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Entry version 204 (13 Feb 2019)
Sequence version 3 (10 May 2005)
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Protein

Histone acetyltransferase KAT2B

Gene

KAT2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4 and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Also acetylates spermidine (PubMed:27389534).8 Publications
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated in vitro by very low concentrations of spermidine, but inhibited at spermidine concentrations higher than 4 µM. The activating effect of low spermidine concentrations may be mediated by N8-acetylspermidine produced by KAT2B/P/CAF itself acting as a positive feedback loop.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.74 µM for acetyl-CoA1 Publication
  2. KM=2.29 µM for spermidine1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei570Proton donor/acceptor1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionActivator, Acyltransferase, Transferase
    Biological processBiological rhythms, Cell cycle, Host-virus interaction, Transcription, Transcription regulation

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.3.1.48 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1912408 Pre-NOTCH Transcription and Translation
    R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
    R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
    R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
    R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
    R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    R-HSA-3214847 HATs acetylate histones
    R-HSA-350054 Notch-HLH transcription pathway
    R-HSA-5250924 B-WICH complex positively regulates rRNA expression
    R-HSA-5578768 Physiological factors
    R-HSA-5689901 Metalloprotease DUBs
    R-HSA-73762 RNA Polymerase I Transcription Initiation
    R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
    R-HSA-8941856 RUNX3 regulates NOTCH signaling
    R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
    R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
    R-HSA-9018519 Estrogen-dependent gene expression
    R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q92831

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Histone acetyltransferase KAT2B (EC:2.3.1.481 Publication)
    Alternative name(s):
    Histone acetyltransferase PCAF1 Publication
    Short name:
    Histone acetylase PCAF1 Publication
    Lysine acetyltransferase 2B1 Publication
    P300/CBP-associated factor1 Publication
    Short name:
    P/CAF1 Publication
    Spermidine acetyltransferase KAT2B (EC:2.3.1.571 Publication)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:KAT2B1 PublicationImported
    Synonyms:PCAF1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000114166.7

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:8638 KAT2B

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    602303 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q92831

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Defects in KAT2B has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi752V → A: Reduced acetyl-lysine binding. 1 Publication1
    Mutagenesisi760Y → A: Reduced acetyl-lysine binding. 1 Publication1
    Mutagenesisi802Y → A: Reduced acetyl-lysine binding. 1 Publication1
    Mutagenesisi809Y → A: Complete loss of acetyl-lysine binding. 1 Publication1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    8850

    Open Targets

    More...
    OpenTargetsi
    ENSG00000114166

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162392705

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5500

    Drug and drug target database

    More...
    DrugBanki
    DB08186 (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
    DB01992 Coenzyme A
    DB08291 N-(3-AMINOPROPYL)-2-NITROBENZENAMINE

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2737

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    KAT2B

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    83287776

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002112081 – 832Histone acetyltransferase KAT2BAdd BLAST832

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q92831

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q92831

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q92831

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q92831

    PeptideAtlas

    More...
    PeptideAtlasi
    Q92831

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q92831

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    75508

    2D gel databases

    REPRODUCTION-2DPAGE

    More...
    REPRODUCTION-2DPAGEi
    Q92831

    PTM databases

    CarbonylDB database of protein carbonylation sites

    More...
    CarbonylDBi
    Q92831

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q92831

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q92831

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitously expressed but most abundant in heart and skeletal muscle.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000114166 Expressed in 230 organ(s), highest expression level in corpus callosum

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q92831 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB004526
    HPA055839

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with SIRT1. Interacts (unsumoylated form) with NR2C1; the interaction promotes transactivation activity (By similarity). Interacts with EP300, CREBBP and DDX17. Interacts with NCOA1 and NCOA3. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with MECOM. Interacts with E2F1; the interaction acetylates E2F1 augmenting its DNA-binding and transcriptional activity. Interacts with NPAS2, ARNTL/BMAL1 and CLOCK. Interacts with BCAS3. Interacts with CEBPB (PubMed:17301242). Interacts with NR4A3 (By similarity). Interacts with NFATC2 (By similarity). Interacts with TBX5 (PubMed:29174768). Interacts with PLK4 (PubMed:27796307).By similarity17 Publications
    (Microbial infection) Interacts with and acetylates HIV-1 Tat.1 Publication
    (Microbial infection) Interacts with HTLV-1 Tax.1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    114375, 193 interactors

