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Protein

Envoplakin

Gene

EVPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cornification Source: Reactome
  • epidermis development Source: ProtInc
  • intermediate filament cytoskeleton organization Source: GO_Central
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: UniProtKB
  • wound healing Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processKeratinization

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6809371 Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Envoplakin
Alternative name(s):
210 kDa cornified envelope precursor protein
210 kDa paraneoplastic pemphigus antigen
p210
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EVPL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167880.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3503 EVPL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601590 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92817

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2125

Open Targets

More...
OpenTargetsi
ENSG00000167880

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27916

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EVPL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439359

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000781471 – 2033EnvoplakinAdd BLAST2033

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1575PhosphoserineBy similarity1
Modified residuei1799PhosphoserineCombined sources1
Modified residuei2025PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92817

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92817

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92817

PeptideAtlas

More...
PeptideAtlasi
Q92817

PRoteomics IDEntifications database

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PRIDEi
Q92817

ProteomicsDB human proteome resource

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ProteomicsDBi
75494

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92817

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92817

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q92817

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Exclusively expressed in stratified squamous epithelia.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

During differentiation of epidermal keratinocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167880 Expressed in 130 organ(s), highest expression level in lower esophagus mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_EVPL

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92817 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92817 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002220
HPA053969

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form a homodimer or a heterodimer with PPL.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108426, 33 interactors

Protein interaction database and analysis system

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IntActi
Q92817, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000301607

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12033
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q92817

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92817

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati229 – 330SpectrinAdd BLAST102
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini413 – 470SH3PROSITE-ProRule annotationAdd BLAST58
Repeati1185 – 1226Plectin 1Add BLAST42
Repeati1678 – 1713Plectin 2Add BLAST36
Repeati1818 – 1855Plectin 3Add BLAST38
Repeati1856 – 1893Plectin 4Add BLAST38
Repeati1894 – 1931Plectin 5Add BLAST38
Repeati1932 – 1969Plectin 6Add BLAST38
Repeati1970 – 2007Plectin 7Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 841Globular 1Add BLAST841
Regioni12 – 284 X 4 AA tandem repeats of K-G-S-PAdd BLAST17
Regioni842 – 1673Central fibrous rod domainAdd BLAST832
Regioni1674 – 2033Globular 2Add BLAST360

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili845 – 1135Sequence analysisAdd BLAST291

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IQBQ Eukaryota
ENOG410XRFQ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153578

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018988

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92817

KEGG Orthology (KO)

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KOi
K10383

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92817

TreeFam database of animal gene trees

More...
TreeFami
TF342779

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.90.1290.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030460 Envoplakin
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin

