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Protein

Homeobox protein Hox-B13

Gene

HOXB13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi216 – 275HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ92826

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B13
Gene namesi
Name:HOXB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000159184.7
HGNCiHGNC:5112 HOXB13
MIMi604607 gene
neXtProtiNX_Q92826

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Prostate cancer (PC)6 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
See also OMIM:176807
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07186684G → E in PC; rare variant associated with disease susceptibility. 6 PublicationsCorresponds to variant dbSNP:rs138213197EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi10481
MalaCardsiHOXB13
MIMi176807 phenotype
OpenTargetsiENSG00000159184
Orphaneti1331 Familial prostate cancer
PharmGKBiPA29388

Polymorphism and mutation databases

BioMutaiHOXB13
DMDMi50403792

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001601 – 284Homeobox protein Hox-B13Add BLAST284

Proteomic databases

MaxQBiQ92826
PaxDbiQ92826
PeptideAtlasiQ92826
PRIDEiQ92826
ProteomicsDBi75504

PTM databases

iPTMnetiQ92826
PhosphoSitePlusiQ92826

Expressioni

Gene expression databases

BgeeiENSG00000159184 Expressed in 24 organ(s), highest expression level in prostate gland
CleanExiHS_HOXB13
GenevisibleiQ92826 HS

Organism-specific databases

HPAiCAB004438
HPA062852
HPA065019

Interactioni

Subunit structurei

Heterodimer with MEIS1 (PubMed:28473536). Heterodimer with MEIS2 (Ref. 8).2 Publications

Protein-protein interaction databases

BioGridi115744, 15 interactors
IntActiQ92826, 6 interactors
MINTiQ92826
STRINGi9606.ENSP00000290295

Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92826
SMRiQ92826
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92826

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni217 – 246Interaction with DNA2 PublicationsAdd BLAST30
Regioni258 – 269Interaction with 5-mCpG DNA1 PublicationAdd BLAST12
Regioni270 – 273Interaction with DNA2 Publications4

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231176
HOVERGENiHBG106958
InParanoidiQ92826
OMAiGCAFRRG
OrthoDBiEOG091G0E5Q
PhylomeDBiQ92826
TreeFamiTF330813

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR022067 HoxA13_N
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF12284 HoxA13_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q92826-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLTSHPAAP TLMPAVNYAP
60 70 80 90 100
LDLPGSAEPP KQCHPCPGVP QGTSPAPVPY GYFGGGYYSC RVSRSSLKPC
110 120 130 140 150
AQAATLAAYP AETPTAGEEY PSRPTEFAFY PGYPGTYQPM ASYLDVSVVQ
160 170 180 190 200
TLGAPGEPRH DSLLPVDSYQ SWALAGGWNS QMCCQGEQNP PGPFWKAAFA
210 220 230 240 250
DSSGQHPPDA CAFRRGRKKR IPYSKGQLRE LEREYAANKF ITKDKRRKIS
260 270 280
AATSLSERQI TIWFQNRRVK EKKVLAKVKN SATP
Length:284
Mass (Da):30,676
Last modified:July 19, 2004 - v2
Checksum:i3EE5898449C33CFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138 – 139QP → HA (PubMed:8756292).Curated2
Sequence conflicti138 – 139QP → HA (PubMed:9665387).Curated2
Sequence conflicti211C → S in AAC50664 (PubMed:8756292).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03184941T → M1 PublicationCorresponds to variant dbSNP:rs199799743EnsemblClinVar.1
Natural variantiVAR_07186684G → E in PC; rare variant associated with disease susceptibility. 6 PublicationsCorresponds to variant dbSNP:rs138213197EnsemblClinVar.1
Natural variantiVAR_07186788Y → D Found in prostate cancer samples; unknown pathological significance. 1 Publication1
Natural variantiVAR_071868144L → P Found in prostate cancer samples; unknown pathological significance. 1 Publication1
Natural variantiVAR_071869216G → C Found in prostate cancer samples; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs375917549Ensembl.1
Natural variantiVAR_077246217R → C1 PublicationCorresponds to variant dbSNP:rs139475791EnsemblClinVar.1
Natural variantiVAR_071870229R → G Found in prostate cancer samples; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57052 mRNA Translation: AAC50664.1
U81599 mRNA Translation: AAB39863.1
BT007410 mRNA Translation: AAP36078.1
AK313266 mRNA Translation: BAG36075.1
CH471109 Genomic DNA Translation: EAW94714.1
BC007092 mRNA Translation: AAH07092.1
BC070233 mRNA Translation: AAH70233.1
CCDSiCCDS11536.1
RefSeqiNP_006352.2, NM_006361.5
UniGeneiHs.66731

