Prospero homeobox protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate."
    Lee S., Kang J., Yoo J., Ganesan S.K., Cook S.C., Aguilar B., Ramu S., Lee J., Hong Y.K.
    Blood 113:1856-1859(2009) [PubMed] [Europe PMC] [Abstract]
• DNA binding domain binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene."
    Qin J., Gao D.M., Jiang Q.F., Zhou Q., Kong Y.Y., Wang Y., Xie Y.H.
    Mol Endocrinol 18:2424-2439(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction."
    Yamazaki T., Yoshimatsu Y., Morishita Y., Miyazono K., Watabe T.
    Genes Cells 14:425-434(2009) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue."
    Steffensen K.R., Holter E., Bavner A., Nilsson M., Pelto-Huikko M., Tomarev S., Treuter E.
    EMBO Rep 5:613-619(2004) [PubMed] [Europe PMC] [Abstract]
  • "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene."
    Qin J., Gao D.M., Jiang Q.F., Zhou Q., Kong Y.Y., Wang Y., Xie Y.H.
    Mol Endocrinol 18:2424-2439(2004) [PubMed] [Europe PMC] [Abstract]
  • "A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene."
    Song K.H., Li T., Chiang J.Y.
    J Biol Chem 281:10081-10088(2006) [PubMed] [Europe PMC] [Abstract]
  • "Prospero-related homeobox protein (Prox1) inhibits hepatitis B virus replication through repressing multiple cis regulatory elements."
    Qin J., Zhai J., Hong R., Shan S., Kong Y., Wen Y., Wang Y., Liu J., Xie Y.
    J Gen Virol 90:1246-1255(2009) [PubMed] [Europe PMC] [Abstract]
• LBD domain binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue."
    Steffensen K.R., Holter E., Bavner A., Nilsson M., Pelto-Huikko M., Tomarev S., Treuter E.
    EMBO Rep 5:613-619(2004) [PubMed] [Europe PMC] [Abstract]
  • "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene."
    Qin J., Gao D.M., Jiang Q.F., Zhou Q., Kong Y.Y., Wang Y., Xie Y.H.
    Mol Endocrinol 18:2424-2439(2004) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue."
    Steffensen K.R., Holter E., Bavner A., Nilsson M., Pelto-Huikko M., Tomarev S., Treuter E.
    EMBO Rep 5:613-619(2004) [PubMed] [Europe PMC] [Abstract]
  • "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene."
    Qin J., Gao D.M., Jiang Q.F., Zhou Q., Kong Y.Y., Wang Y., Xie Y.H.
    Mol Endocrinol 18:2424-2439(2004) [PubMed] [Europe PMC] [Abstract]
  • "A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene."
    Song K.H., Li T., Chiang J.Y.
    J Biol Chem 281:10081-10088(2006) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
• sequence-specific double-stranded DNA binding Source: ARUK-UCLInferred from direct assayⁱ
  • "Impact of cytosine methylation on DNA binding specificities of human transcription factors."
    Yin Y., Morgunova E., Jolma A., Kaasinen E., Sahu B., Khund-Sayeed S., Das P.K., Kivioja T., Dave K., Zhong F., Nitta K.R., Taipale M., Popov A., Ginno P.A., Domcke S., Yan J., Schubeler D., Vinson C., Taipale J.
    Science 356:0-0(2017) [PubMed] [Europe PMC] [Abstract]
• transcription cis-regulatory region binding Source: BHF-UCLInferred from direct assayⁱ
  • "COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction."
    Yamazaki T., Yoshimatsu Y., Morishita Y., Miyazono K., Watabe T.
    Genes Cells 14:425-434(2009) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• acinar cell differentiation Source: Ensembl
• aorta smooth muscle tissue morphogenesis Source: BHF-UCL
• atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
• brain development Source: BHF-UCL <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.1

    "Structure and chromosomal localization of the human homeobox gene Prox 1."
    Zinovieva R.D., Duncan M.K., Johnson T.R., Torres R., Polymeropoulos M.H., Tomarev S.I.
    Genomics 35:517-522(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• branching involved in pancreas morphogenesis Source: Ensembl
• cell fate determination Source: Ensembl
• cerebellar granule cell differentiation Source: BHF-UCL
• circadian rhythm Source: Ensembl
• dentate gyrus development Source: BHF-UCL
• dorsal spinal cord development Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts."
