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Protein

Synapsin-2

Gene

SYN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).By similarity

Caution

There are several mRNAs and ESTs supporting this gene model. However, the genome sequence encoding the N-terminal part contains several sequence discrepancies.Curated

GO - Molecular functioni

  • ATP binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • neurotransmitter secretion Source: ParkinsonsUK-UCL

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
SIGNORiQ92777

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin-2
Alternative name(s):
Synapsin II
Gene namesi
Name:SYN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000157152.16
HGNCiHGNC:11495 SYN2
MIMi600755 gene
neXtProtiNX_Q92777

Subcellular locationi

Keywords - Cellular componenti

Cell junction, Synapse

Pathology & Biotechi

Involvement in diseasei

Schizophrenia (SCZD)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
See also OMIM:181500

Keywords - Diseasei

Schizophrenia

Organism-specific databases

DisGeNETi6854
MalaCardsiSYN2
MIMi181500 phenotype
OpenTargetsiENSG00000157152

Polymorphism and mutation databases

DMDMi223634710

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830211 – 582Synapsin-2Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Phosphoserine; by PKA and CaMK1By similarity1
Modified residuei421PhosphothreonineBy similarity1
Modified residuei425PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92777
PeptideAtlasiQ92777
PRIDEiQ92777
ProteomicsDBi75457
75458 [Q92777-2]

2D gel databases

UCD-2DPAGEiQ92777

PTM databases

iPTMnetiQ92777
PhosphoSitePlusiQ92777

Expressioni

Tissue specificityi

Central and peripheral nervous systems.

Gene expression databases

BgeeiENSG00000157152
CleanExiHS_SYN2

Organism-specific databases

HPAiHPA037012

Interactioni

Subunit structurei

Interacts with CAPON.By similarity

Protein-protein interaction databases

BioGridi112720, 14 interactors
CORUMiQ92777
IntActiQ92777, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ92777
SMRiQ92777
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29AAdd BLAST29
Regioni33 – 112B; linkerAdd BLAST80
Regioni113 – 420C; actin-binding and synaptic-vesicle bindingAdd BLAST308
Regioni421 – 457G; Pro-rich linkerAdd BLAST37
Regioni458 – 533H; Pro/Ser-rich linkerAdd BLAST76
Regioni534 – 582EAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 42Poly-Pro9
Compositional biasi486 – 496Poly-SerAdd BLAST11
Compositional biasi512 – 516Poly-Ser5

Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesi

Belongs to the synapsin family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000063319
HOVERGENiHBG016354
InParanoidiQ92777
KOiK19941
OMAiDWAKCFR
OrthoDBiEOG091G0BZ1
PhylomeDBiQ92777

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR019735 Synapsin_CS
IPR019736 Synapsin_P_site
IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841 PTHR10841, 1 hit
PfamiView protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PF10581 Synapsin_N, 1 hit
PRINTSiPR01368 SYNAPSIN
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS00415 SYNAPSIN_1, 1 hit
PS00416 SYNAPSIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform IIa (identifier: Q92777-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPPPPP GPGAASASAA
60 70 80 90 100
PPTASPGPER RPPPASAPAP QPAPTPSVGS SFFSSLSQAV KQTAASAGLV
110 120 130 140 150
DAPAPAPAAA RKAKVLLVVD EPHADWAKCF RGKKVLGDYD IKVEQAEFSE
160 170 180 190 200
LNLVAHADGT YAVDMQVLRN GTKVVRSFRP DFVLIRQHAF GMAENEDFRH
210 220 230 240 250
LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG GEKFPLIEQT
260 270 280 290 300
YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT
310 320 330 340 350
YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS
360 370 380 390 400
DRYKLWVDTC SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV
410 420 430 440 450
EDRQLITELV ISKMNQLLSR TPALSPQRPL TTQQPQSGTL KDPDSSKTPP
460 470 480 490 500
QRPPPQGGPG QPQGMQPPGK VLPPRRLPPG PSLPPSSSSS SSSSSSAPQR
510 520 530 540 550
PGGPTTHGDA PSSSSSLAEA QPPLAAPPQK PQPHPQLNKS QSLTNAFSFS
560 570 580
ESSFFRSSAN EDEAKAETIR SLRKSFASLF SD
Length:582
Mass (Da):62,996
Last modified:March 28, 2018 - v4
Checksum:i1EB4EC12FF090329
GO
Isoform IIb (identifier: Q92777-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-478: GPGQPQGMQPPGKVLPPRRLP → CLQYILDCNGIAVGPKQVQAS
     479-582: Missing.

Show »
Length:478
Mass (Da):52,311
Checksum:i7EEAB4DD2A95A374
GO

Sequence cautioni

The sequence AC022234 differs from that shown. Several in-frame stop codons.Curated
The sequence AC022234 differs from that shown. Reason: Frameshift at position 71.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61R → K in AAC28368 (PubMed:10565545).Curated1
Sequence conflicti61R → K in AAC33789 (PubMed:10565545).Curated1
Sequence conflicti70P → A in AAC50718 (PubMed:8964517).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059825506T → A. Corresponds to variant dbSNP:rs794999Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006320458 – 478GPGQP…PRRLP → CLQYILDCNGIAVGPKQVQA S in isoform IIb. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_006321479 – 582Missing in isoform IIb. 2 PublicationsAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40215 mRNA Translation: AAC50718.1
AF077671 mRNA Translation: AAC28368.1
AF077737 mRNA Translation: AAC33789.1
ABBA01025208 Genomic DNA No translation available.
AC022234 Genomic DNA No translation available.
AC026166 Genomic DNA No translation available.
AC091492 Genomic DNA No translation available.
CCDSiCCDS74900.1 [Q92777-1]
CCDS74901.1 [Q92777-2]
RefSeqiNP_003169.2, NM_003178.5 [Q92777-2]
NP_598328.1, NM_133625.4 [Q92777-1]
UniGeneiHs.445503

Genome annotation databases

EnsembliENST00000620175; ENSP00000484916; ENSG00000157152 [Q92777-2]
ENST00000621198; ENSP00000480050; ENSG00000157152 [Q92777-1]
GeneIDi6854
KEGGihsa:6854

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSYN2_HUMAN
AccessioniPrimary (citable) accession number: Q92777
Secondary accession number(s): A0A087WW96, A0A087X2E3, A8MY98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 148 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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