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Entry version 221 (29 Sep 2021)
Sequence version 3 (10 May 2005)
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Protein

Histone acetyltransferase KAT2B

Gene

KAT2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (PubMed:8945521).

Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (PubMed:8945521).

Also acetylates non-histone proteins, such as ACLY, PLK4, RRP9/U3-55K and TBX5 (PubMed:9707565, PubMed:10675335, PubMed:27796307, PubMed:23932781, PubMed:26867678, PubMed:29174768).

Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A (PubMed:8684459).

Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221).

Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768).

Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).

Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing (PubMed:26867678).

Also acetylates spermidine (PubMed:27389534).

10 Publications

(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated in vitro by very low concentrations of spermidine, but inhibited at spermidine concentrations higher than 4 µM. The activating effect of low spermidine concentrations may be mediated by N8-acetylspermidine produced by KAT2B/P/CAF itself acting as a positive feedback loop.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.74 µM for acetyl-CoA1 Publication
  2. KM=2.29 µM for spermidine1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei570Proton donor/acceptor1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Acyltransferase, Transferase
Biological processBiological rhythms, Cell cycle, Host-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.3.1.48, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q92831

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1912408, Pre-NOTCH Transcription and Translation
R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-210744, Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214847, HATs acetylate histones
R-HSA-350054, Notch-HLH transcription pathway
R-HSA-5250924, B-WICH complex positively regulates rRNA expression
R-HSA-5578768, Physiological factors
R-HSA-5689901, Metalloprotease DUBs
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8941856, RUNX3 regulates NOTCH signaling
R-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9013695, NOTCH4 Intracellular Domain Regulates Transcription
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9617629, Regulation of FOXO transcriptional activity by acetylation

SIGNOR Signaling Network Open Resource

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SIGNORi
Q92831

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone acetyltransferase KAT2B (EC:2.3.1.481 Publication)
Alternative name(s):
Histone acetyltransferase PCAF1 Publication
Short name:
Histone acetylase PCAF1 Publication
Lysine acetyltransferase 2B1 Publication
P300/CBP-associated factor1 Publication
Short name:
P/CAF1 Publication
Spermidine acetyltransferase KAT2B (EC:2.3.1.571 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KAT2B1 PublicationImported
Synonyms:PCAF1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:8638, KAT2B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602303, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q92831

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000114166

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in KAT2B has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi752V → A: Reduced acetyl-lysine binding. 1 Publication1
Mutagenesisi760Y → A: Reduced acetyl-lysine binding. 1 Publication1
Mutagenesisi802Y → A: Reduced acetyl-lysine binding. 1 Publication1
Mutagenesisi809Y → A: Complete loss of acetyl-lysine binding. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...
DisGeNETi
8850

Open Targets

More...
OpenTargetsi
ENSG00000114166

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162392705

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q92831, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5500

Drug and drug target database

More...
DrugBanki
DB08186, (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
DB01992, Coenzyme A
DB08291, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2737

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KAT2B

Domain mapping of disease mutations (DMDM)

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DMDMi
83287776

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002112081 – 832Histone acetyltransferase KAT2BAdd BLAST832

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q92831

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q92831

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q92831

MaxQB - The MaxQuant DataBase

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MaxQBi
Q92831

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q92831

PeptideAtlas

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PeptideAtlasi
Q92831

PRoteomics IDEntifications database

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PRIDEi
Q92831

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
75508

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
Q92831

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
Q92831

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q92831

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92831

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed but most abundant in heart and skeletal muscle. Also expressed in the skin, in keratinocytes (at protein level) (PubMed:20940255).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Up-regulated during keratinocyte differentiation (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114166, Expressed in corpus callosum and 244 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92831, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000114166, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SIRT1.

Interacts (unsumoylated form) with NR2C1; the interaction promotes transactivation activity (By similarity).

Interacts with EP300, CREBBP and DDX17.

Interacts with NCOA1 and NCOA3.

Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5.

Interacts with NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2.

Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity.

Interacts with NFE4.

Interacts with MECOM.

Interacts with E2F1; the interaction acetylates E2F1 augmenting its DNA-binding and transcriptional activity.

Interacts with NPAS2, ARNTL/BMAL1 and CLOCK.

Interacts with BCAS3.

Interacts with CEBPB (PubMed:17301242).

Interacts with NR4A3 (By similarity).

Interacts with NFATC2 (By similarity).

Interacts with TBX5 (PubMed:29174768).

Interacts with PLK4 (PubMed:27796307).

Interacts with RB1; this interaction leads to RB1 acetylation (By similarity).

By similarity17 Publications

(Microbial infection) Interacts with and acetylates HIV-1 Tat.

