UniProtKB - Q92824 (PCSK5_HUMAN)
Proprotein convertase subtilisin/kexin type 5
PCSK5
Functioni
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.
3 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 171 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 212 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 386 | Charge relay systemPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- endopeptidase activity Source: Reactome
- peptidase activity Source: MGI
- peptide binding Source: BHF-UCL
- serine-type endopeptidase activity Source: BHF-UCL
GO - Biological processi
- anterior/posterior pattern specification Source: BHF-UCL
- cell-cell signaling Source: ProtInc
- cytokine precursor processing Source: BHF-UCL
- embryo implantation Source: BHF-UCL
- embryonic digestive tract development Source: BHF-UCL
- embryonic skeletal system development Source: BHF-UCL
- heart development Source: BHF-UCL
- kidney development Source: BHF-UCL
- limb morphogenesis Source: BHF-UCL
- peptide biosynthetic process Source: BHF-UCL
- peptide hormone processing Source: BHF-UCL
- protein processing Source: BHF-UCL
- regulation of lipoprotein lipase activity Source: Reactome
- renin secretion into blood stream Source: BHF-UCL
- respiratory tube development Source: BHF-UCL
- signal peptide processing Source: HGNC-UCL
- viral life cycle Source: BHF-UCL
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Pregnancy |
Enzyme and pathway databases
BRENDAi | 3.4.21.B26, 2681 |
PathwayCommonsi | Q92824 |
Reactomei | R-HSA-167060, NGF processing R-HSA-8963889, Assembly of active LPL and LIPC lipase complexes |
SignaLinki | Q92824 |
Protein family/group databases
MEROPSi | S08.076 |
Names & Taxonomyi
Protein namesi | Recommended name: Proprotein convertase subtilisin/kexin type 5 (EC:3.4.21.-)Alternative name(s): Proprotein convertase 5 Short name: PC5 Proprotein convertase 6 Short name: PC6 Short name: hPC6 Subtilisin/kexin-like protease PC5 |
Gene namesi | Name:PCSK5 Synonyms:PC5, PC6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8747, PCSK5 |
MIMi | 600488, gene |
neXtProti | NX_Q92824 |
VEuPathDBi | HostDB:ENSG00000099139 |
Subcellular locationi
Extracellular region or secreted
Note: Secreted through the regulated secretory pathway.By similarity
Other locations
Note: Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.By similarity
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Golgi apparatus
- Golgi apparatus Source: HPA
- Golgi lumen Source: Reactome
- integral component of Golgi membrane Source: GO_Central
- trans-Golgi network Source: GO_Central
Other locations
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 115 – 1743 | ExtracellularSequence analysisAdd BLAST | 1629 | |
Transmembranei | 1744 – 1764 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1765 – 1860 | CytoplasmicSequence analysisAdd BLAST | 96 |
Keywords - Cellular componenti
Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5125 |
OpenTargetsi | ENSG00000099139 |
PharmGKBi | PA33093 |
Miscellaneous databases
Pharosi | Q92824, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2826 |
GuidetoPHARMACOLOGYi | 2385 |
Genetic variation databases
BioMutai | PCSK5 |
DMDMi | 357529585 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | By similarityAdd BLAST | 32 | |
PropeptideiPRO_0000027102 | 33 – 114 | By similarityAdd BLAST | 82 | |