    ComplexPortal: manually curated resource of macromolecular complexes

    More...
    ComplexPortali
    CPX-1004 PCAF-containing ATAC complex
    CPX-989 PCAF histone acetylase complex

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q92831

    Database of interacting proteins

    More...
    DIPi
    DIP-29778N

    Protein interaction database and analysis system

    More...
    IntActi
    Q92831, 40 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q92831

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000263754

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q92831

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1832
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1CM0X-ray2.30A/B493-658[»]
    1JM4NMR-B719-832[»]
    1N72NMR-A719-832[»]
    1WUGNMR-A719-832[»]
    1WUMNMR-A719-832[»]
    1ZS5NMR-A719-832[»]
    2RNWNMR-A719-832[»]
    2RNXNMR-A719-832[»]
    3GG3X-ray2.25A/B715-831[»]
    4NSQX-ray2.31A/B/C/D493-658[»]
    5FDZX-ray2.40A/B715-831[»]
    5FE0X-ray2.30A/B715-831[»]
    5FE1X-ray2.22A/B715-831[»]
    5FE2X-ray2.25A/B715-831[»]
    5FE3X-ray2.12A/B715-831[»]
    5FE4X-ray2.15A/B715-831[»]
    5FE5X-ray2.12A/B715-831[»]
    5FE6X-ray1.77A/B715-831[»]
    5FE7X-ray2.08A/B715-831[»]
    5FE8X-ray2.10A/B715-831[»]
    5FE9X-ray2.35A/B715-831[»]
    5LVQX-ray2.05A/B715-831[»]
    5LVRX-ray2.05A/B715-831[»]
    5MKXX-ray1.68A/B715-831[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q92831

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q92831

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q92831

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini503 – 651N-acetyltransferasePROSITE-ProRule annotationBy similarityAdd BLAST149
    Domaini740 – 810BromoPROSITE-ProRule annotationCuratedAdd BLAST71

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni574 – 576Acetyl-CoA binding1 Publication3
    Regioni581 – 587Acetyl-CoA binding1 Publication7
    Regioni612 – 615Acetyl-CoA binding1 Publication4

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    (Microbial infection) The bromodomain mediates binding to HIV-1 Tat.1 Publication

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Bromodomain

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1472 Eukaryota
    COG5076 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000154995

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000007151

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q92831

    KEGG Orthology (KO)

    More...
    KOi
    K06062

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    QVIRFPM

    Database of Orthologous Groups

    More...
    OrthoDBi
    349249at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q92831

