UniProtKB - Q92777 (SYN2_HUMAN)
Synapsin-2
SYN2
Functioni
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).
By similarityCaution
GO - Molecular functioni
- ATP binding Source: ParkinsonsUK-UCL
- identical protein binding Source: Ensembl
GO - Biological processi
- calcium-ion regulated exocytosis Source: Ensembl
- chemical synaptic transmission Source: ProtInc
- neurotransmitter secretion Source: ParkinsonsUK-UCL
- synaptic vesicle clustering Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q92777 |
Reactomei | R-HSA-181429, Serotonin Neurotransmitter Release Cycle R-HSA-212676, Dopamine Neurotransmitter Release Cycle |
SignaLinki | Q92777 |
SIGNORi | Q92777 |
Names & Taxonomyi
Protein namesi | Recommended name: Synapsin-2Alternative name(s): Synapsin II |
Gene namesi | Name:SYN2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11495, SYN2 |
MIMi | 600755, gene |
neXtProti | NX_Q92777 |
VEuPathDBi | HostDB:ENSG00000157152 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- glutamatergic synapse Source: Ensembl
- postsynaptic density Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
- SNARE complex Source: Ensembl
- synapse Source: ParkinsonsUK-UCL
- synaptic vesicle membrane Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
Cell junction, SynapsePathology & Biotechi
Involvement in diseasei
Schizophrenia (SCZD)1 Publication
Keywords - Diseasei
SchizophreniaOrganism-specific databases
DisGeNETi | 6854 |
MalaCardsi | SYN2 |
MIMi | 181500, phenotype |
OpenTargetsi | ENSG00000157152 |
Miscellaneous databases
Pharosi | Q92777, Tbio |
Genetic variation databases
BioMutai | SYN2 |
DMDMi | 223634710 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183021 | 1 – 582 | Synapsin-2Add BLAST | 582 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | Phosphoserine; by PKA and CaMK1By similarity | 1 | |
Modified residuei | 421 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 425 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q92777 |
jPOSTi | Q92777 |
MassIVEi | Q92777 |
PeptideAtlasi | Q92777 |
PRIDEi | Q92777 |
ProteomicsDBi | 75457 [Q92777-1] 75458 [Q92777-2] |
2D gel databases
UCD-2DPAGEi | Q92777 |
PTM databases
GlyGeni | Q92777, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q92777 |
PhosphoSitePlusi | Q92777 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000157152, Expressed in middle temporal gyrus and 168 other tissues |
ExpressionAtlasi | Q92777, baseline and differential |
Organism-specific databases
HPAi | ENSG00000157152, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with CAPON.
By similarityGO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112720, 19 interactors |
CORUMi | Q92777 |
IntActi | Q92777, 8 interactors |
MINTi | Q92777 |
STRINGi | 9606.ENSP00000480050 |
Miscellaneous databases
RNActi | Q92777, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | AAdd BLAST | 29 | |
Regioni | 16 – 84 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 33 – 112 | B; linkerAdd BLAST | 80 | |
Regioni | 113 – 420 | C; actin-binding and synaptic-vesicle bindingAdd BLAST | 308 | |
Regioni | 420 – 545 | DisorderedSequence analysisAdd BLAST | 126 | |
Regioni | 421 – 457 | G; Pro-rich linkerAdd BLAST | 37 | |
Regioni | 458 – 533 | H; Pro/Ser-rich linkerAdd BLAST | 76 | |
Regioni | 534 – 582 | EAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 29 – 46 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 55 – 75 | Pro residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 420 – 446 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 447 – 485 | Pro residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 486 – 520 | Polar residuesSequence analysisAdd BLAST | 35 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3895, Eukaryota |
