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Entry version 193 (18 Sep 2019)
Sequence version 4 (16 Nov 2011)
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Protein

Proprotein convertase subtilisin/kexin type 5

Gene

PCSK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei171Charge relay systemPROSITE-ProRule annotation1
Active sitei212Charge relay systemPROSITE-ProRule annotation1
Active sitei386Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processPregnancy

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.B26 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-167060 NGF processing
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q92824

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S08.076

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proprotein convertase subtilisin/kexin type 5 (EC:3.4.21.-)
Alternative name(s):
Proprotein convertase 5
Short name:
PC5
Proprotein convertase 6
Short name:
PC6
Short name:
hPC6
Subtilisin/kexin-like protease PC5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCSK5
Synonyms:PC5, PC6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8747 PCSK5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600488 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92824

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini115 – 1743ExtracellularSequence analysisAdd BLAST1629
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1744 – 1764HelicalSequence analysisAdd BLAST21
Topological domaini1765 – 1860CytoplasmicSequence analysisAdd BLAST96

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5125

Open Targets

More...
OpenTargetsi
ENSG00000099139

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33093

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92824

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2826

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2385

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCSK5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
357529585

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32By similarityAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002710233 – 114By similarityAdd BLAST82
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000027103115 – 1860Proprotein convertase subtilisin/kexin type 5Add BLAST1746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi665N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi802N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi852N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1014N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1497N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1685N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1707N-linked (GlcNAc...) asparagineSequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei114 – 115Cleavage; by autolysisBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Zymogen

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92824

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92824

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92824

PeptideAtlas

More...
PeptideAtlasi
Q92824

PRoteomics IDEntifications database

More...
PRIDEi
Q92824

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75502 [Q92824-1]
75503 [Q92824-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92824

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92824

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q92824

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in T-lymphocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000099139 Expressed in 214 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q92824 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92824 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031072

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111152, 33 interactors

Protein interaction database and analysis system

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IntActi
Q92824, 80 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000446280

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q92824

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92824

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini134 – 453Peptidase S8PROSITE-ProRule annotationAdd BLAST320
Domaini461 – 601P/Homo BPROSITE-ProRule annotationAdd BLAST141
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati630 – 680FU 1Add BLAST51
Repeati683 – 730FU 2Add BLAST48
Repeati734 – 777FU 3Add BLAST44
Repeati779 – 824FU 4Add BLAST46
Repeati832 – 879FU 5Add BLAST48
Domaini869 – 913PLACAdd BLAST45
Repeati882 – 927FU 6Add BLAST46
Repeati929 – 979FU 7Add BLAST51
Repeati982 – 1028FU 8Add BLAST47
Repeati1032 – 1077FU 9Add BLAST46
Repeati1079 – 1121FU 10Add BLAST43
Repeati1125 – 1168FU 11Add BLAST44
Repeati1177 – 1221FU 12Add BLAST45
Repeati1225 – 1272FU 13Add BLAST48
Repeati1274 – 1318FU 14Add BLAST45
Repeati1320 – 1363FU 15Add BLAST44
Repeati1365 – 1411FU 16Add BLAST47
Repeati1415 – 1461FU 17Add BLAST47
Repeati1465 – 1510FU 18Add BLAST46
Repeati1514 – 1559FU 19Add BLAST46
Repeati1563 – 1610FU 20Add BLAST48
Repeati1614 – 1659FU 21Add BLAST46
Repeati1665 – 1712FU 22Add BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni636 – 1727CRM (Cys-rich motif)Add BLAST1092
Regioni1807 – 1826AC 1By similarityAdd BLAST20
Regioni1838 – 1860AC 2By similarityAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi519 – 521Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1812 – 1853Asp-richAdd BLAST42

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.
AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1 (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3525 Eukaryota
COG1404 LUCA
COG4935 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155770

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000192536

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92824

KEGG Orthology (KO)

