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Protein

Prospero homeobox protein 1

Gene

PROX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.1 Publication1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ92786

Names & Taxonomyi

Protein namesi
Recommended name:
Prospero homeobox protein 1
Alternative name(s):
Homeobox prospero-like protein PROX1
Short name:
PROX-1
Gene namesi
Name:PROX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117707.15
HGNCiHGNC:9459 PROX1
MIMi601546 gene
neXtProtiNX_Q92786

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5629
OpenTargetsiENSG00000117707
PharmGKBiPA33812

Polymorphism and mutation databases

DMDMi85702224

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002088801 – 737Prospero homeobox protein 1Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177PhosphoserineCombined sources1
Modified residuei179PhosphoserineBy similarity1
Modified residuei199PhosphoserineCombined sources1
Modified residuei291PhosphoserineBy similarity1
Modified residuei295PhosphoserineCombined sources1
Cross-linki324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei511PhosphoserineBy similarity1
Modified residuei514PhosphoserineBy similarity1
Modified residuei557PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ92786
PaxDbiQ92786
PeptideAtlasiQ92786
PRIDEiQ92786
ProteomicsDBi75470

PTM databases

iPTMnetiQ92786
PhosphoSitePlusiQ92786

Expressioni

Tissue specificityi

Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000117707 Expressed in 168 organ(s), highest expression level in liver
CleanExiHS_PROX1
ExpressionAtlasiQ92786 baseline and differential
GenevisibleiQ92786 HS

Organism-specific databases

HPAiHPA000842
HPA001030

Interactioni

Subunit structurei

Interacts with RORA and RORG (via AF-2 motif).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111613, 17 interactors
IntActiQ92786, 10 interactors
MINTiQ92786
STRINGi9606.ENSP00000261454

Structurei

Secondary structure

1737
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92786
SMRiQ92786
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini577 – 635Prospero-type homeoPROSITE-ProRule annotationAdd BLAST59
Domaini636 – 735ProsperoPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28Interaction with RORGBy similarityAdd BLAST28
Regioni577 – 735Homeo-ProsperoPROSITE-ProRule annotationAdd BLAST159
Regioni723 – 729Essential for nuclear localization, interaction with RORG, repression of RORG transcriptional activator activityBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi215 – 219Poly-Gln5

Domaini

The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain. The Prospero-type homeodomain is essential for repression of RORG transcriptional activator activity.PROSITE-ProRule annotationBy similarity

Sequence similaritiesi

Belongs to the Prospero homeodomain family.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3779 Eukaryota
ENOG410ZE21 LUCA
GeneTreeiENSGT00530000063507
HOGENOMiHOG000115708
HOVERGENiHBG053693
InParanoidiQ92786
KOiK20211
OMAiSCFMSRN
OrthoDBiEOG091G02KS
PhylomeDBiQ92786
TreeFamiTF316638

Family and domain databases

Gene3Di1.10.10.500, 1 hit
InterProiView protein in InterPro
IPR023082 Homeo_prospero_dom
IPR037131 Homeo_prospero_dom_sf
IPR009057 Homeobox-like_sf
IPR039350 Prospero_homeodomain
IPR007738 Prox1
PANTHERiPTHR12198 PTHR12198, 1 hit
PTHR12198:SF6 PTHR12198:SF6, 1 hit
PfamiView protein in Pfam
PF05044 HPD, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51818 HOMEO_PROSPERO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q92786-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS
60 70 80 90 100
EQDVEYSVVQ HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN
110 120 130 140 150
MNKNGGTEPS FQASGLSSTG SEVHQEDICS NSSRDSPPEC LSPFGRPTMS
160 170 180 190 200
QFDMDRLCDE HLRAKRARVE NIIRGMSHSP SVALRGNENE REMAPQSVSP
210 220 230 240 250
RESYRENKRK QKLPQQQQQS FQQLVSARKE QKREERRQLK QQLEDMQKQL
260 270 280 290 300
RQLQEKFYQI YDSTDSENDE DGNLSEDSMR SEILDARAQD SVGRSDNEMC
310 320 330 340 350
ELDPGQFIDR ARALIREQEM AENKPKREGN NKERDHGPNS LQPEGKHLAE
360 370 380 390 400
TLKQELNTAM SQVVDTVVKV FSAKPSRQVP QVFPPLQIPQ ARFAVNGENH
410 420 430 440 450
NFHTANQRLQ CFGDVIIPNP LDTFGNVQMA SSTDQTEALP LVVRKNSSDQ
460 470 480 490 500
SASGPAAGGH HQPLHQSPLS ATTGFTTSTF RHPFPLPLMA YPFQSPLGAP
510 520 530 540 550
SGSFSGKDRA SPESLDLTRD TTSLRTKMSS HHLSHHPCSP AHPPSTAEGL
560 570 580 590 600
SLSLIKSECG DLQDMSEISP YSGSAMQEGL SPNHLKKAKL MFFYTRYPSS
610 620 630 640 650
NMLKTYFSDV KFNRCITSQL IKWFSNFREF YYIQMEKYAR QAINDGVTST
660 670 680 690 700
EELSITRDCE LYRALNMHYN KANDFEVPER FLEVAQITLR EFFNAIIAGK
710 720 730
DVDPSWKKAI YKVICKLDSE VPEIFKSPNC LQELLHE
Length:737
Mass (Da):83,203
Last modified:September 13, 2005 - v2
Checksum:iD243CEB421B313CA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JU29C9JU29_HUMAN
Prospero homeobox protein 1
PROX1
230Annotation score:
U3KPY6U3KPY6_HUMAN
Prospero homeobox protein 1
PROX1
143Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251 – 253RQL → LHV in AAC50656 (PubMed:8812486).Curated3
Sequence conflicti455 – 457PAA → LV in AAC50656 (PubMed:8812486).Curated3
Sequence conflicti724I → F in AAC50656 (PubMed:8812486).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049362584H → R. Corresponds to variant dbSNP:rs12121210Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44060 mRNA Translation: AAC50656.1
AK290176 mRNA Translation: BAF82865.1
AC011700 Genomic DNA No translation available.
AL606537 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93360.1
BC024201 mRNA Translation: AAH24201.1
CCDSiCCDS31021.1
RefSeqiNP_001257545.1, NM_001270616.1
NP_002754.2, NM_002763.4
XP_016857322.1, XM_017001833.1
UniGeneiHs.741808
Hs.744931

