Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuronal cell adhesion molecule

Gene

NRCAM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.By similarity

GO - Molecular functioni

  • ankyrin binding Source: UniProtKB
  • protein binding involved in heterotypic cell-cell adhesion Source: Ensembl

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-447038 NrCAM interactions
R-HSA-447043 Neurofascin interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal cell adhesion molecule
Short name:
Nr-CAM
Alternative name(s):
Neuronal surface protein Bravo1 Publication
Short name:
hBravo1 Publication
NgCAM-related cell adhesion molecule
Short name:
Ng-CAM-related
Gene namesi
Name:NRCAM
Synonyms:KIAA0343
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000091129.19
HGNCiHGNC:7994 NRCAM
MIMi601581 gene
neXtProtiNX_Q92823

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 1167ExtracellularSequence analysisAdd BLAST1143
Transmembranei1168 – 1190HelicalSequence analysisAdd BLAST23
Topological domaini1191 – 1304CytoplasmicSequence analysisAdd BLAST114

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4897
OpenTargetsiENSG00000091129
PharmGKBiPA31773

Polymorphism and mutation databases

BioMutaiNRCAM
DMDMi215274127

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001505725 – 1304Neuronal cell adhesion moleculeAdd BLAST1280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 123PROSITE-ProRule annotation
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi167 ↔ 218PROSITE-ProRule annotation
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi276N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi292 ↔ 340PROSITE-ProRule annotation
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi382 ↔ 432PROSITE-ProRule annotation
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi476 ↔ 525PROSITE-ProRule annotation
Glycosylationi507N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi567 ↔ 616PROSITE-ProRule annotation
Glycosylationi619N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi716N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi802N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi858N-linked (GlcNAc...) (complex) asparagine1 Publication1
Glycosylationi993N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1009N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1019N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1072N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1083N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1115N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1221PhosphothreonineBy similarity1
Modified residuei1225PhosphotyrosineBy similarity1
Modified residuei1226PhosphoserineBy similarity1
Modified residuei1251PhosphoserineBy similarity1
Modified residuei1254PhosphoserineBy similarity1
Modified residuei1271PhosphoserineBy similarity1
Modified residuei1290PhosphoserineBy similarity1
Modified residuei1291PhosphoserineBy similarity1
Modified residuei1295PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ92823
MaxQBiQ92823
PaxDbiQ92823
PeptideAtlasiQ92823
PRIDEiQ92823
ProteomicsDBi75497
75498 [Q92823-2]
75499 [Q92823-3]
75500 [Q92823-4]
75501 [Q92823-5]

PTM databases

GlyConnecti821
iPTMnetiQ92823
PhosphoSitePlusiQ92823
SwissPalmiQ92823
UniCarbKBiQ92823

Expressioni

Tissue specificityi

Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.

Gene expression databases

BgeeiENSG00000091129 Expressed in 186 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_NRCAM
ExpressionAtlasiQ92823 baseline and differential
GenevisibleiQ92823 HS

Organism-specific databases

HPAiHPA012606

Interactioni

Subunit structurei

Constituent of a NFASC/NRCAM/ankyrin-G complex. Detected in a complex with CNTN1 and PTPRB. Interacts with GLDN/gliomedin (By similarity). Interacts with MYOC (PubMed:23897819).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110953, 8 interactors
IntActiQ92823, 5 interactors
STRINGi9606.ENSP00000368314

Structurei

Secondary structure

11304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92823
SMRiQ92823
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92823

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 134Ig-like 1Add BLAST89
Domaini141 – 235Ig-like 2Add BLAST95
Domaini267 – 356Ig-like 3Add BLAST90
Domaini361 – 448Ig-like 4Add BLAST88
Domaini454 – 541Ig-like 5Add BLAST88
Domaini545 – 632Ig-like 6Add BLAST88
Domaini649 – 744Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini746 – 843Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini848 – 950Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST103
Domaini954 – 1051Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini1064 – 1156Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST93

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00760000118840
HOGENOMiHOG000231380
HOVERGENiHBG000144
InParanoidiQ92823
KOiK06756
OMAiYWIMAPQ
OrthoDBiEOG091G00LY
PhylomeDBiQ92823
TreeFamiTF351098

