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Entry version 177 (08 May 2019)
Sequence version 2 (19 Jul 2004)
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Protein

Homeobox protein Hox-B13

Gene

HOXB13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi216 – 275HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q92826

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein Hox-B13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HOXB13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5112 HOXB13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604607 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92826

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Prostate cancer (PC)6 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
See also OMIM:176807
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07186684G → E in PC; rare variant associated with disease susceptibility. 6 PublicationsCorresponds to variant dbSNP:rs138213197EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
10481

MalaCards human disease database

More...
MalaCardsi
HOXB13
MIMi176807 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000159184

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1331 Familial prostate cancer

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29388

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HOXB13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50403792

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002001601 – 284Homeobox protein Hox-B13Add BLAST284

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92826

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92826

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92826

PeptideAtlas

More...
PeptideAtlasi
Q92826

PRoteomics IDEntifications database

More...
PRIDEi
Q92826

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75504

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q92826

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q92826

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159184 Expressed in 24 organ(s), highest expression level in prostate gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92826 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004438
HPA062852
HPA065019

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with MEIS1 (PubMed:28473536). Heterodimer with MEIS2 (Ref. 8).2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115744, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q92826, 6 interactors

Molecular INTeraction database

More...
MINTi
Q92826

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000290295

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRANMR-A217-273[»]
5EDNX-ray3.20A/B/G/J209-284[»]
5EEAX-ray2.19A/B/G/J217-279[»]
5EF6X-ray3.00A/B/G/J217-278[»]
5EG0X-ray3.10B217-277[»]
5EGOX-ray2.54B217-277[»]
5NO6X-ray2.88A/B217-278[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92826

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q92826

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni217 – 246Interaction with DNA2 PublicationsAdd BLAST30
Regioni258 – 269Interaction with 5-mCpG DNA1 PublicationAdd BLAST12
Regioni270 – 273Interaction with DNA2 Publications4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0487 Eukaryota
ENOG4111FJP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159029

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231176

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92826

Identification of Orthologs from Complete Genome Data

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OMAi
GCAFRRG

Database of Orthologous Groups

More...
OrthoDBi
1190384at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92826

TreeFam database of animal gene trees

More...
TreeFami
TF330813

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR022067 HoxA13_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046 Homeodomain, 1 hit
PF12284 HoxA13_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q92826-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLTSHPAAP TLMPAVNYAP
60 70 80 90 100
LDLPGSAEPP KQCHPCPGVP QGTSPAPVPY GYFGGGYYSC RVSRSSLKPC
110 120 130 140 150
AQAATLAAYP AETPTAGEEY PSRPTEFAFY PGYPGTYQPM ASYLDVSVVQ
160 170 180 190 200
TLGAPGEPRH DSLLPVDSYQ SWALAGGWNS QMCCQGEQNP PGPFWKAAFA
210 220 230 240 250
DSSGQHPPDA CAFRRGRKKR IPYSKGQLRE LEREYAANKF ITKDKRRKIS
260 270 280
AATSLSERQI TIWFQNRRVK EKKVLAKVKN SATP
Length:284
Mass (Da):30,676
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EE5898449C33CFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti138 – 139QP → HA (PubMed:8756292).Curated2
Sequence conflicti138 – 139QP → HA (PubMed:9665387).Curated2
Sequence conflicti211C → S in AAC50664 (PubMed:8756292).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03184941T → M1 PublicationCorresponds to variant dbSNP:rs199799743EnsemblClinVar.1
Natural variantiVAR_07186684G → E in PC; rare variant associated with disease susceptibility. 6 PublicationsCorresponds to variant dbSNP:rs138213197EnsemblClinVar.1
Natural variantiVAR_07186788Y → D Found in prostate cancer samples; unknown pathological significance. 1 Publication1
Natural variantiVAR_071868144L → P Found in prostate cancer samples; unknown pathological significance. 1 Publication1
Natural variantiVAR_071869216G → C Found in prostate cancer samples; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs375917549Ensembl.1
Natural variantiVAR_077246217R → C1 PublicationCorresponds to variant dbSNP:rs139475791EnsemblClinVar.1
Natural variantiVAR_071870229R → G Found in prostate cancer samples; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs529100627Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U57052 mRNA Translation: AAC50664.1
U81599 mRNA Translation: AAB39863.1
BT007410 mRNA Translation: AAP36078.1
AK313266 mRNA Translation: BAG36075.1
CH471109 Genomic DNA Translation: EAW94714.1
BC007092 mRNA Translation: AAH07092.1
BC070233 mRNA Translation: AAH70233.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11536.1

NCBI Reference Sequences

More...
RefSeqi
NP_006352.2, NM_006361.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000290295; ENSP00000290295; ENSG00000159184

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10481

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10481

UCSC genome browser

More...
UCSCi
uc002ioa.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57052 mRNA Translation: AAC50664.1
U81599 mRNA Translation: AAB39863.1
BT007410 mRNA Translation: AAP36078.1
AK313266 mRNA Translation: BAG36075.1
CH471109 Genomic DNA Translation: EAW94714.1
BC007092 mRNA Translation: AAH07092.1
BC070233 mRNA Translation: AAH70233.1
CCDSiCCDS11536.1
RefSeqiNP_006352.2, NM_006361.5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRANMR-A217-273[»]
5EDNX-ray3.20A/B/G/J209-284[»]
5EEAX-ray2.19A/B/G/J217-279[»]
5EF6X-ray3.00A/B/G/J217-278[»]
5EG0X-ray3.10B217-277[»]
5EGOX-ray2.54B217-277[»]
5NO6X-ray2.88A/B217-278[»]
SMRiQ92826
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115744, 15 interactors
IntActiQ92826, 6 interactors
MINTiQ92826
STRINGi9606.ENSP00000290295

PTM databases

iPTMnetiQ92826
PhosphoSitePlusiQ92826

Polymorphism and mutation databases

BioMutaiHOXB13
DMDMi50403792

Proteomic databases

jPOSTiQ92826
MaxQBiQ92826
PaxDbiQ92826
PeptideAtlasiQ92826
PRIDEiQ92826
ProteomicsDBi75504

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10481
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290295; ENSP00000290295; ENSG00000159184
GeneIDi10481
KEGGihsa:10481
UCSCiuc002ioa.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10481
DisGeNETi10481

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HOXB13
HGNCiHGNC:5112 HOXB13
HPAiCAB004438
HPA062852
HPA065019
MalaCardsiHOXB13
MIMi176807 phenotype
604607 gene
neXtProtiNX_Q92826
OpenTargetsiENSG00000159184
Orphaneti1331 Familial prostate cancer
PharmGKBiPA29388

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00940000159029
HOGENOMiHOG000231176
InParanoidiQ92826
OMAiGCAFRRG
OrthoDBi1190384at2759
PhylomeDBiQ92826
TreeFamiTF330813

Enzyme and pathway databases

SIGNORiQ92826

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HOXB13 human
EvolutionaryTraceiQ92826

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HOXB13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10481

Protein Ontology

More...
PROi
PR:Q92826

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000159184 Expressed in 24 organ(s), highest expression level in prostate gland
GenevisibleiQ92826 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR022067 HoxA13_N
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
PF12284 HoxA13_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXB13_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92826
Secondary accession number(s): B2R878, Q96QM4, Q99810
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 19, 2004
Last modified: May 8, 2019
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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