1 Publication

(Microbial infection) Interacts with HTLV-1 Tax.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114375, 216 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1004, PCAF-containing ATAC complex
CPX-989, PCAF histone acetylase complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q92831

Database of interacting proteins

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DIPi
DIP-29778N

Protein interaction database and analysis system

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IntActi
Q92831, 50 interactors

Molecular INTeraction database

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MINTi
Q92831

STRING: functional protein association networks

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STRINGi
9606.ENSP00000263754

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q92831

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q92831, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1832
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

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BMRBi
Q92831

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92831

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q92831

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini503 – 651N-acetyltransferasePROSITE-ProRule annotationBy similarityAdd BLAST149
Domaini740 – 810BromoPROSITE-ProRule annotationCuratedAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 54DisorderedSequence analysisAdd BLAST54
Regioni395 – 436DisorderedSequence analysisAdd BLAST42
Regioni574 – 576Acetyl-CoA binding1 Publication3
Regioni581 – 587Acetyl-CoA binding1 Publication7
Regioni612 – 615Acetyl-CoA binding1 Publication4
Regioni706 – 725DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi26 – 40Pro residuesSequence analysisAdd BLAST15
Compositional biasi395 – 418Polar residuesSequence analysisAdd BLAST24
Compositional biasi711 – 725Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

(Microbial infection) The bromodomain mediates binding to HIV-1 Tat.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Bromodomain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1472, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000154995

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_015901_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92831

Identification of Orthologs from Complete Genome Data

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OMAi
DFAIGYF

Database of Orthologous Groups

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OrthoDBi
349249at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q92831

TreeFam database of animal gene trees

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TreeFami
TF105399

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.920.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00390

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR037800, GCN5
IPR016376, GCN5/PCAF
IPR000182, GNAT_dom
IPR009464, PCAF_N

The PANTHER Classification System

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PANTHERi
PTHR45750, PTHR45750, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00583, Acetyltransf_1, 1 hit
PF00439, Bromodomain, 1 hit
PF06466, PCAF_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003048, Histone_acetylase_PCAF, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00297, BROMO, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47370, SSF47370, 1 hit
SSF55729, SSF55729, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit
PS51186, GNAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q92831-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEAGGAGPG GCGAGAGAGA GPGALPPQPA ALPPAPPQGS PCAAAAGGSG
60 70 80 90 100
ACGPATAVAA AGTAEGPGGG GSARIAVKKA QLRSAPRAKK LEKLGVYSAC
110 120 130 140 150
KAEESCKCNG WKNPNPSPTP PRADLQQIIV SLTESCRSCS HALAAHVSHL
160 170 180 190 200
ENVSEEEMNR LLGIVLDVEY LFTCVHKEED ADTKQVYFYL FKLLRKSILQ
210 220 230 240 250
RGKPVVEGSL EKKPPFEKPS IEQGVNNFVQ YKFSHLPAKE RQTIVELAKM
260 270 280 290 300
FLNRINYWHL EAPSQRRLRS PNDDISGYKE NYTRWLCYCN VPQFCDSLPR
310 320 330 340 350
YETTQVFGRT LLRSVFTVMR RQLLEQARQE KDKLPLEKRT LILTHFPKFL
360 370 380 390 400
SMLEEEVYSQ NSPIWDQDFL SASSRTSQLG IQTVINPPPV AGTISYNSTS
410 420 430 440 450
SSLEQPNAGS SSPACKASSG LEANPGEKRK MTDSHVLEEA KKPRVMGDIP
460 470 480 490 500
MELINEVMST ITDPAAMLGP ETNFLSAHSA RDEAARLEER RGVIEFHVVG
510 520 530 540 550
NSLNQKPNKK ILMWLVGLQN VFSHQLPRMP KEYITRLVFD PKHKTLALIK
560 570 580 590 600
DGRVIGGICF RMFPSQGFTE IVFCAVTSNE QVKGYGTHLM NHLKEYHIKH
610 620 630 640 650
DILNFLTYAD EYAIGYFKKQ GFSKEIKIPK TKYVGYIKDY EGATLMGCEL
660 670 680 690 700
NPRIPYTEFS VIIKKQKEII KKLIERKQAQ IRKVYPGLSC FKDGVRQIPI
710 720 730 740 750
ESIPGIRETG WKPSGKEKSK EPRDPDQLYS TLKSILQQVK SHQSAWPFME
760 770 780 790 800
PVKRTEAPGY YEVIRFPMDL KTMSERLKNR YYVSKKLFMA DLQRVFTNCK
810 820 830
EYNPPESEYY KCANILEKFF FSKIKEAGLI DK
Length:832
Mass (Da):93,013
Last modified:May 10, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72F516E8BC00CC0C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti804 – 805PP → AA in AAC50890 (PubMed:8684459).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079852130V → G Found in a patient with isolated coloboma; unknown pathological significance. 1 Publication1
Natural variantiVAR_034372386N → S. Corresponds to variant dbSNP:rs17006625Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U57317 mRNA Translation: AAC50890.2
BC060823 mRNA Translation: AAH60823.1
BC070075 mRNA Translation: AAH70075.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2634.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S71788

NCBI Reference Sequences

More...
RefSeqi
NP_003875.3, NM_003884.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263754; ENSP00000263754; ENSG00000114166

