UniProtKB - Q92824 (PCSK5_HUMAN)
Proprotein convertase subtilisin/kexin type 5
PCSK5
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 171 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 212 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 386 | Charge relay systemPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- endopeptidase activity Source: Reactome
- peptidase activity Source: MGI
- peptide binding Source: BHF-UCL
- serine-type endopeptidase activity Source: BHF-UCL
GO - Biological processi
- anterior/posterior pattern specification Source: BHF-UCL
- cardiac septum development Source: Ensembl
- cell-cell signaling Source: ProtInc
- coronary vasculature development Source: Ensembl
- cytokine biosynthetic process Source: BHF-UCL
- determination of left/right symmetry Source: Ensembl
- embryo implantation Source: BHF-UCL
- embryonic digestive tract development Source: BHF-UCL
- embryonic skeletal system development Source: BHF-UCL
- heart development Source: BHF-UCL
- kidney development Source: BHF-UCL
- limb morphogenesis Source: BHF-UCL
- nerve growth factor processing Source: Reactome
- peptide biosynthetic process Source: BHF-UCL
- peptide hormone processing Source: BHF-UCL
- protein processing Source: BHF-UCL
- regulation of lipoprotein lipase activity Source: Reactome
- renin secretion into blood stream Source: BHF-UCL
- respiratory tube development Source: BHF-UCL
- signal peptide processing Source: HGNC-UCL
- viral life cycle Source: BHF-UCL
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Pregnancy |
Enzyme and pathway databases
BRENDAi | 3.4.21.B26 2681 |
Reactomei | R-HSA-167060 NGF processing R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes |
SignaLinki | Q92824 |
Protein family/group databases
MEROPSi | S08.076 |
Names & Taxonomyi
Protein namesi | Recommended name: Proprotein convertase subtilisin/kexin type 5 (EC:3.4.21.-)Alternative name(s): Proprotein convertase 5 Short name: PC5 Proprotein convertase 6 Short name: PC6 Short name: hPC6 Subtilisin/kexin-like protease PC5 |
Gene namesi | Name:PCSK5 Synonyms:PC5, PC6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8747 PCSK5 |
MIMi | 600488 gene |
neXtProti | NX_Q92824 |
Subcellular locationi
Extracellular region or secreted
Note: Secreted through the regulated secretory pathway.By similarity
Other locations
Note: Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.By similarity
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Golgi apparatus
- Golgi apparatus Source: HPA
- Golgi lumen Source: Reactome
- integral component of Golgi membrane Source: GO_Central
- trans-Golgi network Source: GO_Central
Other locations
- membrane Source: GO_Central
- secretory granule Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 115 – 1743 | ExtracellularSequence analysisAdd BLAST | 1629 | |
Transmembranei | 1744 – 1764 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1765 – 1860 | CytoplasmicSequence analysisAdd BLAST | 96 |
Keywords - Cellular componenti
Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5125 |
OpenTargetsi | ENSG00000099139 |
PharmGKBi | PA33093 |
Miscellaneous databases
Pharosi | Q92824 |
Chemistry databases
ChEMBLi | CHEMBL2826 |
GuidetoPHARMACOLOGYi | 2385 |
Polymorphism and mutation databases
BioMutai | PCSK5 |
DMDMi | 357529585 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | By similarityAdd BLAST | 32 | |
PropeptideiPRO_0000027102 | 33 – 114 | By similarityAdd BLAST | 82 | |