Genome annotation databases

EnsembliENST00000290295; ENSP00000290295; ENSG00000159184
GeneIDi10481
KEGGihsa:10481
UCSCiuc002ioa.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57052 mRNA Translation: AAC50664.1
U81599 mRNA Translation: AAB39863.1
BT007410 mRNA Translation: AAP36078.1
AK313266 mRNA Translation: BAG36075.1
CH471109 Genomic DNA Translation: EAW94714.1
BC007092 mRNA Translation: AAH07092.1
BC070233 mRNA Translation: AAH70233.1
CCDSiCCDS11536.1
RefSeqiNP_006352.2, NM_006361.5
UniGeneiHs.66731

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRANMR-A217-273[»]
5EDNX-ray3.20A/B/G/J209-284[»]
5EEAX-ray2.19A/B/G/J217-279[»]
5EF6X-ray3.00A/B/G/J217-278[»]
5EG0X-ray3.10B217-277[»]
5EGOX-ray2.54B217-277[»]
5NO6X-ray2.88A/B217-278[»]
ProteinModelPortaliQ92826
SMRiQ92826
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115744, 15 interactors
IntActiQ92826, 6 interactors
MINTiQ92826
STRINGi9606.ENSP00000290295

PTM databases

iPTMnetiQ92826
PhosphoSitePlusiQ92826

Polymorphism and mutation databases

BioMutaiHOXB13
DMDMi50403792

Proteomic databases

MaxQBiQ92826
PaxDbiQ92826
PeptideAtlasiQ92826
PRIDEiQ92826
ProteomicsDBi75504

Protocols and materials databases

DNASUi10481
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290295; ENSP00000290295; ENSG00000159184
GeneIDi10481
KEGGihsa:10481
UCSCiuc002ioa.4 human

Organism-specific databases

CTDi10481
DisGeNETi10481
EuPathDBiHostDB:ENSG00000159184.7
GeneCardsiHOXB13
HGNCiHGNC:5112 HOXB13
HPAiCAB004438
HPA062852
HPA065019
MalaCardsiHOXB13
MIMi176807 phenotype
604607 gene
neXtProtiNX_Q92826
OpenTargetsiENSG00000159184
Orphaneti1331 Familial prostate cancer
PharmGKBiPA29388
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231176
HOVERGENiHBG106958
InParanoidiQ92826
OMAiGCAFRRG
OrthoDBiEOG091G0E5Q
PhylomeDBiQ92826
TreeFamiTF330813

Enzyme and pathway databases

SIGNORiQ92826

Miscellaneous databases

ChiTaRSiHOXB13 human
EvolutionaryTraceiQ92826
GeneWikiiHOXB13
GenomeRNAii10481
PROiPR:Q92826
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159184 Expressed in 24 organ(s), highest expression level in prostate gland
CleanExiHS_HOXB13
GenevisibleiQ92826 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR022067 HoxA13_N
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF12284 HoxA13_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB13_HUMAN
AccessioniPrimary (citable) accession number: Q92826
Secondary accession number(s): B2R878, Q96QM4, Q99810
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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