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8850

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8850

UCSC genome browser

More...
UCSCi
uc003cbq.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57317 mRNA Translation: AAC50890.2
BC060823 mRNA Translation: AAH60823.1
BC070075 mRNA Translation: AAH70075.1
CCDSiCCDS2634.1
PIRiS71788
RefSeqiNP_003875.3, NM_003884.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CM0X-ray2.30A/B493-658[»]
1JM4NMR-B719-832[»]
1N72NMR-A719-832[»]
1WUGNMR-A719-832[»]
1WUMNMR-A719-832[»]
1ZS5NMR-A719-832[»]
2RNWNMR-A719-832[»]
2RNXNMR-A719-832[»]
3GG3X-ray2.25A/B715-831[»]
4NSQX-ray2.31A/B/C/D493-658[»]
5FDZX-ray2.40A/B715-831[»]
5FE0X-ray2.30A/B715-831[»]
5FE1X-ray2.22A/B715-831[»]
5FE2X-ray2.25A/B715-831[»]
5FE3X-ray2.12A/B715-831[»]
5FE4X-ray2.15A/B715-831[»]
5FE5X-ray2.12A/B715-831[»]
5FE6X-ray1.77A/B715-831[»]
5FE7X-ray2.08A/B715-831[»]
5FE8X-ray2.10A/B715-831[»]
5FE9X-ray2.35A/B715-831[»]
5LVQX-ray2.05A/B715-831[»]
5LVRX-ray2.05A/B715-831[»]
5MKXX-ray1.68A/B715-831[»]
6J3OX-ray2.11A/B715-831[»]
BMRBiQ92831
SMRiQ92831
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114375, 216 interactors
ComplexPortaliCPX-1004, PCAF-containing ATAC complex
CPX-989, PCAF histone acetylase complex
CORUMiQ92831
DIPiDIP-29778N
IntActiQ92831, 50 interactors
MINTiQ92831
STRINGi9606.ENSP00000263754

Chemistry databases

BindingDBiQ92831
ChEMBLiCHEMBL5500
DrugBankiDB08186, (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
DB01992, Coenzyme A
DB08291, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
GuidetoPHARMACOLOGYi2737

PTM databases

CarbonylDBiQ92831
iPTMnetiQ92831
PhosphoSitePlusiQ92831

Genetic variation databases

BioMutaiKAT2B
DMDMi83287776

2D gel databases

REPRODUCTION-2DPAGEiQ92831

Proteomic databases

EPDiQ92831
jPOSTiQ92831
MassIVEiQ92831
MaxQBiQ92831
PaxDbiQ92831
PeptideAtlasiQ92831
PRIDEiQ92831
ProteomicsDBi75508

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3865, 452 antibodies

The DNASU plasmid repository

More...
DNASUi
8850

Genome annotation databases

EnsembliENST00000263754; ENSP00000263754; ENSG00000114166
GeneIDi8850
KEGGihsa:8850
UCSCiuc003cbq.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8850
DisGeNETi8850

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KAT2B
HGNCiHGNC:8638, KAT2B
HPAiENSG00000114166, Low tissue specificity
MIMi602303, gene
neXtProtiNX_Q92831
OpenTargetsiENSG00000114166
PharmGKBiPA162392705
VEuPathDBiHostDB:ENSG00000114166

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1472, Eukaryota
GeneTreeiENSGT00940000154995
HOGENOMiCLU_015901_0_0_1
InParanoidiQ92831
OMAiDFAIGYF
OrthoDBi349249at2759
PhylomeDBiQ92831
TreeFamiTF105399

Enzyme and pathway databases

BRENDAi2.3.1.48, 2681
PathwayCommonsiQ92831
ReactomeiR-HSA-1912408, Pre-NOTCH Transcription and Translation
R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-210744, Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214847, HATs acetylate histones
R-HSA-350054, Notch-HLH transcription pathway
R-HSA-5250924, B-WICH complex positively regulates rRNA expression
R-HSA-5578768, Physiological factors
R-HSA-5689901, Metalloprotease DUBs
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8941856, RUNX3 regulates NOTCH signaling
R-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9013695, NOTCH4 Intracellular Domain Regulates Transcription
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9617629, Regulation of FOXO transcriptional activity by acetylation
SIGNORiQ92831

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8850, 6 hits in 1029 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KAT2B, human
EvolutionaryTraceiQ92831

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PCAF

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8850
PharosiQ92831, Tchem

Protein Ontology

More...
PROi
PR:Q92831
RNActiQ92831, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114166, Expressed in corpus callosum and 244 other tissues
GenevisibleiQ92831, HS

Family and domain databases

Gene3Di1.20.920.10, 1 hit
IDEALiIID00390
InterProiView protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR037800, GCN5
IPR016376, GCN5/PCAF
IPR000182, GNAT_dom
IPR009464, PCAF_N
PANTHERiPTHR45750, PTHR45750, 1 hit
PfamiView protein in Pfam
PF00583, Acetyltransf_1, 1 hit
PF00439, Bromodomain, 1 hit
PF06466, PCAF_N, 1 hit
PIRSFiPIRSF003048, Histone_acetylase_PCAF, 1 hit
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF55729, SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit
PS51186, GNAT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAT2B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92831
Secondary accession number(s): Q6NSK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 10, 2005
Last modified: September 29, 2021
This is version 221 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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