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1 to 25 of 42  Show
  1. 1
    "Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes."
    Miranda L., Wolf J., Pichuantes S., Duke R., Franzusoff A.
    Proc. Natl. Acad. Sci. U.S.A. 93:7695-7700(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PC6A), ALTERNATIVE SPLICING.
    Category: Sequences.
    Tissue: T-cell.
    Source: UniProtKB/Swiss-Prot (reviewed).
  2. 2
    Franzusoff A., Miranda L., Wolf J., Pichuantes S., Lu Y., Duke R.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  3. 3
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PC6A).
    Category: Sequences.
    Tissue: Lymph node.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2471 other entries.

  4. 4
    "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2217 other entries.

  5. 5
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  6. 6
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PC6A).
    Category: Sequences.
    Tissue: Kidney.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50448 other entries.

  7. 7
    Reudelhuber T.L.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-913 (ISOFORM PC6A).
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  8. 8
    "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1166-1860 (ISOFORM PC6B).
    Category: Sequences.
    Tissue: Tongue.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 12927 other entries.

  9. 9
    "Proteomic identification of caldesmon as a physiological substrate of proprotein convertase 6 in human uterine decidual cells essential for pregnancy establishment."
    Kilpatrick L.M., Stephens A.N., Hardman B.M., Salamonsen L.A., Li Y., Stanton P.G., Nie G.
    J. Proteome Res. 8:4983-4992(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PREGNANCY ESTABLISHMENT.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 13 other entries.

  10. 10
    "Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment."
    Heng S., Paule S., Hardman B., Li Y., Singh H., Rainczuk A., Stephens A.N., Nie G.
    Endocrinology 151:3909-3917(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PREGNANCY ESTABLISHMENT.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 11 other entries.

  11. 11
    "Cleavage of endometrial alpha-integrins into their functional forms is mediated by proprotein convertase 5/6."
    Paule S., Aljofan M., Simon C., Rombauts L.J., Nie G.
    Hum. Reprod. 27:2766-2774(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 4 other entries.

  12. 12
    "Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains."
    Fugere M., Limperis P.C., Beaulieu-Audy V., Gagnon F., Lavigne P., Klarskov K., Leduc R., Day R.
    J. Biol. Chem. 277:7648-7656(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: we investigated the specificity and potency of complete prodomains and short C-terminal prodomain peptides of each SPC on highly purified soluble enzyme preparations of human SPC1 SPC6 and SPC7.
    Source: GeneRIF:5125.

    This publication is mapped to 8 other entries.

  13. 13
    "Requirement for proprotein convertase 5/6 during decidualization of human endometrial stromal cells in vitro."
    Okada H., Nie G., Salamonsen L.A.
    J. Clin. Endocrinol. Metab. 90:1028-1034(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: PC5/6 plays a key role for decidualization in human endometrium.
    Source: GeneRIF:5125.

    This publication is mapped to 2 other entries.

  14. 14
    "Inhibiting uterine PC6 blocks embryo implantation: an obligatory role for a proprotein convertase in fertility."
    Nie G., Li Y., Wang M., Liu Y.X., Findlay J.K., Salamonsen L.A.
    Biol. Reprod. 72:1029-1036(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation.
    Source: GeneRIF:5125.

    This publication is mapped to 4 other entries.

  15. 15
    "Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis."
    Stawowy P., Meyborg H., Stibenz D., Borges Pereira Stawowy N., Roser M., Thanabalasingam U., Veinot J.P., Chretien M., Seidah N.G., Fleck E., Graf K.
    Circulation 111:2820-2827(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: furin and PC5 play a role in a MT-MMP-MMP-2 proteolytic cascade involving provision of macrophage MT1-MMP for the activation of pro-MMP-2; furin and PC5 are expressed in monocytes and colocalize with MT1-MMP in macrophages in the atherosclerotic plaque.
    Source: GeneRIF:5125.

