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UniProtKB - Q92777 (SYN2_HUMAN)

Entry version 165 (12 Aug 2020)
Sequence version 4 (28 Mar 2018)
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Protein

Synapsin-2

Gene

SYN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).By similarity

Caution

There are several mRNAs and ESTs supporting this gene model. However, the genome sequence encoding the N-terminal part contains several sequence discrepancies.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: ParkinsonsUK-UCL
  • identical protein binding Source: Ensembl
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92777

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-181429, Serotonin Neurotransmitter Release Cycle
R-HSA-212676, Dopamine Neurotransmitter Release Cycle

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92777

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synapsin-2
Alternative name(s):
Synapsin II
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000157152.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:11495, SYN2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600755, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92777

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Schizophrenia (SCZD)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
Related information in OMIM

Keywords - Diseasei

Schizophrenia

Organism-specific databases

DisGeNET

More...DisGeNETi		6854

MalaCards human disease database

More...MalaCardsi		SYN2
MIMi181500, phenotype

Open Targets

More...OpenTargetsi		ENSG00000157152

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92777, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SYN2

Domain mapping of disease mutations (DMDM)

More...DMDMi		223634710

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001830211 – 582Synapsin-2Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10Phosphoserine; by PKA and CaMK1By similarity1
Modified residuei421PhosphothreonineBy similarity1
Modified residuei425PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92777

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92777

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92777

PeptideAtlas

More...PeptideAtlasi		Q92777

PRoteomics IDEntifications database

More...PRIDEi		Q92777

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75457 [Q92777-1]
75458 [Q92777-2]

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		Q92777

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92777

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92777

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Central and peripheral nervous systems.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157152, Expressed in middle temporal gyrus and 167 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92777, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CAPON.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112720, 14 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q92777

Protein interaction database and analysis system

More...IntActi		Q92777, 8 interactors

Molecular INTeraction database

More...MINTi		Q92777

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000480050

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92777, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92777

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29AAdd BLAST29
Regioni33 – 112B; linkerAdd BLAST80
Regioni113 – 420C; actin-binding and synaptic-vesicle bindingAdd BLAST308
Regioni421 – 457G; Pro-rich linkerAdd BLAST37
Regioni458 – 533H; Pro/Ser-rich linkerAdd BLAST76
Regioni534 – 582EAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 42Poly-Pro9
Compositional biasi486 – 496Poly-SerAdd BLAST11
Compositional biasi512 – 516Poly-Ser5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synapsin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3895, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156062

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92777

KEGG Orthology (KO)

More...KOi		K19941

Identification of Orthologs from Complete Genome Data

More...OMAi		HADWAKC

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92777

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1490.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013815, ATP_grasp_subdomain_1
IPR016185, PreATP-grasp_dom_sf
IPR028712, SYN2/3
IPR001359, Synapsin
IPR020898, Synapsin_ATP-bd_dom
IPR019735, Synapsin_CS
IPR019736, Synapsin_P_site
IPR020897, Synapsin_pre-ATP-grasp_dom

The PANTHER Classification System

More...PANTHERi		PTHR10841:SF20, PTHR10841:SF20, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02078, Synapsin, 1 hit
PF02750, Synapsin_C, 1 hit
PF10581, Synapsin_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01368, SYNAPSIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52440, SSF52440, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00415, SYNAPSIN_1, 1 hit
PS00416, SYNAPSIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform IIa (identifier: Q92777-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPPPPP GPGAASASAA 
        60         70         80         90        100
PPTASPGPER RPPPASAPAP QPAPTPSVGS SFFSSLSQAV KQTAASAGLV 
       110        120        130        140        150
DAPAPAPAAA RKAKVLLVVD EPHADWAKCF RGKKVLGDYD IKVEQAEFSE 
       160        170        180        190        200
LNLVAHADGT YAVDMQVLRN GTKVVRSFRP DFVLIRQHAF GMAENEDFRH 
       210        220        230        240        250
LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG GEKFPLIEQT 
       260        270        280        290        300
YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT 
       310        320        330        340        350
YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS 
       360        370        380        390        400
DRYKLWVDTC SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV 
       410        420        430        440        450
EDRQLITELV ISKMNQLLSR TPALSPQRPL TTQQPQSGTL KDPDSSKTPP 
       460        470        480        490        500
QRPPPQGGPG QPQGMQPPGK VLPPRRLPPG PSLPPSSSSS SSSSSSAPQR 
       510        520        530        540        550
PGGPTTHGDA PSSSSSLAEA QPPLAAPPQK PQPHPQLNKS QSLTNAFSFS 
       560        570        580 
ESSFFRSSAN EDEAKAETIR SLRKSFASLF SD
Length:582
Mass (Da):62,996
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1EB4EC12FF090329
GO
Isoform IIb (identifier: Q92777-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-478: GPGQPQGMQPPGKVLPPRRLP → CLQYILDCNGIAVGPKQVQAS
     479-582: Missing.