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KOi
K08654

Identification of Orthologs from Complete Genome Data

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OMAi
TWYNDTW

Database of Orthologous Groups

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OrthoDBi
518530at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q92824

TreeFam database of animal gene trees

More...
TreeFami
TF314277

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00064 FU, 17 hits
cd04059 Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR006212 Furin_repeat
IPR008979 Galactose-bd-like_sf
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14843 GF_recep_IV, 1 hit
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00723 SUBTILISIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 16 hits
SM01411 Ephrin_rec_like, 8 hits
SM00261 FU, 22 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
SSF57184 SSF57184, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS51892 SUBTILASE, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform PC6B (identifier: Q92824-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGWGSRCCCP GRLDLLCVLA LLGGCLLPVC RTRVYTNHWA VKIAGGFPEA
60 70 80 90 100
NRIASKYGFI NIGQIGALKD YYHFYHSRTI KRSVISSRGT HSFISMEPKV
110 120 130 140 150
EWIQQQVVKK RTKRDYDFSR AQSTYFNDPK WPSMWYMHCS DNTHPCQSDM
160 170 180 190 200
NIEGAWKRGY TGKNIVVTIL DDGIERTHPD LMQNYDALAS CDVNGNDLDP
210 220 230 240 250
MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG GVRMLDGDVT
260 270 280 290 300
DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR
310 320 330 340 350
RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE
360 370 380 390 400
CSSTLATTYS SGESYDKKII TTDLRQRCTD NHTGTSASAP MAAGIIALAL
410 420 430 440 450
EANPFLTWRD VQHVIVRTSR AGHLNANDWK TNAAGFKVSH LYGFGLMDAE
460 470 480 490 500
AMVMEAEKWT TVPRQHVCVE STDRQIKTIR PNSAVRSIYK ASGCSDNPNR
510 520 530 540 550
HVNYLEHVVV RITITHPRRG DLAIYLTSPS GTRSQLLANR LFDHSMEGFK
560 570 580 590 600
NWEFMTIHCW GERAAGDWVL EVYDTPSQLR NFKTPGKLKE WSLVLYGTSV
610 620 630 640 650
QPYSPTNEFP KVERFRYSRV EDPTDDYGTE DYAGPCDPEC SEVGCDGPGP
660 670 680 690 700
DHCNDCLHYY YKLKNNTRIC VSSCPPGHYH ADKKRCRKCA PNCESCFGSH
710 720 730 740 750
GDQCMSCKYG YFLNEETNSC VTHCPDGSYQ DTKKNLCRKC SENCKTCTEF
760 770 780 790 800
HNCTECRDGL SLQGSRCSVS CEDGRYFNGQ DCQPCHRFCA TCAGAGADGC
810 820 830 840 850
INCTEGYFME DGRCVQSCSI SYYFDHSSEN GYKSCKKCDI SCLTCNGPGF
860 870 880 890 900
KNCTSCPSGY LLDLGMCQMG AICKDGEYVD EHGHCQTCEA SCAKCQGPTQ
910 920 930 940 950
EDCTTCPMTR IFDDGRCVSN CPSWKFEFEN QCHPCHHTCQ RCQGSGPTHC
960 970 980 990 1000
TSCGADNYGR EHFLYQGECG DSCPEGHYAT EGNTCLPCPD NCELCHSVHV
1010 1020 1030 1040 1050
CTRCMKGYFI APTNHTCQKL ECGQGEVQDP DYEECVPCEE GCLGCSLDDP
1060 1070 1080 1090 1100
GTCTSCAMGY YRFDHHCYKT CPEKTYSEEV ECKACDSNCG SCDQNGCYWC
1110 1120 1130 1140 1150
EEGFFLLGGS CVRKCGPGFY GDQEMGECES CHRACETCTG PGHDECSSCQ
1160 1170 1180 1190 1200
EGLQLLRGMC VHATKTQEEG KFWNDILRKL QPCHSSCKTC NGSATLCTSC
1210 1220 1230 1240 1250
PKGAYLLAQA CVSSCPQGTW PSVRSGSCEN CTEACAICSG ADLCKKCQMQ
1260 1270 1280 1290 1300
PGHPLFLHEG RCYSKCPEGS YAEDGICERC SSPCRTCEGN ATNCHSCEGG
1310 1320 1330 1340 1350
HVLHHGVCQE NCPERHVAVK GVCKHCPEMC QDCIHEKTCK ECTPEFFLHD
1360 1370 1380 1390 1400
DMCHQSCPRG FYADSRHCVP CHKDCLECSG PKADDCELCL ESSWVLYDGL
1410 1420 1430 1440 1450
CLEECPAGTY YEKETKECRD CHKSCLTCSS SGTCTTCQKG LIMNPRGSCM
1460 1470 1480 1490 1500
ANEKCSPSEY WDEDAPGCKP CHVKCFHCMG PAEDQCQTCP MNSLLLNTTC
1510 1520 1530 1540 1550
VKDCPEGYYA DEDSNRCAHC HSSCRTCEGR HSRQCHSCRP GWFQLGKECL
1560 1570 1580 1590 1600
LQCREGYYAD NSTGRCERCN RSCKGCQGPR PTDCLSCDRF FFLLRSKGEC
1610 1620 1630 1640 1650
HRSCPDHYYV EQSTQTCERC HPTCDQCKGK GALNCLSCVW SYHLMGGICT
1660 1670 1680 1690 1700
SDCLVGEYRV GEGEKFNCEK CHESCMECKG PGAKNCTLCP ANLVLHMDDS
1710 1720 1730 1740 1750
HCLHCCNTSD PPSAQECCDC QDTTDECILR TSKVRPATEH FKTALFITSS
1760 1770 1780 1790 1800
MMLVLLLGAA VVVWKKSRGR VQPAAKAGYE KLADPNKSYS SYKSSYREST
1810 1820 1830 1840 1850
SFEEDQVIEY RDRDYDEDDD DDIVYMGQDG TVYRKFKYGL LDDDDIDELE
1860
YDDESYSYYQ
Length:1,860
Mass (Da):206,942
Last modified:November 16, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96B3E7C8215BCC85
GO
Isoform PC6A (identifier: Q92824-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     876-913: GEYVDEHGHC...TTCPMTRIFD → ATEESWAEGG...LCCKTCTFQG
     914-1860: Missing.