ChainiPRO_0000027103 | 115 – 1860 | Proprotein convertase subtilisin/kexin type 5Add BLAST | 1746 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 225 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 381 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 665 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 752 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 802 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 852 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1014 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1191 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1290 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1497 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1685 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1707 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 114 – 115 | Cleavage; by autolysisBy similarity | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Glycoprotein, ZymogenProteomic databases
jPOSTi | Q92824 |
MassIVEi | Q92824 |
PaxDbi | Q92824 |
PeptideAtlasi | Q92824 |
PRIDEi | Q92824 |
ProteomicsDBi | 75502 [Q92824-1] 75503 [Q92824-2] |
PTM databases
iPTMneti | Q92824 |
PhosphoSitePlusi | Q92824 |
Miscellaneous databases
PMAP-CutDBi | Q92824 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000099139 Expressed in 214 organ(s), highest expression level in buccal mucosa cell |
ExpressionAtlasi | Q92824 baseline and differential |
Genevisiblei | Q92824 HS |
Organism-specific databases
HPAi | HPA031072 |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 111152, 33 interactors |
IntActi | Q92824, 80 interactors |
STRINGi | 9606.ENSP00000446280 |
Chemistry databases
BindingDBi | Q92824 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 134 – 453 | Peptidase S8PROSITE-ProRule annotationAdd BLAST | 320 | |
Domaini | 461 – 601 | P/Homo BPROSITE-ProRule annotationAdd BLAST | 141 | |
Repeati | 630 – 680 | FU 1Add BLAST | 51 | |
Repeati | 683 – 730 | FU 2Add BLAST | 48 | |
Repeati | 734 – 777 | FU 3Add BLAST | 44 | |
Repeati | 779 – 824 | FU 4Add BLAST | 46 | |
Repeati | 832 – 879 | FU 5Add BLAST | 48 | |
Domaini | 869 – 913 | PLACAdd BLAST | 45 | |
Repeati | 882 – 927 | FU 6Add BLAST | 46 | |
Repeati | 929 – 979 | FU 7Add BLAST | 51 | |
Repeati | 982 – 1028 | FU 8Add BLAST | 47 | |
Repeati | 1032 – 1077 | FU 9Add BLAST | 46 | |
Repeati | 1079 – 1121 | FU 10Add BLAST | 43 | |
Repeati | 1125 – 1168 | FU 11Add BLAST | 44 | |
Repeati | 1177 – 1221 | FU 12Add BLAST | 45 | |
Repeati | 1225 – 1272 | FU 13Add BLAST | 48 | |
Repeati | 1274 – 1318 | FU 14Add BLAST | 45 | |
Repeati | 1320 – 1363 | FU 15Add BLAST | 44 | |
Repeati | 1365 – 1411 | FU 16Add BLAST | 47 | |
Repeati | 1415 – 1461 | FU 17Add BLAST | 47 | |
Repeati | 1465 – 1510 | FU 18Add BLAST | 46 | |
Repeati | 1514 – 1559 | FU 19Add BLAST | 46 | |
Repeati | 1563 – 1610 | FU 20Add BLAST | 48 | |
Repeati | 1614 – 1659 | FU 21Add BLAST | 46 | |
Repeati | 1665 – 1712 | FU 22Add BLAST | 48 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 636 – 1727 | CRM (Cys-rich motif)Add BLAST | 1092 | |
Regioni | 1807 – 1826 | AC 1By similarityAdd BLAST | 20 | |
Regioni | 1838 – 1860 | AC 2By similarityAdd BLAST | 23 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 519 – 521 | Cell attachment siteSequence analysis | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1812 – 1853 | Asp-richAdd BLAST | 42 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3525 Eukaryota COG1404 LUCA COG4935 LUCA |
GeneTreei | ENSGT00940000155770 |
HOGENOMi | HOG000192536 |
