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Protein

Coronin-2A

Gene

CORO2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: ProtInc

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SignaLinkiQ92828

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-2A
Alternative name(s):
IR10
WD repeat-containing protein 2
Gene namesi
Name:CORO2A
Synonyms:IR10, WDR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106789.12
HGNCiHGNC:2255 CORO2A
MIMi602159 gene
neXtProtiNX_Q92828

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi7464
OpenTargetsiENSG00000106789
PharmGKBiPA26771

Polymorphism and mutation databases

BioMutaiCORO2A
DMDMi28381354

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509281 – 525Coronin-2AAdd BLAST525

Proteomic databases

EPDiQ92828
MaxQBiQ92828
PaxDbiQ92828
PeptideAtlasiQ92828
PRIDEiQ92828
ProteomicsDBi75505

PTM databases

iPTMnetiQ92828
PhosphoSitePlusiQ92828

Expressioni

Gene expression databases

BgeeiENSG00000106789 Expressed in 163 organ(s), highest expression level in testis
CleanExiHS_CORO2A
ExpressionAtlasiQ92828 baseline and differential
GenevisibleiQ92828 HS

Organism-specific databases

HPAiHPA041161
HPA041302

Interactioni

Subunit structurei

Binds actin (By similarity). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NR1H2P550554EBI-2835660,EBI-745354

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113302, 38 interactors
CORUMiQ92828
DIPiDIP-59202N
IntActiQ92828, 36 interactors
MINTiQ92828
STRINGi9606.ENSP00000343746

Structurei

3D structure databases

ProteinModelPortaliQ92828
SMRiQ92828
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 71WD 1Add BLAST48
Repeati72 – 122WD 2Add BLAST51
Repeati123 – 170WD 3Add BLAST48
Repeati171 – 214WD 4Add BLAST44
Repeati215 – 259WD 5Add BLAST45
Repeati260 – 305WD 6Add BLAST46
Repeati306 – 342WD 7Add BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili485 – 524Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00760000119195
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiQ92828
KOiK13887
OMAiFDIFECP
OrthoDBiEOG091G03H5
PhylomeDBiQ92828
TreeFamiTF314280

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR027335 CORO2A
IPR015505 Coronin
IPR015048 DUF1899
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF2 PTHR10856:SF2, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q92828-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWHPQYRSS KFRHVFGKPA SKENCYDSVP ITRSVHDNHF CAVNPHFIAV
60 70 80 90 100
VTECAGGGAF LVIPLHQTGK LDPHYPKVCG HRGNVLDVKW NPFDDFEIAS
110 120 130 140 150
CSEDATIKIW SIPKQLLTRN LTAYRKELVG HARRVGLVEW HPTAANILFS
160 170 180 190 200
AGYDYKVMIW NLDTKESVIT SPMSTISCHQ DVILSMSFNT NGSLLATTCK
210 220 230 240 250
DRKIRVIDPR AGTVLQEASY KGHRASKVLF LGNLKKLMST GTSRWNNRQV
260 270 280 290 300
ALWDQDNLSV PLMEEDLDGS SGVLFPFYDA DTSMLYVVGK GDGNIRYYEV
310 320 330 340 350
SADKPHLSYL TEYRSYNPQK GIGVMPKRGL DVSSCEIFRF YKLITTKSLI
360 370 380 390 400
EPISMIVPRR SESYQEDIYP PTAGAQPSLT AQEWLSGMNR DPILVSLRPG
410 420 430 440 450
SELLRPHPLP AERPIFNSMA PASPRLLNQT EKLAAEDGWR SSSLLEEKMP
460 470 480 490 500
RWAAEHRLEE KKTWLTNGFD VFECPPPKTE NELLQMFYRQ QEEIRRLREL
510 520
LTQREVQAKQ LELEIKNLRM GSEQL
Length:525
Mass (Da):59,763
Last modified:February 12, 2003 - v2
Checksum:i8546E1C5A78CB1FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59A → G in AAB47807 (PubMed:8985118).Curated1
Sequence conflicti88V → A in AAB47808 (PubMed:8985118).Curated1
Sequence conflicti360R → G in AAB47807 (PubMed:8985118).Curated1
Sequence conflicti373A → G in AAB47807 (PubMed:8985118).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053390296R → H. Corresponds to variant dbSNP:rs2231666Ensembl.1
Natural variantiVAR_053391495R → L. Corresponds to variant dbSNP:rs35787916Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57057 mRNA Translation: AAB47807.1
U57058 mRNA Translation: AAB47808.1
AL137073 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58879.1
BC000010 mRNA Translation: AAH00010.1
BC011690 mRNA Translation: AAH11690.1
CCDSiCCDS6735.1
RefSeqiNP_003380.3, NM_003389.3
NP_438171.1, NM_052820.3
XP_011517288.1, XM_011518986.2
UniGeneiHs.113094

Genome annotation databases

EnsembliENST00000343933; ENSP00000343746; ENSG00000106789
ENST00000375077; ENSP00000364218; ENSG00000106789
GeneIDi7464
KEGGihsa:7464
UCSCiuc004ayl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57057 mRNA Translation: AAB47807.1
U57058 mRNA Translation: AAB47808.1
AL137073 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58879.1
BC000010 mRNA Translation: AAH00010.1
BC011690 mRNA Translation: AAH11690.1
CCDSiCCDS6735.1
RefSeqiNP_003380.3, NM_003389.3
NP_438171.1, NM_052820.3
XP_011517288.1, XM_011518986.2
UniGeneiHs.113094

3D structure databases

ProteinModelPortaliQ92828
SMRiQ92828
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113302, 38 interactors
CORUMiQ92828
DIPiDIP-59202N
IntActiQ92828, 36 interactors
MINTiQ92828
STRINGi9606.ENSP00000343746

PTM databases

iPTMnetiQ92828
PhosphoSitePlusiQ92828

Polymorphism and mutation databases

BioMutaiCORO2A
DMDMi28381354

Proteomic databases

EPDiQ92828
MaxQBiQ92828
PaxDbiQ92828
PeptideAtlasiQ92828
PRIDEiQ92828
ProteomicsDBi75505

Protocols and materials databases

DNASUi7464
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343933; ENSP00000343746; ENSG00000106789
ENST00000375077; ENSP00000364218; ENSG00000106789
GeneIDi7464
KEGGihsa:7464
UCSCiuc004ayl.4 human

Organism-specific databases

CTDi7464
DisGeNETi7464
EuPathDBiHostDB:ENSG00000106789.12
GeneCardsiCORO2A
HGNCiHGNC:2255 CORO2A
HPAiHPA041161
HPA041302
MIMi602159 gene
neXtProtiNX_Q92828
OpenTargetsiENSG00000106789
PharmGKBiPA26771
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00760000119195
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiQ92828
KOiK13887
OMAiFDIFECP
OrthoDBiEOG091G03H5
PhylomeDBiQ92828
TreeFamiTF314280

Enzyme and pathway databases

SignaLinkiQ92828

Miscellaneous databases

ChiTaRSiCORO2A human
GeneWikiiCORO2A
GenomeRNAii7464
PROiPR:Q92828
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106789 Expressed in 163 organ(s), highest expression level in testis
CleanExiHS_CORO2A
ExpressionAtlasiQ92828 baseline and differential
GenevisibleiQ92828 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR027335 CORO2A
IPR015505 Coronin
IPR015048 DUF1899
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF2 PTHR10856:SF2, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOR2A_HUMAN
AccessioniPrimary (citable) accession number: Q92828
Secondary accession number(s): Q5TBR5, Q92829, Q9BWS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 12, 2003
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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