Show »
Length:913
Mass (Da):101,649
Checksum:i7A2E63EFC49104BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AMG5B1AMG5_HUMAN
Proprotein convertase subtilisin/ke...
PCSK5
690Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JSG7Q5JSG7_HUMAN
Proprotein convertase subtilisin/ke...
PCSK5
1,560Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AMG8B1AMG8_HUMAN
Proprotein convertase subtilisin/ke...
PCSK5
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2G → D in AAC50643 (PubMed:8755538).Curated1
Sequence conflicti4G → E in AAC50643 (PubMed:8755538).Curated1
Sequence conflicti118F → S in AAC50643 (PubMed:8755538).Curated1
Sequence conflicti121A → V in AAC50643 (PubMed:8755538).Curated1
Sequence conflicti511R → A in AAA91807 (Ref. 7) Curated1
Sequence conflicti601Q → R in AAC50643 (PubMed:8755538).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042017876 – 913GEYVD…TRIFD → ATEESWAEGGFCMLVKKNNL CQRKVLQQLCCKTCTFQG in isoform PC6A. 4 PublicationsAdd BLAST38
Alternative sequenceiVSP_042018914 – 1860Missing in isoform PC6A. 4 PublicationsAdd BLAST947

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U56387 mRNA Translation: AAC50643.2
AL834522 mRNA Translation: CAD39178.1
AL359253 Genomic DNA No translation available.
AL353607 Genomic DNA No translation available.
AL391868 Genomic DNA No translation available.
AL589653 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62575.1
BC012064 mRNA Translation: AAH12064.1
U49114 mRNA Translation: AAA91807.1
AK122718 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55320.1 [Q92824-1]
CCDS6652.1 [Q92824-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
G02428
JC6148