InParanoidi | Q92824 |
KOi | K08654 |
OMAi | TWYNDTW |
OrthoDBi | 518530at2759 |
PhylomeDBi | Q92824 |
TreeFami | TF314277 |
Family and domain databases
CDDi | cd00064 FU, 17 hits cd04059 Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit |
Gene3Di | 2.60.120.260, 1 hit 3.30.70.850, 1 hit 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR000742 EGF-like_dom IPR006212 Furin_repeat IPR008979 Galactose-bd-like_sf IPR032778 GF_recep_IV IPR009030 Growth_fac_rcpt_cys_sf IPR034182 Kexin/furin IPR002884 P_dom IPR000209 Peptidase_S8/S53_dom IPR036852 Peptidase_S8/S53_dom_sf IPR023827 Peptidase_S8_Asp-AS IPR022398 Peptidase_S8_His-AS IPR023828 Peptidase_S8_Ser-AS IPR015500 Peptidase_S8_subtilisin-rel IPR032815 S8_pro-domain IPR038466 S8_pro-domain_sf IPR011641 Tyr-kin_ephrin_A/B_rcpt-like |
Pfami | View protein in Pfam PF14843 GF_recep_IV, 1 hit PF01483 P_proprotein, 1 hit PF00082 Peptidase_S8, 1 hit PF16470 S8_pro-domain, 1 hit |
PRINTSi | PR00723 SUBTILISIN |
SMARTi | View protein in SMART SM00181 EGF, 16 hits SM01411 Ephrin_rec_like, 8 hits SM00261 FU, 22 hits |
SUPFAMi | SSF49785 SSF49785, 1 hit SSF52743 SSF52743, 1 hit SSF57184 SSF57184, 7 hits |
PROSITEi | View protein in PROSITE PS51829 P_HOMO_B, 1 hit PS51892 SUBTILASE, 1 hit PS00136 SUBTILASE_ASP, 1 hit PS00137 SUBTILASE_HIS, 1 hit PS00138 SUBTILASE_SER, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGWGSRCCCP GRLDLLCVLA LLGGCLLPVC RTRVYTNHWA VKIAGGFPEA
60 70 80 90 100
NRIASKYGFI NIGQIGALKD YYHFYHSRTI KRSVISSRGT HSFISMEPKV
110 120 130 140 150
EWIQQQVVKK RTKRDYDFSR AQSTYFNDPK WPSMWYMHCS DNTHPCQSDM
160 170 180 190 200
NIEGAWKRGY TGKNIVVTIL DDGIERTHPD LMQNYDALAS CDVNGNDLDP
210 220 230 240 250
MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG GVRMLDGDVT
260 270 280 290 300
DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR
310 320 330 340 350
RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE
360 370 380 390 400
CSSTLATTYS SGESYDKKII TTDLRQRCTD NHTGTSASAP MAAGIIALAL
410 420 430 440 450
EANPFLTWRD VQHVIVRTSR AGHLNANDWK TNAAGFKVSH LYGFGLMDAE
460 470 480 490 500
AMVMEAEKWT TVPRQHVCVE STDRQIKTIR PNSAVRSIYK ASGCSDNPNR
510 520 530 540 550
HVNYLEHVVV RITITHPRRG DLAIYLTSPS GTRSQLLANR LFDHSMEGFK
560 570 580 590 600
NWEFMTIHCW GERAAGDWVL EVYDTPSQLR NFKTPGKLKE WSLVLYGTSV
610 620 630 640 650
QPYSPTNEFP KVERFRYSRV EDPTDDYGTE DYAGPCDPEC SEVGCDGPGP
660 670 680 690 700
DHCNDCLHYY YKLKNNTRIC VSSCPPGHYH ADKKRCRKCA PNCESCFGSH
710 720 730 740 750
GDQCMSCKYG YFLNEETNSC VTHCPDGSYQ DTKKNLCRKC SENCKTCTEF
760 770 780 790 800
HNCTECRDGL SLQGSRCSVS CEDGRYFNGQ DCQPCHRFCA TCAGAGADGC
810 820 830 840 850
INCTEGYFME DGRCVQSCSI SYYFDHSSEN GYKSCKKCDI SCLTCNGPGF
860 870 880 890 900
KNCTSCPSGY LLDLGMCQMG AICKDGEYVD EHGHCQTCEA SCAKCQGPTQ
910 920 930 940 950
EDCTTCPMTR IFDDGRCVSN CPSWKFEFEN QCHPCHHTCQ RCQGSGPTHC
960 970 980 990 1000
TSCGADNYGR EHFLYQGECG DSCPEGHYAT EGNTCLPCPD NCELCHSVHV
1010 1020 1030 1040 1050
CTRCMKGYFI APTNHTCQKL ECGQGEVQDP DYEECVPCEE GCLGCSLDDP
1060 1070 1080 1090 1100
GTCTSCAMGY YRFDHHCYKT CPEKTYSEEV ECKACDSNCG SCDQNGCYWC
1110 1120 1130 1140 1150
EEGFFLLGGS CVRKCGPGFY GDQEMGECES CHRACETCTG PGHDECSSCQ
1160 1170 1180 1190 1200
EGLQLLRGMC VHATKTQEEG KFWNDILRKL QPCHSSCKTC NGSATLCTSC
1210 1220 1230 1240 1250
PKGAYLLAQA CVSSCPQGTW PSVRSGSCEN CTEACAICSG ADLCKKCQMQ
1260 1270 1280 1290 1300
PGHPLFLHEG RCYSKCPEGS YAEDGICERC SSPCRTCEGN ATNCHSCEGG
1310 1320 1330 1340 1350
HVLHHGVCQE NCPERHVAVK GVCKHCPEMC QDCIHEKTCK ECTPEFFLHD
1360 1370 1380 1390 1400
DMCHQSCPRG FYADSRHCVP CHKDCLECSG PKADDCELCL ESSWVLYDGL
