UniProtKB - Q92819 (HYAS2_HUMAN)
Protein
Hyaluronan synthase 2
Gene
HAS2
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).By similarity
Catalytic activityi
- [hyaluronan](n) + UDP-N-acetyl-α-D-glucosamine = H+ + N-acetyl-β-D-glucosaminyl-(1→4)-[hyaluronan](n) + UDPEC:2.4.1.212
- N-acetyl-β-D-glucosaminyl-(1→4)-[hyaluronan](n) + UDP-α-D-glucuronate = [hyaluronan](n+1) + H+ + UDPEC:2.4.1.212
Cofactori
: hyaluronan biosynthesis Pathwayi
This protein is involved in the pathway hyaluronan biosynthesis, which is part of Glycan biosynthesis.View all proteins of this organism that are known to be involved in the pathway hyaluronan biosynthesis and in Glycan biosynthesis.
GO - Molecular functioni
- hyaluronan synthase activity Source: BHF-UCL
GO - Biological processi
- atrioventricular canal development Source: UniProtKB
- bone morphogenesis Source: Ensembl
- cellular response to fluid shear stress Source: BHF-UCL
- cellular response to interleukin-1 Source: BHF-UCL
- cellular response to platelet-derived growth factor stimulus Source: UniProtKB
- cellular response to tumor necrosis factor Source: BHF-UCL
- endocardial cushion to mesenchymal transition Source: UniProtKB
- estrous cycle Source: Ensembl
- extracellular matrix assembly Source: UniProtKB
- extracellular polysaccharide biosynthetic process Source: UniProtKB
- hyaluronan biosynthetic process Source: UniProtKB
- kidney development Source: UniProtKB
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of hyaluronan biosynthetic process Source: Ensembl
- positive regulation of keratinocyte migration Source: Ensembl
- positive regulation of keratinocyte proliferation Source: Ensembl
- positive regulation of monocyte aggregation Source: BHF-UCL
- positive regulation of smooth muscle cell migration Source: Ensembl
- positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
- positive regulation of urine volume Source: UniProtKB
- regulation of extracellular matrix assembly Source: Ensembl
- renal water absorption Source: UniProtKB
- vasculogenesis Source: UniProtKB
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
BRENDAi | 2.4.1.212, 2681 |
PathwayCommonsi | Q92819 |
Reactomei | R-HSA-2142850, Hyaluronan biosynthesis and export |
SIGNORi | Q92819 |
UniPathwayi | UPA00341 |
Protein family/group databases
CAZyi | GT2, Glycosyltransferase Family 2 |
Names & Taxonomyi
Protein namesi | Recommended name: Hyaluronan synthase 2 (EC:2.4.1.212)Alternative name(s): Hyaluronate synthase 2 Hyaluronic acid synthase 2 Short name: HA synthase 2 |
Gene namesi | Name:HAS2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4819, HAS2 |
MIMi | 601636, gene |
neXtProti | NX_Q92819 |
VEuPathDBi | HostDB:ENSG00000170961.6 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: BHF-UCL
- plasma membrane raft Source: Ensembl
Other locations
- cytoplasmic vesicle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 11 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 12 – 32 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 33 – 45 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 46 – 66 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 67 – 374 | CytoplasmicSequence analysisAdd BLAST | 308 | |
Transmembranei | 375 – 395 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 396 – 402 | ExtracellularSequence analysis | 7 | |
Transmembranei | 403 – 423 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 424 – 429 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 430 – 450 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 451 – 475 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 476 – 496 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 497 – 510 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 511 – 531 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 532 – 552 | ExtracellularSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving HAS2 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. 8q12.1 to 8q24.1 intrachromosomal rearrangement with PLAG1.1 Publication
Organism-specific databases
DisGeNETi | 3037 |
OpenTargetsi | ENSG00000170961 |
PharmGKBi | PA29195 |
Miscellaneous databases
Pharosi | Q92819, Tbio |
Genetic variation databases
BioMutai | HAS2 |
DMDMi | 7387737 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197173 | 1 – 552 | Hyaluronan synthase 2Add BLAST | 552 |
Proteomic databases
jPOSTi | Q92819 |
MassIVEi | Q92819 |
PaxDbi | Q92819 |
PeptideAtlasi | Q92819 |
PRIDEi | Q92819 |
ProteomicsDBi | 75495 |
PTM databases
iPTMneti | Q92819 |
PhosphoSitePlusi | Q92819 |
Expressioni
Tissue specificityi
Expressed in fibroblasts.