Genome annotation databases

EnsembliENST00000261454; ENSP00000261454; ENSG00000117707
ENST00000366958; ENSP00000355925; ENSG00000117707
ENST00000435016; ENSP00000400694; ENSG00000117707
ENST00000498508; ENSP00000420283; ENSG00000117707
GeneIDi5629
KEGGihsa:5629
UCSCiuc001hkg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44060 mRNA Translation: AAC50656.1
AK290176 mRNA Translation: BAF82865.1
AC011700 Genomic DNA No translation available.
AL606537 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93360.1
BC024201 mRNA Translation: AAH24201.1
CCDSiCCDS31021.1
RefSeqiNP_001257545.1, NM_001270616.1
NP_002754.2, NM_002763.4
XP_016857322.1, XM_017001833.1
UniGeneiHs.741808
Hs.744931

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LMDNMR-A575-737[»]
ProteinModelPortaliQ92786
SMRiQ92786
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111613, 17 interactors
IntActiQ92786, 10 interactors
MINTiQ92786
STRINGi9606.ENSP00000261454

PTM databases

iPTMnetiQ92786
PhosphoSitePlusiQ92786

Polymorphism and mutation databases

DMDMi85702224

Proteomic databases

MaxQBiQ92786
PaxDbiQ92786
PeptideAtlasiQ92786
PRIDEiQ92786
ProteomicsDBi75470

Protocols and materials databases

DNASUi5629
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261454; ENSP00000261454; ENSG00000117707
ENST00000366958; ENSP00000355925; ENSG00000117707
ENST00000435016; ENSP00000400694; ENSG00000117707
ENST00000498508; ENSP00000420283; ENSG00000117707
GeneIDi5629
KEGGihsa:5629
UCSCiuc001hkg.3 human

Organism-specific databases

CTDi5629
DisGeNETi5629
EuPathDBiHostDB:ENSG00000117707.15
GeneCardsiPROX1
HGNCiHGNC:9459 PROX1
HPAiHPA000842
HPA001030
MIMi601546 gene
neXtProtiNX_Q92786
OpenTargetsiENSG00000117707
PharmGKBiPA33812
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3779 Eukaryota
ENOG410ZE21 LUCA
GeneTreeiENSGT00530000063507
HOGENOMiHOG000115708
HOVERGENiHBG053693
InParanoidiQ92786
KOiK20211
OMAiSCFMSRN
OrthoDBiEOG091G02KS
PhylomeDBiQ92786
TreeFamiTF316638

Enzyme and pathway databases

SIGNORiQ92786

Miscellaneous databases

ChiTaRSiPROX1 human
GeneWikiiPROX1
GenomeRNAii5629
PROiPR:Q92786
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117707 Expressed in 168 organ(s), highest expression level in liver
CleanExiHS_PROX1
ExpressionAtlasiQ92786 baseline and differential
GenevisibleiQ92786 HS

Family and domain databases

Gene3Di1.10.10.500, 1 hit
InterProiView protein in InterPro
IPR023082 Homeo_prospero_dom
IPR037131 Homeo_prospero_dom_sf
IPR009057 Homeobox-like_sf
IPR039350 Prospero_homeodomain
IPR007738 Prox1
PANTHERiPTHR12198 PTHR12198, 1 hit
PTHR12198:SF6 PTHR12198:SF6, 1 hit
PfamiView protein in Pfam
PF05044 HPD, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51818 HOMEO_PROSPERO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPROX1_HUMAN
AccessioniPrimary (citable) accession number: Q92786
Secondary accession number(s): A6NK29
, A8K2B1, Q5SW76, Q8TB91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 13, 2005
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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