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105399

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.20.920.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016181 Acyl_CoA_acyltransferase
    IPR001487 Bromodomain
    IPR036427 Bromodomain-like_sf
    IPR018359 Bromodomain_CS
    IPR037800 GCN5
    IPR016376 GCN5/PCAF
    IPR000182 GNAT_dom
    IPR009464 PCAF_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR22880:SF124 PTHR22880:SF124, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00583 Acetyltransf_1, 1 hit
    PF00439 Bromodomain, 1 hit
    PF06466 PCAF_N, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF003048 Histone_acetylase_PCAF, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00503 BROMODOMAIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00297 BROMO, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47370 SSF47370, 1 hit
    SSF55729 SSF55729, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00633 BROMODOMAIN_1, 1 hit
    PS50014 BROMODOMAIN_2, 1 hit
    PS51186 GNAT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q92831-1 [UniParc]FASTAAdd to basket
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    MSEAGGAGPG GCGAGAGAGA GPGALPPQPA ALPPAPPQGS PCAAAAGGSG
    60 70 80 90 100
    ACGPATAVAA AGTAEGPGGG GSARIAVKKA QLRSAPRAKK LEKLGVYSAC
    110 120 130 140 150
    KAEESCKCNG WKNPNPSPTP PRADLQQIIV SLTESCRSCS HALAAHVSHL
    160 170 180 190 200
    ENVSEEEMNR LLGIVLDVEY LFTCVHKEED ADTKQVYFYL FKLLRKSILQ
    210 220 230 240 250
    RGKPVVEGSL EKKPPFEKPS IEQGVNNFVQ YKFSHLPAKE RQTIVELAKM
    260 270 280 290 300
    FLNRINYWHL EAPSQRRLRS PNDDISGYKE NYTRWLCYCN VPQFCDSLPR
    310 320 330 340 350
    YETTQVFGRT LLRSVFTVMR RQLLEQARQE KDKLPLEKRT LILTHFPKFL
    360 370 380 390 400
    SMLEEEVYSQ NSPIWDQDFL SASSRTSQLG IQTVINPPPV AGTISYNSTS
    410 420 430 440 450
    SSLEQPNAGS SSPACKASSG LEANPGEKRK MTDSHVLEEA KKPRVMGDIP
    460 470 480 490 500
    MELINEVMST ITDPAAMLGP ETNFLSAHSA RDEAARLEER RGVIEFHVVG
    510 520 530 540 550
    NSLNQKPNKK ILMWLVGLQN VFSHQLPRMP KEYITRLVFD PKHKTLALIK
    560 570 580 590 600
    DGRVIGGICF RMFPSQGFTE IVFCAVTSNE QVKGYGTHLM NHLKEYHIKH
    610 620 630 640 650
    DILNFLTYAD EYAIGYFKKQ GFSKEIKIPK TKYVGYIKDY EGATLMGCEL
    660 670 680 690 700
    NPRIPYTEFS VIIKKQKEII KKLIERKQAQ IRKVYPGLSC FKDGVRQIPI
    710 720 730 740 750
    ESIPGIRETG WKPSGKEKSK EPRDPDQLYS TLKSILQQVK SHQSAWPFME
    760 770 780 790 800
    PVKRTEAPGY YEVIRFPMDL KTMSERLKNR YYVSKKLFMA DLQRVFTNCK
    810 820 830
    EYNPPESEYY KCANILEKFF FSKIKEAGLI DK
    Length:832
    Mass (Da):93,013
    Last modified:May 10, 2005 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72F516E8BC00CC0C
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti804 – 805PP → AA in AAC50890 (PubMed:8684459).Curated2

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079852130V → G Found in a patient with isolated coloboma; unknown pathological significance. 1 Publication1
    Natural variantiVAR_034372386N → S. Corresponds to variant dbSNP:rs17006625Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U57317 mRNA Translation: AAC50890.2
    BC060823 mRNA Translation: AAH60823.1
    BC070075 mRNA Translation: AAH70075.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS2634.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S71788

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_003875.3, NM_003884.4

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.533055

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000263754; ENSP00000263754; ENSG00000114166

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    8850

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:8850

    UCSC genome browser

    More...
    UCSCi
    uc003cbq.4 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U57317 mRNA Translation: AAC50890.2
    BC060823 mRNA Translation: AAH60823.1
    BC070075 mRNA Translation: AAH70075.1
    CCDSiCCDS2634.1
    PIRiS71788
    RefSeqiNP_003875.3, NM_003884.4
    UniGeneiHs.533055

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1CM0X-ray2.30A/B493-658[»]
    1JM4NMR-B719-832[»]
    1N72NMR-A719-832[»]
    1WUGNMR-A719-832[»]
    1WUMNMR-A719-832[»]
    1ZS5NMR-A719-832[»]
    2RNWNMR-A719-832[»]
    2RNXNMR-A719-832[»]
    3GG3X-ray2.25A/B715-831[»]
    4NSQX-ray2.31A/B/C/D493-658[»]
    5FDZX-ray2.40A/B715-831[»]
    5FE0X-ray2.30A/B715-831[»]
    5FE1X-ray2.22A/B715-831[»]
    5FE2X-ray2.25A/B715-831[»]
    5FE3X-ray2.12A/B715-831[»]
    5FE4X-ray2.15A/B715-831[»]
    5FE5X-ray2.12A/B715-831[»]
    5FE6X-ray1.77A/B715-831[»]
    5FE7X-ray2.08A/B715-831[»]
    5FE8X-ray2.10A/B715-831[»]
    5FE9X-ray2.35A/B715-831[»]
    5LVQX-ray2.05A/B715-831[»]
    5LVRX-ray2.05A/B715-831[»]
    5MKXX-ray1.68A/B715-831[»]
    ProteinModelPortaliQ92831
    SMRiQ92831
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi114375, 193 interactors
    ComplexPortaliCPX-1004 PCAF-containing ATAC complex
    CPX-989 PCAF histone acetylase complex
    CORUMiQ92831
    DIPiDIP-29778N
    IntActiQ92831, 40 interactors
    MINTiQ92831
    STRINGi9606.ENSP00000263754