NCBI Reference Sequences

More...
RefSeqi
NP_001177411.1, NM_001190482.1 [Q92824-1]
NP_006191.2, NM_006200.5 [Q92824-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376752; ENSP00000365943; ENSG00000099139 [Q92824-2]
ENST00000545128; ENSP00000446280; ENSG00000099139 [Q92824-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5125

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5125

UCSC genome browser

More...
UCSCi
uc004ajz.5 human [Q92824-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56387 mRNA Translation: AAC50643.2
AL834522 mRNA Translation: CAD39178.1
AL359253 Genomic DNA No translation available.
AL353607 Genomic DNA No translation available.
AL391868 Genomic DNA No translation available.
AL589653 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62575.1
BC012064 mRNA Translation: AAH12064.1
U49114 mRNA Translation: AAA91807.1
AK122718 mRNA No translation available.
CCDSiCCDS55320.1 [Q92824-1]
CCDS6652.1 [Q92824-2]
PIRiG02428
JC6148
RefSeqiNP_001177411.1, NM_001190482.1 [Q92824-1]
NP_006191.2, NM_006200.5 [Q92824-2]

3D structure databases

SMRiQ92824
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111152, 33 interactors
IntActiQ92824, 80 interactors
STRINGi9606.ENSP00000446280

Chemistry databases

BindingDBiQ92824
ChEMBLiCHEMBL2826
GuidetoPHARMACOLOGYi2385

Protein family/group databases

MEROPSiS08.076

PTM databases

iPTMnetiQ92824
PhosphoSitePlusiQ92824

Polymorphism and mutation databases

BioMutaiPCSK5
DMDMi357529585

Proteomic databases

jPOSTiQ92824
MassIVEiQ92824
PaxDbiQ92824
PeptideAtlasiQ92824
PRIDEiQ92824
ProteomicsDBi75502 [Q92824-1]
75503 [Q92824-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5125

Genome annotation databases

EnsembliENST00000376752; ENSP00000365943; ENSG00000099139 [Q92824-2]
ENST00000545128; ENSP00000446280; ENSG00000099139 [Q92824-1]
GeneIDi5125
KEGGihsa:5125
UCSCiuc004ajz.5 human [Q92824-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5125
DisGeNETi5125

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PCSK5
HGNCiHGNC:8747 PCSK5
HPAiHPA031072
MIMi600488 gene
neXtProtiNX_Q92824
OpenTargetsiENSG00000099139
PharmGKBiPA33093

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
COG1404 LUCA
COG4935 LUCA
GeneTreeiENSGT00940000155770
HOGENOMiHOG000192536
InParanoidiQ92824
KOiK08654
OMAiTWYNDTW
OrthoDBi518530at2759
PhylomeDBiQ92824
TreeFamiTF314277

Enzyme and pathway databases

BRENDAi3.4.21.B26 2681
ReactomeiR-HSA-167060 NGF processing
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
SignaLinkiQ92824

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PCSK5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PCSK5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5125
PharosiQ92824
PMAP-CutDBiQ92824

Protein Ontology

More...
PROi
PR:Q92824

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000099139 Expressed in 214 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiQ92824 baseline and differential
GenevisibleiQ92824 HS

Family and domain databases

CDDicd00064 FU, 17 hits
cd04059 Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR006212 Furin_repeat
IPR008979 Galactose-bd-like_sf
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF14843 GF_recep_IV, 1 hit
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SMARTiView protein in SMART
SM00181 EGF, 16 hits
SM01411 Ephrin_rec_like, 8 hits
SM00261 FU, 22 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
SSF57184 SSF57184, 7 hits
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS51892 SUBTILASE, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCSK5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92824
Secondary accession number(s): F5H2G7, Q13527, Q96EP4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 16, 2011
Last modified: September 18, 2019
This is version 193 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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