GeneTreei | ENSGT00940000156062 |
InParanoidi | Q92777 |
OMAi | CCEIFGG |
PhylomeDBi | Q92777 |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR013815, ATP_grasp_subdomain_1 IPR016185, PreATP-grasp_dom_sf IPR028712, SYN2/3 IPR001359, Synapsin IPR020898, Synapsin_ATP-bd_dom IPR019735, Synapsin_CS IPR019736, Synapsin_P_site IPR020897, Synapsin_pre-ATP-grasp_dom |
PANTHERi | PTHR10841:SF20, PTHR10841:SF20, 1 hit |
Pfami | View protein in Pfam PF02078, Synapsin, 1 hit PF02750, Synapsin_C, 1 hit PF10581, Synapsin_N, 1 hit |
PRINTSi | PR01368, SYNAPSIN |
SUPFAMi | SSF52440, SSF52440, 1 hit |
PROSITEi | View protein in PROSITE PS00415, SYNAPSIN_1, 1 hit PS00416, SYNAPSIN_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPPPPP GPGAASASAA
60 70 80 90 100
PPTASPGPER RPPPASAPAP QPAPTPSVGS SFFSSLSQAV KQTAASAGLV
110 120 130 140 150
DAPAPAPAAA RKAKVLLVVD EPHADWAKCF RGKKVLGDYD IKVEQAEFSE
160 170 180 190 200
LNLVAHADGT YAVDMQVLRN GTKVVRSFRP DFVLIRQHAF GMAENEDFRH
210 220 230 240 250
LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG GEKFPLIEQT
260 270 280 290 300
YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT
310 320 330 340 350
YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS
360 370 380 390 400
DRYKLWVDTC SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV
410 420 430 440 450
EDRQLITELV ISKMNQLLSR TPALSPQRPL TTQQPQSGTL KDPDSSKTPP
460 470 480 490 500
QRPPPQGGPG QPQGMQPPGK VLPPRRLPPG PSLPPSSSSS SSSSSSAPQR
510 520 530 540 550
PGGPTTHGDA PSSSSSLAEA QPPLAAPPQK PQPHPQLNKS QSLTNAFSFS
560 570 580
ESSFFRSSAN EDEAKAETIR SLRKSFASLF SD
The sequence of this isoform differs from the canonical sequence as follows:
458-478: GPGQPQGMQPPGKVLPPRRLP → CLQYILDCNGIAVGPKQVQAS
479-582: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WW91 | A0A087WW91_HUMAN | Synapsin-2 | SYN2 | 221 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 | R → K in AAC28368 (PubMed:10565545).Curated | 1 | |
Sequence conflicti | 61 | R → K in AAC33789 (PubMed:10565545).Curated | 1 | |
Sequence conflicti | 70 | P → A in AAC50718 (PubMed:8964517).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059825 | 506 | T → A. Corresponds to variant dbSNP:rs794999Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006320 | 458 – 478 | GPGQP…PRRLP → CLQYILDCNGIAVGPKQVQA S in isoform IIb. 2 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_006321 | 479 – 582 | Missing in isoform IIb. 2 PublicationsAdd BLAST | 104 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40215 mRNA Translation: AAC50718.1 AF077671 mRNA Translation: AAC28368.1 AF077737 mRNA Translation: AAC33789.1 ABBA01025208 Genomic DNA No translation available. AC022234 Genomic DNA No translation available. AC026166 Genomic DNA No translation available. AC091492 Genomic DNA No translation available. |
CCDSi | CCDS74900.1 [Q92777-1] CCDS74901.1 [Q92777-2] |
RefSeqi | NP_003169.2, NM_003178.5 [Q92777-2] NP_598328.1, NM_133625.4 [Q92777-1] |
Genome annotation databases
Ensembli | ENST00000620175.4; ENSP00000484916.1; ENSG00000157152.17 [Q92777-2] ENST00000621198.5; ENSP00000480050.1; ENSG00000157152.17 |
GeneIDi | 6854 |
KEGGi | hsa:6854 |