    Chemistry databases

    BindingDBiQ92831
    ChEMBLiCHEMBL5500
    DrugBankiDB08186 (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
    DB01992 Coenzyme A
    DB08291 N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
    GuidetoPHARMACOLOGYi2737

    PTM databases

    CarbonylDBiQ92831
    iPTMnetiQ92831
    PhosphoSitePlusiQ92831

    Polymorphism and mutation databases

    BioMutaiKAT2B
    DMDMi83287776

    2D gel databases

    REPRODUCTION-2DPAGEiQ92831

    Proteomic databases

    EPDiQ92831
    jPOSTiQ92831
    MaxQBiQ92831
    PaxDbiQ92831
    PeptideAtlasiQ92831
    PRIDEiQ92831
    ProteomicsDBi75508

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000263754; ENSP00000263754; ENSG00000114166
    GeneIDi8850
    KEGGihsa:8850
    UCSCiuc003cbq.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    8850
    DisGeNETi8850
    EuPathDBiHostDB:ENSG00000114166.7

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    KAT2B
    HGNCiHGNC:8638 KAT2B
    HPAiCAB004526
    HPA055839
    MIMi602303 gene
    neXtProtiNX_Q92831
    OpenTargetsiENSG00000114166
    PharmGKBiPA162392705

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1472 Eukaryota
    COG5076 LUCA
    GeneTreeiENSGT00940000154995
    HOGENOMiHOG000007151
    InParanoidiQ92831
    KOiK06062
    OMAiQVIRFPM
    OrthoDBi349249at2759
    PhylomeDBiQ92831
    TreeFamiTF105399

    Enzyme and pathway databases

    BRENDAi2.3.1.48 2681
    ReactomeiR-HSA-1912408 Pre-NOTCH Transcription and Translation
    R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
    R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
    R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
    R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
    R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    R-HSA-3214847 HATs acetylate histones
    R-HSA-350054 Notch-HLH transcription pathway
    R-HSA-5250924 B-WICH complex positively regulates rRNA expression
    R-HSA-5578768 Physiological factors
    R-HSA-5689901 Metalloprotease DUBs
    R-HSA-73762 RNA Polymerase I Transcription Initiation
    R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
    R-HSA-8941856 RUNX3 regulates NOTCH signaling
    R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
    R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
    R-HSA-9018519 Estrogen-dependent gene expression
    R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation
    SIGNORiQ92831

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    KAT2B human
    EvolutionaryTraceiQ92831

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    PCAF

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    8850

    Protein Ontology

    More...
    PROi
    PR:Q92831

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000114166 Expressed in 230 organ(s), highest expression level in corpus callosum
    GenevisibleiQ92831 HS

    Family and domain databases

    Gene3Di1.20.920.10, 1 hit
    InterProiView protein in InterPro
    IPR016181 Acyl_CoA_acyltransferase
    IPR001487 Bromodomain
    IPR036427 Bromodomain-like_sf
    IPR018359 Bromodomain_CS
    IPR037800 GCN5
    IPR016376 GCN5/PCAF
    IPR000182 GNAT_dom
    IPR009464 PCAF_N
    PANTHERiPTHR22880:SF124 PTHR22880:SF124, 1 hit
    PfamiView protein in Pfam
    PF00583 Acetyltransf_1, 1 hit
    PF00439 Bromodomain, 1 hit
    PF06466 PCAF_N, 1 hit
    PIRSFiPIRSF003048 Histone_acetylase_PCAF, 1 hit
    PRINTSiPR00503 BROMODOMAIN
    SMARTiView protein in SMART
    SM00297 BROMO, 1 hit
    SUPFAMiSSF47370 SSF47370, 1 hit
    SSF55729 SSF55729, 1 hit
    PROSITEiView protein in PROSITE
    PS00633 BROMODOMAIN_1, 1 hit
    PS50014 BROMODOMAIN_2, 1 hit
    PS51186 GNAT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAT2B_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92831
    Secondary accession number(s): Q6NSK1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: May 10, 2005
    Last modified: February 13, 2019
    This is version 204 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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