Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 214 (22 Apr 2020)
Sequence version 3 (14 Oct 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Histone acetyltransferase KAT2A

Gene

KAT2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:27796307, PubMed:29174768). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297).By similarity8 Publications
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.1 Publication

Caution

According to a report, has weak protein acyltransferase activity compared to protein acetyltransferase activity (PubMed:27377381). These conclusions are however not supported by subsequent studies (PubMed:29211711, PubMed:31542297).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.83 µM for acetyl-CoA1 Publication
  2. KM=0.91 µM for acetyl-CoA1 Publication
  3. KM=0.36 µM for succinyl-CoA1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei575Proton donor/acceptor2 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei645Acyl-CoACombined sources1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAcyltransferase, Transferase
    Biological processHost-virus interaction, Transcription, Transcription regulation

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.3.1.48 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1912408 Pre-NOTCH Transcription and Translation
    R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
    R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
    R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
    R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    R-HSA-3214847 HATs acetylate histones
    R-HSA-350054 Notch-HLH transcription pathway
    R-HSA-5250924 B-WICH complex positively regulates rRNA expression
    R-HSA-5689880 Ub-specific processing proteases
    R-HSA-73762 RNA Polymerase I Transcription Initiation
    R-HSA-8941856 RUNX3 regulates NOTCH signaling
    R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
    R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription

    SignaLink: a signaling pathway resource with multi-layered regulatory networks

    More...
    SignaLinki
    Q92830

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q92830

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Histone acetyltransferase KAT2A (EC:2.3.1.483 Publications)
    Alternative name(s):
    General control of amino acid synthesis protein 5-like 2By similarity
    Histone acetyltransferase GCN52 Publications
    Short name:
    hGCN52 Publications
    Histone glutaryltransferase KAT2ACurated (EC:2.3.1.-1 Publication)
    Histone succinyltransferase KAT2ACurated (EC:2.3.1.-1 Publication)
    Lysine acetyltransferase 2ACurated
    STAF971 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:KAT2A1 PublicationImported
    Synonyms:GCN51 Publication, GCN5L2By similarity
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:4201 KAT2A

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    602301 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q92830

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Chromosome, Cytoplasm, Cytoskeleton, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi575E → A: Catalytically dead mutant; abolished acyltransferase activity; when associated with A-615. 2 Publications1
    Mutagenesisi615D → A: Catalytically dead mutant; abolished acyltransferase activity; when associated with A-575. 2 Publications1
    Mutagenesisi645Y → A: Reduced histone succinylation without affecting histone acetylation. Reduced gene expression. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    2648

    Open Targets

    More...
    OpenTargetsi
    ENSG00000108773

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162392664

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q92830 Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5501

    Drug and drug target database

    More...
    DrugBanki
    DB01992 Coenzyme A

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    KAT2A

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    209572743

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002112022 – 837Histone acetyltransferase KAT2AAdd BLAST836

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki728Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Cross-linki759Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Cross-linki791Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

    Keywords - PTMi

    Acetylation, Isopeptide bond, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q92830

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q92830

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q92830

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q92830

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q92830

    PeptideAtlas

    More...
    PeptideAtlasi
    Q92830

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q92830

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    75506 [Q92830-1]
    75507 [Q92830-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q92830

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q92830

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in all tissues tested, with most abundant expression in ovary.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000108773 Expressed in right uterine tube and 213 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q92830 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q92830 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000108773 Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homooligomer; may form a tetramer of homodimers (PubMed:30109122).

    Interacts with EP300, CREBBP and ADA2.

    Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP (PubMed:10373431, PubMed:10611234, PubMed:11438666).

    Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (PubMed:18206972). The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22 (PubMed:18206972).

    Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (PubMed:19103755). In the complex, it probably interacts directly with KAT14, MBIP and WDR5 (PubMed:19103755).

    Interacts with PML (By similarity).

    Interacts with CEBPB (PubMed:17301242).

    Interacts with TACC1, TACC2 and TACC3 (PubMed:14767476).

    Interacts with RELA (By similarity).

    Interacts with NFATC2 (By similarity).

    Interacts with TBX5 (PubMed:29174768).

    Interacts with PLK4 (PubMed:27796307). Associates with the 2-oxoglutarate dehydrogenase complex (PubMed:29211711).