The PANTHER Classification System

More...
PANTHERi
PTHR23169:SF7 PTHR23169:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00681 Plectin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00250 PLEC, 8 hits
SM00150 SPEC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75399 SSF75399, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q92817-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKGLSKGSQ GKGSPKGSPA KGSPKGSPSR HSRAATQELA LLISRMQANA
60 70 80 90 100
DQVERDILET QKRLQQDRLN SEQSQALQHQ QETGRSLKEA EVLLKDLFLD
110 120 130 140 150
VDKARRLKHP QAEEIEKDIK QLHERVTQEC AEYRALYEKM VLPPDVGPRV
160 170 180 190 200
DWARVLEQKQ KQVCAGQYGP GMAELEQQIA EHNILQKEID AYGQQLRSLV
210 220 230 240 250
GPDAATIRSQ YRDLLKAASW RGQSLGSLYT HLQGCTRQLS ALAEQQRRIL
260 270 280 290 300
QQDWSDLMAD PAGVRREYEH FKQHELLSQE QSVNQLEDDG ERMVELRHPA
310 320 330 340 350
VGPIQAHQEA LKMEWQNFLN LCICQETQLQ HVEDYRRFQE EADSVSQTLA
360 370 380 390 400
KLNSNLDAKY SPAPGGPPGA PTELLQQLEA EEKRLAVTER ATGDLQRRSR
410 420 430 440 450
DVAPLPQRRN PPQQPLHVDS ICDWDSGEVQ LLQGERYKLV DNTDPHAWVV
460 470 480 490 500
QGPGGETKRA PAACFCIPAP DPDAVARASR LASELQALKQ KLATVQSRLK
510 520 530 540 550
ASAVESLRPS QQAPSGSDLA NPQAQKLLTQ MTRLDGDLGQ IERQVLAWAR
560 570 580 590 600
APLSRPTPLE DLEGRIHSHE GTAQRLQSLG TEKETAQKEC EAFLSTRPVG
610 620 630 640 650
PAALQLPVAL NSVKNKFSDV QVLCSLYGEK AKAALDLERQ IQDADRVIRG
660 670 680 690 700
FEATLVQEAP IPAEPGALQE RVSELQRQRR ELLEQQTCVL RLHRALKASE
710 720 730 740 750
HACAALQNNF QEFCQDLPRQ QRQVRALTDR YHAVGDQLDL REKVVQDAAL
760 770 780 790 800
TYQQFKNCKD NLSSWLEHLP RSQVRPSDGP SQIAYKLQAQ KRLTQEIQSR
810 820 830 840 850
ERDRATASHL SQALQAALQD YELQADTYRC SLEPTLAVSA PKRPRVAPLQ
860 870 880 890 900
ESIQAQEKNL AKAYTEVAAA QQQLLQQLEF ARKMLEKKEL SEDIRRTHDA
910 920 930 940 950
KQGSESPAQA GRESEALKAQ LEEERKRVAR VQHELEAQRS QLLQLRTQRP
960 970 980 990 1000
LERLEEKEVV EFYRDPQLEG SLSRVKAQVE EEGKRRAGLQ ADLEVAAQKV
1010 1020 1030 1040 1050
VQLESKRKTM QPHLLTKEVT QVERDPGLDS QAAQLRIQIQ QLRGEDAVIS
1060 1070 1080 1090 1100
ARLEGLKKEL LALEKREVDV KEKVVVKEVV KVEKNLEMVK AAQALRLQME
1110 1120 1130 1140 1150
EDAARRKQAE EAVAKLQARI EDLERAISSV EPKVIVKEVK KVEQDPGLLQ
1160 1170 1180 1190 1200
ESSRLRSLLE EERTKNATLA RELSDLHSKY SVVEKQRPKV QLQERVHEIF
1210 1220 1230 1240 1250
QVDPETEQEI TRLKAKLQEM AGKRSGVEKE VEKLLPDLEV LRAQKPTVEY
1260 1270 1280 1290 1300
KEVTQEVVRH ERSPEVLREI DRLKAQLNEL VNSHGRSQEQ LIRLQGERDE
1310 1320 1330 1340 1350
WRRERAKVET KTVSKEVVRH EKDPVLEKEA ERLRQEVREA AQKRRAAEDA
1360 1370 1380 1390 1400
VYELQSKRLL LERRKPEEKV VVQEVVVTQK DPKLREEHSR LSGSLDEEVG
1410 1420 1430 1440 1450
RRRQLELEVQ QLRAGVEEQE GLLSFQEDRS KKLAVERELR QLTLRIQELE
1460 1470 1480 1490 1500
KRPPTVQEKI IMEEVVKLEK DPDLEKSTEA LRWDLDQEKT QVTELNRECK
1510 1520 1530 1540 1550
NLQVQIDVLQ KAKSQEKTIY KEVIRVQKDR VLEDERARVW EMLNRERTAR
1560 1570 1580 1590 1600
QAREEEARRL RERIDRAETL GRTWSREESE LQRARDQADQ ECGRLQQELR
1610 1620 1630 1640 1650
ALERQKQQQT LQLQEESKLL SQKTESERQK AAQRGQELSR LEAAILREKD
1660 1670 1680 1690 1700
QIYEKERTLR DLHAKVSREE LSQETQTRET NLSTKISILE PETGKDMSPY
1710 1720 1730 1740 1750
EAYKRGIIDR GQYLQLQELE CDWEEVTTSG PCGEESVLLD RKSGKQYSIE
1760 1770 1780 1790 1800
AALRCRRISK EEYHLYKDGH LPISEFALLV AGETKPSSSL SIGSIISKSP
1810 1820 1830 1840 1850
LASPAPQSTS FFSPSFSLGL GDDSFPIAGI YDTTTDNKCS IKTAVAKNML
1860 1870 1880 1890 1900
DPITGQKLLE AQAATGGIVD LLSRERYSVH KAMERGLIEN TSTQRLLNAQ
1910 1920 1930 1940 1950
KAFTGIEDPV TKKRLSVGEA VQKGWMPRES VLPHLQVQHL TGGLIDPKRT
1960 1970 1980 1990 2000
GRIPIQQALL SGMISEELAQ LLQDESSYEK DLTDPISKER LSYKEAMGRC
2010 2020 2030
RKDPLSGLLL LPAALEGYRC YRSASPTVPR SLR
Length:2,033
Mass (Da):231,604
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A994627703393E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKI0K7EKI0_HUMAN
Envoplakin
EVPL
2,055Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ87K7EQ87_HUMAN
Envoplakin
EVPL
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti444D → E in AAC64662 (PubMed:8707850).Curated1
Sequence conflicti444D → E in AAD00186 (PubMed:10409435).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02457949N → S. Corresponds to variant dbSNP:rs397833081Ensembl.1
Natural variantiVAR_057698168Y → C. Corresponds to variant dbSNP:rs10445216Ensembl.1
Natural variantiVAR_033863433Q → R. Corresponds to variant dbSNP:rs2071192Ensembl.1
Natural variantiVAR_0576991814P → S1 PublicationCorresponds to variant dbSNP:rs7342883Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U53786 mRNA Translation: AAC64662.1
U72849
, U72843, U72845, U72846, U72847, U72848 Genomic DNA Translation: AAD00186.1
AC040980 Genomic DNA No translation available.
BC126103 mRNA Translation: AAI26104.1
BC126105 mRNA Translation: AAI26106.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11737.1