ChainiPRO_0000027103 | 115 – 1860 | Proprotein convertase subtilisin/kexin type 5Add BLAST | 1746 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 225 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 381 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 665 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 752 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 802 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 852 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1014 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1191 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1290 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1497 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1685 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1707 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 114 – 115 | Cleavage; by autolysisBy similarity | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Glycoprotein, ZymogenProteomic databases
MassIVEi | Q92824 |
PaxDbi | Q92824 |
PeptideAtlasi | Q92824 |
PRIDEi | Q92824 |
ProteomicsDBi | 75502 [Q92824-1] 75503 [Q92824-2] |
PTM databases
GlyGeni | Q92824, 12 sites |
iPTMneti | Q92824 |
PhosphoSitePlusi | Q92824 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000099139, Expressed in buccal mucosa cell and 228 other tissues |
ExpressionAtlasi | Q92824, baseline and differential |
Genevisiblei | Q92824, HS |
Organism-specific databases
HPAi | ENSG00000099139, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
Q92824
Isoform PC6A [Q92824-2]
Protein-protein interaction databases
BioGRIDi | 111152, 105 interactors |
IntActi | Q92824, 79 interactors |
STRINGi | 9606.ENSP00000446280 |
Chemistry databases
BindingDBi | Q92824 |
Miscellaneous databases
RNActi | Q92824, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 134 – 453 | Peptidase S8PROSITE-ProRule annotationAdd BLAST | 320 | |
Domaini | 461 – 601 | P/Homo BPROSITE-ProRule annotationAdd BLAST | 141 | |
Repeati | 630 – 680 | FU 1Add BLAST | 51 | |
Repeati | 683 – 730 | FU 2Add BLAST | 48 | |
Repeati | 734 – 777 | FU 3Add BLAST | 44 | |
Repeati | 779 – 824 | FU 4Add BLAST | 46 | |
Repeati | 832 – 879 | FU 5Add BLAST | 48 | |
Domaini | 869 – 913 | PLACAdd BLAST | 45 | |
Repeati | 882 – 927 | FU 6Add BLAST | 46 | |
Repeati | 929 – 979 | FU 7Add BLAST | 51 | |
Repeati | 982 – 1028 | FU 8Add BLAST | 47 | |
Repeati | 1032 – 1077 | FU 9Add BLAST | 46 | |
Repeati | 1079 – 1121 | FU 10Add BLAST | 43 | |
Repeati | 1125 – 1168 | FU 11Add BLAST | 44 | |
Repeati | 1177 – 1221 | FU 12Add BLAST | 45 | |
Repeati | 1225 – 1272 | FU 13Add BLAST | 48 | |
Repeati | 1274 – 1318 | FU 14Add BLAST | 45 | |
Repeati | 1320 – 1363 | FU 15Add BLAST | 44 | |
Repeati | 1365 – 1411 | FU 16Add BLAST | 47 | |
Repeati | 1415 – 1461 | FU 17Add BLAST | 47 | |
Repeati | 1465 – 1510 | FU 18Add BLAST | 46 | |
Repeati | 1514 – 1559 | FU 19Add BLAST | 46 | |
Repeati | 1563 – 1610 | FU 20Add BLAST | 48 | |
Repeati | 1614 – 1659 | FU 21Add BLAST | 46 | |
Repeati | 1665 – 1712 | FU 22Add BLAST | 48 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 636 – 1727 | CRM (Cys-rich motif)Add BLAST | 1092 | |
Regioni | 1807 – 1826 | AC 1By similarityAdd BLAST | 20 | |
Regioni | 1838 – 1860 | AC 2By similarityAdd BLAST | 23 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 519 – 521 | Cell attachment siteSequence analysis | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3525, Eukaryota |
GeneTreei | ENSGT00940000155770 |
HOGENOMi | CLU_003159_0_0_1 |
InParanoidi | Q92824 |
OrthoDBi | 518530at2759 |
PhylomeDBi | Q92824 |
TreeFami | TF314277 |
Family and domain databases