    Interacts with XPC; leading to KAT2A recruitment to promoters and subsequent acetylation of histones (PubMed:29973595, PubMed:31527837).

    Interacts with ERCC3/XPB; leading to KAT2A recruitment to promoters and subsequent acetylation of histones (PubMed:30894545).

    By similarity14 Publications

    (Microbial infection) Interacts with and acetylates HIV-1 Tat.

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Show more details

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    108918, 135 interactors

    ComplexPortal: manually curated resource of macromolecular complexes

    More...
    ComplexPortali
    CPX-900 SAGA complex
    CPX-903 TFTC histone acetylation complex
    CPX-997 GCN5-containing ATAC complex

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q92830

    Database of interacting proteins

    More...
    DIPi
    DIP-28146N

    Protein interaction database and analysis system

    More...
    IntActi
    Q92830, 49 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q92830

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000225916

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q92830

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q92830 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1837
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q92830

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q92830

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini503 – 656N-acetyltransferasePROSITE-ProRule annotationAdd BLAST154
    Domaini745 – 815BromoPROSITE-ProRule annotationAdd BLAST71

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni579 – 581Acetyl-CoA and acyl-CoA bindingCombined sources2 Publications3
    Regioni586 – 592Acetyl-CoA and acyl-CoA bindingCombined sources2 Publications7
    Regioni617 – 620Acetyl-CoA and acyl-CoA bindingCombined sources2 Publications4
    Regioni639 – 648Loop 31 Publication10

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    Loop3 is required for substrate specificity and adopts different structural conformations in succinyl-CoA-bound and acetyl-CoA-bound forms. Tyr-645 has an important role in the selective binding of succinyl-CoA over acetyl-CoA.1 Publication

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Bromodomain

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1472 Eukaryota
    COG5076 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000158799

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_015901_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q92830

    KEGG Orthology (KO)

    More...
    KOi
    K06062

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NHLKDYS

    Database of Orthologous Groups

    More...
    OrthoDBi
    349249at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q92830

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105399

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.20.920.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016181 Acyl_CoA_acyltransferase
    IPR001487 Bromodomain
    IPR036427 Bromodomain-like_sf
    IPR018359 Bromodomain_CS
    IPR037800 GCN5
    IPR016376 GCN5/PCAF
    IPR000182 GNAT_dom
    IPR009464 PCAF_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR45750 PTHR45750, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00583 Acetyltransf_1, 1 hit
    PF00439 Bromodomain, 1 hit
    PF06466 PCAF_N, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF003048 Histone_acetylase_PCAF, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00503 BROMODOMAIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00297 BROMO, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47370 SSF47370, 1 hit
    SSF55729 SSF55729, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00633 BROMODOMAIN_1, 1 hit
    PS50014 BROMODOMAIN_2, 1 hit
    PS51186 GNAT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q92830-1) [UniParc]FASTAAdd to basket
    Also known as: GCN5-L