Show »
Length:478
Mass (Da):52,311
Checksum:i7EEAB4DD2A95A374
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WW91A0A087WW91_HUMAN
Synapsin-2
SYN2
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AC022234 differs from that shown. Several in-frame stop codons.Curated
The sequence AC022234 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61R → K in AAC28368 (PubMed:10565545).Curated1
Sequence conflicti61R → K in AAC33789 (PubMed:10565545).Curated1
Sequence conflicti70P → A in AAC50718 (PubMed:8964517).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059825506T → A. Corresponds to variant dbSNP:rs794999Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006320458 – 478GPGQP…PRRLP → CLQYILDCNGIAVGPKQVQA S in isoform IIb. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_006321479 – 582Missing in isoform IIb. 2 PublicationsAdd BLAST104

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U40215 mRNA Translation: AAC50718.1
AF077671 mRNA Translation: AAC28368.1
AF077737 mRNA Translation: AAC33789.1
ABBA01025208 Genomic DNA No translation available.
AC022234 Genomic DNA No translation available.
AC026166 Genomic DNA No translation available.
AC091492 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS74900.1 [Q92777-1]
CCDS74901.1 [Q92777-2]

NCBI Reference Sequences

More...RefSeqi		NP_003169.2, NM_003178.5 [Q92777-2]
NP_598328.1, NM_133625.4 [Q92777-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000620175; ENSP00000484916; ENSG00000157152 [Q92777-2]
ENST00000621198; ENSP00000480050; ENSG00000157152 [Q92777-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6854

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6854

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40215 mRNA Translation: AAC50718.1
AF077671 mRNA Translation: AAC28368.1
AF077737 mRNA Translation: AAC33789.1
ABBA01025208 Genomic DNA No translation available.
AC022234 Genomic DNA No translation available.
AC026166 Genomic DNA No translation available.
AC091492 Genomic DNA No translation available.
CCDSiCCDS74900.1 [Q92777-1]
CCDS74901.1 [Q92777-2]
RefSeqiNP_003169.2, NM_003178.5 [Q92777-2]
NP_598328.1, NM_133625.4 [Q92777-1]

3D structure databases

SMRiQ92777
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112720, 14 interactors
CORUMiQ92777
IntActiQ92777, 8 interactors
MINTiQ92777
STRINGi9606.ENSP00000480050

PTM databases

iPTMnetiQ92777
PhosphoSitePlusiQ92777

Polymorphism and mutation databases

BioMutaiSYN2
DMDMi223634710

2D gel databases

UCD-2DPAGEiQ92777

Proteomic databases

EPDiQ92777
jPOSTiQ92777
MassIVEiQ92777
PeptideAtlasiQ92777
PRIDEiQ92777
ProteomicsDBi75457 [Q92777-1]
75458 [Q92777-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4054, 107 antibodies

Genome annotation databases

EnsembliENST00000620175; ENSP00000484916; ENSG00000157152 [Q92777-2]
ENST00000621198; ENSP00000480050; ENSG00000157152 [Q92777-1]
GeneIDi6854
KEGGihsa:6854

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6854
DisGeNETi6854
EuPathDBiHostDB:ENSG00000157152.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		SYN2
HGNCiHGNC:11495, SYN2
MalaCardsiSYN2
MIMi181500, phenotype
600755, gene
neXtProtiNX_Q92777
OpenTargetsiENSG00000157152

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3895, Eukaryota
GeneTreeiENSGT00940000156062
InParanoidiQ92777
KOiK19941
OMAiHADWAKC
PhylomeDBiQ92777

Enzyme and pathway databases

PathwayCommonsiQ92777
ReactomeiR-HSA-181429, Serotonin Neurotransmitter Release Cycle
R-HSA-212676, Dopamine Neurotransmitter Release Cycle
SIGNORiQ92777

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6854, 3 hits in 95 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SYN2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6854
PharosiQ92777, Tbio

Protein Ontology

More...PROi		PR:Q92777
RNActiQ92777, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000157152, Expressed in middle temporal gyrus and 167 other tissues
ExpressionAtlasiQ92777, baseline and differential

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815, ATP_grasp_subdomain_1
IPR016185, PreATP-grasp_dom_sf
IPR028712, SYN2/3
IPR001359, Synapsin
IPR020898, Synapsin_ATP-bd_dom
IPR019735, Synapsin_CS
IPR019736, Synapsin_P_site
IPR020897, Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841:SF20, PTHR10841:SF20, 1 hit
PfamiView protein in Pfam
PF02078, Synapsin, 1 hit
PF02750, Synapsin_C, 1 hit
PF10581, Synapsin_N, 1 hit
PRINTSiPR01368, SYNAPSIN
SUPFAMiSSF52440, SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS00415, SYNAPSIN_1, 1 hit
PS00416, SYNAPSIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYN2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92777
Secondary accession number(s): A0A087WW96, A0A087X2E3, A8MY98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 28, 2018
Last modified: August 12, 2020
This is version 165 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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