MANE-Selecti | ENST00000621198.5; ENSP00000480050.1; NM_133625.6; NP_598328.1 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40215 mRNA Translation: AAC50718.1 AF077671 mRNA Translation: AAC28368.1 AF077737 mRNA Translation: AAC33789.1 ABBA01025208 Genomic DNA No translation available. AC022234 Genomic DNA No translation available. AC026166 Genomic DNA No translation available. AC091492 Genomic DNA No translation available. |
CCDSi | CCDS74900.1 [Q92777-1] CCDS74901.1 [Q92777-2] |
RefSeqi | NP_003169.2, NM_003178.5 [Q92777-2] NP_598328.1, NM_133625.4 [Q92777-1] |
3D structure databases
AlphaFoldDBi | Q92777 |
SMRi | Q92777 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112720, 19 interactors |
CORUMi | Q92777 |
IntActi | Q92777, 8 interactors |
MINTi | Q92777 |
STRINGi | 9606.ENSP00000480050 |
PTM databases
GlyGeni | Q92777, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q92777 |
PhosphoSitePlusi | Q92777 |
Genetic variation databases
BioMutai | SYN2 |
DMDMi | 223634710 |
2D gel databases
UCD-2DPAGEi | Q92777 |
Proteomic databases
EPDi | Q92777 |
jPOSTi | Q92777 |
MassIVEi | Q92777 |
PeptideAtlasi | Q92777 |
PRIDEi | Q92777 |
ProteomicsDBi | 75457 [Q92777-1] 75458 [Q92777-2] |
Protocols and materials databases
ABCDi | Q92777, 1 sequenced antibody |
Antibodypediai | 4054, 118 antibodies from 28 providers |
DNASUi | 6854 |
Genome annotation databases
Ensembli | ENST00000620175.4; ENSP00000484916.1; ENSG00000157152.17 [Q92777-2] ENST00000621198.5; ENSP00000480050.1; ENSG00000157152.17 |
GeneIDi | 6854 |
KEGGi | hsa:6854 |
MANE-Selecti | ENST00000621198.5; ENSP00000480050.1; NM_133625.6; NP_598328.1 |
Organism-specific databases
CTDi | 6854 |
DisGeNETi | 6854 |
GeneCardsi | SYN2 |
HGNCi | HGNC:11495, SYN2 |
HPAi | ENSG00000157152, Tissue enriched (brain) |
MalaCardsi | SYN2 |
MIMi | 181500, phenotype 600755, gene |
neXtProti | NX_Q92777 |
OpenTargetsi | ENSG00000157152 |
VEuPathDBi | HostDB:ENSG00000157152 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3895, Eukaryota |
GeneTreei | ENSGT00940000156062 |
InParanoidi | Q92777 |
OMAi | CCEIFGG |
PhylomeDBi | Q92777 |
Enzyme and pathway databases
PathwayCommonsi | Q92777 |
Reactomei | R-HSA-181429, Serotonin Neurotransmitter Release Cycle R-HSA-212676, Dopamine Neurotransmitter Release Cycle |
SignaLinki | Q92777 |
SIGNORi | Q92777 |
Miscellaneous databases
BioGRID-ORCSi | 6854, 10 hits in 228 CRISPR screens |
ChiTaRSi | SYN2, human |
GenomeRNAii | 6854 |
Pharosi | Q92777, Tbio |
PROi | PR:Q92777 |
RNActi | Q92777, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157152, Expressed in middle temporal gyrus and 168 other tissues |
ExpressionAtlasi | Q92777, baseline and differential |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR013815, ATP_grasp_subdomain_1 IPR016185, PreATP-grasp_dom_sf IPR028712, SYN2/3 IPR001359, Synapsin IPR020898, Synapsin_ATP-bd_dom IPR019735, Synapsin_CS IPR019736, Synapsin_P_site IPR020897, Synapsin_pre-ATP-grasp_dom |
PANTHERi | PTHR10841:SF20, PTHR10841:SF20, 1 hit |
Pfami | View protein in Pfam PF02078, Synapsin, 1 hit PF02750, Synapsin_C, 1 hit PF10581, Synapsin_N, 1 hit |
PRINTSi | PR01368, SYNAPSIN |
SUPFAMi | SSF52440, SSF52440, 1 hit |
PROSITEi | View protein in PROSITE PS00415, SYNAPSIN_1, 1 hit PS00416, SYNAPSIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYN2_HUMAN | |
Accessioni | Q92777Primary (citable) accession number: Q92777 Secondary accession number(s): A0A087WW96, A0A087X2E3, A8MY98 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | March 28, 2018 | |
Last modified: | May 25, 2022 | |
This is version 173 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families