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Protein

Cyclin-dependent kinase-like 2

Gene

CDKL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • protein kinase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ92772

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 2Curated (EC:2.7.11.22)
Alternative name(s):
Protein kinase p56 KKIAMRE1 Publication
Serine/threonine-protein kinase KKIAMRE
Gene namesi
Name:CDKL2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138769.10
HGNCiHGNC:1782 CDKL2
MIMi603442 gene
neXtProtiNX_Q92772

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8999
OpenTargetsiENSG00000138769
PharmGKBiPA26318

Chemistry databases

ChEMBLiCHEMBL5728

Polymorphism and mutation databases

BioMutaiCDKL2
DMDMi74762639

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858141 – 493Cyclin-dependent kinase-like 2Add BLAST493

Proteomic databases

EPDiQ92772
MaxQBiQ92772
PaxDbiQ92772
PeptideAtlasiQ92772
PRIDEiQ92772
ProteomicsDBi75456

PTM databases

iPTMnetiQ92772
PhosphoSitePlusiQ92772

Expressioni

Tissue specificityi

Expressed in testis and kidney, and at lower level in brain and lung.1 Publication

Gene expression databases

BgeeiENSG00000138769 Expressed in 98 organ(s), highest expression level in testis
CleanExiHS_CDKL2
ExpressionAtlasiQ92772 baseline and differential
GenevisibleiQ92772 HS

Organism-specific databases

HPAiHPA040672

Interactioni

Protein-protein interaction databases

BioGridi114479, 7 interactors
IntActiQ92772, 2 interactors
STRINGi9606.ENSP00000412365

Chemistry databases

BindingDBiQ92772

Structurei

Secondary structure

1493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92772
SMRiQ92772
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 287Protein kinasePROSITE-ProRule annotationAdd BLAST284

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0593 Eukaryota
ENOG410XNSW LUCA
GeneTreeiENSGT00830000128262
HOVERGENiHBG080204
InParanoidiQ92772
KOiK08824
PhylomeDBiQ92772
TreeFamiTF101031

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q92772-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKYENLGLV GEGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR
60 70 80 90 100
EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY
110 120 130 140 150
QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART
160 170 180 190 200
LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDVWAIGC LVTEMFMGEP
210 220 230 240 250
LFPGDSDIDQ LYHIMMCLGN LIPRHQELFN KNPVFAGVRL PEIKEREPLE
260 270 280 290 300
RRYPKLSEVV IDLAKKCLHI DPDKRPFCAE LLHHDFFQMD GFAERFSQEL
310 320 330 340 350
QLKVQKDARN VSLSKKSQNR KKEKEKDDSL VEERKTLVVQ DTNADPKIKD
360 370 380 390 400
YKLFKIKGSK IDGEKAEKGN RASNASCLHD SRTSHNKIVP STSLKDCSNV
410 420 430 440 450
SVDHTRNPSV AIPPLTHNLS AVAPSINSGM GTETIPIQGY RVDEKTKKCS
460 470 480 490
IPFVKPNRHS PSGIYNINVT TLVSGPPLSD DSGADLPQME HQH
Length:493
Mass (Da):56,019
Last modified:February 1, 1997 - v1
Checksum:i5CC20A91CBF89EFE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNE8J3KNE8_HUMAN
Cyclin-dependent kinase-like 2
CDKL2
570Annotation score:
D6RBJ5D6RBJ5_HUMAN
Cyclin-dependent kinase-like 2
CDKL2
58Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05392877Y → S. Corresponds to variant dbSNP:rs35921414Ensembl.1
Natural variantiVAR_04198798L → I in an ovarian papillary serous adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_053929132I → T. Corresponds to variant dbSNP:rs17000707Ensembl.1
Natural variantiVAR_041988149R → Q in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs755711267Ensembl.1
Natural variantiVAR_041989197M → T1 PublicationCorresponds to variant dbSNP:rs56343717Ensembl.1
Natural variantiVAR_041990411A → V1 PublicationCorresponds to variant dbSNP:rs56231363Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35146 mRNA Translation: AAC50918.1
AK312490 mRNA Translation: BAG35392.1
CH471057 Genomic DNA Translation: EAX05740.1
BC093646 mRNA Translation: AAH93646.1
BC093981 mRNA Translation: AAH93981.1
CCDSiCCDS3570.1
RefSeqiNP_001317653.1, NM_001330724.1
NP_003939.1, NM_003948.4
XP_016864299.1, XM_017008810.1
UniGeneiHs.591698

Genome annotation databases

EnsembliENST00000429927; ENSP00000412365; ENSG00000138769
GeneIDi8999
KEGGihsa:8999
UCSCiuc003hiq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35146 mRNA Translation: AAC50918.1
AK312490 mRNA Translation: BAG35392.1
CH471057 Genomic DNA Translation: EAX05740.1
BC093646 mRNA Translation: AAH93646.1
BC093981 mRNA Translation: AAH93981.1
CCDSiCCDS3570.1
RefSeqiNP_001317653.1, NM_001330724.1
NP_003939.1, NM_003948.4
XP_016864299.1, XM_017008810.1
UniGeneiHs.591698

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AAAX-ray1.53A1-308[»]
4BBMX-ray2.00A/B1-308[»]
ProteinModelPortaliQ92772
SMRiQ92772
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114479, 7 interactors
IntActiQ92772, 2 interactors
STRINGi9606.ENSP00000412365

Chemistry databases

BindingDBiQ92772
ChEMBLiCHEMBL5728

PTM databases

iPTMnetiQ92772
PhosphoSitePlusiQ92772

Polymorphism and mutation databases

BioMutaiCDKL2
DMDMi74762639

Proteomic databases

EPDiQ92772
MaxQBiQ92772
PaxDbiQ92772
PeptideAtlasiQ92772
PRIDEiQ92772
ProteomicsDBi75456

Protocols and materials databases

DNASUi8999
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000429927; ENSP00000412365; ENSG00000138769
GeneIDi8999
KEGGihsa:8999
UCSCiuc003hiq.4 human

Organism-specific databases

CTDi8999
DisGeNETi8999
EuPathDBiHostDB:ENSG00000138769.10
GeneCardsiCDKL2
HGNCiHGNC:1782 CDKL2
HPAiHPA040672
MIMi603442 gene
neXtProtiNX_Q92772
OpenTargetsiENSG00000138769
PharmGKBiPA26318
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0593 Eukaryota
ENOG410XNSW LUCA
GeneTreeiENSGT00830000128262
HOVERGENiHBG080204
InParanoidiQ92772
KOiK08824
PhylomeDBiQ92772
TreeFamiTF101031

Enzyme and pathway databases

SignaLinkiQ92772

Miscellaneous databases

ChiTaRSiCDKL2 human
GeneWikiiCDKL2
GenomeRNAii8999
PROiPR:Q92772
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138769 Expressed in 98 organ(s), highest expression level in testis
CleanExiHS_CDKL2
ExpressionAtlasiQ92772 baseline and differential
GenevisibleiQ92772 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDKL2_HUMAN
AccessioniPrimary (citable) accession number: Q92772
Secondary accession number(s): B2R695
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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