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAEPSQAPTP APAAQPRPLQ SPAPAPTPTP APSPASAPIP TPTPAPAPAP
    60 70 80 90 100
    AAAPAGSTGT GGPGVGSGGA GSGGDPARPG LSQQQRASQR KAQVRGLPRA
    110 120 130 140 150
    KKLEKLGVFS ACKANETCKC NGWKNPKPPT APRMDLQQPA ANLSELCRSC
    160 170 180 190 200
    EHPLADHVSH LENVSEDEIN RLLGMVVDVE NLFMSVHKEE DTDTKQVYFY
    210 220 230 240 250
    LFKLLRKCIL QMTRPVVEGS LGSPPFEKPN IEQGVLNFVQ YKFSHLAPRE
    260 270 280 290 300
    RQTMFELSKM FLLCLNYWKL ETPAQFRQRS QAEDVATYKV NYTRWLCYCH
    310 320 330 340 350
    VPQSCDSLPR YETTHVFGRS LLRSIFTVTR RQLLEKFRVE KDKLVPEKRT
    360 370 380 390 400
    LILTHFPKFL SMLEEEIYGA NSPIWESGFT MPPSEGTQLV PRPASVSAAV
    410 420 430 440 450
    VPSTPIFSPS MGGGSNSSLS LDSAGAEPMP GEKRTLPENL TLEDAKRLRV
    460 470 480 490 500
    MGDIPMELVN EVMLTITDPA AMLGPETSLL SANAARDETA RLEERRGIIE
    510 520 530 540 550
    FHVIGNSLTP KANRRVLLWL VGLQNVFSHQ LPRMPKEYIA RLVFDPKHKT
    560 570 580 590 600
    LALIKDGRVI GGICFRMFPT QGFTEIVFCA VTSNEQVKGY GTHLMNHLKE
    610 620 630 640 650
    YHIKHNILYF LTYADEYAIG YFKKQGFSKD IKVPKSRYLG YIKDYEGATL
    660 670 680 690 700
    MECELNPRIP YTELSHIIKK QKEIIKKLIE RKQAQIRKVY PGLSCFKEGV
    710 720 730 740 750
    RQIPVESVPG IRETGWKPLG KEKGKELKDP DQLYTTLKNL LAQIKSHPSA
    760 770 780 790 800
    WPFMEPVKKS EAPDYYEVIR FPIDLKTMTE RLRSRYYVTR KLFVADLQRV
    810 820 830
    IANCREYNPP DSEYCRCASA LEKFFYFKLK EGGLIDK
    Length:837
    Mass (Da):93,926
    Last modified:October 14, 2008 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i728CC8ACF08600EA
    GO
    Isoform 2 (identifier: Q92830-2) [UniParc]FASTAAdd to basket
    Also known as: GCN5-S

    The sequence of this isoform differs from the canonical sequence as follows:
         1-410: Missing.

    Show »
    Length:427
    Mass (Da):48,921
    Checksum:iA6EAE20DB0B49ADC
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    K7ERS6K7ERS6_HUMAN
    Histone acetyltransferase KAT2A
    KAT2A
    276Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EPC4K7EPC4_HUMAN
    Histone acetyltransferase KAT2A
    KAT2A
    70Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116E → G in AAC39769 (PubMed:8552087).Curated1
    Sequence conflicti134M → I in AAC39769 (PubMed:8552087).Curated1
    Sequence conflicti269K → E in AAC39769 (PubMed:8552087).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0005561 – 410Missing in isoform 2. CuratedAdd BLAST410

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF029777 mRNA Translation: AAC39769.1
    CH471152 Genomic DNA Translation: EAW60803.1
    BC032743 mRNA Translation: AAH32743.1
    BC039907 mRNA Translation: AAH39907.1
    BC105977 mRNA Translation: AAI05978.1
    U57316 Genomic DNA Translation: AAC50641.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11417.1 [Q92830-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S71789

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_066564.2, NM_021078.2 [Q92830-1]
    XP_016879937.1, XM_017024448.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000225916; ENSP00000225916; ENSG00000108773 [Q92830-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2648

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:2648

    UCSC genome browser

    More...
    UCSCi
    uc002hyx.3 human [Q92830-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF029777 mRNA Translation: AAC39769.1
    CH471152 Genomic DNA Translation: EAW60803.1
    BC032743 mRNA Translation: AAH32743.1
    BC039907 mRNA Translation: AAH39907.1
    BC105977 mRNA Translation: AAI05978.1
    U57316 Genomic DNA Translation: AAC50641.1
    CCDSiCCDS11417.1 [Q92830-1]
    PIRiS71789
    RefSeqiNP_066564.2, NM_021078.2 [Q92830-1]
    XP_016879937.1, XM_017024448.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1F68NMR-A730-832[»]
    1Z4RX-ray1.74A497-662[»]
    3D7CX-ray2.06A/B729-837[»]
    5H84X-ray2.00A497-662[»]
    5H86X-ray2.08A497-662[»]
    5MLJX-ray1.80A/B729-837[»]
    5TRLX-ray2.30A/B/C/D/E/F/G/H497-662[»]
    5TRMX-ray2.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X497-662[»]
    6J3PX-ray1.60A/B726-837[»]
    SMRiQ92830
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi108918, 135 interactors
    ComplexPortaliCPX-900 SAGA complex
    CPX-903 TFTC histone acetylation complex
    CPX-997 GCN5-containing ATAC complex
    CORUMiQ92830
    DIPiDIP-28146N
    IntActiQ92830, 49 interactors
    MINTiQ92830
    STRINGi9606.ENSP00000225916