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR026966 Neurofascin/L1/NrCAM_C
PfamiView protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 5 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 6 hits
PS00290 IG_MHC, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92823-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDPKLLE DLVQPPTITQ
60 70 80 90 100
QSPKDYIIDP RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG
110 120 130 140 150
TGTLIINIMS EGKAETYEGV YQCTARNERG AAVSNNIVVR PSRSPLWTKE
160 170 180 190 200
KLEPITLQSG QSLVLPCRPP IGLPPPIIFW MDNSFQRLPQ SERVSQGLNG
210 220 230 240 250
DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISVKVIS VDELNDTIAA
260 270 280 290 300
NLSDTEFYGA KSSRERPPTF LTPEGNASNK EELRGNVLSL ECIAEGLPTP
310 320 330 340 350
IIYWAKEDGM LPKNRTVYKN FEKTLQIIHV SEADSGNYQC IAKNALGAIH
360 370 380 390 400
HTISVRVKAA PYWITAPQNL VLSPGEDGTL ICRANGNPKP RISWLTNGVP
410 420 430 440 450
IEIAPDDPSR KIDGDTIIFS NVQERSSAVY QCNASNEYGY LLANAFVNVL
460 470 480 490 500
AEPPRILTPA NTLYQVIANR PALLDCAFFG SPLPTIEWFK GAKGSALHED
510 520 530 540 550
IYVLHENGTL EIPVAQKDST GTYTCVARNK LGMAKNEVHL EIKDPTWIVK
560 570 580 590 600
QPEYAVVQRG SMVSFECKVK HDHTLSLTVL WLKDNRELPS DERFTVDKDH
610 620 630 640 650
LVVADVSDDD SGTYTCVANT TLDSVSASAV LSVVAPTPTP APVYDVPNPP
660 670 680 690 700
FDLELTDQLD KSVQLSWTPG DDNNSPITKF IIEYEDAMHK PGLWHHQTEV
710 720 730 740 750
SGTQTTAQLK LSPYVNYSFR VMAVNSIGKS LPSEASEQYL TKASEPDKNP
760 770 780 790 800
TAVEGLGSEP DNLVITWKPL NGFESNGPGL QYKVSWRQKD GDDEWTSVVV
810 820 830 840 850
ANVSKYIVSG TPTFVPYLIK VQALNDMGFA PEPAVVMGHS GEDLPMVAPG
860 870 880 890 900
NVRVNVVNST LAEVHWDPVP LKSIRGHLQG YRIYYWKTQS SSKRNRRHIE
910 920 930 940 950
KKILTFQGSK THGMLPGLEP FSHYTLNVRV VNGKGEGPAS PDRVFNTPEG
960 970 980 990 1000
VPSAPSSLKI VNPTLDSLTL EWDPPSHPNG ILTEYTLKYQ PINSTHELGP
1010 1020 1030 1040 1050
LVDLKIPANK TRWTLKNLNF STRYKFYFYA QTSAGSGSQI TEEAVTTVDE
1060 1070 1080 1090 1100
AGILPPDVGA GKVQAVNPRI SNLTAAAAET YANISWEYEG PEHVNFYVEY
1110 1120 1130 1140 1150
GVAGSKEEWR KEIVNGSRSF FGLKGLMPGT AYKVRVGAVG DSGFVSSEDV
1160 1170 1180 1190 1200
FETGPAMASR QVDIATQGWF IGLMCAVALL ILILLIVCFI RRNKGGKYPV
1210 1220 1230 1240 1250
KEKEDAHADP EIQPMKEDDG TFGEYSDAED HKPLKKGSRT PSDRTVKKED
1260 1270 1280 1290 1300
SDDSLVDYGE GVNGQFNEDG SFIGQYSGKK EKEPAEGNES SEAPSPVNAM

NSFV
Length:1,304
Mass (Da):143,890
Last modified:November 25, 2008 - v3
Checksum:i1F2698BC7DB5C363
GO
Isoform 2 (identifier: Q92823-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1226-1236: SDAEDHKPLKK → RLFSFVSSASF
     1237-1304: Missing.

Show »
Length:1,236
Mass (Da):136,614
Checksum:i0C21479D02E6CCE2
GO
Isoform 3 (identifier: Q92823-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-259: Missing.
     1051-1155: Missing.

Note: No experimental confirmation available.
Show »
Length:1,180
Mass (Da):130,668
Checksum:iDF33D4380A609B75
GO
Isoform 4 (identifier: Q92823-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-40: Missing.
     635-644: Missing.
     1051-1155: Missing.

Note: No experimental confirmation available.
Show »
Length:1,183
Mass (Da):131,046
Checksum:iFEF6A39C50DE9664
GO
Isoform 5 (identifier: Q92823-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1225-1225: Y → YRSLE

Show »
Length:1,308
Mass (Da):144,375
Checksum:i7019F3533A0F445E
GO
Isoform 6 (identifier: Q92823-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-259: Missing.
     1063-1155: Missing.