CDDi | cd00064, FU, 16 hits cd04059, Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit |
Gene3Di | 3.30.70.850, 1 hit 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR006212, Furin_repeat IPR008979, Galactose-bd-like_sf IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR034182, Kexin/furin IPR002884, P_dom IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR023827, Peptidase_S8_Asp-AS IPR022398, Peptidase_S8_His-AS IPR023828, Peptidase_S8_Ser-AS IPR015500, Peptidase_S8_subtilisin-rel IPR032815, S8_pro-domain IPR038466, S8_pro-domain_sf |
Pfami | View protein in Pfam PF14843, GF_recep_IV, 1 hit PF01483, P_proprotein, 1 hit PF00082, Peptidase_S8, 1 hit PF16470, S8_pro-domain, 1 hit |
PRINTSi | PR00723, SUBTILISIN |
SMARTi | View protein in SMART SM00181, EGF, 16 hits SM00261, FU, 22 hits |
SUPFAMi | SSF49785, SSF49785, 1 hit SSF52743, SSF52743, 1 hit SSF57184, SSF57184, 7 hits |
PROSITEi | View protein in PROSITE PS51829, P_HOMO_B, 1 hit PS51892, SUBTILASE, 1 hit PS00136, SUBTILASE_ASP, 1 hit PS00137, SUBTILASE_HIS, 1 hit PS00138, SUBTILASE_SER, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGWGSRCCCP GRLDLLCVLA LLGGCLLPVC RTRVYTNHWA VKIAGGFPEA
60 70 80 90 100
NRIASKYGFI NIGQIGALKD YYHFYHSRTI KRSVISSRGT HSFISMEPKV
110 120 130 140 150
EWIQQQVVKK RTKRDYDFSR AQSTYFNDPK WPSMWYMHCS DNTHPCQSDM
160 170 180 190 200
NIEGAWKRGY TGKNIVVTIL DDGIERTHPD LMQNYDALAS CDVNGNDLDP
210 220 230 240 250
MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG GVRMLDGDVT
260 270 280 290 300
DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR
310 320 330 340 350
RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE
360 370 380 390 400
CSSTLATTYS SGESYDKKII TTDLRQRCTD NHTGTSASAP MAAGIIALAL
410 420 430 440 450
EANPFLTWRD VQHVIVRTSR AGHLNANDWK TNAAGFKVSH LYGFGLMDAE
460 470 480 490 500
AMVMEAEKWT TVPRQHVCVE STDRQIKTIR PNSAVRSIYK ASGCSDNPNR
510 520 530 540 550
HVNYLEHVVV RITITHPRRG DLAIYLTSPS GTRSQLLANR LFDHSMEGFK
560 570 580 590 600
NWEFMTIHCW GERAAGDWVL EVYDTPSQLR NFKTPGKLKE WSLVLYGTSV
610 620 630 640 650
QPYSPTNEFP KVERFRYSRV EDPTDDYGTE DYAGPCDPEC SEVGCDGPGP
660 670 680 690 700
DHCNDCLHYY YKLKNNTRIC VSSCPPGHYH ADKKRCRKCA PNCESCFGSH
710 720 730 740 750
GDQCMSCKYG YFLNEETNSC VTHCPDGSYQ DTKKNLCRKC SENCKTCTEF
760 770 780 790 800
HNCTECRDGL SLQGSRCSVS CEDGRYFNGQ DCQPCHRFCA TCAGAGADGC
810 820 830 840 850
INCTEGYFME DGRCVQSCSI SYYFDHSSEN GYKSCKKCDI SCLTCNGPGF
860 870 880 890 900
KNCTSCPSGY LLDLGMCQMG AICKDGEYVD EHGHCQTCEA SCAKCQGPTQ
910 920 930 940 950
EDCTTCPMTR IFDDGRCVSN CPSWKFEFEN QCHPCHHTCQ RCQGSGPTHC
960 970 980 990 1000
TSCGADNYGR EHFLYQGECG DSCPEGHYAT EGNTCLPCPD NCELCHSVHV
1010 1020 1030 1040 1050
CTRCMKGYFI APTNHTCQKL ECGQGEVQDP DYEECVPCEE GCLGCSLDDP
1060 1070 1080 1090 1100
GTCTSCAMGY YRFDHHCYKT CPEKTYSEEV ECKACDSNCG SCDQNGCYWC
1110 1120 1130 1140 1150
EEGFFLLGGS CVRKCGPGFY GDQEMGECES CHRACETCTG PGHDECSSCQ
1160 1170 1180 1190 1200
EGLQLLRGMC VHATKTQEEG KFWNDILRKL QPCHSSCKTC NGSATLCTSC
1210 1220 1230 1240 1250
PKGAYLLAQA CVSSCPQGTW PSVRSGSCEN CTEACAICSG ADLCKKCQMQ
1260 1270 1280 1290 1300
PGHPLFLHEG RCYSKCPEGS YAEDGICERC SSPCRTCEGN ATNCHSCEGG
1310 1320 1330 1340 1350
HVLHHGVCQE NCPERHVAVK GVCKHCPEMC QDCIHEKTCK ECTPEFFLHD
1360 1370 1380 1390 1400
DMCHQSCPRG FYADSRHCVP CHKDCLECSG PKADDCELCL ESSWVLYDGL
1410 1420 1430 1440 1450
CLEECPAGTY YEKETKECRD CHKSCLTCSS SGTCTTCQKG LIMNPRGSCM
1460 1470 1480 1490 1500
ANEKCSPSEY WDEDAPGCKP CHVKCFHCMG PAEDQCQTCP MNSLLLNTTC
1510 1520 1530 1540 1550
VKDCPEGYYA DEDSNRCAHC HSSCRTCEGR HSRQCHSCRP GWFQLGKECL