    Rodriguez-Niedenfuhr M., Papoutsi M., Christ B., Nicolaides K.H., von Kaisenberg C.S., Tomarev S.I., Wilting J.
    Anat Embryol (Berl) 204:399-406(2001) [PubMed] [Europe PMC] [Abstract]
• embryonic retina morphogenesis in camera-type eye Source: BHF-UCLInferred from expression patternⁱ
  • "Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina."
    Dyer M.A., Livesey F.J., Cepko C.L., Oliver G.
    Nat Genet 34:53-58(2003) [PubMed] [Europe PMC] [Abstract]
• endocardium formation Source: BHF-UCL
• hepatocyte cell migration Source: Ensembl
• hepatocyte differentiation Source: BHF-UCLInferred from expression patternⁱ
  • "The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium."
    Dudas J., Papoutsi M., Hecht M., Elmaouhoub A., Saile B., Christ B., Tomarev S.I., von Kaisenberg C.S., Schweigerer L., Ramadori G., Wilting J.
    Anat Embryol (Berl) 208:359-366(2004) [PubMed] [Europe PMC] [Abstract]
• hepatocyte proliferation Source: Ensembl
• kidney development Source: BHF-UCLInferred from expression patternⁱ
  • Ref.1

    "Structure and chromosomal localization of the human homeobox gene Prox 1."
    Zinovieva R.D., Duncan M.K., Johnson T.R., Torres R., Polymeropoulos M.H., Tomarev S.I.
    Genomics 35:517-522(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• lens development in camera-type eye Source: BHF-UCLInferred from expression patternⁱ
  • Ref.1

    "Structure and chromosomal localization of the human homeobox gene Prox 1."
    Zinovieva R.D., Duncan M.K., Johnson T.R., Torres R., Polymeropoulos M.H., Tomarev S.I.
    Genomics 35:517-522(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• lens fiber cell morphogenesis Source: BHF-UCLInferred from expression patternⁱ
  • "Prox1 is differentially localized during lens development."
    Duncan M.K., Cui W., Oh D.J., Tomarev S.I.
    Mech Dev 112:195-198(2002) [PubMed] [Europe PMC] [Abstract]
• lens placode formation involved in camera-type eye formation Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Prox1 is differentially localized during lens development."
    Duncan M.K., Cui W., Oh D.J., Tomarev S.I.
    Mech Dev 112:195-198(2002) [PubMed] [Europe PMC] [Abstract]
• liver development Source: BHF-UCLInferred from expression patternⁱ
  • "Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts."
    Rodriguez-Niedenfuhr M., Papoutsi M., Christ B., Nicolaides K.H., von Kaisenberg C.S., Tomarev S.I., Wilting J.
    Anat Embryol (Berl) 204:399-406(2001) [PubMed] [Europe PMC] [Abstract]
• lung development Source: BHF-UCLInferred from expression patternⁱ
  • Ref.1

    "Structure and chromosomal localization of the human homeobox gene Prox 1."
    Zinovieva R.D., Duncan M.K., Johnson T.R., Torres R., Polymeropoulos M.H., Tomarev S.I.
    Genomics 35:517-522(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• lymphangiogenesis Source: BHF-UCLInferred from direct assayⁱ
  • "Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate."
    Hong Y.K., Harvey N., Noh Y.H., Schacht V., Hirakawa S., Detmar M., Oliver G.
    Dev Dyn 225:351-357(2002) [PubMed] [Europe PMC] [Abstract]
• lymphatic endothelial cell differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor."
    Petrova T.V., Makinen T., Makela T.P., Saarela J., Virtanen I., Ferrell R.E., Finegold D.N., Kerjaschki D., Yla-Herttuala S., Alitalo K.
    EMBO J 21:4593-4599(2002) [PubMed] [Europe PMC] [Abstract]
• lymphatic endothelial cell fate commitment Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate."
    Lee S., Kang J., Yoo J., Ganesan S.K., Cook S.C., Aguilar B., Ramu S., Lee J., Hong Y.K.
    Blood 113:1856-1859(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of bile acid biosynthetic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene."
    Song K.H., Li T., Chiang J.Y.
    J Biol Chem 281:10081-10088(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma."
    Shimoda M., Takahashi M., Yoshimoto T., Kono T., Ikai I., Kubo H.
    Clin Cancer Res 12:6005-6011(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene."