1410 1420 1430 1440 1450
CLEECPAGTY YEKETKECRD CHKSCLTCSS SGTCTTCQKG LIMNPRGSCM
1460 1470 1480 1490 1500
ANEKCSPSEY WDEDAPGCKP CHVKCFHCMG PAEDQCQTCP MNSLLLNTTC
1510 1520 1530 1540 1550
VKDCPEGYYA DEDSNRCAHC HSSCRTCEGR HSRQCHSCRP GWFQLGKECL
1560 1570 1580 1590 1600
LQCREGYYAD NSTGRCERCN RSCKGCQGPR PTDCLSCDRF FFLLRSKGEC
1610 1620 1630 1640 1650
HRSCPDHYYV EQSTQTCERC HPTCDQCKGK GALNCLSCVW SYHLMGGICT
1660 1670 1680 1690 1700
SDCLVGEYRV GEGEKFNCEK CHESCMECKG PGAKNCTLCP ANLVLHMDDS
1710 1720 1730 1740 1750
HCLHCCNTSD PPSAQECCDC QDTTDECILR TSKVRPATEH FKTALFITSS
1760 1770 1780 1790 1800
MMLVLLLGAA VVVWKKSRGR VQPAAKAGYE KLADPNKSYS SYKSSYREST
1810 1820 1830 1840 1850
SFEEDQVIEY RDRDYDEDDD DDIVYMGQDG TVYRKFKYGL LDDDDIDELE
1860
YDDESYSYYQ
The sequence of this isoform differs from the canonical sequence as follows:
876-913: GEYVDEHGHC...TTCPMTRIFD → ATEESWAEGG...LCCKTCTFQG
914-1860: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AMG5 | B1AMG5_HUMAN | Proprotein convertase subtilisin/ke... | PCSK5 | 690 | Annotation score: | ||
Q5JSG7 | Q5JSG7_HUMAN | Proprotein convertase subtilisin/ke... | PCSK5 | 1,560 | Annotation score: | ||
B1AMG8 | B1AMG8_HUMAN | Proprotein convertase subtilisin/ke... | PCSK5 | 101 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | G → D in AAC50643 (PubMed:8755538).Curated | 1 | |
Sequence conflicti | 4 | G → E in AAC50643 (PubMed:8755538).Curated | 1 | |
Sequence conflicti | 118 | F → S in AAC50643 (PubMed:8755538).Curated | 1 | |
Sequence conflicti | 121 | A → V in AAC50643 (PubMed:8755538).Curated | 1 | |
Sequence conflicti | 511 | R → A in AAA91807 (Ref. 7) Curated | 1 | |
Sequence conflicti | 601 | Q → R in AAC50643 (PubMed:8755538).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042017 | 876 – 913 | GEYVD…TRIFD → ATEESWAEGGFCMLVKKNNL CQRKVLQQLCCKTCTFQG in isoform PC6A. 4 PublicationsAdd BLAST | 38 | |
Alternative sequenceiVSP_042018 | 914 – 1860 | Missing in isoform PC6A. 4 PublicationsAdd BLAST | 947 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U56387 mRNA Translation: AAC50643.2 AL834522 mRNA Translation: CAD39178.1 AL359253 Genomic DNA No translation available. AL353607 Genomic DNA No translation available. AL391868 Genomic DNA No translation available. AL589653 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62575.1 BC012064 mRNA Translation: AAH12064.1 U49114 mRNA Translation: AAA91807.1 AK122718 mRNA No translation available. |
CCDSi | CCDS55320.1 [Q92824-1] CCDS6652.1 [Q92824-2] |
PIRi | G02428 JC6148 |
RefSeqi | NP_001177411.1, NM_001190482.1 [Q92824-1] NP_006191.2, NM_006200.5 [Q92824-2] |
Genome annotation databases
Ensembli | ENST00000376752; ENSP00000365943; ENSG00000099139 [Q92824-2] ENST00000545128; ENSP00000446280; ENSG00000099139 [Q92824-1] |
GeneIDi | 5125 |
KEGGi | hsa:5125 |
UCSCi | uc004ajz.5 human [Q92824-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U56387 mRNA Translation: AAC50643.2 AL834522 mRNA Translation: CAD39178.1 AL359253 Genomic DNA No translation available. AL353607 Genomic DNA No translation available. AL391868 Genomic DNA No translation available. AL589653 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62575.1 BC012064 mRNA Translation: AAH12064.1 U49114 mRNA Translation: AAA91807.1 AK122718 mRNA No translation available. |
CCDSi | CCDS55320.1 [Q92824-1] CCDS6652.1 [Q92824-2] |
PIRi | G02428 JC6148 |
RefSeqi | NP_001177411.1, NM_001190482.1 [Q92824-1] NP_006191.2, NM_006200.5 [Q92824-2] |
3D structure databases