Gene expression databases
Bgeei | ENSG00000170961, Expressed in lung and 168 other tissues |
Genevisiblei | Q92819, HS |
Organism-specific databases
HPAi | ENSG00000170961, Tissue enhanced (adipose) |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 109287, 4 interactors |
CORUMi | Q92819 |
IntActi | Q92819, 2 interactors |
STRINGi | 9606.ENSP00000306991 |
Miscellaneous databases
RNActi | Q92819, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the NodC/HAS family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2571, Eukaryota |
GeneTreei | ENSGT00390000010337 |
HOGENOMi | CLU_029695_3_0_1 |
InParanoidi | Q92819 |
OMAi | VLITKCG |
OrthoDBi | 332363at2759 |
PhylomeDBi | Q92819 |
TreeFami | TF332506 |
Family and domain databases
InterProi | View protein in InterPro IPR028371, HAS2 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR22913:SF7, PTHR22913:SF7, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
Q92819-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHCERFLCIL RIIGTTLFGV SLLLGITAAY IVGYQFIQTD NYYFSFGLYG
60 70 80 90 100
AFLASHLIIQ SLFAFLEHRK MKKSLETPIK LNKTVALCIA AYQEDPDYLR
110 120 130 140 150
KCLQSVKRLT YPGIKVVMVI DGNSEDDLYM MDIFSEVMGR DKSATYIWKN
160 170 180 190 200
NFHEKGPGET DESHKESSQH VTQLVLSNKS ICIMQKWGGK REVMYTAFRA
210 220 230 240 250
LGRSVDYVQV CDSDTMLDPA SSVEMVKVLE EDPMVGGVGG DVQILNKYDS
260 270 280 290 300
WISFLSSVRY WMAFNIERAC QSYFGCVQCI SGPLGMYRNS LLHEFVEDWY
310 320 330 340 350
NQEFMGNQCS FGDDRHLTNR VLSLGYATKY TARSKCLTET PIEYLRWLNQ
360 370 380 390 400
QTRWSKSYFR EWLYNAMWFH KHHLWMTYEA IITGFFPFFL IATVIQLFYR
410 420 430 440 450
GKIWNILLFL LTVQLVGLIK SSFASCLRGN IVMVFMSLYS VLYMSSLLPA
460 470 480 490 500
KMFAIATINK AGWGTSGRKT IVVNFIGLIP VSVWFTILLG GVIFTIYKES
510 520 530 540 550
KRPFSESKQT VLIVGTLLYA CYWVMLLTLY VVLINKCGRR KKGQQYDMVL
DV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U54804 mRNA Translation: AAC50692.1 BC069353 mRNA Translation: AAH69353.1 BC109071 mRNA Translation: AAI09072.1 BC109072 mRNA Translation: AAI09073.1 |
CCDSi | CCDS6335.1 |
RefSeqi | NP_005319.1, NM_005328.2 |
Genome annotation databases
Ensembli | ENST00000303924; ENSP00000306991; ENSG00000170961 |
GeneIDi | 3037 |
KEGGi | hsa:3037 |
UCSCi | uc003yph.3, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U54804 mRNA Translation: AAC50692.1 BC069353 mRNA Translation: AAH69353.1 BC109071 mRNA Translation: AAI09072.1 BC109072 mRNA Translation: AAI09073.1 |
CCDSi | CCDS6335.1 |
RefSeqi | NP_005319.1, NM_005328.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 109287, 4 interactors |
CORUMi | Q92819 |
IntActi | Q92819, 2 interactors |
STRINGi | 9606.ENSP00000306991 |
Protein family/group databases
CAZyi | GT2, Glycosyltransferase Family 2 |
PTM databases
iPTMneti | Q92819 |
PhosphoSitePlusi | Q92819 |
Genetic variation databases
BioMutai | HAS2 |
DMDMi | 7387737 |
Proteomic databases
jPOSTi | Q92819 |
MassIVEi | Q92819 |
PaxDbi | Q92819 |
PeptideAtlasi | Q92819 |
PRIDEi | Q92819 |
ProteomicsDBi | 75495 |
Protocols and materials databases
Antibodypediai | 55587, 166 antibodies |
Genome annotation databases
Ensembli | ENST00000303924; ENSP00000306991; ENSG00000170961 |
GeneIDi | 3037 |
KEGGi | hsa:3037 |
UCSCi | uc003yph.3, human |
Organism-specific databases
CTDi | 3037 |
DisGeNETi | 3037 |
GeneCardsi | HAS2 |
HGNCi | HGNC:4819, HAS2 |
HPAi | ENSG00000170961, Tissue enhanced (adipose) |
MIMi | 601636, gene |
neXtProti | NX_Q92819 |
OpenTargetsi | ENSG00000170961 |
PharmGKBi | PA29195 |
VEuPathDBi | HostDB:ENSG00000170961.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2571, Eukaryota |
GeneTreei | ENSGT00390000010337 |
HOGENOMi | CLU_029695_3_0_1 |
InParanoidi | Q92819 |
OMAi | VLITKCG |
OrthoDBi | 332363at2759 |
PhylomeDBi | Q92819 |
TreeFami | TF332506 |
Enzyme and pathway databases
UniPathwayi | UPA00341 |
BRENDAi | 2.4.1.212, 2681 |
PathwayCommonsi | Q92819 |
Reactomei | R-HSA-2142850, Hyaluronan biosynthesis and export |
SIGNORi | Q92819 |
Miscellaneous databases
BioGRID-ORCSi | 3037, 6 hits in 982 CRISPR screens |
ChiTaRSi | HAS2, human |
GeneWikii | HAS2 |
GenomeRNAii | 3037 |
Pharosi | Q92819, Tbio |
PROi | PR:Q92819 |
RNActi | Q92819, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170961, Expressed in lung and 168 other tissues |
Genevisiblei | Q92819, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028371, HAS2 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR22913:SF7, PTHR22913:SF7, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HYAS2_HUMAN | |
Accessioni | Q92819Primary (citable) accession number: Q92819 Secondary accession number(s): Q32MM3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | February 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families