1560 1570 1580 1590 1600
LQCREGYYAD NSTGRCERCN RSCKGCQGPR PTDCLSCDRF FFLLRSKGEC
1610 1620 1630 1640 1650
HRSCPDHYYV EQSTQTCERC HPTCDQCKGK GALNCLSCVW SYHLMGGICT
1660 1670 1680 1690 1700
SDCLVGEYRV GEGEKFNCEK CHESCMECKG PGAKNCTLCP ANLVLHMDDS
1710 1720 1730 1740 1750
HCLHCCNTSD PPSAQECCDC QDTTDECILR TSKVRPATEH FKTALFITSS
1760 1770 1780 1790 1800
MMLVLLLGAA VVVWKKSRGR VQPAAKAGYE KLADPNKSYS SYKSSYREST
1810 1820 1830 1840 1850
SFEEDQVIEY RDRDYDEDDD DDIVYMGQDG TVYRKFKYGL LDDDDIDELE
1860
YDDESYSYYQ
The sequence of this isoform differs from the canonical sequence as follows:
876-913: GEYVDEHGHC...TTCPMTRIFD → ATEESWAEGG...LCCKTCTFQG
914-1860: Missing.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A669KA35 | A0A669KA35_HUMAN | Proprotein convertase subtilisin/ke... | PCSK5 | 1,887 | Annotation score: | ||
Q5JSG7 | Q5JSG7_HUMAN | Proprotein convertase subtilisin/ke... | PCSK5 | 1,560 | Annotation score: | ||
B1AMG5 | B1AMG5_HUMAN | Proprotein convertase subtilisin/ke... | PCSK5 | 690 | Annotation score: | ||
B1AMG8 | B1AMG8_HUMAN | Proprotein convertase subtilisin/ke... | PCSK5 | 101 | Annotation score: | ||
A0A669KBD8 | A0A669KBD8_HUMAN | Proprotein convertase subtilisin/ke... | PCSK5 | 184 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | G → D in AAC50643 (PubMed:8755538).Curated | 1 | |
Sequence conflicti | 4 | G → E in AAC50643 (PubMed:8755538).Curated | 1 | |
Sequence conflicti | 118 | F → S in AAC50643 (PubMed:8755538).Curated | 1 | |
Sequence conflicti | 121 | A → V in AAC50643 (PubMed:8755538).Curated | 1 | |
Sequence conflicti | 511 | R → A in AAA91807 (Ref. 7) Curated | 1 | |
Sequence conflicti | 601 | Q → R in AAC50643 (PubMed:8755538).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042017 | 876 – 913 | GEYVD…TRIFD → ATEESWAEGGFCMLVKKNNL CQRKVLQQLCCKTCTFQG in isoform PC6A. 4 PublicationsAdd BLAST | 38 | |
Alternative sequenceiVSP_042018 | 914 – 1860 | Missing in isoform PC6A. 4 PublicationsAdd BLAST | 947 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U56387 mRNA Translation: AAC50643.2 AL834522 mRNA Translation: CAD39178.1 AL359253 Genomic DNA No translation available. AL353607 Genomic DNA No translation available. AL391868 Genomic DNA No translation available. AL589653 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62575.1 BC012064 mRNA Translation: AAH12064.1 U49114 mRNA Translation: AAA91807.1 AK122718 mRNA No translation available. |
CCDSi | CCDS55320.1 [Q92824-1] CCDS6652.1 [Q92824-2] |
PIRi | G02428 JC6148 |
RefSeqi | NP_001177411.1, NM_001190482.1 [Q92824-1] NP_006191.2, NM_006200.5 [Q92824-2] |
Genome annotation databases
Ensembli | ENST00000376752; ENSP00000365943; ENSG00000099139 [Q92824-2] ENST00000545128; ENSP00000446280; ENSG00000099139 |
GeneIDi | 5125 |
KEGGi | hsa:5125 |
UCSCi | uc004ajz.5, human [Q92824-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U56387 mRNA Translation: AAC50643.2 AL834522 mRNA Translation: CAD39178.1 AL359253 Genomic DNA No translation available. AL353607 Genomic DNA No translation available. AL391868 Genomic DNA No translation available. AL589653 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62575.1 BC012064 mRNA Translation: AAH12064.1 U49114 mRNA Translation: AAA91807.1 AK122718 mRNA No translation available. |
CCDSi | CCDS55320.1 [Q92824-1] CCDS6652.1 [Q92824-2] |
PIRi | G02428 JC6148 |
RefSeqi | NP_001177411.1, NM_001190482.1 [Q92824-1] NP_006191.2, NM_006200.5 [Q92824-2] |
3D structure databases