    Chemistry databases

    BindingDBiQ92830
    ChEMBLiCHEMBL5501
    DrugBankiDB01992 Coenzyme A

    PTM databases

    iPTMnetiQ92830
    PhosphoSitePlusiQ92830

    Polymorphism and mutation databases

    BioMutaiKAT2A
    DMDMi209572743

    Proteomic databases

    EPDiQ92830
    jPOSTiQ92830
    MassIVEiQ92830
    MaxQBiQ92830
    PaxDbiQ92830
    PeptideAtlasiQ92830
    PRIDEiQ92830
    ProteomicsDBi75506 [Q92830-1]
    75507 [Q92830-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    29117 337 antibodies

    Genome annotation databases

    EnsembliENST00000225916; ENSP00000225916; ENSG00000108773 [Q92830-1]
    GeneIDi2648
    KEGGihsa:2648
    UCSCiuc002hyx.3 human [Q92830-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    2648
    DisGeNETi2648

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    KAT2A
    HGNCiHGNC:4201 KAT2A
    HPAiENSG00000108773 Low tissue specificity
    MIMi602301 gene
    neXtProtiNX_Q92830
    OpenTargetsiENSG00000108773
    PharmGKBiPA162392664

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1472 Eukaryota
    COG5076 LUCA
    GeneTreeiENSGT00940000158799
    HOGENOMiCLU_015901_0_0_1
    InParanoidiQ92830
    KOiK06062
    OMAiNHLKDYS
    OrthoDBi349249at2759
    PhylomeDBiQ92830
    TreeFamiTF105399

    Enzyme and pathway databases

    BRENDAi2.3.1.48 2681
    ReactomeiR-HSA-1912408 Pre-NOTCH Transcription and Translation
    R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
    R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
    R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
    R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    R-HSA-3214847 HATs acetylate histones
    R-HSA-350054 Notch-HLH transcription pathway
    R-HSA-5250924 B-WICH complex positively regulates rRNA expression
    R-HSA-5689880 Ub-specific processing proteases
    R-HSA-73762 RNA Polymerase I Transcription Initiation
    R-HSA-8941856 RUNX3 regulates NOTCH signaling
    R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
    R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
    SignaLinkiQ92830
    SIGNORiQ92830

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    KAT2A human
    EvolutionaryTraceiQ92830

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    GCN5L2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    2648
    PharosiQ92830 Tbio

    Protein Ontology

    More...
    PROi
    PR:Q92830
    RNActiQ92830 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000108773 Expressed in right uterine tube and 213 other tissues
    ExpressionAtlasiQ92830 baseline and differential
    GenevisibleiQ92830 HS

    Family and domain databases

    Gene3Di1.20.920.10, 1 hit
    InterProiView protein in InterPro
    IPR016181 Acyl_CoA_acyltransferase
    IPR001487 Bromodomain
    IPR036427 Bromodomain-like_sf
    IPR018359 Bromodomain_CS
    IPR037800 GCN5
    IPR016376 GCN5/PCAF
    IPR000182 GNAT_dom
    IPR009464 PCAF_N
    PANTHERiPTHR45750 PTHR45750, 1 hit
    PfamiView protein in Pfam
    PF00583 Acetyltransf_1, 1 hit
    PF00439 Bromodomain, 1 hit
    PF06466 PCAF_N, 1 hit
    PIRSFiPIRSF003048 Histone_acetylase_PCAF, 1 hit
    PRINTSiPR00503 BROMODOMAIN
    SMARTiView protein in SMART
    SM00297 BROMO, 1 hit
    SUPFAMiSSF47370 SSF47370, 1 hit
    SSF55729 SSF55729, 1 hit
    PROSITEiView protein in PROSITE
    PS00633 BROMODOMAIN_1, 1 hit
    PS50014 BROMODOMAIN_2, 1 hit
    PS51186 GNAT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAT2A_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92830
    Secondary accession number(s): Q8N1A2, Q9UCW1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 14, 2008
    Last modified: April 22, 2020
    This is version 214 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again