NCBI Reference Sequences

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RefSeqi
NP_001307676.1, NM_001320747.1
NP_001979.2, NM_001988.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.500635

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000301607; ENSP00000301607; ENSG00000167880

Database of genes from NCBI RefSeq genomes

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GeneIDi
2125

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2125

UCSC genome browser

More...
UCSCi
uc002jqi.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53786 mRNA Translation: AAC64662.1
U72849
, U72843, U72845, U72846, U72847, U72848 Genomic DNA Translation: AAD00186.1
AC040980 Genomic DNA No translation available.
BC126103 mRNA Translation: AAI26104.1
BC126105 mRNA Translation: AAI26106.1
CCDSiCCDS11737.1
RefSeqiNP_001307676.1, NM_001320747.1
NP_001979.2, NM_001988.3
UniGeneiHs.500635

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QMDX-ray1.60A/B1822-2014[»]
ProteinModelPortaliQ92817
SMRiQ92817
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108426, 33 interactors
IntActiQ92817, 5 interactors
STRINGi9606.ENSP00000301607

PTM databases

iPTMnetiQ92817
PhosphoSitePlusiQ92817
SwissPalmiQ92817

Polymorphism and mutation databases

BioMutaiEVPL
DMDMi296439359

Proteomic databases

EPDiQ92817
MaxQBiQ92817
PaxDbiQ92817
PeptideAtlasiQ92817
PRIDEiQ92817
ProteomicsDBi75494

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301607; ENSP00000301607; ENSG00000167880
GeneIDi2125
KEGGihsa:2125
UCSCiuc002jqi.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2125
DisGeNETi2125
EuPathDBiHostDB:ENSG00000167880.7

GeneCards: human genes, protein and diseases

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GeneCardsi
EVPL

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0013602
HIX0039259
HGNCiHGNC:3503 EVPL
HPAiCAB002220
HPA053969
MIMi601590 gene
neXtProtiNX_Q92817
OpenTargetsiENSG00000167880
PharmGKBiPA27916

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IQBQ Eukaryota
ENOG410XRFQ LUCA
GeneTreeiENSGT00940000153578
HOVERGENiHBG018988
InParanoidiQ92817
KOiK10383
PhylomeDBiQ92817
TreeFamiTF342779

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EVPL human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Envoplakin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2125

Protein Ontology

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PROi
PR:Q92817

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000167880 Expressed in 130 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_EVPL
ExpressionAtlasiQ92817 baseline and differential
GenevisibleiQ92817 HS

Family and domain databases

Gene3Di3.90.1290.10, 1 hit
InterProiView protein in InterPro
IPR030460 Envoplakin
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
PANTHERiPTHR23169:SF7 PTHR23169:SF7, 1 hit
PfamiView protein in Pfam
PF00681 Plectin, 4 hits
SMARTiView protein in SMART
SM00250 PLEC, 8 hits
SM00150 SPEC, 1 hit
SUPFAMiSSF75399 SSF75399, 2 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEVPL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92817
Secondary accession number(s): A0AUV5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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