Note: No experimental confirmation available.
Show »
Length:1,192
Mass (Da):131,744
Checksum:i0D9E6E1CDB666115
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYY6C9JYY6_HUMAN
Neuronal cell adhesion molecule
NRCAM
1,211Annotation score:
F8W775F8W775_HUMAN
Neuronal cell adhesion molecule
NRCAM
1,299Annotation score:
H7C132H7C132_HUMAN
Neuronal cell adhesion molecule
NRCAM
190Annotation score:
C9JH43C9JH43_HUMAN
Neuronal cell adhesion molecule
NRCAM
431Annotation score:
A0A087X2B3A0A087X2B3_HUMAN
Neuronal cell adhesion molecule
NRCAM
771Annotation score:
C9JF43C9JF43_HUMAN
Neuronal cell adhesion molecule
NRCAM
118Annotation score:
C9J8B6C9J8B6_HUMAN
Neuronal cell adhesion molecule
NRCAM
106Annotation score:
C9JUR7C9JUR7_HUMAN
Neuronal cell adhesion molecule
NRCAM
61Annotation score:

Sequence cautioni

The sequence AAC50765 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA20801 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti487E → Q in CAA04507 (Ref. 9) Curated1
Sequence conflicti512I → IKDATWIVKEI in AAC50765 (PubMed:8812479).Curated1
Sequence conflicti541 – 550Missing in AAC50765 (PubMed:8812479).Curated10
Sequence conflicti651F → L in CAA04507 (Ref. 9) Curated1
Sequence conflicti679 – 682KFII → TIHD in CAA04507 (Ref. 9) Curated4
Sequence conflicti710K → N in BAA20801 (PubMed:9205841).Curated1
Sequence conflicti764V → E in AAC50765 (PubMed:8812479).Curated1
Sequence conflicti775S → F in CAA04507 (Ref. 9) Curated1
Sequence conflicti790D → V in CAA04507 (Ref. 9) Curated1
Sequence conflicti921F → L in CAD97960 (PubMed:17974005).Curated1
Sequence conflicti954A → V in CAA04507 (Ref. 9) Curated1
Sequence conflicti994S → N in CAA04507 (Ref. 9) Curated1
Sequence conflicti1008A → T in CAD97960 (PubMed:17974005).Curated1
Sequence conflicti1021S → T in CAA04507 (Ref. 9) Curated1
Sequence conflicti1068P → T in AAC50765 (PubMed:8812479).Curated1
Sequence conflicti1093 – 1094HV → YA in CAA04507 (Ref. 9) Curated2
Sequence conflicti1134V → F in CAA04507 (Ref. 9) Curated1
Sequence conflicti1141 – 1143DSG → GPR in CAA04507 (Ref. 9) Curated3
Sequence conflicti1149D → G in CAA04507 (Ref. 9) Curated1
Sequence conflicti1256V → L in CAA04507 (Ref. 9) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047550545P → A4 PublicationsCorresponds to variant dbSNP:rs6958498Ensembl.1
Natural variantiVAR_0355281093H → P in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0355291116G → V in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00783735 – 40Missing in isoform 4. 1 Publication6
Alternative sequenceiVSP_007838241 – 259Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_007839635 – 644Missing in isoform 4. 1 Publication10
Alternative sequenceiVSP_0078401051 – 1155Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST105
Alternative sequenceiVSP_0450401063 – 1155Missing in isoform 6. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_0078431225Y → YRSLE in isoform 5. Curated1
Alternative sequenceiVSP_0078411226 – 1236SDAEDHKPLKK → RLFSFVSSASF in isoform 2. CuratedAdd BLAST11
Alternative sequenceiVSP_0078421237 – 1304Missing in isoform 2. CuratedAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55258 Genomic DNA Translation: AAC50765.1 Different initiation.
AF172277 Genomic DNA Translation: AAF22282.1
AF172277 Genomic DNA Translation: AAF22283.1
AB002341 mRNA Translation: BAA20801.2 Different initiation.
BX538010 mRNA Translation: CAD97960.1
AC005683 Genomic DNA No translation available.
AC007567 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24386.1
CH471070 Genomic DNA Translation: EAW83429.1
BC115736 mRNA Translation: AAI15737.1
AJ001054 mRNA Translation: CAA04504.1
AJ001057 mRNA Translation: CAA04507.1
CCDSiCCDS47686.1 [Q92823-1]
CCDS55153.1 [Q92823-6]
CCDS5751.1 [Q92823-4]
RefSeqiNP_001032209.1, NM_001037132.2 [Q92823-1]
NP_001180511.1, NM_001193582.1
NP_001180512.1, NM_001193583.1 [Q92823-6]
NP_001180513.1, NM_001193584.1 [Q92823-3]
NP_005001.3, NM_005010.4 [Q92823-4]
XP_005250430.1, XM_005250373.2 [Q92823-1]
XP_006716066.1, XM_006716003.1 [Q92823-5]
XP_016867746.1, XM_017012257.1 [Q92823-6]
UniGeneiHs.21422