    Qin J., Gao D.M., Jiang Q.F., Zhou Q., Kong Y.Y., Wang Y., Xie Y.H.
    Mol Endocrinol 18:2424-2439(2004) [PubMed] [Europe PMC] [Abstract]
  • "A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene."
    Song K.H., Li T., Chiang J.Y.
    J Biol Chem 281:10081-10088(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: BHF-UCLInferred from direct assayⁱ
  • "Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue."
    Steffensen K.R., Holter E., Bavner A., Nilsson M., Pelto-Huikko M., Tomarev S., Treuter E.
    EMBO Rep 5:613-619(2004) [PubMed] [Europe PMC] [Abstract]
  • "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene."
    Qin J., Gao D.M., Jiang Q.F., Zhou Q., Kong Y.Y., Wang Y., Xie Y.H.
    Mol Endocrinol 18:2424-2439(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene."
    Qin J., Gao D.M., Jiang Q.F., Zhou Q., Kong Y.Y., Wang Y., Xie Y.H.
    Mol Endocrinol 18:2424-2439(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of viral genome replication Source: BHF-UCLInferred from direct assayⁱ
  • "Prospero-related homeobox protein (Prox1) inhibits hepatitis B virus replication through repressing multiple cis regulatory elements."
    Qin J., Zhai J., Hong R., Shan S., Kong Y., Wen Y., Wang Y., Liu J., Xie Y.
    J Gen Virol 90:1246-1255(2009) [PubMed] [Europe PMC] [Abstract]
• neural tube development Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts."
    Rodriguez-Niedenfuhr M., Papoutsi M., Christ B., Nicolaides K.H., von Kaisenberg C.S., Tomarev S.I., Wilting J.
    Anat Embryol (Berl) 204:399-406(2001) [PubMed] [Europe PMC] [Abstract]
• neuronal stem cell population maintenance Source: BHF-UCL
• olfactory placode formation Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts."
    Rodriguez-Niedenfuhr M., Papoutsi M., Christ B., Nicolaides K.H., von Kaisenberg C.S., Tomarev S.I., Wilting J.
    Anat Embryol (Berl) 204:399-406(2001) [PubMed] [Europe PMC] [Abstract]
• otic placode formation Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts."
    Rodriguez-Niedenfuhr M., Papoutsi M., Christ B., Nicolaides K.H., von Kaisenberg C.S., Tomarev S.I., Wilting J.
    Anat Embryol (Berl) 204:399-406(2001) [PubMed] [Europe PMC] [Abstract]
• pancreas development Source: BHF-UCLInferred from expression patternⁱ
  • "Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts."
    Rodriguez-Niedenfuhr M., Papoutsi M., Christ B., Nicolaides K.H., von Kaisenberg C.S., Tomarev S.I., Wilting J.
    Anat Embryol (Berl) 204:399-406(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell cycle Source: BHF-UCL
• positive regulation of cell cycle checkpoint Source: Ensembl
• positive regulation of cell population proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor."
    Petrova T.V., Makinen T., Makela T.P., Saarela J., Virtanen I., Ferrell R.E., Finegold D.N., Kerjaschki D., Yla-Herttuala S., Alitalo K.
    EMBO J 21:4593-4599(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCLInferred from direct assayⁱ
  • "COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction."
    Yamazaki T., Yoshimatsu Y., Morishita Y., Miyazono K., Watabe T.
    Genes Cells 14:425-434(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell migration Source: BHF-UCLInferred from direct assayⁱ
  • "COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction."
    Yamazaki T., Yoshimatsu Y., Morishita Y., Miyazono K., Watabe T.
    Genes Cells 14:425-434(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction."
    Yamazaki T., Yoshimatsu Y., Morishita Y., Miyazono K., Watabe T.
    Genes Cells 14:425-434(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of forebrain neuron differentiation Source: BHF-UCL
• positive regulation of heart growth Source: BHF-UCL
• positive regulation of neural precursor cell proliferation Source: BHF-UCL
• positive regulation of sarcomere organization Source: BHF-UCL
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate."
    Lee S., Kang J., Yoo J., Ganesan S.K., Cook S.C., Aguilar B., Ramu S., Lee J., Hong Y.K.
    Blood 113:1856-1859(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of circadian rhythm Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.7

    "Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors alpha- and gamma-mediated transactivation."
    Takeda Y., Jetten A.M.
