic intellectual disability
PharmGKBiPA29995
VEuPathDBiHostDB:ENSG00000008083

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1246, Eukaryota
GeneTreeiENSGT00940000159220
HOGENOMiCLU_007086_0_0_1
InParanoidiQ92833
OMAiVFNGSNR
OrthoDBi664180at2759
PhylomeDBiQ92833
TreeFamiTF323264

Enzyme and pathway databases

PathwayCommonsiQ92833
ReactomeiR-HSA-212300, PRC2 methylates histones and DNA
SignaLinkiQ92833
SIGNORiQ92833

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3720, 18 hits in 1115 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		JARID2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		JARID2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3720
PharosiQ92833, Tbio

Protein Ontology

More...PROi		PR:Q92833
RNActiQ92833, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000008083, Expressed in secondary oocyte and 250 other tissues
GenevisibleiQ92833, HS

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR003347, JmjC_dom
IPR003349, JmjN
IPR004198, Znf_C5HC2
PfamiView protein in Pfam
PF01388, ARID, 1 hit
PF02373, JmjC, 1 hit
PF02375, JmjN, 1 hit
PF02928, zf-C5HC2, 1 hit
SMARTiView protein in SMART
SM00501, BRIGHT, 1 hit
SM00558, JmjC, 1 hit
SM00545, JmjN, 1 hit
SUPFAMiSSF46774, SSF46774, 1 hit
PROSITEiView protein in PROSITE
PS51011, ARID, 1 hit
PS51184, JMJC, 1 hit
PS51183, JMJN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJARD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92833
Secondary accession number(s): A8K9Z6
, B7Z5S5, B7Z8L0, Q5U5L5, Q86X63
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 15, 2005
Last modified: May 25, 2022
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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