SMRi | Q92824 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111152, 105 interactors |
IntActi | Q92824, 79 interactors |
STRINGi | 9606.ENSP00000446280 |
Chemistry databases
BindingDBi | Q92824 |
ChEMBLi | CHEMBL2826 |
GuidetoPHARMACOLOGYi | 2385 |
Protein family/group databases
MEROPSi | S08.076 |
PTM databases
GlyGeni | Q92824, 12 sites |
iPTMneti | Q92824 |
PhosphoSitePlusi | Q92824 |
Genetic variation databases
BioMutai | PCSK5 |
DMDMi | 357529585 |
Proteomic databases
MassIVEi | Q92824 |
PaxDbi | Q92824 |
PeptideAtlasi | Q92824 |
PRIDEi | Q92824 |
ProteomicsDBi | 75502 [Q92824-1] 75503 [Q92824-2] |
Protocols and materials databases
Antibodypediai | 27199, 204 antibodies from 26 providers |
DNASUi | 5125 |
Genome annotation databases
Ensembli | ENST00000376752; ENSP00000365943; ENSG00000099139 [Q92824-2] ENST00000545128; ENSP00000446280; ENSG00000099139 |
GeneIDi | 5125 |
KEGGi | hsa:5125 |
UCSCi | uc004ajz.5, human [Q92824-1] |
Organism-specific databases
CTDi | 5125 |
DisGeNETi | 5125 |
GeneCardsi | PCSK5 |
HGNCi | HGNC:8747, PCSK5 |
HPAi | ENSG00000099139, Tissue enhanced (brain) |
MIMi | 600488, gene |
neXtProti | NX_Q92824 |
OpenTargetsi | ENSG00000099139 |
PharmGKBi | PA33093 |
VEuPathDBi | HostDB:ENSG00000099139 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3525, Eukaryota |
GeneTreei | ENSGT00940000155770 |
HOGENOMi | CLU_003159_0_0_1 |
InParanoidi | Q92824 |
OrthoDBi | 518530at2759 |
PhylomeDBi | Q92824 |
TreeFami | TF314277 |
Enzyme and pathway databases
BRENDAi | 3.4.21.B26, 2681 |
PathwayCommonsi | Q92824 |
Reactomei | R-HSA-167060, NGF processing R-HSA-8963889, Assembly of active LPL and LIPC lipase complexes |
SignaLinki | Q92824 |
Miscellaneous databases
BioGRID-ORCSi | 5125, 2 hits in 1037 CRISPR screens |
ChiTaRSi | PCSK5, human |
GeneWikii | PCSK5 |
GenomeRNAii | 5125 |
Pharosi | Q92824, Tchem |
PROi | PR:Q92824 |
RNActi | Q92824, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000099139, Expressed in buccal mucosa cell and 228 other tissues |
ExpressionAtlasi | Q92824, baseline and differential |
Genevisiblei | Q92824, HS |
Family and domain databases
CDDi | cd00064, FU, 16 hits cd04059, Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit |
Gene3Di | 3.30.70.850, 1 hit 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR006212, Furin_repeat IPR008979, Galactose-bd-like_sf IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR034182, Kexin/furin IPR002884, P_dom IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR023827, Peptidase_S8_Asp-AS IPR022398, Peptidase_S8_His-AS IPR023828, Peptidase_S8_Ser-AS IPR015500, Peptidase_S8_subtilisin-rel IPR032815, S8_pro-domain IPR038466, S8_pro-domain_sf |
Pfami | View protein in Pfam PF14843, GF_recep_IV, 1 hit PF01483, P_proprotein, 1 hit PF00082, Peptidase_S8, 1 hit PF16470, S8_pro-domain, 1 hit |
PRINTSi | PR00723, SUBTILISIN |
SMARTi | View protein in SMART SM00181, EGF, 16 hits SM00261, FU, 22 hits |
SUPFAMi | SSF49785, SSF49785, 1 hit SSF52743, SSF52743, 1 hit SSF57184, SSF57184, 7 hits |
PROSITEi | View protein in PROSITE PS51829, P_HOMO_B, 1 hit PS51892, SUBTILASE, 1 hit PS00136, SUBTILASE_ASP, 1 hit PS00137, SUBTILASE_HIS, 1 hit PS00138, SUBTILASE_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PCSK5_HUMAN | |
Accessioni | Q92824Primary (citable) accession number: Q92824 Secondary accession number(s): F5H2G7, Q13527, Q96EP4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 23, 2022 | |
This is version 206 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families