Genome annotation databases

EnsembliENST00000351718; ENSP00000325269; ENSG00000091129 [Q92823-4]
ENST00000379024; ENSP00000368310; ENSG00000091129 [Q92823-6]
ENST00000379028; ENSP00000368314; ENSG00000091129 [Q92823-1]
ENST00000425651; ENSP00000401244; ENSG00000091129 [Q92823-1]
GeneIDi4897
KEGGihsa:4897
UCSCiuc003vfc.4 human [Q92823-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55258 Genomic DNA Translation: AAC50765.1 Different initiation.
AF172277 Genomic DNA Translation: AAF22282.1
AF172277 Genomic DNA Translation: AAF22283.1
AB002341 mRNA Translation: BAA20801.2 Different initiation.
BX538010 mRNA Translation: CAD97960.1
AC005683 Genomic DNA No translation available.
AC007567 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24386.1
CH471070 Genomic DNA Translation: EAW83429.1
BC115736 mRNA Translation: AAI15737.1
AJ001054 mRNA Translation: CAA04504.1
AJ001057 mRNA Translation: CAA04507.1
CCDSiCCDS47686.1 [Q92823-1]
CCDS55153.1 [Q92823-6]
CCDS5751.1 [Q92823-4]
RefSeqiNP_001032209.1, NM_001037132.2 [Q92823-1]
NP_001180511.1, NM_001193582.1
NP_001180512.1, NM_001193583.1 [Q92823-6]
NP_001180513.1, NM_001193584.1 [Q92823-3]
NP_005001.3, NM_005010.4 [Q92823-4]
XP_005250430.1, XM_005250373.2 [Q92823-1]
XP_006716066.1, XM_006716003.1 [Q92823-5]
XP_016867746.1, XM_017012257.1 [Q92823-6]
UniGeneiHs.21422

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UENNMR-A839-950[»]
1UEYNMR-A638-751[»]
ProteinModelPortaliQ92823
SMRiQ92823
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110953, 8 interactors
IntActiQ92823, 5 interactors
STRINGi9606.ENSP00000368314

PTM databases

GlyConnecti821
iPTMnetiQ92823
PhosphoSitePlusiQ92823
SwissPalmiQ92823
UniCarbKBiQ92823

Polymorphism and mutation databases

BioMutaiNRCAM
DMDMi215274127

Proteomic databases

EPDiQ92823
MaxQBiQ92823
PaxDbiQ92823
PeptideAtlasiQ92823
PRIDEiQ92823
ProteomicsDBi75497
75498 [Q92823-2]
75499 [Q92823-3]
75500 [Q92823-4]
75501 [Q92823-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351718; ENSP00000325269; ENSG00000091129 [Q92823-4]
ENST00000379024; ENSP00000368310; ENSG00000091129 [Q92823-6]
ENST00000379028; ENSP00000368314; ENSG00000091129 [Q92823-1]
ENST00000425651; ENSP00000401244; ENSG00000091129 [Q92823-1]
GeneIDi4897
KEGGihsa:4897
UCSCiuc003vfc.4 human [Q92823-1]

Organism-specific databases

CTDi4897
DisGeNETi4897
EuPathDBiHostDB:ENSG00000091129.19
GeneCardsiNRCAM
HGNCiHGNC:7994 NRCAM
HPAiHPA012606
MIMi601581 gene
neXtProtiNX_Q92823
OpenTargetsiENSG00000091129
PharmGKBiPA31773
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00760000118840
HOGENOMiHOG000231380
HOVERGENiHBG000144
InParanoidiQ92823
KOiK06756
OMAiYWIMAPQ
OrthoDBiEOG091G00LY
PhylomeDBiQ92823
TreeFamiTF351098

Enzyme and pathway databases

ReactomeiR-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-447038 NrCAM interactions
R-HSA-447043 Neurofascin interactions

Miscellaneous databases

ChiTaRSiNRCAM human
EvolutionaryTraceiQ92823
GeneWikiiNRCAM
GenomeRNAii4897
PROiPR:Q92823
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091129 Expressed in 186 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_NRCAM
ExpressionAtlasiQ92823 baseline and differential
GenevisibleiQ92823 HS

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR026966 Neurofascin/L1/NrCAM_C
PfamiView protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 5 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 6 hits
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRCAM_HUMAN
AccessioniPrimary (citable) accession number: Q92823
Secondary accession number(s): A4D0S3
, E9PDA4, O15051, O15179, Q14BM2, Q9UHI3, Q9UHI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again