    Nucleic Acids Res. 41:6992-7008(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• regulation of gene expression Source: BHF-UCLInferred from direct assayⁱ
  • "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor."
    Petrova T.V., Makinen T., Makela T.P., Saarela J., Virtanen I., Ferrell R.E., Finegold D.N., Kerjaschki D., Yla-Herttuala S., Alitalo K.
    EMBO J 21:4593-4599(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to nutrient levels Source: Ensembl
• retina morphogenesis in camera-type eye Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts."
    Rodriguez-Niedenfuhr M., Papoutsi M., Christ B., Nicolaides K.H., von Kaisenberg C.S., Tomarev S.I., Wilting J.
    Anat Embryol (Berl) 204:399-406(2001) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle thin filament assembly Source: BHF-UCL
• venous blood vessel morphogenesis Source: BHF-UCL
• ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
• ventricular cardiac myofibril assembly Source: BHF-UCL
• ventricular septum morphogenesis Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• DNA binding domain binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene."
    Qin J., Gao D.M., Jiang Q.F., Zhou Q., Kong Y.Y., Wang Y., Xie Y.H.
    Mol Endocrinol 18:2424-2439(2004) [PubMed] [Europe PMC] [Abstract]
• LBD domain binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue."
    Steffensen K.R., Holter E., Bavner A., Nilsson M., Pelto-Huikko M., Tomarev S., Treuter E.
    EMBO Rep 5:613-619(2004) [PubMed] [Europe PMC] [Abstract]
  • "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene."
    Qin J., Gao D.M., Jiang Q.F., Zhou Q., Kong Y.Y., Wang Y., Xie Y.H.
    Mol Endocrinol 18:2424-2439(2004) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue."
    Steffensen K.R., Holter E., Bavner A., Nilsson M., Pelto-Huikko M., Tomarev S., Treuter E.
    EMBO Rep 5:613-619(2004) [PubMed] [Europe PMC] [Abstract]
  • "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene."
    Qin J., Gao D.M., Jiang Q.F., Zhou Q., Kong Y.Y., Wang Y., Xie Y.H.
    Mol Endocrinol 18:2424-2439(2004) [PubMed] [Europe PMC] [Abstract]
  • "A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene."
    Song K.H., Li T., Chiang J.Y.
    J Biol Chem 281:10081-10088(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS 
        60         70         80         90        100
EQDVEYSVVQ HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN 
       110        120        130        140        150
MNKNGGTEPS FQASGLSSTG SEVHQEDICS NSSRDSPPEC LSPFGRPTMS 
       160        170        180        190        200
QFDMDRLCDE HLRAKRARVE NIIRGMSHSP SVALRGNENE REMAPQSVSP 
       210        220        230        240        250
RESYRENKRK QKLPQQQQQS FQQLVSARKE QKREERRQLK QQLEDMQKQL 
       260        270        280        290        300
RQLQEKFYQI YDSTDSENDE DGNLSEDSMR SEILDARAQD SVGRSDNEMC 
       310        320        330        340        350
ELDPGQFIDR ARALIREQEM AENKPKREGN NKERDHGPNS LQPEGKHLAE 
       360        370        380        390        400
TLKQELNTAM SQVVDTVVKV FSAKPSRQVP QVFPPLQIPQ ARFAVNGENH 
       410        420        430        440        450
NFHTANQRLQ CFGDVIIPNP LDTFGNVQMA SSTDQTEALP LVVRKNSSDQ 
       460        470        480        490        500
SASGPAAGGH HQPLHQSPLS ATTGFTTSTF RHPFPLPLMA YPFQSPLGAP 
       510        520        530        540        550
SGSFSGKDRA SPESLDLTRD TTSLRTKMSS HHLSHHPCSP AHPPSTAEGL 
       560        570        580        590        600
SLSLIKSECG DLQDMSEISP YSGSAMQEGL SPNHLKKAKL MFFYTRYPSS 
       610        620        630        640        650
NMLKTYFSDV KFNRCITSQL IKWFSNFREF YYIQMEKYAR QAINDGVTST 
       660        670        680        690        700
EELSITRDCE LYRALNMHYN KANDFEVPER FLEVAQITLR EFFNAIIAGK 
       710        720        730 
DVDPSWKKAI YKVICKLDSE VPEIFKSPNC LQELLHE               

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
6. SIMILARITY comments
   Index of protein domains and families