    This publication is mapped to 13 other entries.

  16. 16
    Category: Interaction.
    Source: IntAct:Q92824.

    This publication is mapped to 1504 other entries.

  17. 17
    "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration."
    Lim J., Hao T., Shaw C., Patel A.J., Szabo G., Rual J.F., Fisk C.J., Li N., Smolyar A., Hill D.E., Barabasi A.L., Vidal M., Zoghbi H.Y.
    Cell 125:801-814(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Source: IntAct:Q92824.

    This publication is mapped to 566 other entries.

  18. 18
    "The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications."
    Benjannet S., Rhainds D., Hamelin J., Nassoury N., Seidah N.G.
    J. Biol. Chem. 281:30561-30572(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, PTM / Processing.
    Annotation: PCSK9 levels are finely regulated by the basic amino acid convertases furin and PC5/6A.
    Source: GeneRIF:5125.

    This publication is mapped to 5 other entries.

  19. 19
    "Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue."
    Sukonina V., Lookene A., Olivecrona T., Olivecrona G.
    Proc. Natl. Acad. Sci. U.S.A. 103:17450-17455(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-6784682.

    This publication is mapped to 31 other entries.

  20. 20
    "Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2."
    McColl B.K., Paavonen K., Karnezis T., Harris N.C., Davydova N., Rothacker J., Nice E.C., Harder K.W., Roufail S., Hibbs M.L., Rogers P.A., Alitalo K., Stacker S.A., Achen M.G.
    FASEB J. 21:1088-1098(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Interaction.
    Annotation: in binding VEGFR-2 furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides whereas PC7 promotes cleavage of the C-terminal propeptide only.
    Source: GeneRIF:5125.

    This publication is mapped to 30 other entries.

  21. 21
    "The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates."
    Mayer G., Hamelin J., Asselin M.C., Pasquato A., Marcinkiewicz E., Tang M., Tabibzadeh S., Seidah N.G.
    J. Biol. Chem. 283:2373-2384(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function, PTM / Processing.
    Annotation: after stimulation the protease activity of PC5A is enhanced as evidenced by the cleavage of the PC5A substrates Lefty ADAMTS-4 endothelial lipase and PCSK9.
    Source: GeneRIF:5125.

    This publication is mapped to 32 other entries.

  22. 22
    "The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6."
    Rehfeld J.F., Bundgaard J.R., Hannibal J., Zhu X., Norrbom C., Steiner D.F., Friis-Hansen L.
    Endocrinology 149:1600-1608(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: PC1/3 governs the endocrine and PC2 the neuronal processing of proCCK whereas PC5/6 contributes only to a modest endocrine synthesis of CCK-22.
    Source: GeneRIF:5125.

    This publication is mapped to 16 other entries.

  23. 23
    "Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9."
    Kourimate S., Le May C., Langhi C., Jarnoux A.L., Ouguerram K., Zair Y., Nguyen P., Krempf M., Cariou B., Costet P.
    J. Biol. Chem. 283:9666-9673(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function, PTM / Processing.
    Annotation: fibrates simultaneously decreased PCSK9 expression while increasing PC5/6A and furin expression indicating a broad action of PPARalpha activation in proprotein convertase-mediated lipid homeostasis.
    Source: GeneRIF:5125.

    This publication is mapped to 8 other entries.

  24. 24
    Category: Pathology & Biotech, Sequences.
    Annotation: We propose that Pcsk5 at least in part via GDF11 coordinately regulates caudal Hox paralogs to control anteroposterior patterning nephrogenesis skeletal and anorectal development.
    Source: GeneRIF:5125.

    This publication is mapped to 25 other entries.

  25. 25
    Category: Function, Pathology & Biotech.
    Annotation: Observational study of gene-disease association. (HuGE Navigator).
    Source: GeneRIF:5125.

    This publication is mapped to 18812 other entries.

1 to 25 of 42  Show
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