SMRi | Q92824 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 111152, 33 interactors |
IntActi | Q92824, 80 interactors |
STRINGi | 9606.ENSP00000446280 |
Chemistry databases
BindingDBi | Q92824 |
ChEMBLi | CHEMBL2826 |
GuidetoPHARMACOLOGYi | 2385 |
Protein family/group databases
MEROPSi | S08.076 |
PTM databases
iPTMneti | Q92824 |
PhosphoSitePlusi | Q92824 |
Polymorphism and mutation databases
BioMutai | PCSK5 |
DMDMi | 357529585 |
Proteomic databases
jPOSTi | Q92824 |
MassIVEi | Q92824 |
PaxDbi | Q92824 |
PeptideAtlasi | Q92824 |
PRIDEi | Q92824 |
ProteomicsDBi | 75502 [Q92824-1] 75503 [Q92824-2] |
Protocols and materials databases
DNASUi | 5125 |
Genome annotation databases
Ensembli | ENST00000376752; ENSP00000365943; ENSG00000099139 [Q92824-2] ENST00000545128; ENSP00000446280; ENSG00000099139 [Q92824-1] |
GeneIDi | 5125 |
KEGGi | hsa:5125 |
UCSCi | uc004ajz.5 human [Q92824-1] |
Organism-specific databases
CTDi | 5125 |
DisGeNETi | 5125 |
GeneCardsi | PCSK5 |
HGNCi | HGNC:8747 PCSK5 |
HPAi | HPA031072 |
MIMi | 600488 gene |
neXtProti | NX_Q92824 |
OpenTargetsi | ENSG00000099139 |
PharmGKBi | PA33093 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3525 Eukaryota COG1404 LUCA COG4935 LUCA |
GeneTreei | ENSGT00940000155770 |
HOGENOMi | HOG000192536 |
InParanoidi | Q92824 |
KOi | K08654 |
OMAi | TWYNDTW |
OrthoDBi | 518530at2759 |
PhylomeDBi | Q92824 |
TreeFami | TF314277 |
Enzyme and pathway databases
BRENDAi | 3.4.21.B26 2681 |
Reactomei | R-HSA-167060 NGF processing R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes |
SignaLinki | Q92824 |
Miscellaneous databases
ChiTaRSi | PCSK5 human |
GeneWikii | PCSK5 |
GenomeRNAii | 5125 |
Pharosi | Q92824 |
PMAP-CutDBi | Q92824 |
PROi | PR:Q92824 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000099139 Expressed in 214 organ(s), highest expression level in buccal mucosa cell |
ExpressionAtlasi | Q92824 baseline and differential |
Genevisiblei | Q92824 HS |
Family and domain databases
CDDi | cd00064 FU, 17 hits cd04059 Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit |
Gene3Di | 2.60.120.260, 1 hit 3.30.70.850, 1 hit 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR000742 EGF-like_dom IPR006212 Furin_repeat IPR008979 Galactose-bd-like_sf IPR032778 GF_recep_IV IPR009030 Growth_fac_rcpt_cys_sf IPR034182 Kexin/furin IPR002884 P_dom IPR000209 Peptidase_S8/S53_dom IPR036852 Peptidase_S8/S53_dom_sf IPR023827 Peptidase_S8_Asp-AS IPR022398 Peptidase_S8_His-AS IPR023828 Peptidase_S8_Ser-AS IPR015500 Peptidase_S8_subtilisin-rel IPR032815 S8_pro-domain IPR038466 S8_pro-domain_sf IPR011641 Tyr-kin_ephrin_A/B_rcpt-like |
Pfami | View protein in Pfam PF14843 GF_recep_IV, 1 hit PF01483 P_proprotein, 1 hit PF00082 Peptidase_S8, 1 hit PF16470 S8_pro-domain, 1 hit |
PRINTSi | PR00723 SUBTILISIN |
SMARTi | View protein in SMART SM00181 EGF, 16 hits SM01411 Ephrin_rec_like, 8 hits SM00261 FU, 22 hits |
SUPFAMi | SSF49785 SSF49785, 1 hit SSF52743 SSF52743, 1 hit SSF57184 SSF57184, 7 hits |
PROSITEi | View protein in PROSITE PS51829 P_HOMO_B, 1 hit PS51892 SUBTILASE, 1 hit PS00136 SUBTILASE_ASP, 1 hit PS00137 SUBTILASE_HIS, 1 hit PS00138 SUBTILASE_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCSK5_HUMAN | |
Accessioni | Q92824Primary (citable) accession number: Q92824 Secondary accession number(s): F5H2G7, Q13527, Q96EP4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | November 16, 2011 | |
Last modified: | November 13, 2019 | |
This is version 194 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot